{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:13:52Z","timestamp":1779308032380,"version":"3.51.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2018,4,3]]},"DOI":"10.15252\/embj.201899144","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T20:10:33Z","timestamp":1520626233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metastasis inside\u2010out: dissemination of cancer cell clusters with inverted polarity"],"prefix":"10.1038","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-0740","authenticated-orcid":false,"given":"Andrew J","family":"Ewald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"BFEMBJ201899144_CR1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2014.07.013","volume":"158","author":"N Aceto","year":"2014","unstructured":"Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S (2014) Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 158: 1110\u20131122","journal-title":"Cell"},{"key":"BFEMBJ201899144_CR2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ceb.2013.07.001","volume":"25","author":"S Alexander","year":"2013","unstructured":"Alexander S, Weigelin B, Winkler F, Friedl P (2013) Preclinical intravital microscopy of the tumour\u2010stroma interface: invasion, metastasis, and therapy response. Curr Opin Cell Biol 25: 659\u2013671","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ201899144_CR3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.devcel.2014.08.027","volume":"31","author":"DM Bryant","year":"2014","unstructured":"Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE (2014) A molecular switch for the orientation of epithelial cell polarization. Dev Cell 31: 171\u2013187","journal-title":"Dev Cell"},{"key":"BFEMBJ201899144_CR4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.aaf6546","volume":"352","author":"KJ Cheung","year":"2016","unstructured":"Cheung KJ, Ewald AJ (2016) A collective route to metastasis: seeding by tumor cell clusters. Science 352: 167\u2013169","journal-title":"Science"},{"key":"BFEMBJ201899144_CR5","first-page":"E854","volume":"113","author":"KJ Cheung","year":"2016","unstructured":"Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ (2016) Polyclonal breast cancer metastases arise from collective dissemination of keratin 14\u2010expressing tumor cell clusters. Proc Natl Acad Sci USA 113: E854\u2013E863","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ201899144_CR6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1158\/2159-8290.CD-15-0012","volume":"5","author":"AS Harney","year":"2015","unstructured":"Harney AS, Arwert EN, Entenberg D, Wang Y, Guo P, Qian BZ, Oktay MH, Pollard JW, Jones JG, Condeelis JS (2015) Real\u2010time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage\u2010derived VEGFA. Cancer Discov 5: 932\u2013943","journal-title":"Cancer Discov"},{"key":"BFEMBJ201899144_CR7","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA (2009) The basics of epithelial\u2010mesenchymal transition. J Clin Invest 119: 1420\u20131428","journal-title":"J Clin Invest"},{"key":"BFEMBJ201899144_CR8","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1158\/2159-8290.CD-15-0120","volume":"5","author":"R Maddipati","year":"2015","unstructured":"Maddipati R, Stanger BZ (2015) Pancreatic cancer metastases harbor evidence of polyclonality. Cancer Discov 5: 1086\u20131097","journal-title":"Cancer Discov"},{"key":"BFEMBJ201899144_CR9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2006.11.051","volume":"128","author":"F Mart\u00edn\u2010Belmonte","year":"2007","unstructured":"Mart\u00edn\u2010Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K (2007) PTEN\u2010Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42. Cell 128: 383\u2013397","journal-title":"Cell"},{"key":"BFEMBJ201899144_CR10","first-page":"7","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66: 7\u201330","journal-title":"CA Cancer J Clin"},{"key":"BFEMBJ201899144_CR11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41556-017-0027-6","volume":"20","author":"O Zajac","year":"2018","unstructured":"Zajac O, Raingeaud J, Libanje F, Lefebvre C, Sabino D, Martins I, Roy P, Benatar C, Canet\u2010Jourdan C, Azorin P, Polrot M, Gonin P, Benbarche S, Souquere S, Pierron G, Nowak D, Bigot L, Ducreux M, Malka D, Lobry C et\u00a0al (2018) Tumour spheres with inverted polarity drive the formation of peritoneal metastases in\u00a0patients with hypermethylated colorectal carcinomas. Nat Cell Biol 20: 296\u2013306","journal-title":"Nat Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201899144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.201899144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.201899144\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.201899144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.201899144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:53:28Z","timestamp":1779306808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.201899144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,4,3]]}},"alternative-id":["BFEMBJ201899144"],"URL":"https:\/\/doi.org\/10.15252\/embj.201899144","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"9 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBJ201899144"}}