{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:13:14Z","timestamp":1790439194313,"version":"4.1.0"},"reference-count":62,"publisher":"Society for Neuroscience","issue":"13","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2012,3,28]]},"abstract":"<jats:p>\n                    The C-type lectin chondrolectin (\n                    <jats:italic>chodl<\/jats:italic>\n                    ) represents one of the major gene products dysregulated in spinal muscular atrophy models in mice. However, to date, no function has been determined for the gene. We have identified\n                    <jats:italic>chodl<\/jats:italic>\n                    and other novel genes potentially involved in motor axon differentiation, by expression profiling of transgenically labeled motor neurons in embryonic zebrafish. To enrich the profile for genes involved in differentiation of peripheral motor axons, we inhibited the function of LIM-HDs (LIM homeodomain factors) by overexpression of a dominant-negative cofactor, thereby rendering labeled axons unable to grow out of the spinal cord. Importantly, labeled cells still exhibited axon growth and most cells retained markers of motor neuron identity. Functional tests of\n                    <jats:italic>chodl<\/jats:italic>\n                    , by overexpression and knockdown, confirm crucial functions of this gene for motor axon growth\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Indeed, knockdown of\n                    <jats:italic>chodl<\/jats:italic>\n                    induces arrest or stalling of motor axon growth at the horizontal myoseptum, an intermediate target and navigational choice point, and reduced muscle innervation at later developmental stages. This phenotype is rescued by\n                    <jats:italic>chodl<\/jats:italic>\n                    overexpression, suggesting that correct expression levels of\n                    <jats:italic>chodl<\/jats:italic>\n                    are important for interactions of growth cones of motor axons with the horizontal myoseptum. Combined, these results identify upstream regulators and downstream functions of\n                    <jats:italic>chodl<\/jats:italic>\n                    during motor axon growth.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.5179-11.2012","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T12:39:04Z","timestamp":1332938344000},"page":"4426-4439","source":"Crossref","is-referenced-by-count":30,"title":["<i>Chondrolectin<\/i>\n                    Mediates Growth Cone Interactions of Motor Axons with an Intermediate Target"],"prefix":"10.1523","volume":"32","author":[{"given":"Zhen","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Ohnmacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michell 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