{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:07:35Z","timestamp":1779307655630,"version":"3.51.4"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"NYSCF\u2010Druckenmiller Fellow"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2015,4,1]]},"DOI":"10.15252\/embj.201490685","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T20:34:08Z","timestamp":1425328448000},"page":"841-855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Toward beta cell replacement for diabetes"],"prefix":"10.1038","volume":"34","author":[{"given":"Bjarki","family":"Johannesson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald O","family":"Freytes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remi J","family":"Creusot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Egli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"BFEMBJ201490685_CR1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","volume":"50","author":"S Assady","year":"2001","unstructured":"Assady S, Maor G, Amit M, Itskovitz\u2010Eldor J, Skorecki KL, Tzukerman M (2001) Insulin production by human embryonic stem cells. Diabetes 50: 1691\u20131697","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2008.09.013","volume":"5","author":"SF Badylak","year":"2009","unstructured":"Badylak SF, Freytes DO, Gilbert TW (2009) Extracellular matrix as a biological scaffold material: structure and function. Acta Biomater 5: 1\u201313","journal-title":"Acta Biomater"},{"key":"BFEMBJ201490685_CR3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-bioeng-071910-124743","volume":"13","author":"SF Badylak","year":"2011","unstructured":"Badylak SF, Taylor D, Uygun K (2011) Whole\u2010organ tissue engineering: decellularization and recellularization of three\u2010dimensional matrix scaffolds. Annu Rev Biomed Eng 13: 27\u201353","journal-title":"Annu Rev Biomed Eng"},{"key":"BFEMBJ201490685_CR4","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1073\/pnas.1103509108","volume":"108","author":"H Ban","year":"2011","unstructured":"Ban H, Nishishita N, Fusaki N, Tabata T, Saeki K, Shikamura M, Takada N, Inoue M, Hasegawa M, Kawamata S, Nishikawa S (2011) Efficient generation of transgene\u2010free human induced pluripotent stem cells (iPSCs) by temperature\u2010sensitive Sendai virus vectors. Proc Natl Acad Sci USA 108: 14234\u201314239","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201490685_CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/cei.12019","volume":"171","author":"AE Barcala Tabarrozzi","year":"2013","unstructured":"Barcala Tabarrozzi AE, Castro CN, Dewey RA, Sogayar MC, Labriola L, Perone MJ (2013) Cell\u2010based interventions to halt autoimmunity in type 1 diabetes mellitus. Clin Exp Immunol 171: 135\u2013146","journal-title":"Clin Exp Immunol"},{"key":"BFEMBJ201490685_CR6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.stem.2011.06.007","volume":"9","author":"O Bar\u2010Nur","year":"2011","unstructured":"Bar\u2010Nur O, Russ HA, Efrat S, Benvenisty N (2011) Epigenetic memory and preferential lineage\u2010specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9: 17\u201323","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR7","doi-asserted-by":"crossref","first-page":"39632","DOI":"10.1074\/jbc.M111.253591","volume":"286","author":"J Barthson","year":"2011","unstructured":"Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P, Gysemans C, Mathieu C, Nu\u00f1ez G, Jurisicova A, Eizirik DL, Gurzov EN (2011) Cytokines tumor necrosis factor\u2010alpha and interferon\u2010gamma induce pancreatic beta\u2010cell apoptosis through STAT1\u2010mediated Bim protein activation. J Biol Chem 286: 39632\u201339643","journal-title":"J Biol Chem"},{"key":"BFEMBJ201490685_CR8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/biores.2012.9902","volume":"1","author":"MT Basel","year":"2012","unstructured":"Basel MT, Balivada S, Beck AP, Kerrigan MA, Pyle MM, Dekkers JC, Wyatt CR, Rowland RR, Anderson DE, Bossmann SH, Troyer DL (2012) Human xenografts are not rejected in a naturally occurring immunodeficient porcine line: a human tumor model in pigs. BioRes Open Access 1: 63\u201368","journal-title":"BioRes Open Access"},{"key":"BFEMBJ201490685_CR9","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2337\/db11-0784","volume":"61","author":"M Bettini","year":"2012","unstructured":"Bettini M, Castellaw AH, Lennon GP, Burton AR, Vignali DA (2012) Prevention of autoimmune diabetes by ectopic pancreatic beta\u2010cell expression of interleukin\u201035. Diabetes 61: 1519\u20131526","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR10","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.15252\/emmm.201303376","volume":"6","author":"D Bilbao","year":"2014","unstructured":"Bilbao D, Luciani L, Johannesson B, Piszczek A, Rosenthal N (2014) Insulin\u2010like growth factor\u20101 stimulates regulatory T cells and suppresses autoimmune disease. EMBO Mol Med 6: 1423\u20131435","journal-title":"EMBO Mol Med"},{"key":"BFEMBJ201490685_CR11","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1038\/ncomms5242","volume":"5","author":"R Bouchi","year":"2014","unstructured":"Bouchi R, Foo KS, Hua H, Tsuchiya K, Ohmura Y, Sandoval PR, Ratner LE, Egli D, Leibel RL, Accili D (2014) FOXO1 inhibition yields functional insulin\u2010producing cells in human gut organoid cultures. Nat Commun 5: 4242","journal-title":"Nat Commun"},{"key":"BFEMBJ201490685_CR12","doi-asserted-by":"crossref","first-page":"a007757","DOI":"10.1101\/cshperspect.a007757","volume":"2","author":"MA Brehm","year":"2012","unstructured":"Brehm MA, Powers AC, Shultz LD, Greiner DL (2012) Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Cold Spring Harb Perspect Med 2: a007757","journal-title":"Cold Spring Harb Perspect Med"},{"key":"BFEMBJ201490685_CR13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ceb.2012.07.001","volume":"24","author":"MF Brizzi","year":"2012","unstructured":"Brizzi MF, Tarone G, Defilippi P (2012) Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche. Curr Opin Cell Biol 24: 645\u2013651","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ201490685_CR14","first-page":"211","volume":"7","author":"A Bruni","year":"2014","unstructured":"Bruni A, Gala\u2010Lopez B, Pepper AR, Abualhassan NS, Shapiro AJ (2014) Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes 7: 211\u2013223","journal-title":"Diabetes Metab Syndr Obes"},{"key":"BFEMBJ201490685_CR15","doi-asserted-by":"crossref","first-page":"e11726","DOI":"10.1371\/journal.pone.0011726","volume":"5","author":"TM Brusko","year":"2010","unstructured":"Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA (2010) Human antigen\u2010specific regulatory T cells generated by T cell receptor gene transfer. PLoS ONE 5: e11726","journal-title":"PLoS ONE"},{"key":"BFEMBJ201490685_CR16","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00125-007-0794-x","volume":"50","author":"AE Butler","year":"2007","unstructured":"Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC (2007) Modestly increased beta cell apoptosis but no increased beta cell replication in recent\u2010onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia 50: 2323\u20132331","journal-title":"Diabetologia"},{"key":"BFEMBJ201490685_CR17","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1256864","volume":"344","author":"L Chatenoud","year":"2014","unstructured":"Chatenoud L (2014) Immunology. Teaching the immune system \u201cself\u201d respect and tolerance. Science 344: 1343\u20131344","journal-title":"Science"},{"key":"BFEMBJ201490685_CR18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.celrep.2014.02.013","volume":"6","author":"YJ Chen","year":"2014","unstructured":"Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ (2014) De novo formation of insulin\u2010producing \u201cneo\u2010beta cell islets\u201d from intestinal crypts. Cell Rep 6: 1046\u20131058","journal-title":"Cell Rep"},{"key":"BFEMBJ201490685_CR19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/ten.teb.2011.0004","volume":"17","author":"JYC Cheng","year":"2011","unstructured":"Cheng JYC, Raghunath M, Whitelock J, Poole\u2010Warren L (2011) Matrix components and scaffolds for sustained islet function. Tissue Eng Part B Rev 17: 235\u2013247","journal-title":"Tissue Eng Part B Rev"},{"key":"BFEMBJ201490685_CR20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2007.11.112","volume":"366","author":"YM Cho","year":"2008","unstructured":"Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK (2008) Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta\u2010cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun 366: 129\u2013134","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ201490685_CR21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.stem.2014.03.015","volume":"14","author":"YG Chung","year":"2014","unstructured":"Chung YG, Eum JH, Lee JE, Shim SH, Sepilian V, Hong SW, Lee Y, Treff NR, Choi YH, Kimbrel EA, Dittman RE, Lanza R, Lee DR (2014) Human somatic cell nuclear transfer using adult cells. Cell Stem Cell 14: 777\u2013780","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.clim.2013.02.002","volume":"149","author":"KT Coppieters","year":"2013","unstructured":"Coppieters KT, Harrison LC, von Herrath MG (2013) Trials in type 1 diabetes: antigen\u2010specific therapies. Clin Immunol 149: 345\u2013355","journal-title":"Clin Immunol"},{"key":"BFEMBJ201490685_CR23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2337\/db13-0886","volume":"63","author":"RJ Creusot","year":"2014","unstructured":"Creusot RJ, Giannoukakis N, Trucco M, Clare\u2010Salzler MJ, Fathman CG (2014) It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes 63: 20\u201330","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR24","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nbt1163","volume":"23","author":"KA D'Amour","year":"2005","unstructured":"D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23: 1534\u20131541","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR25","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","volume":"24","author":"KA D'Amour","year":"2006","unstructured":"D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE (2006) Production of pancreatic hormone\u2010expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24: 1392\u20131401","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR26","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.biomaterials.2010.10.036","volume":"32","author":"JT Daoud","year":"2011","unstructured":"Daoud JT, Petropavlovskaia MS, Patapas JM, Degrandpr\u00e9 CE, Diraddo RW, Rosenberg L, Tabrizian M (2011) Long\u2010term in vitro human pancreatic islet culture using three\u2010dimensional microfabricated scaffolds. Biomaterials 32: 1536\u20131542","journal-title":"Biomaterials"},{"key":"BFEMBJ201490685_CR27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"DCCT\u2010Research\u2010Group","year":"1993","unstructured":"DCCT\u2010Research\u2010Group (1993) The effect of intensive treatment of diabetes on the development and progression of long\u2010term complications in insulin\u2010dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329: 977\u2013986","journal-title":"N Engl J Med"},{"key":"BFEMBJ201490685_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2006.03244.x","volume":"148","author":"TP Di Lorenzo","year":"2007","unstructured":"Di Lorenzo TP, Peakman M, Roep BO (2007) Translational mini\u2010review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 148: 1\u201316","journal-title":"Clin Exp Immunol"},{"key":"BFEMBJ201490685_CR29","doi-asserted-by":"crossref","first-page":"179ps177","DOI":"10.1126\/scitranslmed.3005568","volume":"5","author":"MA Fischbach","year":"2013","unstructured":"Fischbach MA, Bluestone JA, Lim WA (2013) Cell\u2010based therapeutics: the next pillar of medicine. Sci Transl Med 5: 179ps177","journal-title":"Sci Transl Med"},{"key":"BFEMBJ201490685_CR30","doi-asserted-by":"crossref","first-page":"39609","DOI":"10.1074\/jbc.M507426200","volume":"280","author":"SG Fonseca","year":"2005","unstructured":"Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y, Urano F (2005) WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta\u2010cells. J Biol Chem 280: 39609\u201339615","journal-title":"J Biol Chem"},{"key":"BFEMBJ201490685_CR31","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1089\/hum.1998.9.18-2717","volume":"9","author":"WS Gallichan","year":"1998","unstructured":"Gallichan WS, Kafri T, Krahl T, Verma IM, Sarvetnick N (1998) Lentivirus\u2010mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum Gene Ther 9: 2717\u20132726","journal-title":"Hum Gene Ther"},{"key":"BFEMBJ201490685_CR32","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dc11-0472","volume":"34","author":"N Giannoukakis","year":"2011","unstructured":"Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M (2011) Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care 34: 2026\u20132032","journal-title":"Diabetes Care"},{"key":"BFEMBJ201490685_CR33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ydbio.2008.10.024","volume":"326","author":"GK Gittes","year":"2009","unstructured":"Gittes GK (2009) Developmental biology of the pancreas: a comprehensive review. Dev Biol 326: 4\u201335","journal-title":"Dev Biol"},{"key":"BFEMBJ201490685_CR34","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.1016\/j.biomaterials.2013.05.066","volume":"34","author":"SK Goh","year":"2013","unstructured":"Goh SK, Bertera S, Olsen P, Candiello JE, Halfter W, Uechi G, Balasubramani M, Johnson SA, Sicari BM, Kollar E, Badylak SF, Banerjee I (2013) Perfusion\u2010decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering. Biomaterials 34: 6760\u20136772","journal-title":"Biomaterials"},{"key":"BFEMBJ201490685_CR35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature09805","volume":"471","author":"A Gore","year":"2011","unstructured":"Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz\u2010Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC et\u00a0al (2011) Somatic coding mutations in human induced pluripotent stem cells. Nature 471: 63\u201367","journal-title":"Nature"},{"key":"BFEMBJ201490685_CR36","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1242\/dev.096628","volume":"140","author":"C Greggio","year":"2013","unstructured":"Greggio C, De Franceschi F, Figueiredo\u2010Larsen M, Gobaa S, Ranga A, Semb H, Lutolf M, Grapin\u2010Botton A (2013) Artificial three\u2010dimensional niches deconstruct pancreas development in vitro. Development 140: 4452\u20134462","journal-title":"Development"},{"key":"BFEMBJ201490685_CR37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2011.06318.x","volume":"1245","author":"DL Greiner","year":"2011","unstructured":"Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD (2011) Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci 1245: 55\u201358","journal-title":"Ann N Y Acad Sci"},{"key":"BFEMBJ201490685_CR38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1900\/RDS.2011.8.6","volume":"8","author":"AC Gruessner","year":"2011","unstructured":"Gruessner AC (2011) 2011 update on pancreas transplantation: comprehensive trend analysis of 25,000 cases followed up over the course of twenty\u2010four years at the International Pancreas Transplant Registry (IPTR). Rev Diabet Stud 8: 6\u201316","journal-title":"Rev Diabet Stud"},{"key":"BFEMBJ201490685_CR39","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1016\/j.transproceed.2006.10.158","volume":"38","author":"K Haga","year":"2006","unstructured":"Haga K, Lemp NA, Logg CR, Nagashima J, Faure\u2010Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Cicciarelli JC (2006) Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: averting cytotoxicity by alloreactive T lymphocytes. Transpl Proc 38: 3184\u20133188","journal-title":"Transpl Proc"},{"key":"BFEMBJ201490685_CR40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2213-8587(13)70113-X","volume":"1","author":"A Hartemann","year":"2013","unstructured":"Hartemann A, Bensimon G, Payan CA, Jacqueminet S, Bourron O, Nicolas N, Fonfrede M, Rosenzwajg M, Bernard C, Klatzmann D (2013) Low\u2010dose interleukin 2 in patients with type 1 diabetes: a phase 1\/2 randomised, double\u2010blind, placebo\u2010controlled trial. Lancet Diabetes Endocrinol 1: 295\u2013305","journal-title":"Lancet Diabetes Endocrinol"},{"key":"BFEMBJ201490685_CR41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF02626171","volume":"25","author":"A Hayek","year":"1989","unstructured":"Hayek A, Lopez AD, Beattie GM (1989) Enhancement of pancreatic islet cell monolayer growth by endothelial cell matrix and insulin. In vitro Cell Dev Biol 25: 146\u2013150","journal-title":"In vitro Cell Dev Biol"},{"key":"BFEMBJ201490685_CR42","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1056\/NEJMoa012864","volume":"346","author":"KC Herold","year":"2002","unstructured":"Herold KC, Hagopian W, Auger JA, Poumian\u2010Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA (2002) Anti\u2010CD3 monoclonal antibody in new\u2010onset type 1 diabetes mellitus. N Engl J Med 346: 1692\u20131698","journal-title":"N Engl J Med"},{"key":"BFEMBJ201490685_CR43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri3422","volume":"13","author":"KC Herold","year":"2013","unstructured":"Herold KC, Vignali DA, Cooke A, Bluestone JA (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol 13: 243\u2013256","journal-title":"Nat Rev Immunol"},{"key":"BFEMBJ201490685_CR44","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1172\/JCI67638","volume":"123","author":"H Hua","year":"2013","unstructured":"Hua H, Shang L, Martinez H, Freeby M, Gallagher MP, Ludwig T, Deng L, Greenberg E, Leduc C, Chung WK, Goland R, Leibel RL, Egli D (2013) iPSC\u2010derived beta cells model diabetes due to glucokinase deficiency. J Clin Invest 123: 3146\u20133153","journal-title":"J Clin Invest"},{"key":"BFEMBJ201490685_CR45","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/emboj.2013.204","volume":"32","author":"M Huch","year":"2013","unstructured":"Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H (2013) Unlimited in vitro expansion of adult bi\u2010potent pancreas progenitors through the Lgr5\/R\u2010spondin axis. EMBO J 32: 2708\u20132721","journal-title":"EMBO J"},{"key":"BFEMBJ201490685_CR46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1074-7613(02)00273-X","volume":"16","author":"S Hugues","year":"2002","unstructured":"Hugues S, Mougneau E, Ferlin W, Jeske D, Hofman P, Homann D, Beaudoin L, Schrike C, Von Herrath M, Lehuen A, Glaichenhaus N (2002) Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity 16: 169\u2013181","journal-title":"Immunity"},{"key":"BFEMBJ201490685_CR47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/2441","volume":"20","author":"H Inoue","year":"1998","unstructured":"Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal\u2010Mizrachi E, Mueckler M, Marshall H, Donis\u2010Keller H, Crock P, Rogers D, Mikuni M, Kumashiro H, Higashi K, Sobue G, Oka Y, Permutt MA (1998) A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 20: 143\u2013148","journal-title":"Nat Genet"},{"key":"BFEMBJ201490685_CR48","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.stem.2014.10.002","volume":"15","author":"B Johannesson","year":"2014","unstructured":"Johannesson B, Sagi I, Gore A, Paull D, Yamada M, Golan\u2010Lev T, Li Z, LeDuc C, Shen Y, Stern S, Xu N, Ma H, Kang E, Mitalipov S, Sauer MV, Zhang K, Benvenisty N, Egli D (2014) Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors. Cell Stem Cell 15: 634\u2013642","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR49","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2007.02.010","volume":"12","author":"KA Johansson","year":"2007","unstructured":"Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin\u2010Botton A (2007) Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 12: 457\u2013465","journal-title":"Dev Cell"},{"key":"BFEMBJ201490685_CR50","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.4049\/jimmunol.163.8.4224","volume":"163","author":"AK Johnsen","year":"1999","unstructured":"Johnsen AK, Templeton DJ, Sy M, Harding CV (1999) Deficiency of transporter for antigen presentation (TAP) in tumor cells allows evasion of immune surveillance and increases tumorigenesis. J Immunol 163: 4224\u20134231","journal-title":"J Immunol"},{"key":"BFEMBJ201490685_CR51","doi-asserted-by":"crossref","first-page":"125ra130","DOI":"10.1126\/scitranslmed.3003481","volume":"4","author":"H Kalscheuer","year":"2012","unstructured":"Kalscheuer H, Danzl N, Onoe T, Faust T, Winchester R, Goland R, Greenberg E, Spitzer TR, Savage DG, Tahara H, Choi G, Yang YG, Sykes M (2012) A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med 4: 125ra130","journal-title":"Sci Transl Med"},{"key":"BFEMBJ201490685_CR52","doi-asserted-by":"crossref","first-page":"241ra278","DOI":"10.1126\/scitranslmed.3008895","volume":"6","author":"S Kasagi","year":"2014","unstructured":"Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, Zanvit P, Jin W, Konkel JE, Chen W (2014) In vivo\u2010generated antigen\u2010specific regulatory T cells treat autoimmunity without compromising antibacterial immune response. Sci Transl Med 6: 241ra278","journal-title":"Sci Transl Med"},{"key":"BFEMBJ201490685_CR53","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nbt.1931","volume":"29","author":"OG Kelly","year":"2011","unstructured":"Kelly OG, Chan MY, Martinson LA, Kadoya K, Ostertag TM, Ross KG, Richardson M, Carpenter MK, D'Amour KA, Kroon E, Moorman M, Baetge EE, Bang AG (2011) Cell\u2010surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol 29: 750\u2013756","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR54","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1056\/NEJMoa043980","volume":"352","author":"B Keymeulen","year":"2005","unstructured":"Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E (2005) Insulin needs after CD3\u2010antibody therapy in new\u2010onset type 1 diabetes. N Engl J Med 352: 2598\u20132608","journal-title":"N Engl J Med"},{"key":"BFEMBJ201490685_CR55","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nbt.2052","volume":"29","author":"K Kim","year":"2011","unstructured":"Kim K, Zhao R, Doi A, Ng K, Unternaehrer J, Cahan P, Huo H, Loh YH, Aryee MJ, Lensch MW, Li H, Collins JJ, Feinberg AP, Daley GQ (2011) Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol 29: 1117\u20131119","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR56","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrg3686","volume":"15","author":"H Kim","year":"2014","unstructured":"Kim H, Kim JS (2014) A guide to genome engineering with programmable nucleases. Nat Rev Genet 15: 321\u2013334","journal-title":"Nat Rev Genet"},{"key":"BFEMBJ201490685_CR57","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/scdb.1999.0277","volume":"10","author":"A Kind","year":"1999","unstructured":"Kind A, Colman A (1999) Therapeutic cloning: needs and prospects. Semin Cell Dev Biol 10: 279\u2013286","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMBJ201490685_CR58","doi-asserted-by":"crossref","first-page":"e1374","DOI":"10.1371\/journal.pone.0001374","volume":"3","author":"DJ Klinke II","year":"2008","unstructured":"Klinke DJ II (2008) Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. PLoS ONE 3: e1374","journal-title":"PLoS ONE"},{"key":"BFEMBJ201490685_CR59","doi-asserted-by":"crossref","first-page":"20569","DOI":"10.1073\/pnas.1319061110","volume":"110","author":"M Koyanagi\u2010Aoi","year":"2013","unstructured":"Koyanagi\u2010Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S (2013) Differentiation\u2010defective phenotypes revealed by large\u2010scale analyses of human pluripotent stem cells. Proc Natl Acad Sci USA 110: 20569\u201320574","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201490685_CR60","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1210\/en.2010-0877","volume":"152","author":"M Krishnamurthy","year":"2011","unstructured":"Krishnamurthy M, Li J, Fellows GF, Rosenberg L, Goodyer CG, Wang R (2011) Integrin {alpha}3, but not {beta}1, regulates islet cell survival and function via PI3K\/Akt signaling pathways. Endocrinology 152: 424\u2013435","journal-title":"Endocrinology"},{"key":"BFEMBJ201490685_CR61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","volume":"26","author":"E Kroon","year":"2008","unstructured":"Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, Young H, Richardson M, Smart NG, Cunningham J, Agulnick AD, D'Amour KA, Carpenter MK, Baetge EE (2008) Pancreatic endoderm derived from human embryonic stem cells generates glucose\u2010responsive insulin\u2010secreting cells in vivo. Nat Biotechnol 26: 443\u2013452","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR62","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1242\/dev.01044","volume":"131","author":"A Kubo","year":"2004","unstructured":"Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, Woo S, Fehling HJ, Keller G (2004) Development of definitive endoderm from embryonic stem cells in culture. Development 131: 1651\u20131662","journal-title":"Development"},{"key":"BFEMBJ201490685_CR63","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.scr.2011.10.002","volume":"8","author":"Y Kunisada","year":"2012","unstructured":"Kunisada Y, Tsubooka\u2010Yamazoe N, Shoji M, Hosoya M (2012) Small molecules induce efficient differentiation into insulin\u2010producing cells from human induced pluripotent stem cells. Stem Cell Res 8: 274\u2013284","journal-title":"Stem Cell Res"},{"key":"BFEMBJ201490685_CR64","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/12404","volume":"5","author":"RP Lanza","year":"1999","unstructured":"Lanza RP, Cibelli JB, West MD (1999a) Human therapeutic cloning. Nat Med 5: 975\u2013977","journal-title":"Nat Med"},{"key":"BFEMBJ201490685_CR65","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/00007890-199904270-00004","volume":"67","author":"RP Lanza","year":"1999","unstructured":"Lanza RP, Jackson R, Sullivan A, Ringeling J, McGrath C, Kuhtreiber W, Chick WL (1999b) Xenotransplantation of cells using biodegradable microcapsules. Transplantation 67: 1105\u20131111","journal-title":"Transplantation"},{"key":"BFEMBJ201490685_CR66","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.1406376111","volume":"111","author":"K Lee","year":"2014","unstructured":"Lee K, Kwon DN, Ezashi T, Choi YJ, Park C, Ericsson AC, Brown AN, Samuel MS, Park KW, Walters EM, Kim DY, Kim JH, Franklin CL, Murphy CN, Roberts RM, Prather RS, Kim JH (2014) Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency. Proc Natl Acad Sci USA 111: 7260\u20137265","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201490685_CR67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3727\/000000005783983232","volume":"14","author":"N Lembert","year":"2005","unstructured":"Lembert N, Wesche J, Petersen P, Doser M, Zschocke P, Becker HD, Ammon HP (2005) Encapsulation of islets in rough surface, hydroxymethylated polysulfone capillaries stimulates VEGF release and promotes vascularization after transplantation. Cell Transplant 14: 97\u2013108","journal-title":"Cell Transplant"},{"key":"BFEMBJ201490685_CR68","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2119\/molmed.2011.00196","volume":"18","author":"EC Lewis","year":"2012","unstructured":"Lewis EC (2012) Expanding the clinical indications for alpha(1)\u2010antitrypsin therapy. Mol Med 18: 957\u2013970","journal-title":"Mol Med"},{"key":"BFEMBJ201490685_CR69","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00125-009-1342-7","volume":"52","author":"EH Liu","year":"2009","unstructured":"Liu EH, Digon BJ 3rd, Hirshberg B, Chang R, Wood BJ, Neeman Z, Kam A, Wesley RA, Polly SM, Hofmann RM, Rother KI, Harlan DM (2009) Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft. Diabetologia 52: 1369\u20131380","journal-title":"Diabetologia"},{"key":"BFEMBJ201490685_CR70","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, Karre K (1990) In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition. Immunol Today 11: 237\u2013244","journal-title":"Immunol Today"},{"key":"BFEMBJ201490685_CR71","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0303-7207(93)90046-M","volume":"94","author":"C Lucas\u2010Clerc","year":"1993","unstructured":"Lucas\u2010Clerc C, Massart C, Campion JP, Launois B, Nicol M (1993) Long\u2010term culture of human pancreatic islets in an extracellular matrix: morphological and metabolic effects. Mol Cell Endocrinol 94: 9\u201320","journal-title":"Mol Cell Endocrinol"},{"key":"BFEMBJ201490685_CR72","doi-asserted-by":"crossref","first-page":"188ra175","DOI":"10.1126\/scitranslmed.3006168","volume":"5","author":"A Lutterotti","year":"2013","unstructured":"Lutterotti A, Yousef S, Sputtek A, St\u00fcrner KH, Stellmann JP, Breiden P, Reinhardt S, Schulze C, Bester M, Heesen C, Schippling S, Miller SD, Sospedra M, Martin R (2013) Antigen\u2010specific tolerance by autologous myelin peptide\u2010coupled cells: a phase 1 trial in multiple sclerosis. Sci Transl Med 5: 188ra175","journal-title":"Sci Transl Med"},{"key":"BFEMBJ201490685_CR73","doi-asserted-by":"crossref","first-page":"15768","DOI":"10.1073\/pnas.0906894106","volume":"106","author":"R Maehr","year":"2009","unstructured":"Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA (2009) Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA 106: 15768\u201315773","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201490685_CR74","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2249.2010.04153.x","volume":"160","author":"JB Matthews","year":"2010","unstructured":"Matthews JB, Staeva TP, Bernstein PL, Peakman M, von Herrath M, Group I.\u2010J.T.D.C.T.A. (2010) Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN\u2010JDRF Type 1 Diabetes Combination Therapy Assessment Group. Clin Exp Immunol 160: 176\u2013184","journal-title":"Clin Exp Immunol"},{"key":"BFEMBJ201490685_CR75","doi-asserted-by":"crossref","first-page":"9943","DOI":"10.1021\/la1004424","volume":"26","author":"AD Mendelsohn","year":"2010","unstructured":"Mendelsohn AD, Bernards DA, Lowe RD, Desai TA (2010) Patterning of mono\u2010 and multilayered pancreatic beta\u2010cell clusters. Langmuir 26: 9943\u20139949","journal-title":"Langmuir"},{"key":"BFEMBJ201490685_CR76","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/CS20050342","volume":"110","author":"S Merani","year":"2006","unstructured":"Merani S, Shapiro AM (2006) Current status of pancreatic islet transplantation. Clin Sci 110: 611\u2013625","journal-title":"Clin Sci"},{"key":"BFEMBJ201490685_CR77","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1053\/j.gastro.2010.02.056","volume":"138","author":"JK Mfopou","year":"2010","unstructured":"Mfopou JK, Chen B, Mateizel I, Sermon K, Bouwens L (2010) Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells. Gastroenterology 138: 2233\u20132245, 2245 e2231\u20102214","journal-title":"Gastroenterology"},{"key":"BFEMBJ201490685_CR78","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1016\/j.biomaterials.2013.03.054","volume":"34","author":"SH Mirmalek\u2010Sani","year":"2013","unstructured":"Mirmalek\u2010Sani SH, Orlando G, McQuilling JP, Pareta R, Mack DL, Salvatori M, Farney AC, Stratta RJ, Atala A, Opara EC, Soker S (2013) Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials 34: 5488\u20135495","journal-title":"Biomaterials"},{"key":"BFEMBJ201490685_CR79","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3727\/000000001783986549","volume":"10","author":"N Nagata","year":"2001","unstructured":"Nagata N, Gu Y, Hori H, Balamurugan AN, Touma M, Kawakami Y, Wang W, Baba TT, Satake A, Nozawa M, Tabata Y, Inoue K (2001) Evaluation of insulin secretion of isolated rat islets cultured in extracellular matrix. Cell Transplant 10: 447\u2013451","journal-title":"Cell Transplant"},{"key":"BFEMBJ201490685_CR80","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.2337\/db13-1093","volume":"62","author":"DM Nathan","year":"2013","unstructured":"Nathan DM, Bayless M, Cleary P, Genuth S, Gubitosi\u2010Klug R, Lachin JM, Lorenzi G, Zinman B, Group D.E.R. (2013) Diabetes control and complications trial\/epidemiology of diabetes interventions and complications study at 30\u00a0years: advances and contributions. Diabetes 62: 3976\u20133986","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR81","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1172\/JCI32959","volume":"117","author":"T Nir","year":"2007","unstructured":"Nir T, Melton DA, Dor Y (2007) Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 117: 2553\u20132561","journal-title":"J Clin Invest"},{"key":"BFEMBJ201490685_CR82","doi-asserted-by":"crossref","first-page":"e1002085","DOI":"10.1371\/journal.pgen.1002085","volume":"7","author":"K Nishino","year":"2011","unstructured":"Nishino K, Toyoda M, Yamazaki\u2010Inoue M, Fukawatase Y, Chikazawa E, Sakaguchi H, Akutsu H, Umezawa A (2011) DNA methylation dynamics in human induced pluripotent stem cells over time. PLoS Genet 7: e1002085\u2013e1002085","journal-title":"PLoS Genet"},{"key":"BFEMBJ201490685_CR83","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1124004","volume":"311","author":"J Nishio","year":"2006","unstructured":"Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D (2006) Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 311: 1775\u20131778","journal-title":"Science"},{"key":"BFEMBJ201490685_CR84","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1242\/dev.055236","volume":"138","author":"MC Nostro","year":"2011","unstructured":"Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G (2011) Stage\u2010specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 138: 861\u2013871","journal-title":"Development"},{"key":"BFEMBJ201490685_CR85","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00006676-200103000-00008","volume":"22","author":"C Oberg\u2010Welsh","year":"2001","unstructured":"Oberg\u2010Welsh C (2001) Long\u2010term culture in matrigel enhances the insulin secretion of fetal porcine islet\u2010like cell clusters in vitro. Pancreas 22: 157\u2013163","journal-title":"Pancreas"},{"key":"BFEMBJ201490685_CR86","doi-asserted-by":"crossref","first-page":"60","DOI":"10.18632\/aging.100428","volume":"4","author":"S Ohmine","year":"2012","unstructured":"Ohmine S, Squillace KA, Hartjes KA, Deeds MC, Armstrong AS, Thatava T, Sakuma T, Terzic A, Kudva Y, Ikeda Y (2012) Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency. Aging 4: 60\u201373","journal-title":"Aging"},{"key":"BFEMBJ201490685_CR87","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00125-013-3067-x","volume":"57","author":"RA Oram","year":"2014","unstructured":"Oram RA, Jones AG, Besser RE, Knight BA, Shields BM, Brown RJ, Hattersley AT, McDonald TJ (2014) The majority of patients with long\u2010duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia 57: 187\u2013191","journal-title":"Diabetologia"},{"key":"BFEMBJ201490685_CR88","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2337\/db13-1742","volume":"63","author":"G Orlando","year":"2014","unstructured":"Orlando G, Gianello P, Salvatori M, Stratta RJ, Soker S, Ricordi C, Dominguez\u2010Bendala J (2014) Cell replacement strategies aimed at reconstitution of the beta\u2010cell compartment in type 1 diabetes. Diabetes 63: 1433\u20131444","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR89","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","volume":"159","author":"FW Pagliuca","year":"2014","unstructured":"Pagliuca FW, Millman JR, Gurtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA (2014) Generation of functional human pancreatic beta cells in vitro. Cell 159: 428\u2013439","journal-title":"Cell"},{"key":"BFEMBJ201490685_CR90","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.stem.2013.04.004","volume":"13","author":"AV Parent","year":"2013","unstructured":"Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M (2013) Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell 13: 219\u2013229","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR91","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00006676-199607000-00006","volume":"13","author":"R Perfetti","year":"1996","unstructured":"Perfetti R, Henderson TE, Wang Y, Montrose\u2010Rafizadeh C, Egan JM (1996) Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix. Pancreas 13: 47\u201354","journal-title":"Pancreas"},{"key":"BFEMBJ201490685_CR92","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1016\/j.biomaterials.2013.03.012","volume":"34","author":"EA Phelps","year":"2013","unstructured":"Phelps EA, Headen DM, Taylor WR, Thule PM, Garcia AJ (2013) Vasculogenic bio\u2010synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes. Biomaterials 34: 4602\u20134611","journal-title":"Biomaterials"},{"key":"BFEMBJ201490685_CR93","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1900\/RDS.2012.9.319","volume":"9","author":"S Prasad","year":"2012","unstructured":"Prasad S, Xu D, Miller SD (2012) Tolerance strategies employing antigen\u2010coupled apoptotic cells and carboxylated PLG nanoparticles for the treatment of type 1 diabetes. Rev Diabet Stud 9: 319\u2013327","journal-title":"Rev Diabet Stud"},{"key":"BFEMBJ201490685_CR94","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1016\/j.biomaterials.2004.01.050","volume":"25","author":"M Qi","year":"2004","unstructured":"Qi M, Gu Y, Sakata N, Kim D, Shirouzu Y, Yamamoto C, Hiura A, Sumi S, Inoue K (2004) PVA hydrogel sheet macroencapsulation for the bioartificial pancreas. Biomaterials 25: 5885\u20135892","journal-title":"Biomaterials"},{"key":"BFEMBJ201490685_CR95","first-page":"429710","volume":"2014","author":"M Qi","year":"2014","unstructured":"Qi M (2014) Transplantation of encapsulated pancreatic islets as a treatment for patients with type 1 diabetes mellitus. Adv Med 2014: 429710","journal-title":"Adv Med"},{"key":"BFEMBJ201490685_CR96","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molimm.2012.10.009","volume":"55","author":"ME Ressing","year":"2013","unstructured":"Ressing ME, Luteijn RD, Horst D, Wiertz EJ (2013) Viral interference with antigen presentation: trapping TAP. Mol Immunol 55: 139\u2013142","journal-title":"Mol Immunol"},{"key":"BFEMBJ201490685_CR97","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db11-1711","volume":"61","author":"A Rezania","year":"2012","unstructured":"Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, Ao Z, Warnock GL, Kieffer TJ (2012) Maturation of human embryonic stem cell\u2010derived pancreatic progenitors into functional islets capable of treating pre\u2010existing diabetes in mice. Diabetes 61: 2016\u20132029","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR98","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/stem.1489","volume":"31","author":"A Rezania","year":"2013","unstructured":"Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ (2013) Enrichment of human embryonic stem cell\u2010derived NKX6.1\u2010expressing pancreatic progenitor cells accelerates the maturation of insulin\u2010secreting cells in vivo. Stem Cells 31: 2432\u20132442","journal-title":"Stem Cells"},{"key":"BFEMBJ201490685_CR99","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","volume":"32","author":"A Rezania","year":"2014","unstructured":"Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M, Albrecht T, Yang YH, Johnson JD, Kieffer TJ (2014) Reversal of diabetes with insulin\u2010producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol 32: 1121\u20131133","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ201490685_CR100","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature10761","volume":"481","author":"DA Robinton","year":"2012","unstructured":"Robinton DA, Daley GQ (2012) The promise of induced pluripotent stem cells in research and therapy. Nature 481: 295\u2013305","journal-title":"Nature"},{"key":"BFEMBJ201490685_CR101","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.gassur.2003.09.008","volume":"7","author":"HL Rodriguez Rilo","year":"2003","unstructured":"Rodriguez Rilo HL, Ahmad SA, D'Alessio D, Iwanaga Y, Kim J, Choe KA, Moulton JS, Martin J, Pennington LJ, Soldano DA, Biliter J, Martin SP, Ulrich CD, Somogyi L, Welge J, Matthews JB, Lowy AM (2003) Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis. J Gastrointest Surg 7: 978\u2013989","journal-title":"J Gastrointest Surg"},{"key":"BFEMBJ201490685_CR102","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2249.2009.04087.x","volume":"159","author":"BO Roep","year":"2010","unstructured":"Roep BO, Kleijwegt FS, van Halteren AG, Bonato V, Boggi U, Vendrame F, Marchetti P, Dotta F (2010) Islet inflammation and CXCL10 in recent\u2010onset type 1 diabetes. Clin Exp Immunol 159: 338\u2013343","journal-title":"Clin Exp Immunol"},{"key":"BFEMBJ201490685_CR103","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4291\/wjgp.v3.i1.19","volume":"3","author":"N Sakata","year":"2012","unstructured":"Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M (2012) Encapsulated islets transplantation: past, present and future. World J Gastrointest Pathophysiol 3: 19\u201326","journal-title":"World J Gastrointest Pathophysiol"},{"key":"BFEMBJ201490685_CR104","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1242\/dev.127.24.5533","volume":"127","author":"M Sander","year":"2000","unstructured":"Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes\u2010Jordan A, German M (2000) Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta\u2010cell formation in the pancreas. Development 127: 5533\u20135540","journal-title":"Development"},{"key":"BFEMBJ201490685_CR105","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2337\/diab.43.9.1167","volume":"43","author":"DW Scharp","year":"1994","unstructured":"Scharp DW, Swanson CJ, Olack BJ, Latta PP, Hegre OD, Doherty EJ, Gentile FT, Flavin KS, Ansara MF, Lacy PE (1994) Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects. Diabetes 43: 1167\u20131170","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR106","doi-asserted-by":"crossref","first-page":"e37004","DOI":"10.1371\/journal.pone.0037004","volume":"7","author":"TC Schulz","year":"2012","unstructured":"Schulz TC, Young HY, Agulnick AD, Babin MJ, Baetge EE, Bang AG, Bhoumik A, Cepa I, Cesario RM, Haakmeester C, Kadoya K, Kelly JR, Kerr J, Martinson LA, McLean AB, Moorman MA, Payne JK, Richardson M, Ross KG, Sherrer ES et\u00a0al (2012) A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS ONE 7: e37004 sernova.com.","journal-title":"PLoS ONE"},{"key":"BFEMBJ201490685_CR107","doi-asserted-by":"crossref","first-page":"923","DOI":"10.2337\/db13-0717","volume":"63","author":"L Shang","year":"2014","unstructured":"Shang L, Hua H, Foo K, Martinez H, Watanabe K, Zimmer M, Kahler DJ, Freeby M, Chung W, LeDuc C, Goland R, Leibel RL, Egli D (2014) beta\u2010cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes 63: 923\u2013933","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR108","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.4049\/jimmunol.0900679","volume":"183","author":"SJ Shieh","year":"2009","unstructured":"Shieh SJ, Chou FC, Yu PN, Lin WC, Chang DM, Roffler SR, Sytwu HK (2009) Transgenic expression of single\u2010chain anti\u2010CTLA\u20104 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes. J Immunol 183: 2277\u20132285","journal-title":"J Immunol"},{"key":"BFEMBJ201490685_CR109","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1242\/dev.078634","volume":"139","author":"HP Shih","year":"2012","unstructured":"Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin\u2010Botton A, Sander M (2012) A Notch\u2010dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139: 2488\u20132499","journal-title":"Development"},{"key":"BFEMBJ201490685_CR110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/db12-0562","volume":"62","author":"TP Staeva","year":"2013","unstructured":"Staeva TP, Chatenoud L, Insel R, Atkinson MA (2013) Recent lessons learned from prevention and recent\u2010onset type 1 diabetes immunotherapy trials. Diabetes 62: 9\u201317","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR111","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/MED.0b013e3283488275","volume":"18","author":"AK Steck","year":"2011","unstructured":"Steck AK, Winter WE (2011) Review on monogenic diabetes. Curr Opin Endocrinol Diabetes Obes 18: 252\u2013258","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"BFEMBJ201490685_CR112","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3727\/000000002783985503","volume":"11","author":"WL Suarez\u2010Pinzon","year":"2002","unstructured":"Suarez\u2010Pinzon WL, Marcoux Y, Ghahary A, Rabinovitch A (2002) Gene transfection and expression of transforming growth factor\u2010beta1 in nonobese diabetic mouse islets protects beta\u2010cells in syngeneic islet grafts from autoimmune destruction. Cell Transplant 11: 519\u2013528","journal-title":"Cell Transplant"},{"key":"BFEMBJ201490685_CR113","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12015-013-9435-6","volume":"9","author":"L Sui","year":"2013","unstructured":"Sui L, Geens M, Sermon K, Bouwens L, Mfopou JK (2013) Role of BMP signaling in pancreatic progenitor differentiation from human embryonic stem cells. Stem Cell Rev 9: 569\u2013577","journal-title":"Stem Cell Rev"},{"key":"BFEMBJ201490685_CR114","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.stem.2013.06.014","volume":"13","author":"X Sun","year":"2013","unstructured":"Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H (2013) Directed differentiation of human embryonic stem cells into thymic epithelial progenitor\u2010like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell 13: 230\u2013236","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR115","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI31405","volume":"117","author":"JB Swann","year":"2007","unstructured":"Swann JB, Smyth MJ (2007) Immune surveillance of tumors. J Clin Invest 117: 1137\u20131146","journal-title":"J Clin Invest"},{"key":"BFEMBJ201490685_CR116","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.cell.2013.05.006","volume":"153","author":"M Tachibana","year":"2013","unstructured":"Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner\u2010Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler\u2010Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S et\u00a0al (2013) Human embryonic stem cells derived by somatic cell nuclear transfer. Cell 153: 1228\u20131238","journal-title":"Cell"},{"key":"BFEMBJ201490685_CR117","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861\u2013872","journal-title":"Cell"},{"key":"BFEMBJ201490685_CR118","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ng.2215","volume":"44","author":"C Talchai","year":"2012","unstructured":"Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D (2012) Generation of functional insulin\u2010producing cells in the gut by Foxo1 ablation. Nat Genet 44: 406\u2013412, S401","journal-title":"Nat Genet"},{"key":"BFEMBJ201490685_CR119","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0959-437X(03)00085-6","volume":"13","author":"PP Tam","year":"2003","unstructured":"Tam PP, Kanai\u2010Azuma M, Kanai Y (2003) Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev 13: 393\u2013400","journal-title":"Curr Opin Genet Dev"},{"key":"BFEMBJ201490685_CR120","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1074\/jbc.C112.428979","volume":"288","author":"AK Teo","year":"2013","unstructured":"Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN (2013) Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem 288: 5353\u20135356","journal-title":"J Biol Chem"},{"key":"BFEMBJ201490685_CR121","doi-asserted-by":"crossref","first-page":"d6044","DOI":"10.1136\/bmj.d6044","volume":"343","author":"G Thanabalasingham","year":"2011","unstructured":"Thanabalasingham G, Owen KR (2011) Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ 343: d6044","journal-title":"BMJ"},{"key":"BFEMBJ201490685_CR122","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/35000200","volume":"403","author":"B Thisse","year":"2000","unstructured":"Thisse B, Wright CV, Thisse C (2000) Activin\u2010 and Nodal\u2010related factors control antero\u2010posterior patterning of the zebrafish embryo. Nature 403: 425\u2013428","journal-title":"Nature"},{"key":"BFEMBJ201490685_CR123","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11892-012-0304-5","volume":"12","author":"JA Thompson","year":"2012","unstructured":"Thompson JA, Perry D, Brusko TM (2012) Autologous regulatory T cells for the treatment of type 1 diabetes. Curr Diab Rep 12: 623\u2013632","journal-title":"Curr Diab Rep"},{"key":"BFEMBJ201490685_CR124","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2010.04.001","volume":"32","author":"JA Todd","year":"2010","unstructured":"Todd JA (2010) Etiology of type 1 diabetes. Immunity 32: 457\u2013467","journal-title":"Immunity"},{"key":"BFEMBJ201490685_CR125","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1182\/blood-2013-03-478255","volume":"122","author":"H Torikai","year":"2013","unstructured":"Torikai H, Reik A, Soldner F, Warren EH, Yuen C, Zhou Y, Crossland DL, Huls H, Littman N, Zhang Z, Tykodi SS, Kebriaei P, Lee DA, Miller JC, Rebar EJ, Holmes MC, Jaenisch R, Champlin RE, Gregory PD, Cooper LJ (2013) Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood 122: 1341\u20131349","journal-title":"Blood"},{"key":"BFEMBJ201490685_CR126","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.stem.2013.08.003","volume":"13","author":"M Turner","year":"2013","unstructured":"Turner M, Leslie S, Martin NG, Peschanski M, Rao M, Taylor CJ, Trounson A, Turner D, Yamanaka S, Wilmut I (2013) Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell 13: 382\u2013384","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR127","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1056\/NEJM199609193351205","volume":"335","author":"G Tyden","year":"1996","unstructured":"Tyden G, Reinholt FP, Sundkvist G, Bolinder J (1996) Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N Engl J Med 335: 860\u2013863","journal-title":"N Engl J Med"},{"key":"BFEMBJ201490685_CR128","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1210\/er.2007-0024","volume":"29","author":"M Vaxillaire","year":"2008","unstructured":"Vaxillaire M, Froguel P (2008) Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocr Rev 29: 254\u2013264","journal-title":"Endocr Rev"},{"key":"BFEMBJ201490685_CR129","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/db09-0498","volume":"59","author":"F Vendrame","year":"2010","unstructured":"Vendrame F, Pileggi A, Laughlin E, Allende G, Martin\u2010Pagola A, Molano RD, Diamantopoulos S, Standifer N, Geubtner K, Falk BA, Ichii H, Takahashi H, Snowhite I, Chen Z, Mendez A, Chen L, Sageshima J, Ruiz P, Ciancio G, Ricordi C et\u00a0al (2010) Recurrence of type 1 diabetes after simultaneous pancreas\u2010kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T\u2010cells. Diabetes 59: 947\u2013957","journal-title":"Diabetes"},{"key":"BFEMBJ201490685_CR130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4827(92)90397-Q","volume":"202","author":"S Vukicevic","year":"1992","unstructured":"Vukicevic S, Kleinman HK, Luyten FP, Roberts AB, Roche NS, Reddi AH (1992) Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 202: 1\u20138","journal-title":"Exp Cell Res"},{"key":"BFEMBJ201490685_CR131","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1174497","volume":"324","author":"E Wandzioch","year":"2009","unstructured":"Wandzioch E, Zaret KS (2009) Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science 324: 1707\u20131710","journal-title":"Science"},{"key":"BFEMBJ201490685_CR132","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ncb2748","volume":"15","author":"T Wang","year":"2013","unstructured":"Wang T, Wu H, Li Y, Szulwach KE, Lin L, Li X, Chen IP, Goldlust IS, Chamberlain SJ, Dodd A, Gong H, Ananiev G, Han JW, Yoon YS, Rudd MK, Yu M, Song CX, He C, Chang Q, Warren ST, Jin P (2013) Subtelomeric hotspots of aberrant 5\u2010hydroxymethylcytosine\u2010mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol 15: 700\u2013711","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ201490685_CR133","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.stem.2010.08.012","volume":"7","author":"L Warren","year":"2010","unstructured":"Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7: 618\u2013630","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR134","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3727\/000000007783472336","volume":"16","author":"LM Weber","year":"2008","unstructured":"Weber LM, Cheung CY, Anseth KS (2008) Multifunctional pancreatic islet encapsulation barriers achieved via multilayer PEG hydrogels. Cell Transplant 16: 1049\u20131057","journal-title":"Cell Transplant"},{"key":"BFEMBJ201490685_CR135","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.stem.2014.10.018","volume":"15","author":"U Weissbein","year":"2014","unstructured":"Weissbein U, Ben\u2010David U, Benvenisty N (2014) Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells. Cell Stem Cell 15: 687\u2013691","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ201490685_CR136","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1534-5807(01)00076-4","volume":"1","author":"M Whitman","year":"2001","unstructured":"Whitman M (2001) Nodal signaling in early vertebrate embryos: themes and variations. Dev Cell 1: 605\u2013617","journal-title":"Dev Cell"},{"key":"BFEMBJ201490685_CR137","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature13287","volume":"510","author":"M Yamada","year":"2014","unstructured":"Yamada M, Johannesson B, Sagi I, Burnett LC, Kort DH, Prosser RW, Paull D, Nestor MW, Freeby M, Greenberg E, Goland RS, Leibel RL, Solomon SL, Benvenisty N, Sauer MV, Egli D (2014) Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature 510: 533\u2013536","journal-title":"Nature"},{"key":"BFEMBJ201490685_CR138","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00007890-199707150-00006","volume":"64","author":"H Yang","year":"1997","unstructured":"Yang H, O'Hali W, Kearns H, Wright JR Jr (1997) Long\u2010term function of fish islet xenografts in mice by alginate encapsulation. Transplantation 64: 28\u201332","journal-title":"Transplantation"},{"key":"BFEMBJ201490685_CR139","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/mt.2013.105","volume":"21","author":"A Zaldumbide","year":"2013","unstructured":"Zaldumbide A, Alkemade G, Carlotti F, Nikolic T, Abreu JR, Engelse MA, Skowera A, de Koning EJ, Peakman M, Roep BO, Hoeben RC, Wiertz EJ (2013) Genetically engineered human islets protected from CD8\u2010mediated autoimmune destruction in vivo. Mol Ther 21: 1592\u20131601","journal-title":"Mol Ther"},{"key":"BFEMBJ201490685_CR140","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","volume":"455","author":"Q Zhou","year":"2008","unstructured":"Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta\u2010cells. Nature 455: 627\u2013632","journal-title":"Nature"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201490685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.201490685","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.201490685\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.201490685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201490685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:31:15Z","timestamp":1779305475000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.201490685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,2]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,4,1]]}},"alternative-id":["BFEMBJ201490685"],"URL":"https:\/\/doi.org\/10.15252\/embj.201490685","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,2]]},"assertion":[{"value":"27 November 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}