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Here we show that WAVE1 and pancortin-2 interact in a novel cell death cascade in adult, but not embryonic, cerebral cortical neurons. Focal ischemic stroke induces the formation of a protein complex that includes pancortin-2, WAVE1, and the anti-apoptotic protein Bcl-xL. The three-protein complex is associated with mitochondria resulting in increased association of Bax with mitochondria, cytochrome<jats:italic>c<\/jats:italic>release, and neuronal apoptosis. In pancortin null mice generated using a Cre-loxP system, ischemia-induced WAVE1\u2013Bcl-xL interaction is diminished, and cortical neurons in these mice are protected against ischemic injury. Thus, pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex and functions in a novel mitochondrial\/actin-associated protein complex that sequesters Bcl-xL.<\/jats:p>","DOI":"10.1523\/jneurosci.5154-06.2007","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:35:10Z","timestamp":1171470910000},"page":"1519-1528","source":"Crossref","is-referenced-by-count":54,"title":["Pancortin-2 Interacts with WAVE1 and Bcl-xL in a Mitochondria-Associated Protein Complex That Mediates Ischemic Neuronal Death"],"prefix":"10.1523","volume":"27","author":[{"given":"Aiwu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiruma 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