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NMDAR\u2013NR2B subunits are a major NR2 subunit expressed by striatal medium spiny neurons that degenerate in HD. To test the excitotoxic hypothesis, we crossed a well validated murine genetic model of HD (Hdh<jats:sup>(CAG)150<\/jats:sup>) with a transgenic line overexpressing NMDAR\u2013NR2B subunits. In the resulting double-mutant line, we show exacerbation of selective striatal neuron degeneration. This is the first direct<jats:italic>in vivo<\/jats:italic>evidence of NR2B\u2013NMDAR-mediated excitotoxicity in the context of HD. Our results are consistent with previous suggestions that direct and\/or indirect interactions of mutant huntingtin with NMDARs are a proximate cause of neurodegeneration in HD.<\/jats:p>","DOI":"10.1523\/jneurosci.5599-08.2009","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T21:34:03Z","timestamp":1236807243000},"page":"3200-3205","source":"Crossref","is-referenced-by-count":111,"title":["<i>In Vivo<\/i>Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease"],"prefix":"10.1523","volume":"29","author":[{"given":"Mary Y.","family":"Heng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Detloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe 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