{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:24:18Z","timestamp":1791275058036,"version":"4.1.0"},"reference-count":33,"publisher":"Society for Neuroscience","issue":"11","license":[{"start":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T00:00:00Z","timestamp":1158278400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:p>Abnormal function of NMDA receptor has been suggested to be correlated with the pathogenesis of Parkinson\u2019s disease (PD) as well as with the development of<jats:sc>l<\/jats:sc>-3,4-dihydroxyphenylalanine (<jats:sc>l<\/jats:sc>-DOPA)-induced dyskinesia. Here we show that NMDA receptor NR2 subunits display specific alterations of their subcellular distribution in striata from unilateral 6-hydroxydopamine-lesioned,<jats:sc>l<\/jats:sc>-DOPA-treated dyskinetic, and<jats:sc>l<\/jats:sc>-DOPA-treated nondyskinetic rats. Dyskinetic animals have significantly higher levels of NR2A subunit in the postsynaptic compartment than all other experimental groups, whereas NR2B subunit shows a significant reduction in both dopamine-denervated and dyskinetic rats. These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements, i.e., members of the membrane-associated guanylate kinase (MAGUK) protein family postsynaptic density-95, synapse-associated protein-97 and synapse-associated protein-102. Treatment of nondyskinetic animals with a synthetic peptide (TAT2B) able to affect NR2B binding to MAGUK proteins as well as synaptic localization of this subunit in nondyskinetic rats was sufficient to induce a shift of treated rats toward a dyskinetic motor behavior. These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in<jats:sc>l<\/jats:sc>-DOPA-induced dyskinesia.<\/jats:p>","DOI":"10.1523\/jneurosci.5326-05.2006","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T18:18:10Z","timestamp":1142446690000},"page":"2914-2922","source":"Crossref","is-referenced-by-count":249,"title":["A Critical Interaction between NR2B and MAGUK in l-DOPA Induced 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