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These oscillations are known to take part in encoding of sensory information before their transfer to higher subcortical and cortical areas. To characterize the cellular mechanisms underlying \u03b3 (30\u201380 Hz) local field potential (LFP) oscillations, we simultaneously recorded multiunit discharges, intracellular responses, and LFP in rat OB slices. We showed that a single and brief electrical stimulation of olfactory nerve elicited LFP oscillations in the mitral cell body layer lasting &gt;1 sec. Both action potentials and subthreshold oscillations of mitral\/tufted cells, the bulbar output neurons, were precisely synchronized with LFP oscillations. This synchronization arises from the interaction between output neurons and granule cells, the main population of local circuit inhibitory interneurons, through dendrodendritic synapses. Interestingly enough, the synchronization exerted by reciprocal synaptic interactions did not require action potentials initiated in granule cell somata. Finally, local application of a GABA<jats:sub>A<\/jats:sub>receptor antagonist at the mitral cell and external plexiform layers confirmed the exclusive role of the granule cell reciprocal synapses in generating the evoked oscillations. We concluded that interneurons located in the granule cell layer generate synaptic activity capable of synchronizing activity of output neurons by interacting with both their subthreshold and spiking activity.<\/jats:p>","DOI":"10.1523\/jneurosci.5570-03.2004","type":"journal-article","created":{"date-parts":[[2004,5,5]],"date-time":"2004-05-05T19:41:22Z","timestamp":1083786082000},"page":"4382-4392","source":"Crossref","is-referenced-by-count":226,"title":["Interplay between Local GABAergic Interneurons and Relay Neurons Generates \u03b3 Oscillations in the Rat Olfactory Bulb"],"prefix":"10.1523","volume":"24","author":[{"given":"Samuel","family":"Lagier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Carleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Lledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2004,5,5]]},"reference":[{"key":"2023041303063702000_24.18.4382.1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1113\/jphysiol.1942.sp003955","volume":"100","year":"1942","journal-title":"J Physiol (Lond)"},{"key":"2023041303063702000_24.18.4382.2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901370404"},{"key":"2023041303063702000_24.18.4382.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00284-7"},{"key":"2023041303063702000_24.18.4382.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00286-0"},{"key":"2023041303063702000_24.18.4382.5","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(68)90119-4"},{"key":"2023041303063702000_24.18.4382.6","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(84)90128-7"},{"key":"2023041303063702000_24.18.4382.7","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(80)90319-3"},{"key":"2023041303063702000_24.18.4382.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02619.x"},{"key":"2023041303063702000_24.18.4382.9","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1523\/JNEUROSCI.23-10-04108.2003","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303063702000_24.18.4382.10","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1523\/JNEUROSCI.20-05-02011.2000","volume":"20","year":"2000","journal-title":"J Neurosci"},{"key":"2023041303063702000_24.18.4382.11","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1523\/JNEUROSCI.19-21-09180.1999","volume":"19","year":"1999","journal-title":"J Neurosci"},{"key":"2023041303063702000_24.18.4382.12","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.5.561"},{"key":"2023041303063702000_24.18.4382.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01150-X"},{"key":"2023041303063702000_24.18.4382.14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00623.2002"},{"key":"2023041303063702000_24.18.4382.15","doi-asserted-by":"crossref","first-page":"10727","DOI":"10.1523\/JNEUROSCI.19-24-10727.1999","volume":"19","year":"1999","journal-title":"J Neurosci"},{"key":"2023041303063702000_24.18.4382.16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91663-2"},{"key":"2023041303063702000_24.18.4382.17","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1523\/JNEUROSCI.23-20-07551.2003","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303063702000_24.18.4382.18","doi-asserted-by":"crossref","unstructured":"Fisher NI (1993) Statistical analysis of circular data. 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