{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:09:16Z","timestamp":1790482156919,"version":"4.1.0"},"reference-count":48,"publisher":"Society for Neuroscience","issue":"21","license":[{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2008,5,21]]},"abstract":"<jats:p>Nicotinic mechanisms acting on the hippocampus influence attention, learning, and memory and constitute a significant therapeutic target for many neurodegenerative, neurological, and psychiatric disorders. Here, we report that brain-derived neurotrophic factor (BDNF) (1\u2013100 ng\/ml), a member of the neurotrophin gene family, rapidly decreases \u03b17 nicotinic acetylcholine receptor responses in interneurons of the hippocampal CA1 stratum radiatum. Such effect is dependent on the activation of the TrkB receptor and involves the actin cytoskeleton; noteworthy, it is compromised when the extracellular levels of the endogenous neuromodulator adenosine are reduced with adenosine deaminase (1 U\/ml) or when adenosine A<jats:sub>2A<\/jats:sub>receptors are blocked with SCH 58261 (2-(2-furanyl)-7-(2-phenylethyl)-7<jats:italic>H<\/jats:italic>-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine) (100 n<jats:sc>m<\/jats:sc>). The intracellular application of U73122 (1-[6[[(17\u03b2)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1<jats:italic>H<\/jats:italic>-pyrrole-2,5-dione) (5 \u03bc<jats:sc>m<\/jats:sc>), a broad-spectrum inhibitor of phospholipase C, or GF 109203X (bisindolylmaleimide I) (2 \u03bc<jats:sc>m<\/jats:sc>), a general inhibitor of protein kinase C isoforms, blocks BDNF-induced inhibition of \u03b17 nicotinic acetylcholine receptor function. Moreover, in conditions of simultaneous intracellular dialysis of the fast Ca<jats:sup>2+<\/jats:sup>chelator BAPTA (10 m<jats:sc>m<\/jats:sc>) and removal of extracellular Ca<jats:sup>2+<\/jats:sup>ions, the inhibitory action of BDNF is further prevented. The present findings disclose a novel target for rapid actions of BDNF that might play important roles on synaptic transmission and plasticity in the brain.<\/jats:p>","DOI":"10.1523\/jneurosci.5378-07.2008","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T19:32:12Z","timestamp":1211398332000},"page":"5611-5618","source":"Crossref","is-referenced-by-count":39,"title":["Postsynaptic Action of Brain-Derived Neurotrophic Factor Attenuates \u03b17 Nicotinic Acetylcholine Receptor-Mediated Responses in Hippocampal Interneurons"],"prefix":"10.1523","volume":"28","author":[{"given":"Catarina C.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Pinto-Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim Alexandre","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"2023041303315967000_28.21.5611.1","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0022-3565(24)37139-3","article-title":"Neuronal nicotinic acetylcholine receptor activation modulates \u03b3-aminobutyric acid release from CA1 neurons of rat hippocampal slices","volume":"283","author":"Alkondon","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"2023041303315967000_28.21.5611.2","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1523\/JNEUROSCI.19-07-02693.1999","article-title":"Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 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