{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:12:45Z","timestamp":1790453565304,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"The Norwegian Research Council","doi-asserted-by":"crossref","award":["262652"],"award-info":[{"award-number":["262652"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005416","name":"The Norwegian Research Council","doi-asserted-by":"crossref","award":["276070"],"award-info":[{"award-number":["276070"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"South Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["40041"],"award-info":[{"award-number":["40041"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Division of Intramural Research at the National Institute of Health\/National Heart, Lung and Blood Institute","award":["1K22HL137902"],"award-info":[{"award-number":["1K22HL137902"]}]},{"name":"Division of Intramural Research at the National Institute of Health\/National Heart, Lung and Blood Institute","award":["1ZIAHL006126"],"award-info":[{"award-number":["1ZIAHL006126"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2021,9,15]]},"DOI":"10.15252\/embj.2020107336","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T06:16:01Z","timestamp":1627280161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Host autophagy mediates organ wasting and nutrient mobilization for tumor growth"],"prefix":"10.1038","volume":"40","author":[{"given":"Rojyar","family":"Khezri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd Andrew","family":"Schoborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifat","family":"Abramovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"Tak\u00e1ts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-2788","authenticated-orcid":false,"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal","family":"O'Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3661-2178","authenticated-orcid":false,"given":"Sebastian Wolfgang","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M","family":"Hagopian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Martin","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-9628","authenticated-orcid":false,"given":"Rachel","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja Sandra","family":"Katheder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5327-4193","authenticated-orcid":false,"given":"Mohammed Mahidur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Gerardo","family":"Teles Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Brech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Jasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser M","family":"Rusan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Hope","family":"Jahren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-0956","authenticated-orcid":false,"given":"Eyal","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-2676","authenticated-orcid":false,"given":"Tor Erik","family":"Rusten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"BFEMBJ2020107336_CR1","doi-asserted-by":"crossref","DOI":"10.1038\/srep30340","volume":"6","author":"Z Aversa","year":"2016","unstructured":"Aversa Z, Pin F, Lucia S, Penna F, Verzaro R, Fazi M, Colasante G, Tirone A, Fanelli FR, Ramaccini C et\u00a0al (2016) Autophagy is induced in the skeletal muscle of cachectic cancer patients. Sci Rep 6: 30340","journal-title":"Sci Rep"},{"key":"BFEMBJ2020107336_CR2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"VE Baracos","year":"2018","unstructured":"Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH (2018) Cancer\u2010associated cachexia. Nat Rev Dis Primers 4: 17105","journal-title":"Nat Rev Dis Primers"},{"key":"BFEMBJ2020107336_CR3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1101\/gad.320481.118","volume":"33","author":"V Bhatt","year":"2019","unstructured":"Bhatt V, Khayati K, Hu ZS, Lee A, Kamran W, Su X, Guo JY (2019) Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1\u2010deficient Kras\u2010driven lung tumorigenesis. Genes Dev 33: 150\u2013165","journal-title":"Genes Dev"},{"key":"BFEMBJ2020107336_CR4","unstructured":"Blighe K, Rana S, Lewis M (2019) EnhancedVolcano: Publication\u2010ready volcano plots with enhanced colouring and labeling. R package version 1.4.0. https:\/\/github.com\/kevinblighe\/EnhancedVolcano"},{"key":"BFEMBJ2020107336_CR5","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1093\/emboj\/cdg548","volume":"22","author":"AM Brumby","year":"2003","unstructured":"Brumby AM, Richardson HE (2003) scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22: 5769\u20135779","journal-title":"EMBO J"},{"key":"BFEMBJ2020107336_CR6","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1091\/mbc.e08-12-1250","volume":"20","author":"YY Chang","year":"2009","unstructured":"Chang YY, Neufeld TP (2009) An Atg1\/Atg13 complex with multiple roles in TOR\u2010mediated autophagy regulation. Mol Biol Cell 20: 2004\u20132014","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ2020107336_CR7","volume":"300","author":"MMG Chartrand","year":"2019","unstructured":"Chartrand MMG, Mester Z (2019) Carbon isotope measurements of foods containing sugar: a survey. Food Chem 300: 125106","journal-title":"Food Chem"},{"key":"BFEMBJ2020107336_CR8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.1216689","volume":"336","author":"J Colombani","year":"2012","unstructured":"Colombani J, Andersen DS, Leopold P (2012) Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science (New York NY) 336: 582\u2013585","journal-title":"Science (New York NY)"},{"key":"BFEMBJ2020107336_CR9","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/cdd.2012.43","volume":"19","author":"D Denton","year":"2012","unstructured":"Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ 19: 1299\u20131307","journal-title":"Cell Death Differ"},{"key":"BFEMBJ2020107336_CR10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2015.03.001","volume":"33","author":"A Figueroa\u2010Clarevega","year":"2015","unstructured":"Figueroa\u2010Clarevega A, Bilder D (2015) Malignant Drosophila tumors interrupt insulin signaling to induce cachexia\u2010like wasting. Dev Cell 33: 47\u201355","journal-title":"Dev Cell"},{"key":"BFEMBJ2020107336_CR11","doi-asserted-by":"crossref","first-page":"856","DOI":"10.15252\/embj.201490784","volume":"34","author":"L Galluzzi","year":"2015","unstructured":"Galluzzi L, Pietrocola F, Bravo\u2010San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V et\u00a0al (2015) Autophagy in malignant transformation and cancer progression. The EMBO journal 34: 856\u2013880","journal-title":"The EMBO journal"},{"key":"BFEMBJ2020107336_CR12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1126\/science.1216735","volume":"336","author":"A Garelli","year":"2012","unstructured":"Garelli A, Gontijo AM, Miguela V, Caparros E, Dominguez M (2012) Imaginal discs secrete insulin\u2010like peptide 8 to mediate plasticity of growth and maturation. Science (New York NY) 336: 579\u2013582","journal-title":"Science (New York NY)"},{"key":"BFEMBJ2020107336_CR13","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.cell.2013.11.019","volume":"155","author":"JY Guo","year":"2013","unstructured":"Guo JY, Xia B, White E (2013) Autophagy\u2010mediated tumor promotion. Cell 155: 1216\u20131219","journal-title":"Cell"},{"key":"BFEMBJ2020107336_CR14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12915-021-01012-5","volume":"19","author":"P Holland","year":"2021","unstructured":"Holland P, Hagopian WM, Jahren AH, Rusten TE (2021) Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in\u00a0vivo. BMC Biol 19: 85","journal-title":"BMC Biol"},{"key":"BFEMBJ2020107336_CR15","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1093\/ajcn\/84.6.1380","volume":"84","author":"AH Jahren","year":"2006","unstructured":"Jahren AH, Saudek C, Yeung EH, Kao WH, Kraft RA, Caballero B (2006) An isotopic method for quantifying sweeteners derived from corn and sugar cane. Am J Clin Nutr 84: 1380\u20131384","journal-title":"Am J Clin Nutr"},{"key":"BFEMBJ2020107336_CR16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1158\/2159-8290.CD-14-0363","volume":"4","author":"G Karsli\u2010Uzunbas","year":"2014","unstructured":"Karsli\u2010Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD et\u00a0al (2014) Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov 4: 914\u2013927","journal-title":"Cancer Discov"},{"key":"BFEMBJ2020107336_CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature20815","volume":"541","author":"NS Katheder","year":"2017","unstructured":"Katheder NS, Khezri R, O\u2019Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juh\u00e1sz G et\u00a0al (2017) Microenvironmental autophagy promotes tumour growth. Nature 541: 417\u2013420","journal-title":"Nature"},{"key":"BFEMBJ2020107336_CR18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cmet.2017.04.004","volume":"25","author":"AC Kimmelman","year":"2017","unstructured":"Kimmelman AC, White E (2017) Autophagy and tumor metabolism. Cell Metab 25: 1037\u20131043","journal-title":"Cell Metab"},{"key":"BFEMBJ2020107336_CR19","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N (2004) The role of autophagy during the early neonatal starvation period. Nature 432: 1032\u20131036","journal-title":"Nature"},{"key":"BFEMBJ2020107336_CR20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0166-2236(00)01791-4","volume":"24","author":"T Lee","year":"2001","unstructured":"Lee T, Luo L (2001) Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci 24: 251\u2013254","journal-title":"Trends Neurosci"},{"key":"BFEMBJ2020107336_CR21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.mie.2015.05.016","volume":"561","author":"GM Mackay","year":"2015","unstructured":"Mackay GM, Zheng L, van den Broek NJ, Gottlieb E (2015) Analysis of cell metabolism using LC\u2010MS and isotope tracers. Methods Enzymol 561: 171\u2013196","journal-title":"Methods Enzymol"},{"key":"BFEMBJ2020107336_CR22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm.3686","volume":"20","author":"JR Mayers","year":"2014","unstructured":"Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS et\u00a0al (2014) Elevation of circulating branched\u2010chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 20: 1193\u20131198","journal-title":"Nat Med"},{"key":"BFEMBJ2020107336_CR23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jmi.12385","volume":"263","author":"AG Morales","year":"2016","unstructured":"Morales AG, Stempinski ES, Xiao X, Patel A, Panna A, Olivier KN, McShane PJ, Robinson C, George AJ, Donahue DR et\u00a0al (2016) Micro\u2010CT scouting for transmission electron microscopy of human tissue specimens. J Microsc 263: 113\u2013117","journal-title":"J Microsc"},{"key":"BFEMBJ2020107336_CR24","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1038\/s41467-020-18502-9","volume":"11","author":"H Newton","year":"2020","unstructured":"Newton H, Wang YF, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S (2020) Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat Commun 11: 4653","journal-title":"Nat Commun"},{"key":"BFEMBJ2020107336_CR25","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.1088474","volume":"302","author":"RA Pagliarini","year":"2003","unstructured":"Pagliarini RA, Xu T (2003) A genetic screen in Drosophila for metastatic behavior. Science (New York NY) 302: 1227\u20131231","journal-title":"Science (New York NY)"},{"key":"BFEMBJ2020107336_CR26","first-page":"241","volume":"17","author":"F Penna","year":"2014","unstructured":"Penna F, Baccino FM, Costelli P (2014) Coming back: autophagy in cachexia. Curr Opin Clin Nutr Metab Care 17: 241\u2013246","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"BFEMBJ2020107336_CR27","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1016\/j.jmb.2019.05.032","volume":"431","author":"F Penna","year":"2019","unstructured":"Penna F, Ballar\u00f2 R, Martinez\u2010Cristobal P, Sala D, Sebastian D, Busquets S, Muscaritoli M, Argil\u00e9s JM, Costelli P, Zorzano A (2019) Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function. J Mol Biol 431: 2674\u20132686","journal-title":"J Mol Biol"},{"key":"BFEMBJ2020107336_CR28","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ajpath.2012.12.023","volume":"182","author":"F Penna","year":"2013","unstructured":"Penna F, Costamagna D, Pin F, Camperi A, Fanzani A, Chiarpotto EM, Cavallini G, Bonelli G, Baccino FM, Costelli P (2013) Autophagic degradation contributes to muscle wasting in cancer cachexia. The American journal of pathology 182: 1367\u20131378","journal-title":"The American journal of pathology"},{"key":"BFEMBJ2020107336_CR29","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1101\/gad.325514.119","volume":"33","author":"L Poillet\u2010Perez","year":"2019","unstructured":"Poillet\u2010Perez L, White E (2019) Role of tumor and host autophagy in cancer metabolism. Genes Dev 33: 610\u2013619","journal-title":"Genes Dev"},{"key":"BFEMBJ2020107336_CR30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41586-018-0697-7","volume":"563","author":"L Poillet\u2010Perez","year":"2018","unstructured":"Poillet\u2010Perez L, Xie X, Zhan Le, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W et\u00a0al (2018) Autophagy maintains tumour growth through circulating arginine. Nature 563: 569\u2013573","journal-title":"Nature"},{"key":"BFEMBJ2020107336_CR31","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2019","unstructured":"R Core Team (2019) R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing. https:\/\/www.R\u2010project.org\/"},{"key":"BFEMBJ2020107336_CR32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nature12865","volume":"504","author":"MT Rosenfeldt","year":"2013","unstructured":"Rosenfeldt MT, O\u2019Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R et\u00a0al (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature 504: 296\u2013300","journal-title":"Nature"},{"key":"BFEMBJ2020107336_CR33","first-page":"161","volume":"17","author":"PL Salmon","year":"2009","unstructured":"Salmon PL, Liu X, Sasov A (2009) A post\u2010scan method for correcting artefacts of slow geometry changes during micro\u2010tomographic scans. J Xray Sci Technol 17: 161\u2013174","journal-title":"J Xray Sci Technol"},{"key":"BFEMBJ2020107336_CR34","doi-asserted-by":"crossref","first-page":"dev176685","DOI":"10.1242\/dev.176685","volume":"146","author":"TA Schoborg","year":"2019","unstructured":"Schoborg TA, Smith SL, Smith LN, Morris HD, Rusan NM (2019) Micro\u2010computed tomography as a platform for exploring Drosophila development. Development 146: dev176685","journal-title":"Development"},{"key":"BFEMBJ2020107336_CR35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature19084","volume":"536","author":"CM Sousa","year":"2016","unstructured":"Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang Li, Kremer D, Hwang RF, Witkiewicz AK, Ying H et\u00a0al (2016) Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature 536: 479\u2013483","journal-title":"Nature"},{"key":"BFEMBJ2020107336_CR36","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1158\/2159-8290.CD-13-0397","volume":"3","author":"AM Strohecker","year":"2013","unstructured":"Strohecker AM, Guo JY, Karsli\u2010Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E (2013) Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E\u2010driven lung tumors. Cancer Discov 3: 1272\u20131285","journal-title":"Cancer Discov"},{"key":"BFEMBJ2020107336_CR37","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3945\/ajcn.113.063859","volume":"98","author":"N Tardif","year":"2013","unstructured":"Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O (2013) Autophagic\u2010lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients. Am J Clin Nutr 98: 1485\u20131492","journal-title":"Am J Clin Nutr"},{"key":"BFEMBJ2020107336_CR38","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1158\/2159-8290.CD-14-1473","volume":"5","author":"X Xie","year":"2015","unstructured":"Xie X, Koh JY, Price S, White E, Mehnert JM (2015) Atg7 overcomes senescence and promotes growth of BrafV600E\u2010driven melanoma. Cancer Discov 5: 410\u2013423","journal-title":"Cancer Discov"},{"key":"BFEMBJ2020107336_CR39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1158\/2159-8290.CD-17-0952","volume":"8","author":"A Yang","year":"2018","unstructured":"Yang A, Herter\u2010Sprie G, Zhang H, Lin EY, Biancur D, Wang X, Deng J, Hai J, Yang S, Wong K\u2010K et\u00a0al (2018) Autophagy sustains pancreatic cancer growth through both cell\u2010autonomous and nonautonomous mechanisms. Cancer Discov 8: 276\u2013287","journal-title":"Cancer Discov"},{"key":"BFEMBJ2020107336_CR40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1158\/2159-8290.CD-14-0362","volume":"4","author":"A Yang","year":"2014","unstructured":"Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC (2014) Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov 4: 905\u2013913","journal-title":"Cancer Discov"},{"key":"BFEMBJ2020107336_CR41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001708","volume":"11","author":"J Zirin","year":"2013","unstructured":"Zirin J, Nieuwenhuis J, Perrimon N (2013) Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol 11: e1001708","journal-title":"PLoS Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2020107336.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.2020107336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2020107336\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2020107336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2020107336.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:31:40Z","timestamp":1779309100000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2020107336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":41,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9,15]]}},"alternative-id":["BFEMBJ2020107336"],"URL":"https:\/\/doi.org\/10.15252\/embj.2020107336","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.04.411561","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"3 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"EG is a Board member and a shareholder of Metabomed Ltd, Israel. NSK and HJ are employees at Genentech, Inc.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"EMBJ2020107336"}}