{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:21:24Z","timestamp":1792203684087,"version":"4.4.0"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EC|European Research Council","award":["742732"],"award-info":[{"award-number":["742732"]}]},{"name":"EC|Horizon Europe|Excellent Science|HORIZON EUROPE Marie Sklodowska\u2010Curie Actions","award":["798573"],"award-info":[{"award-number":["798573"]}]},{"DOI":"10.13039\/100013060","name":"European Molecular Biology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"crossref","award":["LSHM21020"],"award-info":[{"award-number":["LSHM21020"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021800","name":"Hubrecht Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100021800","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Human Frontier Science Program","award":["LT000209\/2018\u2010L"],"award-info":[{"award-number":["LT000209\/2018\u2010L"]}]},{"DOI":"10.13039\/100008662","name":"Joachim Herz Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2023,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Embryo implantation into the uterus marks a key transition in mammalian development. In mice, implantation is mediated by the trophoblast and is accompanied by a morphological transition from the blastocyst to the egg cylinder. However, the roles of trophoblast\u2010uterine interactions in embryo morphogenesis during implantation are poorly understood due to inaccessibility\n                    <jats:italic>in utero<\/jats:italic>\n                    and the remaining challenges to recapitulate it\n                    <jats:italic>ex vivo<\/jats:italic>\n                    from the blastocyst. Here, we engineer a uterus\u2010like microenvironment to recapitulate peri\u2010implantation development of the whole mouse embryo\n                    <jats:italic>ex vivo<\/jats:italic>\n                    and reveal essential roles of the physical embryo\u2010uterine interaction. We demonstrate that adhesion between the trophoblast and the uterine matrix is required for\n                    <jats:italic>in utero<\/jats:italic>\n                    \u2010like transition of the blastocyst to the egg cylinder. Modeling the implanting embryo as a wetting droplet links embryo shape dynamics to the underlying changes in trophoblast adhesion and suggests that the adhesion\u2010mediated tension release facilitates egg cylinder formation. Light\u2010sheet live imaging and the experimental control of the engineered uterine geometry and trophoblast velocity uncovers the coordination between trophoblast motility and embryo growth, where the trophoblast delineates space for embryo morphogenesis.\n                  <\/jats:p>","DOI":"10.15252\/embj.2022113280","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T10:25:02Z","timestamp":1690799102000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Embryo\u2010uterine interaction coordinates mouse embryogenesis during implantation"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-2743","authenticated-orcid":false,"given":"Vladyslav","family":"Bondarenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Nikolaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-1644","authenticated-orcid":false,"given":"Dimitri","family":"Kromm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-8109","authenticated-orcid":false,"given":"Roman","family":"Belousov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-4266","authenticated-orcid":false,"given":"Adrian","family":"Wolny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"Blotenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Rezakhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-2356","authenticated-orcid":false,"given":"Johannes","family":"Hugger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Uhlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hufnagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kreshuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Ellenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"van Oudenaarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-4665","authenticated-orcid":false,"given":"Anna","family":"Erzberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-305X","authenticated-orcid":false,"given":"Matthias P","family":"Lutolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-7203","authenticated-orcid":false,"given":"Takashi","family":"Hiiragi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"BFEMBJ2022113280_CR1","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.1021\/acs.langmuir.8b02037","volume":"35","author":"R Alert","year":"2019","unstructured":"Alert R, Casademunt J (2019) Role of substrate stiffness in tissue spreading: wetting transition and tissue durotaxis. Langmuir 35: 7571\u20137577","journal-title":"Langmuir"},{"key":"BFEMBJ2022113280_CR2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-fluid-010719-060147","volume":"52","author":"B Andreotti","year":"2020","unstructured":"Andreotti B, Snoeijer JH (2020) Statics and dynamics of soft wetting. Annu Rev Fluid Mech 52: 285\u2013308","journal-title":"Annu Rev Fluid Mech"},{"key":"BFEMBJ2022113280_CR3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41586-019-1492-9","volume":"572","author":"A Bailles","year":"2019","unstructured":"Bailles A, Collinet C, Philippe JM, Lenne PF, Munro E, Lecuit T (2019) Genetic induction and mechanochemical propagation of a morphogenetic wave. Nature 572: 467\u2013473","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR4","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1038\/nprot.2014.186","volume":"9","author":"I Bedzhov","year":"2014","unstructured":"Bedzhov I, Leung CY, Bialecka M, Zernicka\u2010Goetz M (2014) In vitro culture of mouse blastocysts beyond the implantation stages. Nat Protoc 9: 2732\u20132739","journal-title":"Nat Protoc"},{"key":"BFEMBJ2022113280_CR5","volume-title":"Manipulating the mouse embryo: a laboratory manual","author":"R Behringer","year":"2014","unstructured":"Behringer R, Gertsenstein M, Nagy K, Nagy A (2014) Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press"},{"key":"BFEMBJ2022113280_CR6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","volume":"16","author":"S Berg","year":"2019","unstructured":"Berg S, Kutra D, Kroeger T, Straehle CN, Kausler BX, Haubold C, Schiegg M, Ales J, Beier T, Rudy M et\u00a0al (2019) Ilastik: interactive machine learning for (bio)image analysis. Nat Methods 16: 1226\u20131232","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR7","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.148478","volume":"144","author":"M Boretto","year":"2017","unstructured":"Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H, Amant F, Timmerman D, Tomassetti C, Vanhie A et\u00a0al (2017) Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long\u2010term expandability. Development 144: 1775\u20131786","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.stem.2019.05.005","volume":"24","author":"JA Brassard","year":"2019","unstructured":"Brassard JA, Lutolf MP (2019) Engineering stem cell self\u2010organization to build better organoids. Cell Stem Cell 24: 860\u2013876","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2022113280_CR9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/35082103","volume":"411","author":"J Brennan","year":"2001","unstructured":"Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RSP, Robertson EJ (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411: 965\u2013969","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR11","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/BF02976179","volume":"57","author":"G Burckhard","year":"1901","unstructured":"Burckhard G (1901) Die Implantation des Eies der Maus in die Uterusschleimhaut und die Umbildung derselben zur Decidua. Archiv f mikrosk Anat 57: 528\u2013569","journal-title":"Archiv f mikrosk Anat"},{"key":"BFEMBJ2022113280_CR12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nmeth.3839","volume":"13","author":"SR Caliari","year":"2016","unstructured":"Caliari SR, Burdick JA (2016) A practical guide to hydrogels for cell culture. Nat Methods 13: 405\u2013414","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.celrep.2014.06.027","volume":"8","author":"J Cha","year":"2014","unstructured":"Cha J, Bartos A, Park C, Sun X, Li Y, Cha SW, Ajima R, Ho HYH, Yamaguchi TP, Dey SK (2014) Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a\u2010ROR signaling. Cell Rep 8: 382\u2013392","journal-title":"Cell Rep"},{"key":"BFEMBJ2022113280_CR14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-019-1309-x","volume":"571","author":"CJ Chan","year":"2019","unstructured":"Chan CJ, Costanzo M, Ruiz\u2010Herrero T, M\u00f6nke G, Petrie RJ, Bergert M, Diz\u2010Mu\u00f1oz A, Mahadevan L, Hiiragi T (2019) Hydraulic control of mammalian embryo size and cell fate. Nature 571: 112\u2013116","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR15","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nmeth.2075","volume":"9","author":"F de Chaumont","year":"2012","unstructured":"de Chaumont F, Dallongeville S, Chenouard N, Herv\u00e9 N, Pop S, Provoost T, Meas\u2010Yedid V, Pankajakshan P, Lecomte T, le Montagner Y et\u00a0al (2012) Icy: an open bioimage informatics platform for extended reproducible research. Nat Methods 9: 690\u2013696","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR16","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1242\/dev.127.21.4681","volume":"127","author":"S\u2010R Chen","year":"2000","unstructured":"Chen S\u2010R, Kimelman D (2000) The role of the yolk syncytial layer in germ layer patterning in zebrafish. Development 127: 4681\u20134689","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41563-021-01136-7","volume":"21","author":"A Chrisnandy","year":"2022","unstructured":"Chrisnandy A, Blondel D, Rezakhani S, Broguiere N, Lutolf MP (2022) Synthetic dynamic hydrogels promote degradation\u2010independent in vitro organogenesis. Nat Mater 21: 479\u2013487","journal-title":"Nat Mater"},{"key":"BFEMBJ2022113280_CR18","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41556-018-0211-3","volume":"20","author":"N Christodoulou","year":"2018","unstructured":"Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N, Zernicka\u2010Goetz M (2018) Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nat Cell Biol 20: 1278\u20131289","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ2022113280_CR19","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1606.06650","author":"\u00d6 \u00c7i\u00e7ek","year":"2016","unstructured":"\u00c7i\u00e7ek \u00d6, Abdulkadir A, Lienkamp SS, Brox T, Ronneberger O (2016) 3D U\u2010net: learning dense volumetric segmentation from sparse annotation. arXiv https:\/\/doi.org\/10.48550\/arXiv.1606.06650 [PREPRINT]","journal-title":"arXiv"},{"key":"BFEMBJ2022113280_CR21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01386390","volume":"1","author":"EW Dijkstra","year":"1959","unstructured":"Dijkstra EW (1959) A note on two problems in connexion with graphs. Numer Math 1: 269\u2013271","journal-title":"Numer Math"},{"key":"BFEMBJ2022113280_CR22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA\u2010seq aligner. Bioinformatics 29: 15\u201321","journal-title":"Bioinformatics"},{"key":"BFEMBJ2022113280_CR23","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1073\/pnas.1018057108","volume":"108","author":"S Douezan","year":"2011","unstructured":"Douezan S, Guevorkian K, Naouar R, Dufour S, Cuvelier D, Brochard\u2010Wyart F (2011) Spreading dynamics and wetting transition of cellular aggregates. Proc Natl Acad Sci USA 108: 7315\u20137320","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022113280_CR24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1095\/biolreprod46.6.1095","volume":"46","author":"JD Farrar","year":"1992","unstructured":"Farrar JD, Carson DD (1992) Differential temporal and spatial expression of mRNA encoding extracellular matrix components in decidua during the pen\u2010implantation period. Biol Reprod 46: 1095\u20131108","journal-title":"Biol Reprod"},{"key":"BFEMBJ2022113280_CR25","doi-asserted-by":"crossref","DOI":"10.1242\/dev.193490","volume":"147","author":"D Flores","year":"2020","unstructured":"Flores D, Madhavan M, Wright S, Arora R (2020) Mechanical and signaling mechanisms that guide pre\u2010implantation embryo movement. Development 147: dev193490","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071491","volume":"8","author":"HP Foote","year":"2013","unstructured":"Foote HP, Sumigray KD, Lechler T (2013) FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. PloS One 8: e71491","journal-title":"PloS One"},{"key":"BFEMBJ2022113280_CR27","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1073\/pnas.0307512101","volume":"101","author":"Y Gao","year":"2004","unstructured":"Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y (2004) Rational design and characterization of a Rac GTPase\u2010specific small molecule inhibitor. Proc Natl Acad Sci USA 101: 7618\u20137623","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2022113280_CR28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1103\/RevModPhys.57.827","volume":"57","author":"PG de Gennes","year":"1985","unstructured":"de Gennes PG (1985) Wetting: statics and dynamics. Rev Mod Phys 57: 827\u2013863","journal-title":"Rev Mod Phys"},{"key":"BFEMBJ2022113280_CR29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature20168","volume":"539","author":"N Gjorevski","year":"2016","unstructured":"Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ord\u00f3\u00f1ez\u2010Mor\u00e1n P, Clevers H, Lutolf MP (2016) Designer matrices for intestinal stem cell and organoid culture. Nature 539: 560\u2013564","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR30","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw9021","volume":"375","author":"N Gjorevski","year":"2022","unstructured":"Gjorevski N, Nikolaev M, Brown TE, Mitrofanova O, Brandenberg N, DelRio FW, Yavitt FM, Liberali P, Anseth KS, Lutolf MP (2022) Tissue geometry drives deterministic organoid patterning. Science 375: eaaw9021","journal-title":"Science"},{"key":"BFEMBJ2022113280_CR31","volume":"108","author":"D Gonzalez\u2010Rodriguez","year":"2021","unstructured":"Gonzalez\u2010Rodriguez D, Maddugoda MP, Stefani C, Janel S, Lafont F, Cuvelier D, Lemichez E, Brochard\u2010Wyart F (2021) Cellular dewetting: opening of macroapertures in endothelial cells. Phys Rev Lett 108: 218105","journal-title":"Phys Rev Lett"},{"key":"BFEMBJ2022113280_CR32","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1016\/j.devcel.2021.10.014","volume":"56","author":"N Govindasamy","year":"2021","unstructured":"Govindasamy N, Long H, Jeong HW, Raman R, \u00d6zcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH et\u00a0al (2021) 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Dev Cell 56: 3276\u20133287","journal-title":"Dev Cell"},{"key":"BFEMBJ2022113280_CR33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1472-6750-4-33","volume":"4","author":"AK Hadjantonakis","year":"2004","unstructured":"Hadjantonakis AK, Papaioannou VE (2004) Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice. BMC Biotechnol 4: 33","journal-title":"BMC Biotechnol"},{"key":"BFEMBJ2022113280_CR34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.devcel.2013.09.026","volume":"27","author":"R Hiramatsu","year":"2013","unstructured":"Hiramatsu R, Matsuoka T, Kimura\u2010Yoshida C, Han SW, Mochida K, Adachi T, Takayama S, Matsuo I (2013) External mechanical cues trigger the establishment of the anterior\u2010posterior axis in early mouse embryos. Dev Cell 27: 131\u2013144","journal-title":"Dev Cell"},{"key":"BFEMBJ2022113280_CR35","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/239200a0","volume":"239","author":"Y\u2010C Hsu","year":"1972","unstructured":"Hsu Y\u2010C (1972) Differentiation in vitro embryos beyond the implantation stage. Nature 239: 200\u2013202","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0012-1606(73)90145-0","volume":"33","author":"Y\u2010C Hsu","year":"1973","unstructured":"Hsu Y\u2010C (1973) Differentiation in vitro of mouse embryos to the stage of early somite. Dev Biol 33: 403\u2013411","journal-title":"Dev Biol"},{"key":"BFEMBJ2022113280_CR37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aba0210","volume":"368","author":"Q Huang","year":"2020","unstructured":"Huang Q, Cohen MA, Alsina FC, Devlin G, Garrett A, McKey J, Havlik P, Rakhilin N, Wang E, Xiang K et\u00a0al (2020) Intravital imaging of mouse embryos. Science 368: 181\u2013186","journal-title":"Science"},{"key":"BFEMBJ2022113280_CR38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.devcel.2021.12.023","volume":"57","author":"T Ichikawa","year":"2022","unstructured":"Ichikawa T, Zhang HT, Panavaite L, Erzberger A, Fabr\u00e8ges D, Snajder R, Wolny A, Korotkevich E, Tsuchida\u2010Straeten N, Hufnagel L et\u00a0al (2022) An ex vivo system to study cellular dynamics underlying mouse peri\u2010implantation development. Dev Cell 57: 373\u2013386","journal-title":"Dev Cell"},{"key":"BFEMBJ2022113280_CR39","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/s41467-018-04848-8","volume":"9","author":"AM Kelleher","year":"2018","unstructured":"Kelleher AM, Milano\u2010Foster J, Behura SK, Spencer TE (2018) Uterine glands coordinate on\u2010time embryo implantation and impact endometrial decidualization for pregnancy success. Nat Commun 9: 2435","journal-title":"Nat Commun"},{"key":"BFEMBJ2022113280_CR40","volume":"149","author":"EJY Kim","year":"2022","unstructured":"Kim EJY, Sorokin L, Hiiragi T (2022) ECM\u2010integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development 149: dev200140","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR41","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1412.6980","author":"DP Kingma","year":"2014","unstructured":"Kingma DP, Ba J (2014) Adam: a method for stochastic optimization. arXiv https:\/\/doi.org\/10.48550\/arXiv.1412.6980 [PREPRINT]","journal-title":"arXiv"},{"key":"BFEMBJ2022113280_CR42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/dbio.2001.0404","volume":"239","author":"E Klaffky","year":"2001","unstructured":"Klaffky E, Williams R, Yao CC, Ziober B, Kramer R, Sutherland A (2001) Trophoblast\u2010specific expression and function of the integrin alpha 7 subunit in the peri\u2010implantation mouse embryo. Dev Biol 239: 161\u2013175","journal-title":"Dev Biol"},{"key":"BFEMBJ2022113280_CR43","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2064","volume":"9","author":"U Krzic","year":"2012","unstructured":"Krzic U, Gunther S, Saunders TE, Streichan SJ, Hufnagel L (2012) Multiview light\u2010sheet microscope for rapid in toto imaging. Nat Methods 9: 730\u2013733","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR44","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","volume":"560","author":"G La Manno","year":"2018","unstructured":"La Manno G, Soldatov R, Zeisel A, Braun E, Hochgerner H, Petukhov V, Lidschreiber K, Kastriti ME, L\u00f6nnerberg P, Furlan A et\u00a0al (2018) RNA velocity of single cells. Nature 560: 494\u2013498","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature06304","volume":"450","author":"T Lecuit","year":"2007","unstructured":"Lecuit T, le Goff L (2007) Orchestrating size and shape during morphogenesis. Nature 450: 189\u2013192","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0960-9822(06)00059-5","volume":"7","author":"M Lewandoski","year":"1997","unstructured":"Lewandoski M, Montzka Wassarman K, Martin GR (1997) Zp3\u2010cre, a transgenic mouse line for the activation or inactivation of loxP\u2010flanked target genes specifically in the female germ line. Curr Biol 7: 148\u2013151","journal-title":"Curr Biol"},{"key":"BFEMBJ2022113280_CR48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R, 1000 Genome Project Data Processing Subgroup (2009) The sequence alignment\/map format and SAMtools. Bioinformatics 25: 2078\u20132079","journal-title":"Bioinformatics"},{"key":"BFEMBJ2022113280_CR49","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.celrep.2015.03.035","volume":"11","author":"Y Li","year":"2015","unstructured":"Li Y, Sun X, Dey SK (2015) Entosis allows timely elimination of the luminal epithelial barrier for embryo implantation. Cell Rep 11: 358\u2013365","journal-title":"Cell Rep"},{"key":"BFEMBJ2022113280_CR50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nbt1055","volume":"23","author":"MP Lutolf","year":"2005","unstructured":"Lutolf MP, Hubbell JA (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23: 47\u201355","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ2022113280_CR51","first-page":"10","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin M (2011) Cutadapt removes adapter sequences from high\u2010throughput sequencing reads. EMBnetjournal 17: 10\u201312","journal-title":"EMBnetjournal"},{"key":"BFEMBJ2022113280_CR93","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mod.2016.09.002","volume":"144","author":"I Matsuo","year":"2017","unstructured":"Matsuo I, Hiramatsu R (2017) Mechanical perspectives on the anterior-posterior axis polarization of mouse implanted embryos. Mech Dev 144: 62\u201370","journal-title":"Mech Dev"},{"key":"BFEMBJ2022113280_CR52","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/dvg.22049","volume":"50","author":"K McDole","year":"2012","unstructured":"McDole K, Zheng Y (2012) Generation and live imaging of an endogenous Cdx2 reporter mouse line. Genesis 50: 775\u2013782","journal-title":"Genesis"},{"key":"BFEMBJ2022113280_CR53","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2018.09.031","volume":"175","author":"K McDole","year":"2018","unstructured":"McDole K, Guignard L, Amat F, Berger A, Malandain G, Royer LA, Turaga SC, Branson K, Keller PJ (2018) In toto imaging and reconstruction of post\u2010implantation mouse development at the single\u2010cell level. Cell 175: 859\u2013876.e33","journal-title":"Cell"},{"key":"BFEMBJ2022113280_CR54","volume":"6","author":"G de Medeiros","year":"2015","unstructured":"de Medeiros G, Norlin N, Gunther S, Albert M, Panavaite L, Fiuza UM, Peri F, Hiiragi T, Krzic U, Hufnagel L (2015) Confocal multiview light\u2010sheet microscopy. Nat Commun 6: 8881","journal-title":"Nat Commun"},{"key":"BFEMBJ2022113280_CR55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cub.2004.01.026","volume":"14","author":"D Mesnard","year":"2004","unstructured":"Mesnard D, Filipe M, Belo JA, Zernicka\u2010Goetz M (2004) The anterior\u2010posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation. Curr Biol 14: 184\u2013196","journal-title":"Curr Biol"},{"key":"BFEMBJ2022113280_CR56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1371\/journal.pbio.1000442","volume":"8","author":"I Migeotte","year":"2010","unstructured":"Migeotte I, Omelchenko T, Hall A, Anderson KV (2010) Rac1\u2010dependent collective cell migration is required for specification of the anterior\u2010posterior body axis of the mouse. PLoS Biol 8: 37\u201338","journal-title":"PLoS Biol"},{"key":"BFEMBJ2022113280_CR57","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ncomms1671","volume":"14","author":"SA Morris","year":"2012","unstructured":"Morris SA, Grewal S, Barrios F, Patankar SN, Strauss B, Buttery L, Alexander M, Shakesheff KM, Zernicka\u2010Goetz M (2012) Dynamics of anterior\u2010posterior axis formation in the developing mouse embryo. Nat Commun 14: 673","journal-title":"Nat Commun"},{"key":"BFEMBJ2022113280_CR58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41586-019-1044-3","volume":"568","author":"S M\u00fcnster","year":"2019","unstructured":"M\u00fcnster S, Jain A, Mietke A, Pavlopoulos A, Grill SW, Tomancak P (2019) Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects. Nature 568: 395\u2013399","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR59","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","volume":"45","author":"MD Muzumdar","year":"2007","unstructured":"Muzumdar MD, Tasic B, Miyamichi K, Li N, Luo L (2007) A global double\u2010fluorescent cre reporter mouse. Genesis 45: 593\u2013605","journal-title":"Genesis"},{"key":"BFEMBJ2022113280_CR60","volume-title":"Manipulating the mouse embryo: a laboratory manual","author":"A Nagy","year":"2003","unstructured":"Nagy A, Gertsenstein M, Nagy KV, Behringer R (2003) Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press"},{"key":"BFEMBJ2022113280_CR61","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-020-2724-8","volume":"585","author":"M Nikolaev","year":"2020","unstructured":"Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, Elci B, Brandenberg N, Kolotuev I, Gjorevski N et\u00a0al (2020) Homeostatic mini\u2010intestines through scaffold\u2010guided organoid morphogenesis. Nature 585: 574\u2013578","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR63","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","volume":"91","author":"I Palmeirim","year":"1997","unstructured":"Palmeirim I, Henrique D, Ish\u2010Horowicz D, Pourqui\u00e9 O (1997) Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell 91: 639\u2013648","journal-title":"Cell"},{"key":"BFEMBJ2022113280_CR64","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1912.01703","author":"A Paszke","year":"2019","unstructured":"Paszke A, Gross S, Massa F, Lerer A, Bradbury J, Chanan G, Killeen T, Lin Z, Gimelshein N, Antiga L et\u00a0al (2019) PyTorch: an imperative style, high\u2010performance deep learning library. arXiv https:\/\/doi.org\/10.48550\/arXiv.1912.01703 [PREPRINT]","journal-title":"arXiv"},{"key":"BFEMBJ2022113280_CR65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41567-018-0279-5","volume":"15","author":"C P\u00e9rez\u2010Gonz\u00e1lez","year":"2019","unstructured":"P\u00e9rez\u2010Gonz\u00e1lez C, Alert R, Blanch\u2010Mercader C, G\u00f3mez\u2010Gonz\u00e1lez M, Kolodziej T, Bazellieres E, Casademunt J, Trepat X (2019) Active wetting of epithelial tissues. Nat Phys 15: 79\u201388","journal-title":"Nat Phys"},{"key":"BFEMBJ2022113280_CR66","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.stem.2022.03.013","volume":"29","author":"TH Qazi","year":"2022","unstructured":"Qazi TH, Blatchley MR, Davidson MD, Yavitt FM, Cooke ME, Anseth KS, Burdick JA (2022) Programming hydrogels to probe spatiotemporal cell biology. Cell Stem Cell 29: 678\u2013691","journal-title":"Cell Stem Cell"},{"key":"BFEMBJ2022113280_CR67","volume":"30","author":"S Rezakhani","year":"2020","unstructured":"Rezakhani S, Gjorevski N, Lutolf MP (2020) Low\u2010defect thiol\u2010michael addition hydrogels as matrigel substitutes for epithelial organoid derivation. Adv Funct Mater 30: 2000761","journal-title":"Adv Funct Mater"},{"key":"BFEMBJ2022113280_CR68","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nmeth0310-168","volume":"7","author":"J Riedl","year":"2010","unstructured":"Riedl J, Flynn KC, Raducanu A, G\u00e4rtner F, Beck G, B\u00f6sl M, Bradke F, Massberg S, Aszodi A, Sixt M et\u00a0al (2010) Lifeact mice for studying F\u2010actin dynamics. Nat Methods 7: 168\u2013169","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR69","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1242\/dev.01847","volume":"132","author":"TA Rodriguez","year":"2005","unstructured":"Rodriguez TA, Srinivas S, Clements MP, Smith JC, Beddington RSP (2005) Induction and migration of the anterior visceral endoderm is regulated by the extra\u2010embryonic ectoderm. Development 132: 2513\u20132520","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR70","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature12602","volume":"502","author":"P Rompolas","year":"2013","unstructured":"Rompolas P, Mesa KR, Greco V (2013) Spatial organization within a niche as a determinant of stem\u2010cell fate. Nature 502: 513\u2013518","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR71","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41587-022-01361-8","volume":"40","author":"F Salmen","year":"2022","unstructured":"Salmen F, De Jonghe J, Kaminski TS, Alemany A, Parada GE, Verity\u2010Legg J, Yanagida A, Kohler TN, Battich N, van den Brekel F et\u00a0al (2022) High\u2010throughput total RNA sequencing in single cells using VASA\u2010seq. Nat Biotechnol 40: 1780\u20131793","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ2022113280_CR72","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda\u2010Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B et\u00a0al (2012) Fiji: an open\u2010source platform for biological\u2010image analysis. Nat Methods 9: 676\u2013682","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0021-9045(69)90040-9","volume":"2","author":"J Schoenberg","year":"1969","unstructured":"Schoenberg J (1969) Cardinal interpolation and spline functions. J Approx Theory 2: 167\u2013206","journal-title":"J Approx Theory"},{"key":"BFEMBJ2022113280_CR74","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","volume":"336","author":"D Seliktar","year":"2012","unstructured":"Seliktar D (2012) Designing cell\u2010compatible hydrogels for biomedical applications. Science 336: 1124\u20131128","journal-title":"Science"},{"key":"BFEMBJ2022113280_CR75","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature24675","volume":"552","author":"MN Shahbazi","year":"2017","unstructured":"Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC et\u00a0al (2017) Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature 552: 239\u2013243","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR76","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nmeth.3690","volume":"13","author":"P Strnad","year":"2016","unstructured":"Strnad P, Gunther S, Reichmann J, Krzic U, Balazs B, de Medeiros G, Norlin N, Hiiragi T, Hufnagel L, Ellenberg J (2016) Inverted light\u2010sheet microscope for imaging mouse pre\u2010implantation development. Nat Methods 13: 139\u2013142","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR77","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1038\/sj.onc.1202595","volume":"17","author":"K Sugihara","year":"1998","unstructured":"Sugihara K, Nakatsuji N, Nakamura K, Nakao K, Hashimoto R, Otani H, Sakagami H, Kondo H, Nozawa S, Aiba A et\u00a0al (1998) Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17: 3427\u20133433","journal-title":"Oncogene"},{"key":"BFEMBJ2022113280_CR78","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.119.4.1175","volume":"119","author":"AE Sutherland","year":"1993","unstructured":"Sutherland AE, Calarco PG, Damsky CH (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119: 1175\u20131186","journal-title":"Development"},{"key":"BFEMBJ2022113280_CR79","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.21105\/joss.02505","volume":"5","author":"A Tejero\u2010Cantero","year":"2020","unstructured":"Tejero\u2010Cantero A, Boelts J, Deistler M, Lueckmann JM, Durkan C, Gon\u00e7alves PJ, Greenberg DS, Macke JH (2020) Sbi: a toolkit for simulation\u2010based inference. J Open Source Softw 5: 2505","journal-title":"J Open Source Softw"},{"key":"BFEMBJ2022113280_CR80","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","volume":"352","author":"I Tirosh","year":"2016","unstructured":"Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G et\u00a0al (2016) Dissecting the multicellular ecosystem of metastatic melanoma by single\u2010cell RNA\u2010seq. Science 352: 189\u2013196","journal-title":"Science"},{"key":"BFEMBJ2022113280_CR81","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1093\/bioinformatics\/btab106","volume":"37","author":"C Tischer","year":"2021","unstructured":"Tischer C, Ravindran A, Reither S, Chiaruttini N, Pepperkok R, Norlin N (2021) BigDataProcessor2: a free and open\u2010source Fiji plugin for inspection and processing of TB sized image data. Bioinformatics 37: 3079\u20133081","journal-title":"Bioinformatics"},{"key":"BFEMBJ2022113280_CR82","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/s41598-019-41695-z","volume":"9","author":"VA Traag","year":"2019","unstructured":"Traag VA, Waltman L, van Eck NJ (2019) From Louvain to Leiden: guaranteeing well\u2010connected communities. Sci Rep 9: 5233","journal-title":"Sci Rep"},{"key":"BFEMBJ2022113280_CR83","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ncb3516","volume":"19","author":"MY Turco","year":"2017","unstructured":"Turco MY, Gardner L, Hughes J, Cindrova\u2010Davies T, Gomez MJ, Farrell L, Hollinshead M, Marsh SGE, Brosens JJ, Critchley HO et\u00a0al (2017) Long\u2010term, hormone\u2010responsive organoid cultures of human endometrium in a chemically defined medium. Nat Cell Biol 19: 568\u2013577","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ2022113280_CR84","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107637","volume":"31","author":"Y Ueda","year":"2020","unstructured":"Ueda Y, Kimura\u2010Yoshida C, Mochida K, Tsume M, Kameo Y, Adachi T, Lefebvre O, Hiramatsu R, Matsuo I (2020) Intrauterine pressures adjusted by Reichert's membrane are crucial for early mouse morphogenesis. Cell Rep 31: 107637","journal-title":"Cell Rep"},{"key":"BFEMBJ2022113280_CR85","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2019.02.024","volume":"48","author":"S Vianello","year":"2019","unstructured":"Vianello S, Lutolf MP (2019) Understanding the mechanobiology of early mammalian development through bioengineered models. Dev Cell 48: 751\u2013763","journal-title":"Dev Cell"},{"key":"BFEMBJ2022113280_CR91","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","volume":"17","author":"P Virtanen","year":"2020","unstructured":"Virtanen P, Gommers R, Oliphant TE, Haberland M, Reddy T, Cournapeau D, Burovski E, Peterson P, Weckesser W, Bright J et\u00a0al (2020) SciPy 1.0: fundamental algorithms for scientific computing in Python. Nat Methods 17: 261\u2013272","journal-title":"Nat Methods"},{"key":"BFEMBJ2022113280_CR86","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1089709","volume":"302","author":"MJ Walmsley","year":"2003","unstructured":"Walmsley MJ, Ooi SK, Reynolds LF, Smith SH, Ruf S, Mathiot A, Vanes L, Williams DA, Cancro MP, Tybulewicz VL (2003) Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302: 459\u2013462","journal-title":"Science"},{"key":"BFEMBJ2022113280_CR87","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.cub.2007.06.067","volume":"17","author":"Y Wang","year":"2007","unstructured":"Wang Y, Riechmann V (2007) The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis. Curr Biol 17: 1349\u20131355","journal-title":"Curr Biol"},{"key":"BFEMBJ2022113280_CR88","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/1801436a0","volume":"180","author":"MK Whitten","year":"1957","unstructured":"Whitten MK (1957) Effect of exteroceptive factors on the \u0152strous cycle of mice. Nature 180: 1436","journal-title":"Nature"},{"key":"BFEMBJ2022113280_CR89","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","volume":"19","author":"F Wolf","year":"2018","unstructured":"Wolf F, Angerer P, Theis F (2018) SCANPY: large\u2010scale single\u2010cell gene expression data analysis. Genome Biol 19: 15","journal-title":"Genome Biol"},{"key":"BFEMBJ2022113280_CR92","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57613","volume":"9","author":"A Wolny","year":"2020","unstructured":"Wolny A, Cerrone L, Vijayan A, Tofanelli R, Barro AV, Louveaux M, Wenzl C, Strauss S, Wilson-S\u00e1nchez D, Lymbouridou R et\u00a0al (2020) Accurate and versatile 3D segmentation of plant tissues at cellular resolution. eLife 9: e57613","journal-title":"eLife"},{"key":"BFEMBJ2022113280_CR90","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood-2011-06-358853","volume":"119","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Conti MA, Malide D, Dong F, Wang A, Shmist YA, Liu C, Zerfas P, Daniels MP, Chan C\u2010C et\u00a0al (2012) Mouse models of MYH9\u2010related disease: mutations in nonmuscle myosin II\u2010A. Blood 119: 238\u2013250","journal-title":"Blood"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2022113280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2022113280\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2022113280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2022113280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:33:52Z","timestamp":1779309232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2022113280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":89,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9,4]]}},"alternative-id":["BFEMBJ2022113280"],"URL":"https:\/\/doi.org\/10.15252\/embj.2022113280","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.13.495767","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"13 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMBJ2022113280"}}