{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:22:50Z","timestamp":1789924970320,"version":"4.0.1"},"reference-count":101,"publisher":"Society for Neuroscience","issue":"15","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2013,4,10]]},"abstract":"<jats:p>Although the contribution of Ca<jats:sup>2+<\/jats:sup>buffering systems can vary between neuronal types and cellular compartments, it is unknown whether distinct Ca<jats:sup>2+<\/jats:sup>sources within a neuron have different buffers. As individual Ca<jats:sup>2+<\/jats:sup>sources can have separate functions, we propose that each is handled by unique systems. Using<jats:italic>Aplysia californica<\/jats:italic>bag cell neurons, which initiate reproduction through an afterdischarge involving multiple Ca<jats:sup>2+<\/jats:sup>-dependent processes, we investigated the role of endoplasmic reticulum (ER) and mitochondrial sequestration, as well as extrusion via the plasma membrane Ca<jats:sup>2+<\/jats:sup>-ATPase (PMCA) and Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchanger, to the clearance of voltage-gated Ca<jats:sup>2+<\/jats:sup>influx, Ca<jats:sup>2+<\/jats:sup>-induced Ca<jats:sup>2+<\/jats:sup>-release (CICR), and store-operated Ca<jats:sup>2+<\/jats:sup>influx. Cultured bag cell neurons were filled with the Ca<jats:sup>2+<\/jats:sup>indicator, fura-PE3, to image Ca<jats:sup>2+<\/jats:sup>under whole-cell voltage clamp. A 5 Hz, 1 min train of depolarizing voltage steps elicited voltage-gated Ca<jats:sup>2+<\/jats:sup>influx followed by EGTA-sensitive CICR from the mitochondria. A compartment model of Ca<jats:sup>2+<\/jats:sup>indicated the effect of EGTA on CICR was due to buffering of released mitochondrial Ca<jats:sup>2+<\/jats:sup>rather than uptake competition. Removal of voltage-gated Ca<jats:sup>2+<\/jats:sup>influx was dominated by the mitochondria and PMCA, with no contribution from the Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchanger or sarcoplasmic\/endoplasmic Ca<jats:sup>2+<\/jats:sup>-ATPase (SERCA). In contrast, CICR recovery was slowed by eliminating the Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup>exchanger and PMCA. Last, store-operated influx, evoked by ER depletion, was removed by the SERCA and depended on the mitochondrial membrane potential. Our results demonstrate that distinct buffering systems are dedicated to particular Ca<jats:sup>2+<\/jats:sup>sources. In general, this may represent a means to differentially regulate Ca<jats:sup>2+<\/jats:sup>-dependent processes, and for<jats:italic>Aplysia<\/jats:italic>, influence how reproductive behavior is triggered.<\/jats:p>","DOI":"10.1523\/jneurosci.6384-11.2013","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T16:34:32Z","timestamp":1365611672000},"page":"6476-6491","source":"Crossref","is-referenced-by-count":16,"title":["Separate Ca<sup>2+<\/sup>Sources Are Buffered by Distinct Ca<sup>2+<\/sup>Handling Systems in<i>Aplysia<\/i>Neuroendocrine Cells"],"prefix":"10.1523","volume":"33","author":[{"given":"Christopher J.","family":"Groten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan T.","family":"Rebane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Blohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil S.","family":"Magoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"2023041304031941000_33.15.6476.1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.59.1.47"},{"key":"2023041304031941000_33.15.6476.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80981-2"},{"key":"2023041304031941000_33.15.6476.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4150.535"},{"key":"2023041304031941000_33.15.6476.4","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.4.833"},{"key":"2023041304031941000_33.15.6476.5","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"2023041304031941000_33.15.6476.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1155"},{"key":"2023041304031941000_33.15.6476.7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol Rev"},{"key":"2023041304031941000_33.15.6476.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.21.7972"},{"key":"2023041304031941000_33.15.6476.9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/physrev.1991.71.1.129","article-title":"Calcium pump of the plasma membrane","volume":"71","author":"Carafoli","year":"1991","journal-title":"Physiol Rev"},{"key":"2023041304031941000_33.15.6476.10","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.2001.0212"},{"key":"2023041304031941000_33.15.6476.11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061609-165311"},{"key":"2023041304031941000_33.15.6476.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.005"},{"key":"2023041304031941000_33.15.6476.13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1301-11.2012"},{"key":"2023041304031941000_33.15.6476.14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1242\/jcs.115.3.599","article-title":"pH-dependent regulation of lysosomal calcium in macrophages","volume":"115","author":"Christensen","year":"2002","journal-title":"J Cell Sci"},{"key":"2023041304031941000_33.15.6476.15","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90408-5"},{"key":"2023041304031941000_33.15.6476.16","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.115.3.351"},{"key":"2023041304031941000_33.15.6476.17","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.115.3.371"},{"key":"2023041304031941000_33.15.6476.18","doi-asserted-by":"publisher","DOI":"10.1038\/32448"},{"key":"2023041304031941000_33.15.6476.19","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1523\/JNEUROSCI.04-06-01618.1984","article-title":"Calcium\/calmodulin-dependent protein phosphorylation in the nervous system of Aplysia","volume":"4","author":"DeRiemer","year":"1984","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.499bk.x"},{"key":"2023041304031941000_33.15.6476.21","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1523\/JNEUROSCI.08-07-02544.1988","article-title":"Inositol triphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons","volume":"8","author":"Fink","year":"1988","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.22","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1152\/jn.1994.71.3.1254","article-title":"Transient changes in intracellular calcium associated with a prolonged increase in excitability in neurons of Aplysia californica","volume":"71","author":"Fisher","year":"1994","journal-title":"J Neurophysiol"},{"key":"2023041304031941000_33.15.6476.23","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1523\/JNEUROSCI.14-07-04007.1994","article-title":"An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i","volume":"14","author":"Friel","year":"1994","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81247-7"},{"key":"2023041304031941000_33.15.6476.25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110841"},{"key":"2023041304031941000_33.15.6476.26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90265.2008"},{"key":"2023041304031941000_33.15.6476.27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90356.2008"},{"key":"2023041304031941000_33.15.6476.28","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6401"},{"key":"2023041304031941000_33.15.6476.29","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf675"},{"key":"2023041304031941000_33.15.6476.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00183-7"},{"key":"2023041304031941000_33.15.6476.31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1113\/jphysiol.1980.sp013471","article-title":"Intracellular calcium accumulation during depolarization in a molluscan neuron","volume":"308","author":"Gorman","year":"1980","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.32","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"2023041304031941000_33.15.6476.33","doi-asserted-by":"publisher","DOI":"10.1007\/BF00762732"},{"key":"2023041304031941000_33.15.6476.34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1152\/ajpcell.1990.258.5.C755","article-title":"Mechanisms by which mitochondria transport calcium","volume":"258","author":"Gunter","year":"1990","journal-title":"Am J Physiol"},{"key":"2023041304031941000_33.15.6476.35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.1959.sp006279","article-title":"Voltage-current relations in nerve cell membrane of Onchidium verruculatum","volume":"148","author":"Hagiwara","year":"1959","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80038-0"},{"key":"2023041304031941000_33.15.6476.37","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(62)90189-4"},{"key":"2023041304031941000_33.15.6476.38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01121.2009"},{"key":"2023041304031941000_33.15.6476.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00576-7"},{"key":"2023041304031941000_33.15.6476.40","doi-asserted-by":"publisher","DOI":"10.1038\/355353a0"},{"key":"2023041304031941000_33.15.6476.41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1113\/jphysiol.1993.sp019633","article-title":"Characteristics of Ca2+ release induced by Ca2+ influx in cultured bullfrog sympathetic neurons","volume":"464","author":"Hua","year":"1993","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00941.2006"},{"key":"2023041304031941000_33.15.6476.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00334-9"},{"key":"2023041304031941000_33.15.6476.44","doi-asserted-by":"publisher","DOI":"10.1038\/385343a0"},{"key":"2023041304031941000_33.15.6476.45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb44804.x"},{"key":"2023041304031941000_33.15.6476.46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00974.x"},{"key":"2023041304031941000_33.15.6476.47","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00118.2006"},{"key":"2023041304031941000_33.15.6476.48","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1152\/jn.1984.52.2.340","article-title":"A voltage-clamp analysis of currents in isolated peptidergic neurons of Aplysia","volume":"52","author":"Kaczmarek","year":"1984","journal-title":"J Neurophysiol"},{"key":"2023041304031941000_33.15.6476.49","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90774-0"},{"key":"2023041304031941000_33.15.6476.50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000903200"},{"key":"2023041304031941000_33.15.6476.51","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(86)90014-X"},{"key":"2023041304031941000_33.15.6476.52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000123356","article-title":"Electrophysiological correlates of pulsatile gonadotropin release in rats","volume":"55","author":"Kawakami","year":"1982","journal-title":"Neuroendocrinology"},{"key":"2023041304031941000_33.15.6476.53","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1523\/JNEUROSCI.23-37-11673.2003","article-title":"Distribution of K+-dependent Na+\/Ca2+ exchangers in the rat supraoptic magnocellular neuron is polarized to axon terminals","volume":"23","author":"Kim","year":"2003","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0454-05.2005"},{"key":"2023041304031941000_33.15.6476.55","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3384-09.2009"},{"key":"2023041304031941000_33.15.6476.56","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1996.sp021520","article-title":"Ca2+ influx and activation of a cation current are coupled to intracellular Ca2+ release in peptidergic neurons of Aplysia californica","volume":"494","author":"Knox","year":"1996","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80531-0"},{"key":"2023041304031941000_33.15.6476.58","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1152\/jn.1970.33.6.865","article-title":"Electrophysiological properties and functional interconnections of two symmetrical neurosecretory clusters (bag cells) in abdominal ganglion of Aplysia","volume":"33","author":"Kupfermann","year":"1970","journal-title":"J Neurophysiol"},{"key":"2023041304031941000_33.15.6476.59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3985-07.2007"},{"key":"2023041304031941000_33.15.6476.60","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1113\/jphysiol.1974.sp010722","article-title":"Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin","volume":"242","author":"Lincoln","year":"1974","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.61","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1152\/jn.1990.63.4.738","article-title":"Progressive potentiation of peptide release during a neuronal discharge","volume":"63","author":"Loechner","year":"1990","journal-title":"J Neurophysiol"},{"key":"2023041304031941000_33.15.6476.62","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.105833"},{"key":"2023041304031941000_33.15.6476.63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00271.x"},{"key":"2023041304031941000_33.15.6476.64","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1523\/JNEUROSCI.20-24-09059.2000","article-title":"Origin sites of calcium release and calcium oscillations in frog sympathetic neurons","volume":"20","author":"McDonough","year":"2000","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.65","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1523\/JNEUROSCI.22-20-09063.2002","article-title":"Neurohormone secretion persists after post-afterdischarge membrane depolarization and cytosolic calcium elevation in peptidergic neurons in intact nervous tissue","volume":"22","author":"Michel","year":"2002","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.66","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1523\/JNEUROSCI.18-07-02467.1998","article-title":"Calcium extrusion from mammalian photoreceptor terminals","volume":"18","author":"Morgans","year":"1998","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.901"},{"key":"2023041304031941000_33.15.6476.68","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.070151"},{"key":"2023041304031941000_33.15.6476.69","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75435-0"},{"key":"2023041304031941000_33.15.6476.70","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(97)90064-6"},{"key":"2023041304031941000_33.15.6476.71","doi-asserted-by":"publisher","DOI":"10.1038\/309158a0"},{"key":"2023041304031941000_33.15.6476.72","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1992.sp019127","article-title":"Calcium gradients and buffers in bovine chromaffin cells","volume":"450","author":"Neher","year":"1992","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.73","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(93)81342-0"},{"key":"2023041304031941000_33.15.6476.74","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00057.2003"},{"key":"2023041304031941000_33.15.6476.75","doi-asserted-by":"publisher","DOI":"10.1126\/science.197.4302.490"},{"key":"2023041304031941000_33.15.6476.76","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(03)00143-X"},{"key":"2023041304031941000_33.15.6476.77","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2005"},{"key":"2023041304031941000_33.15.6476.78","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5370.1763"},{"key":"2023041304031941000_33.15.6476.79","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/ajpcell.1987.252.6.C595","article-title":"Role of sodium-calcium exchange in regulation of intracellular calcium in nerve terminals","volume":"252","author":"Sanchez-Armass","year":"1987","journal-title":"Am J Physiol"},{"key":"2023041304031941000_33.15.6476.80","doi-asserted-by":"crossref","first-page":"17816","DOI":"10.1016\/S0021-9258(19)84646-X","article-title":"Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum","volume":"264","author":"Seidler","year":"1989","journal-title":"J Biol Chem"},{"key":"2023041304031941000_33.15.6476.81","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050761"},{"key":"2023041304031941000_33.15.6476.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904775106"},{"key":"2023041304031941000_33.15.6476.83","doi-asserted-by":"publisher","DOI":"10.1038\/304350a0"},{"key":"2023041304031941000_33.15.6476.84","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00118.2010"},{"key":"2023041304031941000_33.15.6476.85","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00669.2009"},{"key":"2023041304031941000_33.15.6476.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.01.037"},{"key":"2023041304031941000_33.15.6476.87","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81248-9"},{"key":"2023041304031941000_33.15.6476.88","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.1990.sp018094","article-title":"Regulation of the intracellular free calcium concentration in single dorsal root ganglion neurones in vitro","volume":"425","author":"Thayer","year":"1990","journal-title":"J Physiol"},{"key":"2023041304031941000_33.15.6476.89","doi-asserted-by":"publisher","DOI":"10.1038\/nature11539"},{"key":"2023041304031941000_33.15.6476.90","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(95)80082-2"},{"key":"2023041304031941000_33.15.6476.91","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1998.00235.x"},{"key":"2023041304031941000_33.15.6476.92","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1447"},{"key":"2023041304031941000_33.15.6476.93","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2456-12.2012"},{"key":"2023041304031941000_33.15.6476.94","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1523\/JNEUROSCI.14-01-00348.1994","article-title":"Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons","volume":"14","author":"Werth","year":"1994","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.041"},{"key":"2023041304031941000_33.15.6476.96","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1523\/JNEUROSCI.18-22-09171.1998","article-title":"Expression of Kv3.1 in bag cell neurons prevents the induction of a depolarizing afterpotential","volume":"18","author":"Whim","year":"1998","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.97","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1523\/JNEUROSCI.17-05-01582.1997","article-title":"Identification of a vesicular pool of calcium channels in the bag cell neurons of Aplysia californica","volume":"17","author":"White","year":"1997","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.98","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1523\/JNEUROSCI.15-02-01318.1995","article-title":"Mitochondria and Na\/Ca exchange buffer glutamate-induced calcium loads in cultured cortical neurons","volume":"15","author":"White","year":"1995","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.99","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1523\/JNEUROSCI.16-11-03661.1996","article-title":"Identification and characterization of a Ca2+-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neurons","volume":"16","author":"Wilson","year":"1996","journal-title":"J Neurosci"},{"key":"2023041304031941000_33.15.6476.100","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80885-5"},{"key":"2023041304031941000_33.15.6476.101","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00411.2004"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.6384-11.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T21:36:57Z","timestamp":1681421817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.6384-11.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":101,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2013,4,10]]},"published-print":{"date-parts":[[2013,4,10]]}},"alternative-id":["10.1523\/JNEUROSCI.6384-11.2013"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.6384-11.2013","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]}}}