{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:11:52Z","timestamp":1790784712971,"version":"4.1.0"},"reference-count":75,"publisher":"Society for Neuroscience","issue":"15","license":[{"start":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:00:00Z","timestamp":1318464000000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2011,4,13]]},"abstract":"<jats:p>Down syndrome (DS) is a developmental disorder caused by a third chromosome 21 in humans (Trisomy 21), leading to neurological deficits and cognitive impairment. Studies in mouse models of DS suggest that cognitive deficits in the adult are associated with deficits in synaptic learning and memory mechanisms, but it is unclear whether alterations in the early wiring and refinement of neuronal circuits contribute to these deficits. Here, we show that early developmental refinement of visual circuits is perturbed in mouse models of Down syndrome. Specifically, we find excessive eye-specific segregation of retinal axons in the dorsal lateral geniculate nucleus. Indeed, the degree of refinement scales with defects in the \u201cDown syndrome critical region\u201d (DSCR) in a dose-dependent manner. We further identify<jats:italic>Dscam<\/jats:italic>(Down syndrome cell adhesion molecule), a gene within the DSCR, as a regulator of eye-specific segregation of retinogeniculate projections. Although<jats:italic>Dscam<\/jats:italic>is not the sole gene in the DSCR contributing to enhanced refinement in trisomy,<jats:italic>Dscam<\/jats:italic>dosage clearly regulates cell spacing and dendritic fasciculation in a specific class of retinal ganglion cells. Thus, altered developmental refinement of visual circuits that occurs before sensory experience is likely to contribute to visual impairment in individuals with Down syndrome.<\/jats:p>","DOI":"10.1523\/jneurosci.6015-10.2011","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T16:44:25Z","timestamp":1302713065000},"page":"5764-5776","source":"Crossref","is-referenced-by-count":45,"title":["The Down Syndrome Critical Region Regulates Retinogeniculate Refinement"],"prefix":"10.1523","volume":"31","author":[{"given":"Martina","family":"Blank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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