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Active UPR signaling leads to unconventional, enzymatic splicing of\n                    <jats:italic>XBP1<\/jats:italic>\n                    mRNA enabling expression of the transcription factor XBP1s to control ER homeostasis. While IRE1 has been identified as the endoribonuclease required for cleavage of this mRNA, the corresponding ligase in mammalian cells has remained elusive. Here, we report that RTCB, the catalytic subunit of the tRNA ligase complex, and its co\u2010factor archease mediate\n                    <jats:italic>XBP1<\/jats:italic>\n                    mRNA splicing both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Depletion of RTCB in plasma cells of\n                    <jats:italic>Rtcb<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    <jats:italic>Cd23<\/jats:italic>\n                    \u2010Cre mice prevents XBP1s expression, which normally is strongly induced during plasma cell development. RTCB\u2010depleted plasma cells show reduced and disorganized ER structures as well as severe defects in antibody secretion. Targeting RTCB and\/or archease thus represents a promising strategy for the treatment of a growing number of diseases associated with elevated expression of XBP1s.\n                  <\/jats:p>","DOI":"10.15252\/embj.201490332","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T01:33:41Z","timestamp":1415324021000},"page":"2922-2936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":236,"title":["The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells"],"prefix":"10.1038","volume":"33","author":[{"given":"Jennifer","family":"Jurkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F\u00e6rch","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Minnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Popow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Heindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Busslinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"BFEMBJ201490332_CR1","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1016\/S0021-9258(20)89467-8","volume":"266","author":"BL Apostol","year":"1991","unstructured":"Apostol BL, Westaway SK, Abelson J, Greer CL (1991) Deletion analysis of a multifunctional yeast tRNA ligase polypeptide. 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