{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:35:55Z","timestamp":1791430555347,"version":"4.3.3"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","award":["15026"],"award-info":[{"award-number":["15026"]}],"id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","award":["17012"],"award-info":[{"award-number":["17012"]}],"id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["375876048 \u2010 SFB\u2010TRR 241 B01"],"award-info":[{"award-number":["375876048 \u2010 SFB\u2010TRR 241 B01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EC | European Research Council","award":["AdG 670930"],"award-info":[{"award-number":["AdG 670930"]}]},{"name":"EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska\u2010Curie Actions","award":["893676"],"award-info":[{"award-number":["893676"]}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35 ES030443\u201001"],"award-info":[{"award-number":["R35 ES030443\u201001"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES004699"],"award-info":[{"award-number":["P42 ES004699"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016580","name":"Kennedy Trust for Rheumatology Research","doi-asserted-by":"publisher","award":["KEN192001"],"award-info":[{"award-number":["KEN192001"]}],"id":[{"id":"10.13039\/100016580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009576","name":"Kenneth Rainin Foundation","doi-asserted-by":"publisher","award":["20210017"],"award-info":[{"award-number":["20210017"]}],"id":[{"id":"10.13039\/100009576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["103830\/Z\/14\/Z"],"award-info":[{"award-number":["103830\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220784\/Z\/20\/Z"],"award-info":[{"award-number":["220784\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["212240\/Z\/18\/Z"],"award-info":[{"award-number":["212240\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203803\/Z16\/Z"],"award-info":[{"award-number":["203803\/Z16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["108869\/Z\/15\/Z"],"award-info":[{"award-number":["108869\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipids play a major role in inflammatory diseases by altering inflammatory cell functions, either through their function as energy substrates or as lipid mediators such as oxylipins. Autophagy, a lysosomal degradation pathway that limits inflammation, is known to impact on lipid availability, however, whether this controls inflammation remains unexplored. We found that upon intestinal inflammation visceral adipocytes upregulate autophagy and that adipocyte\u2010specific loss of the autophagy gene\n                    <jats:italic>Atg7<\/jats:italic>\n                    exacerbates inflammation. While autophagy decreased lipolytic release of free fatty acids, loss of the major lipolytic enzyme\n                    <jats:italic>Pnpla2\/Atgl<\/jats:italic>\n                    in adipocytes did not alter intestinal inflammation, ruling out free fatty acids as anti\u2010inflammatory energy substrates. Instead,\n                    <jats:italic>Atg7<\/jats:italic>\n                    \u2010deficient adipose tissues exhibited an oxylipin imbalance, driven through an NRF2\u2010mediated upregulation of\n                    <jats:italic>Ephx1<\/jats:italic>\n                    . This shift reduced secretion of IL\u201010 from adipose tissues, which was dependent on the cytochrome P450\u2010EPHX pathway, and lowered circulating levels of IL\u201010 to exacerbate intestinal inflammation. These results suggest an underappreciated fat\u2010gut crosstalk through an autophagy\u2010dependent regulation of anti\u2010inflammatory oxylipins via the cytochrome P450\u2010EPHX pathway, indicating a protective effect of adipose tissues for distant inflammation.\n                  <\/jats:p>","DOI":"10.15252\/embj.2022112202","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T09:47:42Z","timestamp":1676540862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL\u201010"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-3449","authenticated-orcid":false,"given":"Felix Clemens","family":"Richter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-4853","authenticated-orcid":false,"given":"Matthias","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-9939","authenticated-orcid":false,"given":"Nadja","family":"Kampschulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Piletic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4211-3420","authenticated-orcid":false,"given":"Ghada","family":"Alsaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-6520","authenticated-orcid":false,"given":"Ramona","family":"Zummach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2809-9498","authenticated-orcid":false,"given":"Mathilde","family":"Pohin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-8622","authenticated-orcid":false,"given":"Nicholas","family":"Ilott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Guschina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-9894","authenticated-orcid":false,"given":"Sarah Karin","family":"Wideman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errin","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-2597","authenticated-orcid":false,"given":"Mariana","family":"Borsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4246-6821","authenticated-orcid":false,"given":"Paula","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Morriseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-8317","authenticated-orcid":false,"given":"Bruce D","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-8060","authenticated-orcid":false,"given":"Henk Simon","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-5659","authenticated-orcid":false,"given":"Claire M","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-1182","authenticated-orcid":false,"given":"Rudolf","family":"Zechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-958X","authenticated-orcid":false,"given":"Britta","family":"Siegmund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-0088","authenticated-orcid":false,"given":"Carl","family":"Weidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-6629","authenticated-orcid":false,"given":"Nils Helge","family":"Schebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-5929","authenticated-orcid":false,"given":"Fiona","family":"Powrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-7995","authenticated-orcid":false,"given":"Anna Katharina","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"BFEMBJ2022112202_CR1","volume":"10","author":"YA An","year":"2020","unstructured":"An YA, Scherer PE (2020) Mouse adipose tissue protein extraction. Bio Protoc 10: e3631","journal-title":"Bio Protoc"},{"key":"BFEMBJ2022112202_CR2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41590-019-0397-y","volume":"20","author":"H Baazim","year":"2019","unstructured":"Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L et\u00a0al (2019) CD8+ T cells induce cachexia during chronic viral infection. Nat Immunol 20: 701\u2013710","journal-title":"Nat Immunol"},{"key":"BFEMBJ2022112202_CR3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41577-021-00624-w","volume":"22","author":"H Baazim","year":"2021","unstructured":"Baazim H, Antonio\u2010Herrera L, Bergthaler A (2021) The interplay of immunology and cachexia in infection and cancer. Nat Rev Immunol 22: 309\u2013321","journal-title":"Nat Rev Immunol"},{"key":"BFEMBJ2022112202_CR4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/mi.2012.33","volume":"5","author":"A Batra","year":"2012","unstructured":"Batra A, Heimesaat MM, Bereswill S, Fischer A, Glauben R, Kunkel D, Scheffold A, Erben U, Kuhl A, Loddenkemper C et\u00a0al (2012) Mesenteric fat \u2010 control site for bacterial translocation in colitis? Mucosal Immunol 5: 580\u2013591","journal-title":"Mucosal Immunol"},{"key":"BFEMBJ2022112202_CR5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","volume":"34","author":"NL Bray","year":"2016","unstructured":"Bray NL, Pimentel H, Melsted P, Pachter L (2016) Near\u2010optimal probabilistic RNA\u2010seq quantification. Nat Biotechnol 34: 525\u2013527","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ2022112202_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature07416","volume":"456","author":"K Cadwell","year":"2008","unstructured":"Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S et\u00a0al (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456: 259\u2013263","journal-title":"Nature"},{"key":"BFEMBJ2022112202_CR7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4161\/auto.5.2.7560","volume":"5","author":"K Cadwell","year":"2009","unstructured":"Cadwell K, Patel KK, Komatsu M, Virgin HWT, Stappenbeck TS (2009) A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy 5: 250\u2013252","journal-title":"Autophagy"},{"key":"BFEMBJ2022112202_CR8","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.celrep.2018.10.040","volume":"25","author":"J Cai","year":"2018","unstructured":"Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE et\u00a0al (2018) Autophagy ablation in adipocytes induces insulin resistance and reveals roles for lipid peroxide and Nrf2 signaling in adipose\u2010liver crosstalk. Cell Rep 25: 1708\u20131717","journal-title":"Cell Rep"},{"key":"BFEMBJ2022112202_CR9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.febslet.2007.11.051","volume":"582","author":"WP Cawthorn","year":"2008","unstructured":"Cawthorn WP, Sethi JK (2008) TNF\u2010alpha and adipocyte biology. FEBS Lett 582: 117\u2013131","journal-title":"FEBS Lett"},{"key":"BFEMBJ2022112202_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","volume":"486","author":"D Cipolletta","year":"2012","unstructured":"Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D (2012) PPAR\u2010gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486: 549\u2013553","journal-title":"Nature"},{"key":"BFEMBJ2022112202_CR11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41577-018-0095-2","volume":"19","author":"AJ Clarke","year":"2019","unstructured":"Clarke AJ, Simon AK (2019) Autophagy in the renewal, differentiation and homeostasis of immune cells. Nat Rev Immunol 19: 170\u2013183","journal-title":"Nat Rev Immunol"},{"key":"BFEMBJ2022112202_CR12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd7954","volume":"7","author":"S Crittenden","year":"2021","unstructured":"Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A et\u00a0al (2021) Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota\u2010dependent regulatory T cells. Sci Adv 7: eabd7954","journal-title":"Sci Adv"},{"key":"BFEMBJ2022112202_CR13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.chom.2017.11.002","volume":"22","author":"C Danne","year":"2017","unstructured":"Danne C, Ryzhakov G, Martinez\u2010Lopez M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F (2017) A large polysaccharide produced by helicobacter hepaticus induces an anti\u2010inflammatory gene signature in macrophages. Cell Host Microbe 22: 733\u2013745","journal-title":"Cell Host Microbe"},{"key":"BFEMBJ2022112202_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","volume":"333","author":"SK Das","year":"2011","unstructured":"Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, Gorkiewicz G, Tamilarasan KP, Kumari P, Trauner M et\u00a0al (2011) Adipose triglyceride lipase contributes to cancer\u2010associated cachexia. Science 333: 233\u2013238","journal-title":"Science"},{"key":"BFEMBJ2022112202_CR15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","volume":"54","author":"V Deretic","year":"2021","unstructured":"Deretic V (2021) Autophagy in inflammation, infection, and immunometabolism. Immunity 54: 437\u2013453","journal-title":"Immunity"},{"key":"BFEMBJ2022112202_CR16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2249.1998.00728.x","volume":"114","author":"LA Dieleman","year":"1998","unstructured":"Dieleman LA, Palmen MJ, Akol H, Bloemena E, Pena AS, Meuwissen SG, Van Rees EP (1998) Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 114: 385\u2013391","journal-title":"Clin Exp Immunol"},{"key":"BFEMBJ2022112202_CR17","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1074\/jbc.RA117.000298","volume":"293","author":"ML Edin","year":"2018","unstructured":"Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM et\u00a0al (2018) Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia. J Biol Chem 293: 3281\u20133292","journal-title":"J Biol Chem"},{"key":"BFEMBJ2022112202_CR18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497\u2013509","journal-title":"J Biol Chem"},{"key":"BFEMBJ2022112202_CR19","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","volume":"50","author":"M Friedrich","year":"2019","unstructured":"Friedrich M, Pohin M, Powrie F (2019) Cytokine networks in the pathophysiology of inflammatory bowel disease. Immunity 50: 992\u20131006","journal-title":"Immunity"},{"key":"BFEMBJ2022112202_CR20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68445","volume":"10","author":"J Gautheron","year":"2021","unstructured":"Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J et\u00a0al (2021) EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife 10: e68445","journal-title":"Elife"},{"key":"BFEMBJ2022112202_CR21","doi-asserted-by":"crossref","first-page":"E3240","DOI":"10.1073\/pnas.1521453113","volume":"113","author":"DW Gilroy","year":"2016","unstructured":"Gilroy DW, Edin ML, De Maeyer RP, Bystrom J, Newson J, Lih FB, Stables M, Zeldin DC, Bishop\u2010Bailey D (2016) CYP450\u2010derived oxylipins mediate inflammatory resolution. Proc Natl Acad Sci USA 113: E3240\u2013E3249","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022112202_CR22","volume":"183","author":"CWY Ha","year":"2020","unstructured":"Ha CWY, Martin A, Sepich\u2010Poore GD, Shi B, Wang Y, Gouin K, Humphrey G, Sanders K, Ratnayake Y, Chan KSL et\u00a0al (2020) Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans. Cell 183: e617","journal-title":"Cell"},{"key":"BFEMBJ2022112202_CR23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"J Hampe","year":"2007","unstructured":"Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J et\u00a0al (2007) A genome\u2010wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207\u2013211","journal-title":"Nat Genet"},{"key":"BFEMBJ2022112202_CR24","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","volume":"15","author":"SC Huang","year":"2014","unstructured":"Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love\u2010Gregory L, Lam WY, O'Neill CM et\u00a0al (2014) Cell\u2010intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol 15: 846\u2013855","journal-title":"Nat Immunol"},{"key":"BFEMBJ2022112202_CR25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nrd2875","volume":"8","author":"JD Imig","year":"2009","unstructured":"Imig JD, Hammock BD (2009) Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nat Rev Drug Discov 8: 794\u2013805","journal-title":"Nat Rev Drug Discov"},{"key":"BFEMBJ2022112202_CR26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","volume":"356","author":"WKE Ip","year":"2017","unstructured":"Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R (2017) Anti\u2010inflammatory effect of IL\u201010 mediated by metabolic reprogramming of macrophages. Science 356: 513\u2013519","journal-title":"Science"},{"key":"BFEMBJ2022112202_CR27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA et\u00a0al (2012) Host\u2010microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491: 119\u2013124","journal-title":"Nature"},{"key":"BFEMBJ2022112202_CR28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41419-019-1393-8","volume":"10","author":"L Ju","year":"2019","unstructured":"Ju L, Han J, Zhang X, Deng Y, Yan H, Wang C, Li X, Chen S, Alimujiang M, Li X et\u00a0al (2019) Obesity\u2010associated inflammation triggers an autophagy\u2010lysosomal response in adipocytes and causes degradation of perilipin 1. Cell Death Dis 10: 121","journal-title":"Cell Death Dis"},{"key":"BFEMBJ2022112202_CR29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12444","volume":"5","author":"AM Kabat","year":"2016","unstructured":"Kabat AM, Harrison OJ, Riffelmacher T, Moghaddam AE, Pearson CF, Laing A, Abeler\u2010Dorner L, Forman SP, Grencis RK, Sattentau Q et\u00a0al (2016) The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife 5: e12444","journal-title":"Elife"},{"key":"BFEMBJ2022112202_CR30","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1080\/15548627.2015.1124226","volume":"12","author":"S Kaushik","year":"2016","unstructured":"Kaushik S, Cuervo AM (2016) AMPK\u2010dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy 12: 432\u2013438","journal-title":"Autophagy"},{"key":"BFEMBJ2022112202_CR31","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.4049\/jimmunol.1203074","volume":"191","author":"IR Klein\u2010Wieringa","year":"2013","unstructured":"Klein\u2010Wieringa IR, Andersen SN, Kwekkeboom JC, Giera M, de Lange\u2010Brokaar BJ, van Osch GJ, Zuurmond AM, Stojanovic\u2010Susulic V, Nelissen RG, Pijl H et\u00a0al (2013) Adipocytes modulate the phenotype of human macrophages through secreted lipids. J Immunol 191: 1356\u20131363","journal-title":"J Immunol"},{"key":"BFEMBJ2022112202_CR32","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","volume":"40","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo\u2010San Pedro JM, Cadwell K, Cecconi F, Choi AMK et\u00a0al (2021) Autophagy in major human diseases. EMBO J 40: e108863","journal-title":"EMBO J"},{"key":"BFEMBJ2022112202_CR33","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1007\/s00216-021-03525-y","volume":"413","author":"E Koch","year":"2021","unstructured":"Koch E, Wiebel M, Hopmann C, Kampschulte N, Schebb NH (2021) Rapid quantification of fatty acids in plant oils and biological samples by LC\u2010MS. Anal Bioanal Chem 413: 5439\u20135451","journal-title":"Anal Bioanal Chem"},{"key":"BFEMBJ2022112202_CR34","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1021\/acs.jafc.1c07743","volume":"70","author":"E Koch","year":"2022","unstructured":"Koch E, Kampschulte N, Schebb NH (2022) Comprehensive analysis of fatty acid and oxylipin patterns in n3\u2010PUFA supplements. J Agric Food Chem 70: 3979\u20133988","journal-title":"J Agric Food Chem"},{"key":"BFEMBJ2022112202_CR35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1083\/jcb.200412022","volume":"169","author":"M Komatsu","year":"2005","unstructured":"Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y et\u00a0al (2005) Impairment of starvation\u2010induced and constitutive autophagy in Atg7\u2010deficient mice. J Cell Biol 169: 425\u2013434","journal-title":"J Cell Biol"},{"key":"BFEMBJ2022112202_CR36","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/gutjnl-2011-301424","volume":"62","author":"LI Kredel","year":"2013","unstructured":"Kredel LI, Batra A, Stroh T, Kuhl AA, Zeitz M, Erben U, Siegmund B (2013) Adipokines from local fat cells shape the macrophage compartment of the creeping fat in Crohn's disease. Gut 62: 852\u2013862","journal-title":"Gut"},{"key":"BFEMBJ2022112202_CR37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fphar.2019.00169","volume":"10","author":"L Kutzner","year":"2019","unstructured":"Kutzner L, Rund KM, Ostermann AI, Hartung NM, Galano JM, Balas L, Durand T, Balzer MS, David S, Schebb NH (2019) Development of an optimized LC\u2010MS method for the detection of specialized pro\u2010resolving mediators in biological samples. Front Pharmacol 10: 169","journal-title":"Front Pharmacol"},{"key":"BFEMBJ2022112202_CR38","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41564-019-0498-2","volume":"4","author":"SR Levan","year":"2019","unstructured":"Levan SR, Stamnes KA, Lin DL, Panzer AR, Fukui E, McCauley K, Fujimura KE, McKean M, Ownby DR, Zoratti EM et\u00a0al (2019) Elevated faecal 12,13\u2010diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance. Nat Microbiol 4: 1851\u20131861","journal-title":"Nat Microbiol"},{"key":"BFEMBJ2022112202_CR39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/mi.2013.103","volume":"7","author":"B Li","year":"2014","unstructured":"Li B, Alli R, Vogel P, Geiger TL (2014) IL\u201010 modulates DSS\u2010induced colitis through a macrophage\u2010ROS\u2010NO axis. Mucosal Immunol 7: 869\u2013878","journal-title":"Mucosal Immunol"},{"key":"BFEMBJ2022112202_CR40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1073\/pnas.1422590112","volume":"112","author":"C Lopez\u2010Vicario","year":"2015","unstructured":"Lopez\u2010Vicario C, Alcaraz\u2010Quiles J, Garcia\u2010Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Claria J (2015) Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega\u20103 epoxides. Proc Natl Acad Sci USA 112: 536\u2013541","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022112202_CR41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA\u2010seq data with DESeq2. Genome Biol 15: 550","journal-title":"Genome Biol"},{"key":"BFEMBJ2022112202_CR42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nm.4297","volume":"23","author":"MD Lynes","year":"2017","unstructured":"Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A et\u00a0al (2017) The cold\u2010induced lipokine 12,13\u2010diHOME promotes fatty acid transport into brown adipose tissue. Nat Med 23: 631\u2013637","journal-title":"Nat Med"},{"key":"BFEMBJ2022112202_CR43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","volume":"6","author":"C Mammucari","year":"2007","unstructured":"Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J et\u00a0al (2007) FoxO3 controls autophagy in skeletal muscle in\u00a0vivo. Cell Metab 6: 458\u2013471","journal-title":"Cell Metab"},{"key":"BFEMBJ2022112202_CR44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ibd\/izy331","volume":"25","author":"R Mao","year":"2019","unstructured":"Mao R, Kurada S, Gordon IO, Baker ME, Gandhi N, McDonald C, Coffey JC, Rieder F (2019) The mesenteric fat and intestinal muscle interface: creeping fat influencing stricture formation in Crohn's disease. Inflamm Bowel Dis 25: 421\u2013426","journal-title":"Inflamm Bowel Dis"},{"key":"BFEMBJ2022112202_CR45","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ng.215","volume":"40","author":"SA McCarroll","year":"2008","unstructured":"McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH et\u00a0al (2008) Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 40: 1107\u20131112","journal-title":"Nat Genet"},{"key":"BFEMBJ2022112202_CR46","doi-asserted-by":"crossref","first-page":"E6034","DOI":"10.1073\/pnas.1610325114","volume":"114","author":"DR McDougle","year":"2017","unstructured":"McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, Johnson RW, Kilian KA, Holinstat M, Das A (2017) Anti\u2010inflammatory omega\u20103 endocannabinoid epoxides. Proc Natl Acad Sci USA 114: E6034\u2013E6043","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022112202_CR47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-030-50621-6_5","volume":"1274","author":"C McReynolds","year":"2020","unstructured":"McReynolds C, Morisseau C, Wagner K, Hammock B (2020) Epoxy fatty acids are promising targets for treatment of pain, cardiovascular disease and other indications characterized by mitochondrial dysfunction, endoplasmic stress and inflammation. Adv Exp Med Biol 1274: 71\u201399","journal-title":"Adv Exp Med Biol"},{"key":"BFEMBJ2022112202_CR48","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","volume":"10","author":"M Murai","year":"2009","unstructured":"Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M (2009) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 10: 1178\u20131184","journal-title":"Nat Immunol"},{"key":"BFEMBJ2022112202_CR49","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","volume":"447","author":"JI Odegaard","year":"2007","unstructured":"Odegaard JI, Ricardo\u2010Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW et\u00a0al (2007) Macrophage\u2010specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447: 1116\u20131120","journal-title":"Nature"},{"key":"BFEMBJ2022112202_CR50","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cmet.2008.04.003","volume":"7","author":"JI Odegaard","year":"2008","unstructured":"Odegaard JI, Ricardo\u2010Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity\u2010induced insulin resistance. Cell Metab 7: 496\u2013507","journal-title":"Cell Metab"},{"key":"BFEMBJ2022112202_CR51","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba3066","volume":"369","author":"M Oliva","year":"2020","unstructured":"Oliva M, Munoz\u2010Aguirre M, Kim\u2010Hellmuth S, Wucher V, Gewirtz ADH, Cotter DJ, Parsana P, Kasela S, Balliu B, Vinuela A et\u00a0al (2020) The impact of sex on gene expression across human tissues. Science 369: eaba3066","journal-title":"Science"},{"key":"BFEMBJ2022112202_CR52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197039","volume":"21","author":"H Overby","year":"2020","unstructured":"Overby H, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD et\u00a0al (2020) Soluble epoxide hydrolase inhibition by t\u2010TUCB promotes Brown adipogenesis and reduces serum triglycerides in diet\u2010induced obesity. Int J Mol Sci 21: 7039","journal-title":"Int J Mol Sci"},{"key":"BFEMBJ2022112202_CR53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/imm.12978","volume":"155","author":"FC Richter","year":"2018","unstructured":"Richter FC, Obba S, Simon AK (2018) Local exchange of metabolites shapes immunity. Immunology 155: 309\u2013319","journal-title":"Immunology"},{"key":"BFEMBJ2022112202_CR54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.immuni.2017.08.005","volume":"47","author":"T Riffelmacher","year":"2017","unstructured":"Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T et\u00a0al (2017) Autophagy\u2010dependent generation of free fatty acids is critical for normal neutrophil differentiation. Immunity 47: 466\u2013480","journal-title":"Immunity"},{"key":"BFEMBJ2022112202_CR55","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/ibd\/izy201","volume":"25","author":"ED Rivera","year":"2019","unstructured":"Rivera ED, Coffey JC, Walsh D, Ehrenpreis ED (2019) The mesentery, systemic inflammation, and Crohn's disease. Inflamm Bowel Dis 25: 226\u2013234","journal-title":"Inflamm Bowel Dis"},{"key":"BFEMBJ2022112202_CR56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aca.2017.11.002","volume":"1037","author":"KM Rund","year":"2018","unstructured":"Rund KM, Ostermann AI, Kutzner L, Galano JM, Oger C, Vigor C, Wecklein S, Seiwert N, Durand T, Schebb NH (2018) Development of an LC\u2010ESI(\u2212)\u2010MS\/MS method for the simultaneous quantification of 35 isoprostanes and isofurans derived from the major n3\u2010 and n6\u2010PUFAs. Anal Chim Acta 1037: 63\u201374","journal-title":"Anal Chim Acta"},{"key":"BFEMBJ2022112202_CR57","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/imm.13002","volume":"155","author":"L Russo","year":"2018","unstructured":"Russo L, Lumeng CN (2018) Properties and functions of adipose tissue macrophages in obesity. Immunology 155: 407\u2013417","journal-title":"Immunology"},{"key":"BFEMBJ2022112202_CR58","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/dvg.20665","volume":"48","author":"A Sassmann","year":"2010","unstructured":"Sassmann A, Offermanns S, Wettschureck N (2010) Tamoxifen\u2010inducible Cre\u2010mediated recombination in adipocytes. Genesis 48: 618\u2013625","journal-title":"Genesis"},{"key":"BFEMBJ2022112202_CR59","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1210\/en.2015-1322","volume":"156","author":"G Schoiswohl","year":"2015","unstructured":"Schoiswohl G, Stefanovic\u2010Racic M, Menke MN, Wills RC, Surlow BA, Basantani MK, Sitnick MT, Cai L, Yazbeck CF, Stolz DB et\u00a0al (2015) Impact of reduced ATGL\u2010mediated adipocyte lipolysis on obesity\u2010associated insulin resistance and inflammation in male mice. Endocrinology 156: 3610\u20133624","journal-title":"Endocrinology"},{"key":"BFEMBJ2022112202_CR60","doi-asserted-by":"crossref","first-page":"40236","DOI":"10.1074\/jbc.M608048200","volume":"281","author":"M Schweiger","year":"2006","unstructured":"Schweiger M, Schreiber R, Haemmerle G, Lass A, Fledelius C, Jacobsen P, Tornqvist H, Zechner R, Zimmermann R (2006) Adipose triglyceride lipase and hormone\u2010sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem 281: 40236\u201340241","journal-title":"J Biol Chem"},{"key":"BFEMBJ2022112202_CR61","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/bjs.1800790934","volume":"79","author":"AL Sheehan","year":"1992","unstructured":"Sheehan AL, Warren BF, Gear MW, Shepherd NA (1992) Fat\u2010wrapping in Crohn's disease: pathological basis and relevance to surgical practice. Br J Surg 79: 955\u2013958","journal-title":"Br J Surg"},{"key":"BFEMBJ2022112202_CR62","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1053\/gast.2002.33631","volume":"122","author":"B Siegmund","year":"2002","unstructured":"Siegmund B, Lehr HA, Fantuzzi G (2002) Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 122: 2011\u20132025","journal-title":"Gastroenterology"},{"key":"BFEMBJ2022112202_CR63","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1172\/JCI35541","volume":"119","author":"R Singh","year":"2009","unstructured":"Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ (2009) Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119: 3329\u20133339","journal-title":"J Clin Invest"},{"key":"BFEMBJ2022112202_CR64","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.2337\/db13-0500","volume":"62","author":"MT Sitnick","year":"2013","unstructured":"Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, DeLany JP, Schreiber R, Stolz DB et\u00a0al (2013) Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 62: 3350\u20133361","journal-title":"Diabetes"},{"key":"BFEMBJ2022112202_CR65","volume":"39","author":"Y Son","year":"2020","unstructured":"Son Y, Cho YK, Saha A, Kwon HJ, Park JH, Kim M, Jung YS, Kim SN, Choi C, Seong JK et\u00a0al (2020) Adipocyte\u2010specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue. Mol Metab 39: 101005","journal-title":"Mol Metab"},{"key":"BFEMBJ2022112202_CR66","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES et\u00a0al (2005) Gene set enrichment analysis: a knowledge\u2010based approach for interpreting genome\u2010wide expression profiles. Proc Natl Acad Sci USA 102: 15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022112202_CR67","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41577-021-00635-7","volume":"22","author":"WV Trim","year":"2021","unstructured":"Trim WV, Lynch L (2021) Immune and non\u2010immune functions of adipose tissue leukocytes. Nat Rev Immunol 22: 371\u2013386","journal-title":"Nat Rev Immunol"},{"key":"BFEMBJ2022112202_CR68","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.3748\/wjg.v25.i27.3572","volume":"25","author":"S Vidal\u2010Lletjos","year":"2019","unstructured":"Vidal\u2010Lletjos S, Andriamihaja M, Blais A, Grauso M, Lepage P, Davila AM, Gaudichon C, Leclerc M, Blachier F, Lan A (2019) Mucosal healing progression after acute colitis in mice. World J Gastroenterol 25: 3572\u20133589","journal-title":"World J Gastroenterol"},{"key":"BFEMBJ2022112202_CR69","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3389\/fimmu.2018.01974","volume":"9","author":"C Weidinger","year":"2018","unstructured":"Weidinger C, Ziegler JF, Letizia M, Schmidt F, Siegmund B (2018) Adipokines and their role in intestinal inflammation. Front Immunol 9: 1974","journal-title":"Front Immunol"},{"key":"BFEMBJ2022112202_CR70","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41590-019-0351-z","volume":"20","author":"N Whibley","year":"2019","unstructured":"Whibley N, Tucci A, Powrie F (2019) Regulatory T cell adaptation in the intestine and skin. Nat Immunol 20: 386\u2013396","journal-title":"Nat Immunol"},{"key":"BFEMBJ2022112202_CR71","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.prostaglandins.2015.04.002","volume":"120","author":"I Willenberg","year":"2015","unstructured":"Willenberg I, Ostermann AI, Giovannini S, Kershaw O, von Keutz A, Steinberg P, Schebb NH (2015) Effect of acute and chronic DSS induced colitis on plasma eicosanoid and oxylipin levels in the rat. Prostaglandins Other Lipid Mediat 120: 155\u2013160","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"BFEMBJ2022112202_CR72","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L et\u00a0al (2021) clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2: 100141","journal-title":"Innovation"},{"key":"BFEMBJ2022112202_CR73","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1002\/jcp.22682","volume":"226","author":"R Yazbeck","year":"2011","unstructured":"Yazbeck R, Howarth GS, Butler RN, Geier MS, Abbott CA (2011) Biochemical and histological changes in the small intestine of mice with dextran sulfate sodium colitis. J Cell Physiol 226: 3219\u20133224","journal-title":"J Cell Physiol"},{"key":"BFEMBJ2022112202_CR74","doi-asserted-by":"crossref","first-page":"19860","DOI":"10.1073\/pnas.0906048106","volume":"106","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S (2009) Adipose\u2010specific deletion of autophagy\u2010related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 106: 19860\u201319865","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022112202_CR75","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molcel.2019.08.005","volume":"76","author":"H Zhang","year":"2019","unstructured":"Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, Charles P, Frau L, Hublitz P, Yu Z et\u00a0al (2019) Polyamines control eIF5A Hypusination, TFEB translation, and autophagy to reverse B cell senescence. Mol Cell 76: 110\u2013125","journal-title":"Mol Cell"},{"key":"BFEMBJ2022112202_CR76","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1080\/15548627.2019.1703355","volume":"16","author":"X Zhang","year":"2020","unstructured":"Zhang X, Wu D, Wang C, Luo Y, Ding X, Yang X, Silva F, Arenas S, Weaver JM, Mandell M et\u00a0al (2020) Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis\u2010dependent mechanism. Autophagy 16: 1668\u20131682","journal-title":"Autophagy"},{"key":"BFEMBJ2022112202_CR77","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/MIB.0000000000000571","volume":"22","author":"L Zuo","year":"2016","unstructured":"Zuo L, Li Y, Zhu W, Shen B, Gong J, Guo Z, Zhang W, Wu R, Gu L, Li N et\u00a0al (2016) Mesenteric adipocyte dysfunction in Crohn's disease is associated with hypoxia. Inflamm Bowel Dis 22: 114\u2013126","journal-title":"Inflamm Bowel Dis"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2022112202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embj.2022112202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2022112202\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2022112202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2022112202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:47:29Z","timestamp":1779310049000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2022112202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3,15]]}},"alternative-id":["BFEMBJ2022112202"],"URL":"https:\/\/doi.org\/10.15252\/embj.2022112202","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.25.465200","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]},"assertion":[{"value":"26 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMBJ2022112202"}}