{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:49:58Z","timestamp":1790430598120,"version":"4.1.0"},"reference-count":28,"publisher":"Society for Neuroscience","issue":"5","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2009,2,4]]},"abstract":"<jats:p>Narcolepsy is a human sleep disorder resulting from the loss of neurons containing the neuropeptide orexin, also known as hypocretin. Cataplexy, which is a sudden loss of muscle tone during waking, is an important diagnostic symptom of narcolepsy. In humans and canines with narcolepsy, cataplexy is considered to be a separate and distinct behavioral state. However, in the mouse model of the disease this issue is not resolved. The present study monitored the activity of forty four neurons in the rostral pons in hypocretin knock-out mice. Majority of the neurons were active during wake and REM sleep, while four neurons were selectively active during REM sleep. All of these neurons were less active during cataplexy compared with REM sleep. Thus, although cataplexy and REM sleep share many common features, including the muscle atonia, cataplexy is a distinct state in mice.<\/jats:p>","DOI":"10.1523\/jneurosci.5151-08.2009","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T18:33:35Z","timestamp":1233772415000},"page":"1580-1585","source":"Crossref","is-referenced-by-count":21,"title":["Activity of Pontine Neurons during Sleep and Cataplexy in Hypocretin Knock-Out Mice"],"prefix":"10.1523","volume":"29","author":[{"given":"Stephen","family":"Thankachan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyattam J.","family":"Shiromani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"2023041303363421000_29.5.1580.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5023-07.2008"},{"key":"2023041303363421000_29.5.1580.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81973-X"},{"key":"2023041303363421000_29.5.1580.3","unstructured":"Franklin KBJ Paxinos G (1997) The mouse brain in stereotaxic coordinates (Academic, San Diego)."},{"key":"2023041303363421000_29.5.1580.4","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1523\/JNEUROSCI.21-18-07273.2001","article-title":"Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat","volume":"21","author":"Gerashchenko","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303363421000_29.5.1580.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00089-1"},{"key":"2023041303363421000_29.5.1580.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00293-8"},{"key":"2023041303363421000_29.5.1580.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00247-8"},{"key":"2023041303363421000_29.5.1580.8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90632-J"},{"key":"2023041303363421000_29.5.1580.9","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1523\/JNEUROSCI.23-04-01548.2003","article-title":"Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study","volume":"23","author":"Kodama","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303363421000_29.5.1580.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81965-0"},{"key":"2023041303363421000_29.5.1580.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06446.x"},{"key":"2023041303363421000_29.5.1580.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2007.05.006"},{"key":"2023041303363421000_29.5.1580.13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90480-7"},{"key":"2023041303363421000_29.5.1580.14","doi-asserted-by":"publisher","DOI":"10.1038\/79690"},{"key":"2023041303363421000_29.5.1580.15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5665\/sleep\/32.1.111","article-title":"A consensus definition of cataplexy in mouse models of narcolepsy","volume":"32","author":"Scammell","year":"2009","journal-title":"Sleep"},{"key":"2023041303363421000_29.5.1580.16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320103"},{"key":"2023041303363421000_29.5.1580.17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00138.2004"},{"key":"2023041303363421000_29.5.1580.18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/ncpneuro0300","article-title":"Narcolepsy and the hypocretin system\u2013where motion meets emotion","volume":"2","author":"Siegel","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"2023041303363421000_29.5.1580.19","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90260-0"},{"key":"2023041303363421000_29.5.1580.20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925546"},{"key":"2023041303363421000_29.5.1580.21","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1523\/JNEUROSCI.12-05-01640.1992","article-title":"Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog","volume":"12","author":"Siegel","year":"1992","journal-title":"J Neurosci"},{"key":"2023041303363421000_29.5.1580.22","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1523\/JNEUROSCI.10-08-02541.1990","article-title":"Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems","volume":"10","author":"Steriade","year":"1990","journal-title":"J Neurosci"},{"key":"2023041303363421000_29.5.1580.23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0006-8993(02)02914-1","article-title":"Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons","volume":"945","author":"Thakkar","year":"2002","journal-title":"Brain Res"},{"key":"2023041303363421000_29.5.1580.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00486-5"},{"key":"2023041303363421000_29.5.1580.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00058-1"},{"key":"2023041303363421000_29.5.1580.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00330-1"},{"key":"2023041303363421000_29.5.1580.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00600-9"},{"key":"2023041303363421000_29.5.1580.28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.052134"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.5151-08.2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T19:05:06Z","timestamp":1681412706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.5151-08.2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,4]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,2,4]]},"published-print":{"date-parts":[[2009,2,4]]}},"alternative-id":["10.1523\/JNEUROSCI.5151-08.2009"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.5151-08.2009","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,4]]}}}