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Recent reports directly link age-related neuronal loss in cerebral cortex with the loss of high-affinity nicotine acetylcholine receptors (nAChRs). In cochlea, cholinergic synapses are made by olivocochlear efferent fibers on the outer hair cells that express \u03b19 nAChR subunits and on the peripheral projections of SGNs that express \u03b12, \u03b14-7, and \u03b22-3 nAChR subunits. A significantly decreased expression of the \u03b22 nAChR subunit in SGNs was found specifically in mice susceptible to presbycusis. Furthermore, mice lacking the \u03b22 nAChR subunit (\u03b22-\/-), but not mice lacking the \u03b15 nAChR subunit (\u03b15-\/-), have dramatic hearing loss and significant reduction in the number of SGNs. Our findings clearly established a requirement for \u03b22 nAChR subunit in the maintenance of SGNs during aging.<\/jats:p>","DOI":"10.1523\/jneurosci.5277-04.2005","type":"journal-article","created":{"date-parts":[[2005,3,23]],"date-time":"2005-03-23T23:30:54Z","timestamp":1111620654000},"page":"3041-3045","source":"Crossref","is-referenced-by-count":48,"title":["Requirement of Nicotinic Acetylcholine Receptor Subunit \u03b22 in the Maintenance of Spiral Ganglion Neurons during Aging"],"prefix":"10.1523","volume":"25","author":[{"given":"Jianxin","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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