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These mice are as adults sufficiently robust to permit comparative cellular, physiological, and behavioral studies. GluR-B loss induced moderate long-term changes in the hippocampus of<jats:italic>GluR-B<\/jats:italic><jats:sup>\u0394<jats:italic>Fb<\/jats:italic><\/jats:sup>mice. Parvalbumin-expressing interneurons in the dentate gyrus and the pyramidal cells in CA3 were decreased in number, and neurogenesis in the subgranular zone was diminished. Excitatory synaptic CA3-to-CA1 transmission was reduced, although synaptic excitability, as quantified by the lowered threshold for population spike initiation, was increased compared with control mice. These changes did not alter CA3-to-CA1 long-term potentiation (LTP), which in magnitude was similar to LTP in control mice. The altered hippocampal circuitry, however, affected spatial learning in<jats:italic>GluR-B<\/jats:italic><jats:sup>\u0394<jats:italic>Fb<\/jats:italic><\/jats:sup>mice. The primary source for the observed changes is most likely the AMPA receptor-mediated Ca<jats:sup>2+<\/jats:sup>signaling that appears after GluR-B depletion, because we observed similar alterations in<jats:italic>GluR-B<jats:sup>QFb<\/jats:sup><\/jats:italic>mice in which the expression of Ca<jats:sup>2+<\/jats:sup>-permeable AMPA receptors in principal neurons was induced by postnatal activation of a Q\/R-site editing-deficient GluR-B allele.<\/jats:p>","DOI":"10.1523\/jneurosci.5410-05.2006","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T19:42:55Z","timestamp":1155757375000},"page":"8428-8440","source":"Crossref","is-referenced-by-count":64,"title":["Forebrain-Specific Glutamate Receptor B Deletion Impairs Spatial Memory But Not Hippocampal Field Long-Term Potentiation"],"prefix":"10.1523","volume":"26","author":[{"given":"Derya R.","family":"Shimshek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidar","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tansu","family":"Celikel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Schupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Bus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ivind","family":"Hvalby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Seeburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Sprengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"2023041303200068000_26.33.8428.1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045575"},{"key":"2023041303200068000_26.33.8428.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(03)00023-3"},{"key":"2023041303200068000_26.33.8428.3","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.118.3.643"},{"key":"2023041303200068000_26.33.8428.4","unstructured":"Borchardt T (2002) Die Konstruktion von M\u00e4usen mit ver\u00e4nderten AMPA-Rezeptoren. 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