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However, whether dopamine receptor activation can influence GABA neuron migration is not known. We show that dopamine D<jats:sub>1<\/jats:sub>receptor activation promotes and D<jats:sub>2<\/jats:sub>receptor activation decreases GABA neuron migration from the medial and caudal ganglionic eminences to the cerebral cortex in slice preparations of embryonic mouse forebrain. Slice preparations from D<jats:sub>1<\/jats:sub>or D<jats:sub>2<\/jats:sub>receptor knock-out mouse embryos confirm the findings. In addition, D<jats:sub>1<\/jats:sub>receptor electroporation into cells of the basal forebrain and pharmacological activation of the receptor promote migration of the electroporated cells to the cerebral cortex. Analysis of GABA neuron numbers in the cerebral wall of the dopamine receptor knock-out mouse embryos further confirmed the effects of dopamine receptor activation on GABA neuron migration. Finally, dopamine receptor activation mobilizes striatal neuronal cytoskeleton in a manner consistent with the effects on neuronal migration. These data show that impairing the physiological balance between D<jats:sub>1<\/jats:sub>and D<jats:sub>2<\/jats:sub>receptors can alter GABA neuron migration from the basal forebrain to the cerebral cortex. The intimate relationship between dopamine and GABA neuron development revealed here may offer novel insights into developmental disorders such as schizophrenia, attention deficit or autism, and fetal cocaine exposure, all of which are associated with dopamine and GABA imbalance.<\/jats:p>","DOI":"10.1523\/jneurosci.5124-06.2007","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T17:02:44Z","timestamp":1175706164000},"page":"3813-3822","source":"Crossref","is-referenced-by-count":119,"title":["Dopamine Receptor Activation Modulates GABA Neuron Migration from the Basal Forebrain to the Cerebral Cortex"],"prefix":"10.1523","volume":"27","author":[{"given":"James E.","family":"Crandall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi 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