{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:08:16Z","timestamp":1779307696301,"version":"3.51.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2015,4,15]]},"DOI":"10.15252\/embj.201591240","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T22:13:36Z","timestamp":1425420816000},"page":"981-983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity"],"prefix":"10.1038","volume":"34","author":[{"given":"Meghan S","family":"Soustek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Puigserver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"BFEMBJ201591240_CR1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/35050524","volume":"3","author":"NW Bays","year":"2001","unstructured":"Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY (2001) Hrd1p\/Der3p is a membrane\u2010anchored ubiquitin ligase required for ER\u2010associated degradation. Nat Cell Biol 3: 24\u201329","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ201591240_CR2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.15252\/embj.201489897","volume":"34","author":"H Fujita","year":"2015","unstructured":"Fujita H, Yagishita N, Aratani S, Saito\u2010Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y et\u00a0al (2015) The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC\u20101\u03b2. EMBO J 34: 1042\u20131055","journal-title":"EMBO J"},{"key":"BFEMBJ201591240_CR3","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar2081","volume":"8","author":"B Gao","year":"2006","unstructured":"Gao B, Calhoun K, Fang D (2006) The proinflammatory cytokines IL\u20101beta and TNF\u2010alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1\/2\u2010ETS1 pathway. Arthritis Res Ther 8: R172","journal-title":"Arthritis Res Ther"},{"key":"BFEMBJ201591240_CR4","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900\u2013917","journal-title":"Cell"},{"key":"BFEMBJ201591240_CR5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","volume":"24","author":"P Puigserver","year":"2003","unstructured":"Puigserver P, Spiegelman BM (2003) Peroxisome proliferator\u2010activated receptor\u2010gamma coactivator 1 alpha (PGC\u20101 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24: 78\u201390","journal-title":"Endocr Rev"},{"key":"BFEMBJ201591240_CR6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBJ201591240_CR7","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1210\/jc.2008-1001","volume":"93","author":"NK Sharma","year":"2008","unstructured":"Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao\u2010Borengasser A, Elbein SC (2008) Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab 93: 4532\u20134541","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMBJ201591240_CR8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd3138","volume":"9","author":"YH Tseng","year":"2010","unstructured":"Tseng YH, Cypess AM, Kahn CR (2010) Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9: 465\u2013482","journal-title":"Nat Rev Drug Discov"},{"key":"BFEMBJ201591240_CR9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2006.04.002","volume":"3","author":"M Uldry","year":"2006","unstructured":"Uldry M, Yang W, St\u2010Pierre J, Lin J, Seale P, Spiegelman BM (2006) Complementary action of the PGC\u20101 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 3: 333\u2013341","journal-title":"Cell Metab"},{"key":"BFEMBJ201591240_CR10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/ncprheum0699","volume":"4","author":"N Yagishita","year":"2008","unstructured":"Yagishita N, Yamasaki S, Nishioka K, Nakajima T (2008) Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol 4: 91\u201397","journal-title":"Nat Clin Pract Rheumatol"},{"key":"BFEMBJ201591240_CR11","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3892\/ijmm.2012.1129","volume":"30","author":"N Yagishita","year":"2012","unstructured":"Yagishita N, Aratani S, Leach C, Amano T, Yamano Y, Nakatani K, Nishioka K, Nakajima T (2012) RING\u2010finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis. Int J Mol Med 30: 1281\u20131286","journal-title":"Int J Mol Med"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201591240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.201591240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.201591240\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.201591240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201591240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:33:56Z","timestamp":1779305636000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.201591240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,4,15]]}},"alternative-id":["BFEMBJ201591240"],"URL":"https:\/\/doi.org\/10.15252\/embj.201591240","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,3]]},"assertion":[{"value":"3 March 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}