{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:16:22Z","timestamp":1779308182226,"version":"3.51.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFA0110102"],"award-info":[{"award-number":["2019YFA0110102"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0108600"],"award-info":[{"award-number":["2018YFA0108600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS|National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS098370"],"award-info":[{"award-number":["R01NS098370"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS|National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS089795"],"award-info":[{"award-number":["R01NS089795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["22120190149"],"award-info":[{"award-number":["22120190149"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2020,3,2]]},"DOI":"10.15252\/embj.2019101679","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T04:36:47Z","timestamp":1580704607000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ependyma\u2010expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular\u2010subventricular zone"],"prefix":"10.1038","volume":"39","author":[{"given":"Jun","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-8778","authenticated-orcid":false,"given":"Han","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-2147","authenticated-orcid":false,"given":"Xuerui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester F","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Troy","family":"Ghashghaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-494X","authenticated-orcid":false,"given":"Qin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"BFEMBJ2019101679_CR1","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1073\/pnas.95.11.6355","volume":"95","author":"AM Babic","year":"1998","unstructured":"Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998) CYR61, a product of a growth factor\u2010inducible immediate early gene, promotes angiogenesis\u00a0and tumor growth. Proc Natl Acad Sci USA 95: 6355\u20136360","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2019101679_CR2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ et\u00a0al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003\u20131007","journal-title":"Nature"},{"key":"BFEMBJ2019101679_CR3","doi-asserted-by":"crossref","first-page":"E610","DOI":"10.1073\/pnas.1715911114","volume":"115","author":"O Basak","year":"2018","unstructured":"Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias\u2010Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A et\u00a0al (2018) Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proc Natl Acad Sci USA 115: E610\u2013E619","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2019101679_CR4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","volume":"17","author":"AM Bond","year":"2015","unstructured":"Bond AM, Ming GL, Song H (2015) Adult mammalian neural stem cells and neurogenesis: five decades later. Cell Stem Cell 17: 385\u2013395","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2010.11.032","volume":"173","author":"M Bouab","year":"2011","unstructured":"Bouab M, Paliouras GN, Aumont A, Forest\u2010Berard K, Fernandes KJL (2011) Aging of the subventricular zone neural stem cell niche: evidence for quiescence\u2010associated changes between early and mid\u2010adulthood. Neuroscience 173: 135\u2013149","journal-title":"Neuroscience"},{"key":"BFEMBJ2019101679_CR6","doi-asserted-by":"crossref","first-page":"e98791","DOI":"10.15252\/embj.201798791","volume":"38","author":"S Bragado Alonso","year":"2019","unstructured":"Bragado Alonso S, Reinert JK, Marichal N, Massalini S, Berninger B, Kuner T, Calegari F (2019) An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants. EMBO J 38: e98791","journal-title":"EMBO J"},{"key":"BFEMBJ2019101679_CR7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nn.3963","volume":"18","author":"F Calzolari","year":"2015","unstructured":"Calzolari F, Michel J, Baumgart EV, Theis F, Gotz M, Ninkovic J (2015) Fast clonal expansion and limited neural stem cell self\u2010renewal in the adult subependymal zone. Nat Neurosci 18: 490\u2013492","journal-title":"Nat Neurosci"},{"key":"BFEMBJ2019101679_CR8","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1242\/dev.01199","volume":"131","author":"LS Campos","year":"2004","unstructured":"Campos LS, Leone DP, Relvas JB, Brakebusch C, Fassler R, Suter U, ffrench\u2010Constant C (2004) beta 1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development 131: 3433\u20133444","journal-title":"Development"},{"key":"BFEMBJ2019101679_CR9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/glia.22642","volume":"62","author":"V Capilla\u2010Gonzalez","year":"2014","unstructured":"Capilla\u2010Gonzalez V, Cebrian\u2010Silla A, Guerrero\u2010Cazares H, Garcia\u2010Verdugo JM, Quinones\u2010Hinojosa A (2014) Age\u2010related changes in astrocytic and ependymal cells of the subventricular zone. Glia 62: 790\u2013803","journal-title":"Glia"},{"key":"BFEMBJ2019101679_CR10","doi-asserted-by":"crossref","unstructured":"Chacon\u2010Martinez CA, Koester J, Wickstrom SA (2018) Signaling in the stem cell niche: regulating cell fate, function and plasticity. Development 145: dev165399","DOI":"10.1242\/dev.165399"},{"key":"BFEMBJ2019101679_CR11","doi-asserted-by":"crossref","first-page":"24953","DOI":"10.1074\/jbc.M003040200","volume":"275","author":"NY Chen","year":"2000","unstructured":"Chen NY, Chen CC, Lau LF (2000) Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. J Biol Chem 275: 24953\u201324961","journal-title":"J Biol Chem"},{"key":"BFEMBJ2019101679_CR12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.biocel.2008.07.025","volume":"41","author":"CC Chen","year":"2009","unstructured":"Chen CC, Lau LF (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41: 771\u2013783","journal-title":"Int J Biochem Cell Biol"},{"key":"BFEMBJ2019101679_CR13","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/onc.2015.190","volume":"35","author":"CC Chen","year":"2016","unstructured":"Chen CC, Kim KH, Lau LF (2016) The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene 35: 1314\u20131323","journal-title":"Oncogene"},{"key":"BFEMBJ2019101679_CR14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.neuron.2014.02.039","volume":"82","author":"P Codega","year":"2014","unstructured":"Codega P, Silva\u2010Vargas V, Paul A, Maldonado\u2010Soto AR, DeLeo AM, Pastrana E, Doetsch F (2014) Prospective identification and purification of quiescent adult neural stem cells from their in\u00a0vivo niche. Neuron 82: 545\u2013559","journal-title":"Neuron"},{"key":"BFEMBJ2019101679_CR15","first-page":"149","volume":"2","author":"JC Conover","year":"2011","unstructured":"Conover JC, Shook BA (2011a) Aging of the subventricular zone neural stem cell niche. Aging Dis 2: 149\u2013163","journal-title":"Aging Dis"},{"key":"BFEMBJ2019101679_CR16","first-page":"49","volume":"2","author":"JC Conover","year":"2011","unstructured":"Conover JC, Shook BA (2011b) Aging of the subventricular zone neural stem cell niche. Aging Dis 2: 49\u201363","journal-title":"Aging Dis"},{"key":"BFEMBJ2019101679_CR17","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1523\/JNEUROSCI.16-08-02649.1996","volume":"16","author":"CG Craig","year":"1996","unstructured":"Craig CG, Tropepe V, Morshead CM, Reynolds BA, Weiss S, vanderKooy D (1996) In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neurosci 16: 2649\u20132658","journal-title":"J Neurosci"},{"key":"BFEMBJ2019101679_CR18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","volume":"97","author":"F Doetsch","year":"1999","unstructured":"Doetsch F, Caille I, Lim DA, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (1999a) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97: 703\u2013716","journal-title":"Cell"},{"key":"BFEMBJ2019101679_CR19","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1073\/pnas.96.20.11619","volume":"96","author":"F Doetsch","year":"1999","unstructured":"Doetsch F, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (1999b) Regeneration of a germinal layer in the adult mammalian brain. Proc Natl Acad Sci USA 96: 11619\u201311624","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2019101679_CR20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0896-6273(02)01133-9","volume":"36","author":"F Doetsch","year":"2002","unstructured":"Doetsch F, Petreanu L, Caille I, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (2002) EGF converts transit\u2010amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36: 1021\u20131034","journal-title":"Neuron"},{"key":"BFEMBJ2019101679_CR21","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/emboj.2013.50","volume":"32","author":"S Furutachi","year":"2013","unstructured":"Furutachi S, Matsumoto A, Nakayama KI, Gotoh Y (2013) p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis. EMBO J 32: 970\u2013981","journal-title":"EMBO J"},{"key":"BFEMBJ2019101679_CR22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0960-9822(98)70402-6","volume":"8","author":"E Georges\u2010Labouesse","year":"1998","unstructured":"Georges\u2010Labouesse E, Mark M, Messaddeq N, Gansmuller A (1998) Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol 8: 983\u2013986","journal-title":"Curr Biol"},{"key":"BFEMBJ2019101679_CR23","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1073\/pnas.1016199109","volume":"109","author":"MV Gomez\u2010Gaviro","year":"2012","unstructured":"Gomez\u2010Gaviro MV, Scott CE, Sesay AK, Matheu A, Booth S, Galichet C, Lovell\u2010Badge R (2012) Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis. Proc Natl Acad Sci USA 109: 1317\u20131322","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2019101679_CR24","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1210\/endo.143.4.8731","volume":"143","author":"TM Grzeszkiewicz","year":"2002","unstructured":"Grzeszkiewicz TM, Lindner V, Chen N, Lam SC, Lau LF (2002) The angiogenic factor cysteine\u2010rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology 143: 1441\u20131450","journal-title":"Endocrinology"},{"key":"BFEMBJ2019101679_CR25","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1158\/0008-5472.CAN-11-2526","volume":"72","author":"A Haseley","year":"2012","unstructured":"Haseley A, Boone S, Wojton J, Yu L, Yoo JY, Yu J, Kurozumi K, Glorioso JC, Caligiuri MA, Kaur B (2012) Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res 72: 1353\u20131362","journal-title":"Cancer Res"},{"key":"BFEMBJ2019101679_CR26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuron.2017.06.047","volume":"95","author":"XL Hu","year":"2017","unstructured":"Hu XL, Chen G, Zhang SG, Zheng JL, Wu J, Bai QR, Wang Y, Li J, Wang HH, Feng H et\u00a0al (2017) Persistent expression of VCAM1 in radial glial cells is required for the embryonic origin of postnatal neural stem cells. Neuron 95: 309\u2013325","journal-title":"Neuron"},{"key":"BFEMBJ2019101679_CR27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10014-015-0227-3","volume":"32","author":"J Ishida","year":"2015","unstructured":"Ishida J, Kurozumi K, Ichikawa T, Otani Y, Onishi M, Fujii K, Shimazu Y, Oka T, Shimizu T, Date I (2015) Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma. Brain Tumor Pathol 32: 245\u2013252","journal-title":"Brain Tumor Pathol"},{"key":"BFEMBJ2019101679_CR28","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1242\/dev.041129","volume":"136","author":"BV Jacquet","year":"2009","unstructured":"Jacquet BV, Salinas\u2010Mondragon R, Liang HX, Therit B, Buie JD, Dykstra M, Campbell K, Ostrowski LE, Brody SL, Ghashghaei HT (2009) FoxJ1\u2010dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development 136: 4021\u20134031","journal-title":"Development"},{"key":"BFEMBJ2019101679_CR29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/stem.1822","volume":"33","author":"KM Jones","year":"2015","unstructured":"Jones KM, Saric N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA (2015) CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus. Stem Cells 33: 196\u2013210","journal-title":"Stem Cells"},{"key":"BFEMBJ2019101679_CR30","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1523\/JNEUROSCI.0700-10.2010","volume":"30","author":"I Kazanis","year":"2010","unstructured":"Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP et\u00a0al (2010) Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci 30: 9771\u20139781","journal-title":"J Neurosci"},{"key":"BFEMBJ2019101679_CR31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stem.2018.04.014","volume":"23","author":"L Kester","year":"2018","unstructured":"Kester L, van Oudenaarden A (2018) Single\u2010cell transcriptomics meets lineage tracing. Cell Stem Cell 23: 166\u2013179","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR32","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1128\/MCB.00049-13","volume":"33","author":"KH Kim","year":"2013","unstructured":"Kim KH, Chen CC, Monzon RI, Lau LF (2013) Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol 33: 2078\u20132090","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2019101679_CR33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.1272305","volume":"19","author":"TE Kippin","year":"2005","unstructured":"Kippin TE, Martens DJ, van der Kooy D (2005) p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 19: 756\u2013767","journal-title":"Genes Dev"},{"key":"BFEMBJ2019101679_CR34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.stem.2012.06.016","volume":"11","author":"E Kokovay","year":"2012","unstructured":"Kokovay E, Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q, Temple S (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression. Cell Stem Cell 11: 220\u2013230","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR35","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1089\/scd.2016.0319","volume":"26","author":"PH Krebsbach","year":"2017","unstructured":"Krebsbach PH, Villa\u2010Diaz LG (2017) The role of integrin alpha 6 (CD49f) in stem cells: more than a conserved biomarker. Stem Cells Dev 26: 1090\u20131099","journal-title":"Stem Cells Dev"},{"key":"BFEMBJ2019101679_CR36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","volume":"32","author":"A Kriegstein","year":"2009","unstructured":"Kriegstein A, Alvarez\u2010Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32: 149\u2013184","journal-title":"Annu Rev Neurosci"},{"key":"BFEMBJ2019101679_CR37","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","volume":"17","author":"HG Kuhn","year":"1997","unstructured":"Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH (1997) Epidermal growth factor and fibroblast growth factor\u20102 have different effects on neural progenitors in the adult rat brain. J Neurosci 17: 5820\u20135829","journal-title":"J Neurosci"},{"key":"BFEMBJ2019101679_CR38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12079-016-0324-z","volume":"10","author":"LF Lau","year":"2016","unstructured":"Lau LF (2016) Cell surface receptors for CCN proteins. J Cell Commun Signal 10: 121\u2013127","journal-title":"J Cell Commun Signal"},{"key":"BFEMBJ2019101679_CR39","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(00)00148-3","volume":"28","author":"DA Lim","year":"2000","unstructured":"Lim DA, Tramontin AD, Trevejo JM, Herrera DG, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (2000) Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron 28: 713\u2013726","journal-title":"Neuron"},{"key":"BFEMBJ2019101679_CR40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2015.07.002","volume":"17","author":"E Llorens\u2010Bobadilla","year":"2015","unstructured":"Llorens\u2010Bobadilla E, Zhao S, Baser A, Saiz\u2010Castro G, Zwadlo K, Martin\u2010Villalba A (2015) Single\u2010cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury. Cell Stem Cell 17: 329\u2013340","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR41","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2015.04.001","volume":"161","author":"YP Luo","year":"2015","unstructured":"Luo YP, Coskun V, Liang AB, Yu JH, Cheng LM, Ge WH, Shi ZP, Zhang KS, Li C, Cui Y et\u00a0al (2015) Single\u2010cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell 161: 1175\u20131186","journal-title":"Cell"},{"key":"BFEMBJ2019101679_CR42","doi-asserted-by":"crossref","first-page":"e02669","DOI":"10.7554\/eLife.02669","volume":"3","author":"JK Mich","year":"2014","unstructured":"Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ (2014) Prospective identification of functionally distinct stem cells and neurosphere\u2010initiating cells in adult mouse forebrain. Elife 3: e02669","journal-title":"Elife"},{"key":"BFEMBJ2019101679_CR43","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.stem.2010.04.016","volume":"7","author":"H Mira","year":"2010","unstructured":"Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortiguela R, Marques\u2010Torrejon MA, Nakashima K et\u00a0al (2010) Signaling through BMPR\u2010IA regulates quiescence and long\u2010term activity of neural stem cells in the adult hippocampus. Cell Stem Cell 7: 78\u201389","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.stem.2008.07.004","volume":"3","author":"Z Mirzadeh","year":"2008","unstructured":"Mirzadeh Z, Merkle FT, Soriano\u2010Navarro M, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (2008) Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain. Cell Stem Cell 3: 265\u2013278","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR45","first-page":"1938","volume":"39","author":"Z Mirzadeh","year":"2010","unstructured":"Mirzadeh Z, Doetsch F, Sawamoto K, Wichterle H, Alvarez\u2010Buylla A (2010) The subventricular zone en\u2010face: wholemount staining and ependymal flow. J Vis Exp 39: 1938","journal-title":"J Vis Exp"},{"key":"BFEMBJ2019101679_CR46","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.125.12.2251","volume":"125","author":"CM Morshead","year":"1998","unstructured":"Morshead CM, Craig CG, van der Kooy D (1998) In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development 125: 2251\u20132261","journal-title":"Development"},{"key":"BFEMBJ2019101679_CR47","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/dvg.22753","volume":"52","author":"N Muthusamy","year":"2014","unstructured":"Muthusamy N, Vijayakumar A, Cheng G, Ghashghaei HT (2014) A Knock\u2010in Foxj1(CreERT2: GFP)mouse for recombination in epithelial cells with motile cilia. Genesis 52: 350\u2013358","journal-title":"Genesis"},{"key":"BFEMBJ2019101679_CR48","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.stemcr.2017.07.015","volume":"9","author":"EJ Neuberger","year":"2017","unstructured":"Neuberger EJ, Swietek B, Corrubia L, Prasanna A, Santhakumar V (2017) Enhanced dentate neurogenesis after brain injury undermines long\u2010term neurogenic potential and promotes seizure susceptibility. Stem Cell Rep 9: 972\u2013984","journal-title":"Stem Cell Rep"},{"key":"BFEMBJ2019101679_CR49","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.stem.2018.01.003","volume":"22","author":"K Obernier","year":"2018","unstructured":"Obernier K, Cebrian\u2010Silla A, Thomson M, Parraguez JI, Anderson R, Guinto C, Rodas Rodriguez J, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (2018) Adult neurogenesis is sustained by symmetric self\u2010renewal and differentiation. Cell Stem Cell 22: 221\u2013234 e8","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR50","first-page":"3569","volume":"10","author":"TP Obrien","year":"1990","unstructured":"Obrien TP, Yang GP, Sanders L, Lau LF (1990) Expression of Cyr61, a growth factor\u2010inducible immediate\u2010early gene. Mol Cell Biol 10: 3569\u20133577","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2019101679_CR51","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1038\/s41598-017-07745-0","volume":"7","author":"Y Otani","year":"2017","unstructured":"Otani Y, Ishida J, Kurozumi K, Oka T, Shimizu T, Tomita Y, Hattori Y, Uneda A, Matsumoto Y, Michiue H et\u00a0al (2017) PIK3R1Met326Ile germline mutation correlates with cysteine\u2010rich protein 61 expression and poor prognosis in glioblastoma. Sci Rep 7: 7391","journal-title":"Sci Rep"},{"key":"BFEMBJ2019101679_CR52","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1038\/sj.emboj.7600447","volume":"23","author":"CM Parras","year":"2004","unstructured":"Parras CM, Galli R, Britz O, Soares S, Galichet C, Battiste J, Johnson JE, Nakafuku M, Vescovi A, Guillemot F (2004) Mash1 specifies neurons and\u00a0oligodendrocytes in the postnatal brain. EMBO J 23: 4495\u20134505","journal-title":"EMBO J"},{"key":"BFEMBJ2019101679_CR53","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1073\/pnas.0810407106","volume":"106","author":"E Pastrana","year":"2009","unstructured":"Pastrana E, Cheng LC, Doetsch F (2009) Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proc Natl Acad Sci USA 106: 6387\u20136392","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2019101679_CR54","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12079-018-0491-1","volume":"12","author":"B Perbal","year":"2018","unstructured":"Perbal B, Tweedie S, Bruford E (2018) The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1\u20106, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1\u20103 respectively. J Cell Commun Signal 12: 625\u2013629","journal-title":"J Cell Commun Signal"},{"key":"BFEMBJ2019101679_CR55","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuroscience.2004.06.053","volume":"128","author":"P Peretto","year":"2004","unstructured":"Peretto P, Dati C, De Marchis S, Kim HH, Ukhanova M, Fasolo A, Margolis FL (2004) Expression of the secreted factors noggin and bone morphogenetic proteins in the subependymal layer and olfactory bulb of the adult mouse brain. Neuroscience 128: 685\u2013696","journal-title":"Neuroscience"},{"key":"BFEMBJ2019101679_CR56","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1072530","volume":"298","author":"M Ramalho\u2010Santos","year":"2002","unstructured":"Ramalho\u2010Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA (2002) \u201cStemness\u201d: transcriptional profiling of embryonic and adult stem cells. Science 298: 597\u2013600","journal-title":"Science"},{"key":"BFEMBJ2019101679_CR57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nn1657","volume":"9","author":"C Ramirez\u2010Castillejo","year":"2006","unstructured":"Ramirez\u2010Castillejo C, Sanchez\u2010Sanchez F, Andreu\u2010Agullo C, Ferron SR, Aroca\u2010Aguilar JD, Sanchez P, Mira H, Escribano J, Farinas I (2006) Pigment epithelium\u2010derived factor is a niche signal for neural stem cell renewal. Nat Neurosci 9: 331\u2013339","journal-title":"Nat Neurosci"},{"key":"BFEMBJ2019101679_CR58","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cell.2018.03.063","volume":"173","author":"PT Shah","year":"2018","unstructured":"Shah PT, Stratton JA, Stykel MG, Abbasi S, Sharma S, Mayr KA, Koblinger K, Whelan PJ, Biernaskie J (2018) Single\u2010cell transcriptomics and fate mapping of ependymal cells reveals an absence of neural stem cell function. Cell 173: 1045\u20131057 e9","journal-title":"Cell"},{"key":"BFEMBJ2019101679_CR59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.stem.2008.07.026","volume":"3","author":"Q Shen","year":"2008","unstructured":"Shen Q, Wang Y, Kokovay E, Lin G, Chuang SM, Goderie SK, Roysam B, Temple S (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell\u2010cell interactions. Cell Stem Cell 3: 289\u2013300","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2019101679_CR60","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1523\/JNEUROSCI.5987-11.2012","volume":"32","author":"BA Shook","year":"2012","unstructured":"Shook BA, Manz DH, Peters JJ, Kang S, Conover JC (2012) Spatiotemporal changes to the subventricular zone stem cell pool through aging. J Neurosci 32: 6947\u20136956","journal-title":"J Neurosci"},{"key":"BFEMBJ2019101679_CR61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.cellbio.042308.113256","volume":"25","author":"H Suh","year":"2009","unstructured":"Suh H, Deng W, Gage FH (2009) Signaling in adult neurogenesis. Annu Rev Cell Dev Biol 25: 253\u2013275","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBJ2019101679_CR62","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1126\/science.1213214","volume":"334","author":"N Takeda","year":"2011","unstructured":"Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, Epstein JA (2011) Interconversion between intestinal stem cell populations in distinct niches. Science 334: 1420\u20131424","journal-title":"Science"},{"key":"BFEMBJ2019101679_CR63","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.devcel.2016.02.023","volume":"36","author":"X Tan","year":"2016","unstructured":"Tan X, Liu WA, Zhang XJ, Shi W, Ren SQ, Li ZZ, Brown KN, Shi SH (2016) Vascular influence on ventral telencephalic progenitors and neocortical interneuron production. Dev Cell 36: 624\u2013638","journal-title":"Dev Cell"},{"key":"BFEMBJ2019101679_CR64","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.aaf4802","volume":"353","author":"N Urban","year":"2016","unstructured":"Urban N, van den Berg DL, Forget A, Andersen J, Demmers JA, Hunt C, Ayrault O, Guillemot F (2016) Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science 353: 292\u2013295","journal-title":"Science"},{"key":"BFEMBJ2019101679_CR65","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.290.5490.328","volume":"290","author":"T Xie","year":"2000","unstructured":"Xie T, Spradling AC (2000) A niche maintaining germ line stem cells in the Drosophila ovary. Science 290: 328\u2013330","journal-title":"Science"},{"key":"BFEMBJ2019101679_CR66","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.stem.2018.08.005","volume":"23","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Bond AM, Shade JE, Zhu Y, Davis CO, Wang X, Su Y, Yoon KJ, Phan AT, Chen WJ et\u00a0al (2018) Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool. Cell Stem Cell 23: 444\u2013452 e4","journal-title":"Cell Stem Cell"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2019101679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.2019101679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2019101679\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2019101679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2019101679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:01:52Z","timestamp":1779307312000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2019101679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,3]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3,2]]}},"alternative-id":["BFEMBJ2019101679"],"URL":"https:\/\/doi.org\/10.15252\/embj.2019101679","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,3]]},"assertion":[{"value":"31 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBJ2019101679"}}