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Here, we ask whether R-type calcium channels in presynaptic terminals also signal through calcium microdomains to control presynaptic LTP. We focus on presynaptic LTP at parallel fiber to Purkinje cell synapses in the cerebellum (PF-LTP), which is mediated by calcium\/calmodulin-stimulated adenylyl cyclases. Although most presynaptic calcium influx is through N-type and P\/Q-type calcium channels, blocking these channels does not disrupt PF-LTP, but blocking R-type calcium channels does. Moreover, global calcium signaling cannot account for the calcium dependence of PF-LTP because R-type channels contribute modestly to overall calcium entry. These findings indicate that, within presynaptic terminals, R-type calcium channels produce calcium microdomains that evoke presynaptic LTP at moderate frequencies that do not greatly increase global calcium levels.<\/jats:p>","DOI":"10.1523\/jneurosci.5252-10.2011","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T05:52:13Z","timestamp":1302155533000},"page":"5235-5243","source":"Crossref","is-referenced-by-count":53,"title":["Calcium Microdomains Near R-Type Calcium Channels Control the Induction of Presynaptic Long-Term Potentiation at Parallel Fiber to Purkinje Cell Synapses"],"prefix":"10.1523","volume":"31","author":[{"given":"Michael H.","family":"Myoga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade 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