{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:20:23Z","timestamp":1780406423795,"version":"3.54.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"crossref","award":["950\u2010231848"],"award-info":[{"award-number":["950\u2010231848"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gouvernement du Canada | Canadian Institutes of Health Research","award":["PJT 159785"],"award-info":[{"award-number":["PJT 159785"]}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA080728"],"award-info":[{"award-number":["RO1CA080728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1CA098571"],"award-info":[{"award-number":["RO1CA098571"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["R6513\u201020"],"award-info":[{"award-number":["R6513\u201020"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2023,4,3]]},"DOI":"10.15252\/embj.2021110496","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:24:53Z","timestamp":1677468293000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The eukaryotic translation initiation factor eIF4E reprograms alternative splicing"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-0141","authenticated-orcid":false,"given":"Mehdi","family":"Ghram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-4378","authenticated-orcid":false,"given":"Gavin","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-3014","authenticated-orcid":false,"given":"Biljana","family":"Culjkovic\u2010Kraljacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-9502","authenticated-orcid":false,"given":"Jean\u2010Clement","family":"Mars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-2600","authenticated-orcid":false,"given":"Patrick","family":"Gendron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Skrabanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-0713","authenticated-orcid":false,"given":"Maria Victoria","family":"Revuelta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-1350","authenticated-orcid":false,"given":"Leandro","family":"Cerchietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica L","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-5074","authenticated-orcid":false,"given":"Katherine L B","family":"Borden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"BFEMBJ2021110496_CR1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/wrna.4","volume":"1","author":"K Abdelmohsen","year":"2010","unstructured":"Abdelmohsen K, Gorospe M (2010) Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA 1: 214\u2013229","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"BFEMBJ2021110496_CR2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1158\/1078-0432.CCR-13-0956","volume":"20","author":"S Adamia","year":"2014","unstructured":"Adamia S, Haibe\u2010Kains B, Pilarski PM, Bar\u2010Natan M, Pevzner S, Avet\u2010Loiseau H, Lode L, Verselis S, Fox EA, Burke J et al (2014) A genome\u2010wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets. Clin Cancer Res 20: 1135\u20131145","journal-title":"Clin Cancer Res"},{"key":"BFEMBJ2021110496_CR3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood-2009-02-205153","volume":"114","author":"S Assouline","year":"2009","unstructured":"Assouline S, Culjkovic B, Cocolakis E, Rousseau C, Beslu N, Amri A, Caplan S, Leber B, Roy DC, Miller WH Jr et al (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof\u2010of\u2010principle clinical trial with ribavirin. Blood 114: 257\u2013260","journal-title":"Blood"},{"key":"BFEMBJ2021110496_CR4","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3324\/haematol.2014.111245","volume":"100","author":"S Assouline","year":"2015","unstructured":"Assouline S, Culjkovic\u2010Kraljacic B, Bergeron J, Caplan S, Cocolakis E, Lambert C, Lau CJ, Zahreddine HA, Miller WH Jr, Borden KL (2015) A phase I trial of ribavirin and low\u2010dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E. Haematologica 100: e7\u2013e9","journal-title":"Haematologica"},{"key":"BFEMBJ2021110496_CR5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbagrm.2017.12.006","volume":"1861","author":"T Bakheet","year":"2018","unstructured":"Bakheet T, Hitti E, Al\u2010Saif M, Moghrabi WN, Khabar KSA (2018) The AU\u2010rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1\/HuR. Biochim Biophys Acta Gene Regul Mech 1861: 167\u2013177","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"BFEMBJ2021110496_CR6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/wrna.1264","volume":"6","author":"E Batsche","year":"2015","unstructured":"Batsche E, Ameyar\u2010Zazoua M (2015) The influence of Argonaute proteins on alternative RNA splicing. Wiley Interdiscip Rev RNA 6: 141\u2013156","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"BFEMBJ2021110496_CR7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcdb.2014.05.014","volume":"34","author":"JG Blackinton","year":"2014","unstructured":"Blackinton JG, Keene JD (2014) Post\u2010transcriptional RNA regulons affecting cell cycle and proliferation. Semin Cell Dev Biol 34: 44\u201354","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMBJ2021110496_CR8","volume":"4","author":"KL Borden","year":"2016","unstructured":"Borden KL (2016) The eukaryotic translation initiation factor eIF4E wears a \u201ccap\u201d for many occasions. Translation (Austin) 4: e1220899","journal-title":"Translation (Austin)"},{"key":"BFEMBJ2021110496_CR9","volume":"13","author":"KLB Borden","year":"2020","unstructured":"Borden KLB (2020) The nuclear pore complex and mRNA export in cancer. Cancers (Basel) 13: 42","journal-title":"Cancers (Basel)"},{"key":"BFEMBJ2021110496_CR10","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1042\/BST20220621","volume":"50","author":"KLB Borden","year":"2022","unstructured":"Borden KLB (2022) Cancer cells hijack RNA processing to rewrite the message. Biochem Soc Trans 50: 1447\u20131456","journal-title":"Biochem Soc Trans"},{"key":"BFEMBJ2021110496_CR11","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1080\/15476286.2020.1766179","volume":"17","author":"KLB Borden","year":"2020","unstructured":"Borden KLB, Volpon L (2020) The diversity, plasticity, and adaptability of cap\u2010dependent translation initiation and the associated machinery. RNA Biol 17: 1239\u20131251","journal-title":"RNA Biol"},{"key":"BFEMBJ2021110496_CR12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1101\/gad.247361.114","volume":"29","author":"PL Boutz","year":"2015","unstructured":"Boutz PL, Bhutkar A, Sharp PA (2015) Detained introns are a novel, widespread class of post\u2010transcriptionally spliced introns. Genes Dev 29: 63\u201380","journal-title":"Genes Dev"},{"key":"BFEMBJ2021110496_CR13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.37751","volume":"7","author":"JE Braun","year":"2018","unstructured":"Braun JE, Friedman LJ, Gelles J, Moore MJ (2018) Synergistic assembly of human pre\u2010spliceosomes across introns and exons. Elife 7: e37751","journal-title":"Elife"},{"key":"BFEMBJ2021110496_CR14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.molcel.2021.01.034","volume":"81","author":"M Ciesla","year":"2021","unstructured":"Ciesla M, Ngoc PCT, Cordero E, Martinez AS, Morsing M, Muthukumar S, Beneventi G, Madej M, Munita R, Jonsson T et al (2021) Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer. Mol Cell 81: 1453\u20131468","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR15","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1093\/emboj\/20.16.4547","volume":"20","author":"N Cohen","year":"2001","unstructured":"Cohen N, Sharma M, Kentsis A, Perez JM, Strudwick S, Borden KL (2001) PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. EMBO J 20: 4547\u20134559","journal-title":"EMBO J"},{"key":"BFEMBJ2021110496_CR16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2016.08.003","volume":"19","author":"LA Crews","year":"2016","unstructured":"Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R et al (2016) RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML. Cell Stem Cell 19: 599\u2013612","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2021110496_CR17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1083\/jcb.200501019","volume":"169","author":"B Culjkovic","year":"2005","unstructured":"Culjkovic B, Topisirovic I, Skrabanek L, Ruiz\u2010Gutierrez M, Borden KL (2005) eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3\u2032UTR. J Cell Biol 169: 245\u2013256","journal-title":"J Cell Biol"},{"key":"BFEMBJ2021110496_CR18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.200607020","volume":"175","author":"B Culjkovic","year":"2006","unstructured":"Culjkovic B, Topisirovic I, Skrabanek L, Ruiz\u2010Gutierrez M, Borden KL (2006) eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol 175: 415\u2013426","journal-title":"J Cell Biol"},{"key":"BFEMBJ2021110496_CR19","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00512","volume":"9","author":"B Culjkovic\u2010Kraljacic","year":"2018","unstructured":"Culjkovic\u2010Kraljacic B, Borden KLB (2018) The impact of post\u2010transcriptional control: better living through RNA regulons. Front Genet 9: 512","journal-title":"Front Genet"},{"key":"BFEMBJ2021110496_CR20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-0716-2337-4_6","volume":"2502","author":"B Culjkovic\u2010Kraljacic","year":"2022","unstructured":"Culjkovic\u2010Kraljacic B, Borden KLB (2022) Subcellular fractionation suitable for studies of RNA and protein trafficking. Methods Mol Biol 2502: 91\u2013104","journal-title":"Methods Mol Biol"},{"key":"BFEMBJ2021110496_CR21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.celrep.2012.07.007","volume":"2","author":"B Culjkovic\u2010Kraljacic","year":"2012","unstructured":"Culjkovic\u2010Kraljacic B, Baguet A, Volpon L, Amri A, Borden KLB (2012) The oncogene eIF4E reprograms the nuclear pore complext to promote mRNA export and oncogenic transformation. Cell Rep 2: 207\u2013215","journal-title":"Cell Rep"},{"key":"BFEMBJ2021110496_CR22","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood-2015-05-645069","volume":"127","author":"B Culjkovic\u2010Kraljacic","year":"2016","unstructured":"Culjkovic\u2010Kraljacic B, Fernando TM, Marullo R, Calvo\u2010Vidal N, Verma A, Yang S, Tabbo F, Gaudiano M, Zahreddine H, Goldstein RL et al (2016) Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B\u2010cell lymphomas. Blood 127: 858\u2013868","journal-title":"Blood"},{"key":"BFEMBJ2021110496_CR23","doi-asserted-by":"crossref","first-page":"26773","DOI":"10.1073\/pnas.2002360117","volume":"117","author":"B Culjkovic\u2010Kraljacic","year":"2020","unstructured":"Culjkovic\u2010Kraljacic B, Skrabanek L, Revuelta MV, Gasiorek J, Cowling VH, Cerchietti L, Borden KLB (2020a) The eukaryotic translation initiation factor eIF4E elevates steady\u2010state m7G capping of coding and noncoding transcripts. Proc Natl Acad Sci USA 117: 26773\u201326783","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2021110496_CR24","unstructured":"Culjkovic\u2010Kraljacic B, Skrabanek LA, Revuelta M, Gasiorek J, Cowling VH, Cerchietti L, Borden KL (2020b) Gene Expression Omnibus GSE158728 (https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE158728). [DATASET]"},{"key":"BFEMBJ2021110496_CR25","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.celrep.2019.04.008","volume":"27","author":"MR Davis","year":"2019","unstructured":"Davis MR, Delaleau M, Borden KLB (2019) Nuclear eIF4E stimulates 3\u2032\u2010end cleavage of target RNAs. Cell Rep 27: 1397\u20131408","journal-title":"Cell Rep"},{"key":"BFEMBJ2021110496_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-016-0315-9","volume":"9","author":"R de Necochea\u2010Campion","year":"2016","unstructured":"de Necochea\u2010Campion R, Shouse GP, Zhou Q, Mirshahidi S, Chen CS (2016) Aberrant splicing and drug resistance in AML. J Hematol Oncol 9: 85","journal-title":"J Hematol Oncol"},{"key":"BFEMBJ2021110496_CR27","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1039\/B908315D","volume":"5","author":"R de Sousa Abreu","year":"2009","unstructured":"de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C (2009) Global signatures of protein and mRNA expression levels. Mol Biosyst 5: 1512\u20131526","journal-title":"Mol Biosyst"},{"key":"BFEMBJ2021110496_CR28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1083\/jcb.148.2.239","volume":"148","author":"J Dostie","year":"2000","unstructured":"Dostie J, Lejbkowicz F, Sonenberg N (2000) Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. J Cell Biol 148: 239\u2013247","journal-title":"J Cell Biol"},{"key":"BFEMBJ2021110496_CR29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hed.24938","volume":"40","author":"LA Dunn","year":"2017","unstructured":"Dunn LA, Fury MG, Sherman EJ, Ho AA, Katabi N, Haque SS, Pfister DG (2017) Phase I study of induction chemotherapy with afatinib, ribavirin, and weekly carboplatin and paclitaxel for stage IVA\/IVB human papillomavirus\u2010associated oropharyngeal squamous cell cancer. Head Neck 40: 233\u2013241","journal-title":"Head Neck"},{"key":"BFEMBJ2021110496_CR30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13073-015-0168-9","volume":"7","author":"H Dvinge","year":"2015","unstructured":"Dvinge H, Bradley RK (2015) Widespread intron retention diversifies most cancer transcriptomes. Genome Med 7: 45","journal-title":"Genome Med"},{"key":"BFEMBJ2021110496_CR31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1432-1033.1976.tb10051.x","volume":"61","author":"VG Edy","year":"1976","unstructured":"Edy VG, Szekely M, Loviny T, Dreyer C (1976) Action of nucleases on double\u2010stranded RNA. Eur J Biochem 61: 563\u2013572","journal-title":"Eur J Biochem"},{"key":"BFEMBJ2021110496_CR32","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1381","volume":"8","author":"KA Effenberger","year":"2017","unstructured":"Effenberger KA, Urabe VK, Jurica MS (2017) Modulating splicing with small molecular inhibitors of the spliceosome. Wiley Interdiscip Rev RNA 8: e1381","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"BFEMBJ2021110496_CR33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","volume":"68","author":"AC Gingras","year":"1999","unstructured":"Gingras AC, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913\u2013963","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ2021110496_CR34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molcel.2005.05.007","volume":"19","author":"J Gornemann","year":"2005","unstructured":"Gornemann J, Kotovic KM, Hujer K, Neugebauer KM (2005) Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. Mol Cell 19: 53\u201363","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002185","volume":"7","author":"PL Graham","year":"2011","unstructured":"Graham PL, Yanowitz JL, Penn JK, Deshpande G, Schedl P (2011) The translation initiation factor eIF4E regulates the sex\u2010specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet 7: e1002185","journal-title":"PLoS Genet"},{"key":"BFEMBJ2021110496_CR36","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/s41375-020-1002-y","volume":"35","author":"CE Hershberger","year":"2021","unstructured":"Hershberger CE, Moyer DC, Adema V, Kerr CM, Walter W, Hutter S, Meggendorfer M, Baer C, Kern W, Nadarajah N et al (2021) Complex landscape of alternative splicing in myeloid neoplasms. Leukemia 35: 1108\u20131120","journal-title":"Leukemia"},{"key":"BFEMBJ2021110496_CR37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0092-8674(94)90530-4","volume":"78","author":"E Izaurralde","year":"1994","unstructured":"Izaurralde E, Lewis J, McGuigan C, Jankowska M, Darzynkiewicz E, Mattaj IW (1994) A nuclear cap binding protein complex involved in pre\u2010mRNA splicing. Cell 78: 657\u2013668","journal-title":"Cell"},{"key":"BFEMBJ2021110496_CR38","doi-asserted-by":"crossref","first-page":"19077","DOI":"10.1074\/jbc.M800017200","volume":"283","author":"JM Izquierdo","year":"2008","unstructured":"Izquierdo JM (2008) Hu antigen R (HuR) functions as an alternative pre\u2010mRNA splicing regulator of Fas apoptosis\u2010promoting receptor on exon definition. J Biol Chem 283: 19077\u201319084","journal-title":"J Biol Chem"},{"key":"BFEMBJ2021110496_CR39","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.1093\/nar\/gkq698","volume":"38","author":"JM Izquierdo","year":"2010","unstructured":"Izquierdo JM (2010) Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T\u2010cell intracellular antigen\u20101\u2010related\/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R. Nucleic Acids Res 38: 8001\u20138014","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ2021110496_CR40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.molcel.2005.06.015","volume":"19","author":"JM Izquierdo","year":"2005","unstructured":"Izquierdo JM, Majos N, Bonnal S, Martinez C, Castelo R, Guigo R, Bilbao D, Valcarcel J (2005) Regulation of Fas alternative splicing by antagonistic effects of TIA\u20101 and PTB on exon definition. Mol Cell 19: 475\u2013484","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.biochem.73.030403.080419","volume":"73","author":"LD Kapp","year":"2004","unstructured":"Kapp LD, Lorsch JR (2004) The molecular mechanics of eukaryotic translation. Annu Rev Biochem 73: 657\u2013704","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ2021110496_CR42","doi-asserted-by":"crossref","first-page":"11902","DOI":"10.1016\/S0021-9258(19)50285-X","volume":"268","author":"RJ Kaufman","year":"1993","unstructured":"Kaufman RJ, Murtha\u2010Riel P, Pittman DD, Davies MV (1993) Characterization of wild\u2010type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells. J Biol Chem 268: 11902\u201311909","journal-title":"J Biol Chem"},{"key":"BFEMBJ2021110496_CR43","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S1097-2765(02)00559-2","volume":"9","author":"JD Keene","year":"2002","unstructured":"Keene JD, Tenenbaum SA (2002) Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell 9: 1161\u20131167","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR44","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2017.35.15_suppl.e14010","volume":"35","author":"T Kosaka","year":"2017","unstructured":"Kosaka T, Maeda T, Shinojima T, Nagata H, Ryuchi R, Oya M (2017) A clinical study to evaluate the efficacy and safety of docetaxal with ribavirin in patients with progressive castration resistant prostate cancer who have previously received docetaxol alone. J Clin Oncol 35: e14010","journal-title":"J Clin Oncol"},{"key":"BFEMBJ2021110496_CR45","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/leu.2011.57","volume":"25","author":"BC Kraljacic","year":"2011","unstructured":"Kraljacic BC, Arguello M, Amri A, Cormack G, Borden K (2011) Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens. Leukemia 25: 1197\u20131200","journal-title":"Leukemia"},{"key":"BFEMBJ2021110496_CR46","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/345544a0","volume":"345","author":"A Lazaris\u2010Karatzas","year":"1990","unstructured":"Lazaris\u2010Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5\u2032 cap. Nature 345: 544\u2013547","journal-title":"Nature"},{"key":"BFEMBJ2021110496_CR47","unstructured":"Leucegene (2015) AML Sequencing Gene Expression Omnibus GSE67040 (https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE67040). [DATASET]"},{"key":"BFEMBJ2021110496_CR48","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1101\/gad.10.13.1683","volume":"10","author":"JD Lewis","year":"1996","unstructured":"Lewis JD, Izaurralde E, Jarmolowski A, McGuigan C, Mattaj IW (1996) A nuclear cap\u2010binding complex facilitates association of U1 snRNP with the cap\u2010proximal 5\u2032 splice site. Genes Dev 10: 1683\u20131698","journal-title":"Genes Dev"},{"key":"BFEMBJ2021110496_CR49","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA\u2010seq data with DESeq2. Genome Biol 15: 550","journal-title":"Genome Biol"},{"key":"BFEMBJ2021110496_CR50","volume":"13","author":"JC Mars","year":"2021","unstructured":"Mars JC, Ghram M, Culjkovic\u2010Kraljacic B, Borden KLB (2021) The cap\u2010binding complex CBC and the eukaryotic translation factor eIF4E: co\u2010conspirators in cap\u2010dependent RNA maturation and translation. Cancers (Basel) 13: 6185","journal-title":"Cancers (Basel)"},{"key":"BFEMBJ2021110496_CR51","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/bib\/bbz126","volume":"21","author":"A Mehmood","year":"2020","unstructured":"Mehmood A, Laiho A, Venalainen MS, McGlinchey AJ, Wang N, Elo LL (2020) Systematic evaluation of differential splicing tools for RNA\u2010seq studies. Brief Bioinform 21: 2052\u20132065","journal-title":"Brief Bioinform"},{"key":"BFEMBJ2021110496_CR52","doi-asserted-by":"crossref","DOI":"10.3390\/genes12071085","volume":"12","author":"N Mehterov","year":"2021","unstructured":"Mehterov N, Kazakova M, Sbirkov Y, Vladimirov B, Belev N, Yaneva G, Todorova K, Hayrabedyan S, Sarafian V (2021) Alternative RNA splicing\u2010the trojan horse of cancer cells in chemotherapy. Genes (Basel) 12: 1085","journal-title":"Genes (Basel)"},{"key":"BFEMBJ2021110496_CR53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2011.06.007","volume":"43","author":"N Mukherjee","year":"2011","unstructured":"Mukherjee N, Corcoran DL, Nusbaum JD, Reid DW, Georgiev S, Hafner M, Ascano M Jr, Tuschl T, Ohler U, Keene JD (2011) Integrative regulatory mapping indicates that the RNA\u2010binding protein HuR couples pre\u2010mRNA processing and mRNA stability. Mol Cell 43: 327\u2013339","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR54","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/imr.12240","volume":"263","author":"MJ Osborne","year":"2015","unstructured":"Osborne MJ, Borden KL (2015) The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled. Immunol Rev 263: 210\u2013223","journal-title":"Immunol Rev"},{"key":"BFEMBJ2021110496_CR55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2022.167451","volume":"434","author":"MJ Osborne","year":"2022","unstructured":"Osborne MJ, Volpon L, Memarpoor\u2010Yazdi M, Pillay S, Thambipillai A, Czarnota S, Culjkovic\u2010Kraljacic B, Trahan C, Oeffinger M, Cowling VH et al (2022) Identification and characterization of the interaction between the Methyl\u20107\u2010guanosine cap maturation enzyme RNMT and the cap\u2010binding protein eIF4E. J Mol Biol 434: 167451","journal-title":"J Mol Biol"},{"key":"BFEMBJ2021110496_CR56","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","volume":"40","author":"Q Pan","year":"2008","unstructured":"Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high\u2010throughput sequencing. Nat Genet 40: 1413\u20131415","journal-title":"Nat Genet"},{"key":"BFEMBJ2021110496_CR57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2014.10.030","volume":"57","author":"P Papasaikas","year":"2015","unstructured":"Papasaikas P, Tejedor JR, Vigevani L, Valcarcel J (2015) Functional splicing network reveals extensive regulatory potential of the core spliceosomal machinery. Mol Cell 57: 7\u201322","journal-title":"Mol Cell"},{"key":"BFEMBJ2021110496_CR58","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1073\/pnas.1915975117","volume":"117","author":"JW Phillips","year":"2020","unstructured":"Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D et al (2020) Pathway\u2010guided analysis identifies Myc\u2010dependent alternative pre\u2010mRNA splicing in aggressive prostate cancers. Proc Natl Acad Sci USA 117: 5269\u20135279","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2021110496_CR59","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.339986.120","volume":"34","author":"X Rambout","year":"2020","unstructured":"Rambout X, Maquat LE (2020) The nuclear cap\u2010binding complex as choreographer of gene transcription and pre\u2010mRNA processing. Genes Dev 34: 1113\u20131127","journal-title":"Genes Dev"},{"key":"BFEMBJ2021110496_CR60","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014967118","volume":"118","author":"OD Rivera","year":"2021","unstructured":"Rivera OD, Mallory MJ, Quesnel\u2010Vallieres M, Chatrikhi R, Schultz DC, Carroll M, Barash Y, Cherry S, Lynch KW (2021) Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci USA 118: e2014967118","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2021110496_CR61","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1182\/blood-2016-10-692400","volume":"129","author":"B Saez","year":"2017","unstructured":"Saez B, Walter MJ, Graubert TA (2017) Splicing factor gene mutations in hematologic malignancies. Blood 129: 1260\u20131269","journal-title":"Blood"},{"key":"BFEMBJ2021110496_CR62","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498\u20132504","journal-title":"Genome Res"},{"key":"BFEMBJ2021110496_CR63","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr713","volume":"40","author":"S Shen","year":"2012","unstructured":"Shen S, Park JW, Huang J, Dittmar KA, Lu ZX, Zhou Q, Carstens RP, Xing Y (2012) MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA\u2010seq data. Nucleic Acids Res 40: e61","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ2021110496_CR64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gde.2012.12.006","volume":"23","author":"LE Simone","year":"2013","unstructured":"Simone LE, Keene JD (2013) Mechanisms coordinating ELAV\/Hu mRNA regulons. Curr Opin Genet Dev 23: 35\u201343","journal-title":"Curr Opin Genet Dev"},{"key":"BFEMBJ2021110496_CR65","first-page":"42","volume":"44","author":"H Sung","year":"2006","unstructured":"Sung H, Kang SH, Bae YJ, Hong JT, Chung YB, Lee CK, Song S (2006) PCR\u2010based detection of mycoplasma species. J Microbiol 44: 42\u201349","journal-title":"J Microbiol"},{"key":"BFEMBJ2021110496_CR66","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/gcc.22784","volume":"58","author":"J Taylor","year":"2019","unstructured":"Taylor J, Lee SC (2019) Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies. Genes Chromosomes Cancer 58: 889\u2013902","journal-title":"Genes Chromosomes Cancer"},{"key":"BFEMBJ2021110496_CR68","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1128\/MCB.23.24.8992-9002.2003","volume":"23","author":"I Topisirovic","year":"2003","unstructured":"Topisirovic I, Guzman ML, McConnell MJ, Licht JD, Culjkovic B, Neering SJ, Jordan CT, Borden KL (2003) Aberrant eukaryotic translation initiation factor 4E\u2010dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Mol Cell Biol 23: 8992\u20139002","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2021110496_CR69","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/emboj.2009.53","volume":"28","author":"I Topisirovic","year":"2009","unstructured":"Topisirovic I, Siddiqui N, Lapointe VL, Trost M, Thibault P, Bangeranye C, Pinol\u2010Roma S, Borden KL (2009a) Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export\u2010competent RNP. EMBO J 28: 1087\u20131098","journal-title":"EMBO J"},{"key":"BFEMBJ2021110496_CR70","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1128\/MCB.01532-08","volume":"29","author":"I Topisirovic","year":"2009","unstructured":"Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KL (2009b) Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer. Mol Cell Biol 29: 1152\u20131162","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ2021110496_CR71","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1476","volume":"9","author":"LM Urbanski","year":"2018","unstructured":"Urbanski LM, Leclair N, Anczukow O (2018) Alternative\u2010splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics. Wiley Interdiscip Rev RNA 9: e1476","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"BFEMBJ2021110496_CR72","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121844","volume":"11","author":"V Visconte","year":"2019","unstructured":"Visconte V, Nakashima MO, Rogers HJ (2019) Mutations in splicing factor genes in myeloid malignancies: significance and impact on clinical features. Cancers (Basel) 11: 1844","journal-title":"Cancers (Basel)"},{"key":"BFEMBJ2021110496_CR73","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1073\/pnas.1524291113","volume":"113","author":"L Volpon","year":"2016","unstructured":"Volpon L, Culjkovic\u2010Kraljacic B, Osborne MJ, Ramteke A, Sun Q, Niesman A, Chook YM, Borden KL (2016) Importin 8 mediates m7G cap\u2010sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. Proc Natl Acad Sci USA 113: 5263\u20135268","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2021110496_CR74","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1261\/rna.060137.116","volume":"23","author":"L Volpon","year":"2017","unstructured":"Volpon L, Culjkovic\u2010Kraljacic B, Sohn HS, Blanchet\u2010Cohen A, Osborne MJ, Borden KLB (2017) A biochemical framework for eIF4E\u2010dependent mRNA export and nuclear recycling of the export machinery. RNA 23: 927\u2013937","journal-title":"RNA"},{"key":"BFEMBJ2021110496_CR75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cell.2009.02.009","volume":"136","author":"MC Wahl","year":"2009","unstructured":"Wahl MC, Will CL, Luhrmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701\u2013718","journal-title":"Cell"},{"key":"BFEMBJ2021110496_CR76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36530","volume":"7","author":"H Yoshikawa","year":"2018","unstructured":"Yoshikawa H, Larance M, Harney DJ, Sundaramoorthy R, Ly T, Owen\u2010Hughes T, Lamond AI (2018) Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega\u2010SEC. Elife 7: e36530","journal-title":"Elife"},{"key":"BFEMBJ2021110496_CR77","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4106","volume":"11","author":"H Yoshikawa","year":"2021","unstructured":"Yoshikawa H, Sundaramoorthy R, Mariyappa D, Jiang H, Lamond AI (2021) Efficient and rapid analysis of polysomes and ribosomal subunits in cells and tissues using Ribo Mega\u2010SEC. Bio Protoc 11: e4106","journal-title":"Bio Protoc"},{"key":"BFEMBJ2021110496_CR78","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature13283","volume":"511","author":"HA Zahreddine","year":"2014","unstructured":"Zahreddine HA, Culjkovic\u2010Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E et al (2014) The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature 511: 90\u201393","journal-title":"Nature"},{"key":"BFEMBJ2021110496_CR79","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29830","volume":"6","author":"HA Zahreddine","year":"2017","unstructured":"Zahreddine HA, Culjkovic\u2010Kraljacic B, Emond A, Pettersson F, Midura R, Lauer M, Del Rincon S, Cali V, Assouline S, Miller WH et al (2017) The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity. Elife 6: e29830","journal-title":"Elife"},{"key":"BFEMBJ2021110496_CR80","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0378-1119(95)00302-M","volume":"163","author":"Y Zhang","year":"1995","unstructured":"Zhang Y, Klein HL, Schneider RJ (1995) Role of Ser\u201053 phosphorylation in the activity of human translation initiation factor eIF\u20104E in mammalian and yeast cells. Gene 163: 283\u2013288","journal-title":"Gene"},{"key":"BFEMBJ2021110496_CR81","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist\u2010oriented resource for the analysis of systems\u2010level datasets. Nat Commun 10: 1523","journal-title":"Nat Commun"},{"key":"BFEMBJ2021110496_CR82","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1091\/mbc.e06-02-0099","volume":"17","author":"H Zhu","year":"2006","unstructured":"Zhu H, Hasman RA, Barron VA, Luo G, Lou H (2006) A nuclear function of Hu proteins as neuron\u2010specific alternative RNA processing regulators. Mol Biol Cell 17: 5105\u20135114","journal-title":"Mol Biol Cell"},{"key":"BFEMBJ2021110496_CR83","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1128\/MCB.01509-07","volume":"28","author":"H Zhu","year":"2008","unstructured":"Zhu H, Hinman MN, Hasman RA, Mehta P, Lou H (2008) Regulation of neuron\u2010specific alternative splicing of neurofibromatosis type 1 pre\u2010mRNA. Mol Cell Biol 28: 1240\u20131251","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2021110496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.2021110496","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2021110496\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2021110496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2021110496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:38:20Z","timestamp":1779309500000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2021110496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":82,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,4,3]]}},"alternative-id":["BFEMBJ2021110496"],"URL":"https:\/\/doi.org\/10.15252\/embj.2021110496","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.07.471666","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,27]]},"assertion":[{"value":"20 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMBJ2021110496"}}