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In the present work, we devised a dual-lesion paradigm to determine its possible contribution after partial SCI. After a partial section of the left thoracic segment T10 or T11, cats gradually recovered voluntary quadrupedal locomotion. Then, a complete transection was performed two to three segments more caudally (T13\u2013L1) several weeks after the first partial lesion. Cats that received intensive treadmill training after the partial lesion expressed bilateral hindlimb locomotion within hours of the complete lesion. Untrained cats however showed asymmetrical hindlimb locomotion with the limb on the side of the partial lesion walking well before the other hindlimb. Thus, the complete spinalization revealed that the spinal CPG underwent plastic changes after the partial lesions, which were shaped by locomotor training. Over time, with further treadmill training, the asymmetry disappeared and a bilateral locomotion was reinstated. Therefore, although remnant intact descending pathways must contribute to voluntary goal-oriented locomotion after partial SCI, the recovery and re-expression of the hindlimb locomotor pattern mostly results from intrinsic changes below the lesion in the CPG and afferent inputs.<\/jats:p>","DOI":"10.1523\/jneurosci.5692-07.2008","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T16:28:20Z","timestamp":1207758500000},"page":"3976-3987","source":"Crossref","is-referenced-by-count":193,"title":["Prominent Role of the Spinal Central Pattern Generator in the Recovery of Locomotion after Partial Spinal Cord Injuries"],"prefix":"10.1523","volume":"28","author":[{"given":"Gr\u00e9gory","family":"Barri\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Leblond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janyne","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Rossignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"2023041303311231000_28.15.3976.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04726.x"},{"key":"2023041303311231000_28.15.3976.2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91442-9"},{"key":"2023041303311231000_28.15.3976.3","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199412000-00008"},{"key":"2023041303311231000_28.15.3976.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(03)00361-7"},{"key":"2023041303311231000_28.15.3976.5","doi-asserted-by":"publisher","DOI":"10.1038\/nn1195"},{"key":"2023041303311231000_28.15.3976.6","first-page":"151","article-title":"Spinal locomotion: a comparison of the kinematics and the electromyographic activity in the same animal before and after spinalization","volume":"39","author":"B\u00e9langer","year":"1988","journal-title":"Acta Biol Hungarica"},{"key":"2023041303311231000_28.15.3976.7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1152\/jn.1996.76.1.471","article-title":"A comparison of treadmill locomotion in adult cats before and after spinal transection","volume":"76","author":"B\u00e9langer","year":"1996","journal-title":"J Neurophysiol"},{"key":"2023041303311231000_28.15.3976.8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00497.2003"},{"key":"2023041303311231000_28.15.3976.9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1152\/jn.1998.80.3.1245","article-title":"Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. 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