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A variety of studies designed to perturb CAPS function indicate that CAPS is involved in the secretion of large dense-core vesicles, but where in the secretory pathway CAPS acts is still under debate. Mice in which one allele of the<jats:italic>CAPS-1<\/jats:italic>gene is deleted exhibit a deficit in catecholamine secretion from chromaffin cells. We have examined catecholamine secretion from chromaffin cells in which both<jats:italic>CAPS<\/jats:italic>genes were deleted and show that the deletion of both CAPS isoforms causes a strong reduction in the pool of rapidly releasable chromaffin granules and of sustained release during ongoing stimulation. We conclude that CAPS is required for the adequate refilling and\/or maintenance of a rapidly releasable granule pool.<\/jats:p>","DOI":"10.1523\/jneurosci.5672-07.2008","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T19:32:12Z","timestamp":1211398332000},"page":"5594-5601","source":"Crossref","is-referenced-by-count":72,"title":["CAPS Facilitates Filling of the Rapidly Releasable Pool of Large Dense-Core Vesicles"],"prefix":"10.1523","volume":"28","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schirra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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