{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:59:50Z","timestamp":1792173590523,"version":"4.4.0"},"reference-count":48,"publisher":"Society for Neuroscience","issue":"9","license":[{"start":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T00:00:00Z","timestamp":1346198400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2012,2,29]]},"abstract":"<jats:p>\n                    Rett syndrome and\n                    <jats:italic>MECP2<\/jats:italic>\n                    duplication syndrome are neurodevelopmental disorders that arise from loss-of-function and gain-of-function alterations in methyl-CpG binding protein 2 (MeCP2) expression, respectively. Although there have been studies examining MeCP2 loss of function in animal models, there is limited information on MeCP2 overexpression in animal models. Here, we characterize a mouse line with MeCP2 overexpression restricted to neurons (\n                    <jats:italic>Tau\u2013Mecp2<\/jats:italic>\n                    ). This MeCP2 overexpression line shows motor coordination deficits, heightened anxiety, and impairments in learning and memory that are accompanied by deficits in long-term potentiation and short-term synaptic plasticity. Whole-cell voltage-clamp recordings of cultured hippocampal neurons from\n                    <jats:italic>Tau\u2013Mecp2<\/jats:italic>\n                    mice reveal augmented frequency of miniature EPSCs with no change in miniature IPSCs, indicating that overexpression of MeCP2 selectively impacts excitatory synapse function. Moreover, we show that alterations in transcriptional repression mechanisms underlie the synaptic phenotypes in hippocampal neurons from the\n                    <jats:italic>Tau\u2013Mecp2<\/jats:italic>\n                    mice. These results demonstrate that the\n                    <jats:italic>Tau\u2013Mecp2<\/jats:italic>\n                    mouse line recapitulates many key phenotypes of\n                    <jats:italic>MECP2<\/jats:italic>\n                    duplication syndrome and support the use of these mice to further study this devastating disorder.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.6000-11.2012","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T19:58:28Z","timestamp":1330545508000},"page":"3109-3117","source":"Crossref","is-referenced-by-count":124,"title":["A Mouse Model for\n                    <i>MeCP2<\/i>\n                    Duplication Syndrome: MeCP2 Overexpression Impairs Learning and Memory and Synaptic Transmission"],"prefix":"10.1523","volume":"32","author":[{"given":"Elisa S.","family":"Na","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika D.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita E.","family":"Autry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Mahgoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ege T.","family":"Kavalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Monteggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"2023041303551357000_32.9.3109.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0097-09.2009"},{"key":"2023041303551357000_32.9.3109.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.07.005"},{"key":"2023041303551357000_32.9.3109.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802679105"},{"key":"2023041303551357000_32.9.3109.4","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp181"},{"key":"2023041303551357000_32.9.3109.5","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.205"},{"key":"2023041303551357000_32.9.3109.6","doi-asserted-by":"crossref","first-page":"d118","DOI":"10.2741\/A120","article-title":"The tau proteins in neuronal growth and development","volume":"1","author":"Brandt","year":"1996","journal-title":"Front Biosci"},{"key":"2023041303551357000_32.9.3109.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153252"},{"key":"2023041303551357000_32.9.3109.8","doi-asserted-by":"crossref","unstructured":"Chang CH Knapska E Orsini CA Rabinak CA Zimmerman JM Maren S (2009) Fear extinction in rodents. 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