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We found sAC protein expressed in multiple RGC compartments including the nucleus, cytoplasm and axons. sAC activation increased cAMP above the level seen with transmembrane adenylate cyclase (tmAC) activation. Electrical activity and bicarbonate, both physiologic sAC activators, significantly increased survival and axon growth, whereas pharmacologic or siRNA-mediated sAC inhibition dramatically decreased RGC survival and axon growth<jats:italic>in vitro<\/jats:italic>, and survival<jats:italic>in vivo<\/jats:italic>. Conversely, RGC survival and axon growth were unaltered in RGCs from AC1\/AC8 double knock-out mice or after specifically inhibiting tmACs. These data identify a novel sAC-mediated cAMP signaling pathway regulating RGC survival and axon growth, and suggest new neuroprotective or regenerative strategies based on sAC modulation.<\/jats:p>","DOI":"10.1523\/jneurosci.5288-11.2012","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T18:59:42Z","timestamp":1338404382000},"page":"7734-7744","source":"Crossref","is-referenced-by-count":91,"title":["Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth"],"prefix":"10.1523","volume":"32","author":[{"given":"Raul G.","family":"Corredor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephraim 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