{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:01:05Z","timestamp":1779354065839,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22234008"],"award-info":[{"award-number":["22234008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21927807"],"award-info":[{"award-number":["21927807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22021003"],"award-info":[{"award-number":["22021003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scaming Project of Medicine in Shenzhen","award":["SZM201811070"],"award-info":[{"award-number":["SZM201811070"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2023,8,1]]},"DOI":"10.15252\/embj.2023113684","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T05:35:10Z","timestamp":1687844110000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aberrant DNA N6\u2010methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase\u2010dependent 2\u2032\u2010deoxynucleotide pool sanitation"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-9415","authenticated-orcid":false,"given":"Shaokun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-4860","authenticated-orcid":false,"given":"Yanan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-1238","authenticated-orcid":false,"given":"Xiangjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guibin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-999X","authenticated-orcid":false,"given":"Hailin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"BFEMBJ2023113684_CR1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.chembiol.2014.09.011","volume":"21","author":"T Admyre","year":"2014","unstructured":"Admyre T, Amrot\u2010Fors L, Andersson M, Bauer M, Bjursell M, Drmota T, Hall\u00e9n S, Hartleib\u2010Geschwindner J, Lindmark B, Liu J et\u00a0al (2014) Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol 21: 1486\u20131496","journal-title":"Chem Biol"},{"key":"BFEMBJ2023113684_CR2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0006-2952(77)90192-7","volume":"26","author":"RP Agarwal","year":"1977","unstructured":"Agarwal RP, Spector T, Parks RE (1977) Tight\u2010binding inhibitors\u2014IV. Inhibition of adenosine deaminases by various inhibitors. Biochem Pharmacol 26: 359\u2013367","journal-title":"Biochem Pharmacol"},{"key":"BFEMBJ2023113684_CR3","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.cell.2019.04.028","volume":"177","author":"LY Beh","year":"2019","unstructured":"Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF (2019) Identification of a DNA N6\u2010adenine methyltransferase complex and its impact on chromatin organization. Cell 177: 1781\u20131796","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR4","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000243","volume":"43","author":"M Bochtler","year":"2021","unstructured":"Bochtler M, Fernandes H (2021) DNA adenine methylation in eukaryotes: enzymatic mark or a form of DNA damage? Bioessays 43: e2000243","journal-title":"Bioessays"},{"key":"BFEMBJ2023113684_CR5","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1105\/tpc.18.00236","volume":"30","author":"M Chen","year":"2018","unstructured":"Chen M, Urs MJ, Sanchez\u2010Gonzalez I, Olayioye MA, Herde M, Witte CP (2018) m6A RNA degradation products are catabolized by an evolutionarily conserved N6\u2010methyl\u2010AMP deaminase in plant and mammalian cells. Plant Cell 30: 1511\u20131522","journal-title":"Plant Cell"},{"key":"BFEMBJ2023113684_CR6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch\u2010Moshkovitz S, Schwartz S, Salmon\u2010Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob\u2010Hirsch J, Amariglio N, Kupiec M et\u00a0al (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A\u2010seq. Nature 485: 201\u2013206","journal-title":"Nature"},{"key":"BFEMBJ2023113684_CR7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay3335","volume":"6","author":"K Douvlataniotis","year":"2020","unstructured":"Douvlataniotis K, Bensberg M, Lentini A, Gylemo B, Nestor CE (2020) No evidence for DNA N6\u2010methyladenine in mammals. Sci Adv 6: eaay3335","journal-title":"Sci Adv"},{"key":"BFEMBJ2023113684_CR8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/nbt.2432","volume":"30","author":"G Fang","year":"2012","unstructured":"Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng ZX, Losic B, Mahajan MC, Jabado OJ et\u00a0al (2012) Genome\u2010wide mapping of methylated adenine residues in pathogenic Escherichia coli using single\u2010molecule real\u2010time sequencing. Nat Biotechnol 30: 1232\u20131239","journal-title":"Nat Biotechnol"},{"key":"BFEMBJ2023113684_CR9","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2015.04.010","volume":"161","author":"Y Fu","year":"2015","unstructured":"Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Dore LC et\u00a0al (2015) N6\u2010methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell 161: 879\u2013892","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR10","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cell.2015.04.005","volume":"161","author":"EL Greer","year":"2015","unstructured":"Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizabal\u2010Corrales D, Hsu CH, Aravind L, He C, Shi Y (2015) DNA methylation on N6\u2010adenine in C. elegans. Cell 161: 868\u2013878","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s00438-003-0883-6","volume":"269","author":"G Hambraeus","year":"2003","unstructured":"Hambraeus G, von Wachenfeldt C, Hederstedt L (2003) Genome\u2010wide survey of mRNA half\u2010lives in Bacillus subtilis identifies extremely stable mRNAs. Mol Genet Genomics 269: 706\u2013714","journal-title":"Mol Genet Genomics"},{"key":"BFEMBJ2023113684_CR12","volume":"40","author":"PC He","year":"2021","unstructured":"He PC, He C (2021) m6A RNA methylation: from mechanisms to therapeutic potential. EMBO J 40: e105977","journal-title":"EMBO J"},{"key":"BFEMBJ2023113684_CR13","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2009.01.019","volume":"136","author":"J Houseley","year":"2009","unstructured":"Houseley J, Tollervey D (2009) The many pathways of RNA degradation. Cell 136: 763\u2013776","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(83)90265-4","volume":"32","author":"A Jekunen","year":"1983","unstructured":"Jekunen A, Puukka M, Vilpo J (1983) Exclusion of exogenous 5\u2010methyl\u20102\u2032\u2010deoxycytidine from DNA in human leukemic cells: a study with [2\u201014C]\u2010and [methyl\u201014C] 5\u2010methyl\u20102\u2032\u2010deoxycytidine. Biochem Pharmacol 32: 1165\u20131168","journal-title":"Biochem Pharmacol"},{"key":"BFEMBJ2023113684_CR15","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1039\/C7SC05472F","volume":"9","author":"HP Jiang","year":"2018","unstructured":"Jiang HP, Xiong J, Liu FL, Ma CJ, Tang XL, Yuan BF, Feng YQ (2018) Modified nucleoside triphosphates exist in mammals. Chem Sci 9: 4160\u20134167","journal-title":"Chem Sci"},{"key":"BFEMBJ2023113684_CR16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.abe7489","volume":"375","author":"Y Kong","year":"2022","unstructured":"Kong Y, Cao L, Deikus G, Fan Y, Mead EA, Lai W, Zhang Y, Yong R, Sebra R, Wang H et\u00a0al (2022) Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution. Science 375: 515\u2013522","journal-title":"Science"},{"key":"BFEMBJ2023113684_CR17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/acs.chemrestox.8b00348","volume":"32","author":"B Li","year":"2019","unstructured":"Li B, Du K, Gu S, Xie J, Liang T, Xu Z, Gao H, Ling Y, Lu S, Sun Z et\u00a0al (2019) Epigenetic DNA modification N(6)\u2010methyladenine inhibits DNA replication by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Chem Res Toxicol 32: 840\u2013849","journal-title":"Chem Res Toxicol"},{"key":"BFEMBJ2023113684_CR18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.devcel.2018.03.012","volume":"45","author":"Z Liang","year":"2018","unstructured":"Liang Z, Shen L, Cui X, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X et\u00a0al (2018) DNA N(6)\u2010adenine methylation in Arabidopsis thaliana. Dev Cell 45: 406\u2013416","journal-title":"Dev Cell"},{"key":"BFEMBJ2023113684_CR19","volume":"7","author":"J Liu","year":"2016","unstructured":"Liu J, Zhu Y, Luo GZ, Wang X, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y et\u00a0al (2016) Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nat Commun 7: 13052","journal-title":"Nat Commun"},{"key":"BFEMBJ2023113684_CR20","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1021\/acs.analchem.7b01152","volume":"89","author":"B Liu","year":"2017","unstructured":"Liu B, Liu X, Lai W, Wang H (2017) Metabolically generated stable isotope\u2010labeled Deoxynucleoside code for tracing DNA N(6)\u2010methyladenine in human cells. Anal Chem 89: 6202\u20136209","journal-title":"Anal Chem"},{"key":"BFEMBJ2023113684_CR21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41422-020-0317-6","volume":"31","author":"X Liu","year":"2021","unstructured":"Liu X, Lai W, Li Y, Chen S, Liu B, Zhang N, Mo J, Lyu C, Zheng J, Du Y\u2010R et\u00a0al (2021) N6\u2010methyladenine is incorporated into mammalian genome by DNA polymerase. Cell Res 31: 94\u201397","journal-title":"Cell Res"},{"key":"BFEMBJ2023113684_CR22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nsmb.3412","volume":"24","author":"GZ Luo","year":"2017","unstructured":"Luo GZ, He C (2017) DNA N\u20106\u2010methyladenine in metazoans: functional epigenetic mark or bystander? Nat Struct Mol Biol 24: 503\u2013506","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBJ2023113684_CR23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41556-018-0238-5","volume":"21","author":"CC Ma","year":"2019","unstructured":"Ma CC, Niu R, Huang TX, Shao LW, Peng Y, Ding WQ, Wang Y, Jia GF, He C, Li CY et\u00a0al (2019) N6\u2010methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nat Cell Biol 21: 319\u2013327","journal-title":"Nat Cell Biol"},{"key":"BFEMBJ2023113684_CR24","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR (2012) Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2032 UTRs and near stop codons. Cell 149: 1635\u20131646","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/ng.3859","volume":"49","author":"SJ Mondo","year":"2017","unstructured":"Mondo SJ, Dannebaum RO, Kuo RC, Louie KB, Bewick AJ, LaButti K, Haridas S, Kuo A, Salamov A, Ahrendt SR et\u00a0al (2017) Widespread adenine N6\u2010methylation of active genes in fungi. Nat Genet 49: 964\u2013968","journal-title":"Nat Genet"},{"key":"BFEMBJ2023113684_CR26","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1021\/jm200650j","volume":"54","author":"E Murakami","year":"2011","unstructured":"Murakami E, Bao H, Mosley RT, Du J, Sofia MJ, Furman PA (2011) Adenosine deaminase\u2010like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)\u2010 or O(6)\u2010substituted purine or 2\u2010aminopurine nucleoside monophosphates. J Med Chem 54: 5902\u20135914","journal-title":"J Med Chem"},{"key":"BFEMBJ2023113684_CR27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41589-020-0504-2","volume":"16","author":"MU Musheev","year":"2020","unstructured":"Musheev MU, Baumgartner A, Krebs L, Niehrs C (2020) The origin of genomic N(6)\u2010methyl\u2010deoxyadenosine in mammalian cells. Nat Chem Biol 16: 630\u2013634","journal-title":"Nat Chem Biol"},{"key":"BFEMBJ2023113684_CR28","volume-title":"Encyclopedia of Life Sciences","author":"WL Nyhan","year":"2005","unstructured":"Nyhan WL (2005) Nucleotide synthesis via salvage pathway. In Encyclopedia of Life Sciences. Chichester: John Wiley & Sons Ltd"},{"key":"BFEMBJ2023113684_CR29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s12864-019-5754-6","volume":"20","author":"ZK O'Brown","year":"2019","unstructured":"O'Brown ZK, Boulias K, Wang J, Wang SY, O'Brown NM, Hao Z, Shibuya H, Fady P\u2010E, Shi Y, He C et\u00a0al (2019) Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA. BMC Genomics 20: 445","journal-title":"BMC Genomics"},{"key":"BFEMBJ2023113684_CR30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0092-8674(93)80043-E","volume":"74","author":"AB Sachs","year":"1993","unstructured":"Sachs AB (1993) Messenger RNA degradation in eukaryotes. Cell 74: 413\u2013421","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR31","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1074\/jbc.RA120.012636","volume":"295","author":"ER Scaletti","year":"2020","unstructured":"Scaletti ER, Vallin KS, Br\u00e4utigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth A\u2010S (2020) MutT homologue 1 (MTH1) removes N6\u2010methyl\u2010dATP from the dNTP pool. J Biol Chem 295: 4761\u20134772","journal-title":"J Biol Chem"},{"key":"BFEMBJ2023113684_CR32","doi-asserted-by":"crossref","first-page":"11268","DOI":"10.1002\/anie.201700424","volume":"56","author":"S Schiffers","year":"2017","unstructured":"Schiffers S, Ebert C, Rahimoff R, Kosmatchev O, Steinbacher J, Bohne AV, Spada F, Michalakis S, Nickelsen J, Muller M et\u00a0al (2017) Quantitative LC\u2010MS provides no evidence for m(6) dA or m(4) dC in the genome of mouse embryonic stem cells and tissues. Angew Chem Int Ed 56: 11268\u201311271","journal-title":"Angew Chem Int Ed"},{"key":"BFEMBJ2023113684_CR33","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.bcp.2006.01.013","volume":"71","author":"M Schinkmanov\u00e1","year":"2006","unstructured":"Schinkmanov\u00e1 M, Votruba I, Hol\u00fd A (2006) N6\u2010methyl\u2010AMP aminohydrolase activates N6\u2010substituted purine acyclic nucleoside phosphonates. Biochem Pharmacol 71: 1370\u20131376","journal-title":"Biochem Pharmacol"},{"key":"BFEMBJ2023113684_CR34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/dnares\/dsn030","volume":"16","author":"LV Sharova","year":"2009","unstructured":"Sharova LV, Sharov AA, Nedorezov T, Piao Y, Shaik N, Ko MS (2009) Database for mRNA half\u2010life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res 16: 45\u201358","journal-title":"DNA Res"},{"key":"BFEMBJ2023113684_CR35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","volume":"20","author":"MA Valencia\u2010Sanchez","year":"2006","unstructured":"Valencia\u2010Sanchez MA, Liu J, Hannon GJ, Parker R (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20: 515\u2013524","journal-title":"Genes Dev"},{"key":"BFEMBJ2023113684_CR36","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/2181066a0","volume":"218","author":"BF Vanyushin","year":"1968","unstructured":"Vanyushin BF, Belozersky AN, Kokurina NA, Kadirova DX (1968) 5\u2010methylcytosine and 6\u2010methylaminopurine in bacterial DNA. Nature 218: 1066\u20131067","journal-title":"Nature"},{"key":"BFEMBJ2023113684_CR37","first-page":"217","volume":"286","author":"JA Vilpo","year":"1993","unstructured":"Vilpo JA, Vilpo LM (1993) Nucleoside monophosphate kinase may be the key enzyme preventing salvage of DNA 5\u2010methylcytosine. Mutat Res 286: 217\u2013220","journal-title":"Mutat Res"},{"key":"BFEMBJ2023113684_CR38","doi-asserted-by":"crossref","first-page":"11594","DOI":"10.1093\/nar\/gkx883","volume":"45","author":"Y Wang","year":"2017","unstructured":"Wang Y, Chen X, Sheng Y, Liu Y, Gao S (2017a) N6\u2010adenine DNA methylation is associated with the linker DNA of H2A. Z\u2010containing well\u2010positioned nucleosomes in pol II\u2010transcribed genes in Tetrahymena. Nucleic Acids Res 45: 11594\u201311606","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ2023113684_CR39","doi-asserted-by":"crossref","first-page":"14436","DOI":"10.1021\/jacs.7b06381","volume":"139","author":"W Wang","year":"2017","unstructured":"Wang W, Xu L, Hu L, Chong J, He C, Wang D (2017b) Epigenetic DNA modification N(6)\u2010methyladenine causes site\u2010specific RNA polymerase II transcriptional pausing. J Am Chem Soc 139: 14436\u201314442","journal-title":"J Am Chem Soc"},{"key":"BFEMBJ2023113684_CR40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature17640","volume":"532","author":"TP Wu","year":"2016","unstructured":"Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M et\u00a0al (2016) DNA methylation on N(6)\u2010adenine in mammalian embryonic stem cells. Nature 532: 329\u2013333","journal-title":"Nature"},{"key":"BFEMBJ2023113684_CR41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2018.06.015","volume":"71","author":"CL Xiao","year":"2018","unstructured":"Xiao CL, Zhu S, He M, Chen D, Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F et\u00a0al (2018) N(6)\u2010Methyladenine DNA modification in the human genome. Mol Cell 71: 306\u2013318","journal-title":"Mol Cell"},{"key":"BFEMBJ2023113684_CR42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11434-014-0695-6","volume":"60","author":"Y Yang","year":"2015","unstructured":"Yang Y, Sun BF, Xiao W, Yang X, Sun HY, Zhao YL, Yang YG (2015) Dynamic m(6)a modification and its emerging regulatory role in mRNA splicing. Sci Bull 60: 21\u201332","journal-title":"Sci Bull"},{"key":"BFEMBJ2023113684_CR43","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/s41467-017-01195-y","volume":"8","author":"B Yao","year":"2017","unstructured":"Yao B, Cheng Y, Wang ZQ, Li YJ, Chen L, Huang LX, Zhang WX, Chen DH, Wu H, Tang BS et\u00a0al (2017) DNA N6\u2010methyladenine is dynamically regulated in the mouse brain following environmental stress. Nat Commun 8: 1122","journal-title":"Nat Commun"},{"key":"BFEMBJ2023113684_CR44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature14948","volume":"524","author":"M Zauri","year":"2015","unstructured":"Zauri M, Berridge G, Thezenas ML, Pugh KM, Goldin R, Kessler BM, Kriaucionis S (2015) CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature 524: 114\u2013118","journal-title":"Nature"},{"key":"BFEMBJ2023113684_CR45","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2015.04.018","volume":"161","author":"G Zhang","year":"2015","unstructured":"Zhang G, Huang H, Liu D, Cheng Y, Liu X, Zhang W, Yin R, Zhang D, Zhang P, Liu J et\u00a0al (2015) N6\u2010methyladenine DNA modification in drosophila. Cell 161: 893\u2013906","journal-title":"Cell"},{"key":"BFEMBJ2023113684_CR46","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41477-018-0214-x","volume":"4","author":"C Zhou","year":"2018","unstructured":"Zhou C, Wang CS, Liu HB, Zhou QW, Liu Q, Guo Y, Peng T, Song JM, Zhang JW, Chen LL et\u00a0al (2018) Identification and analysis of adenine N\u20106\u2010methylation sites in the rice genome. Nat Plants 4: 554\u2013563","journal-title":"Nat Plants"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2023113684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2023113684\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2023113684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2023113684.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:39:47Z","timestamp":1779309587000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2023113684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":46,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["BFEMBJ2023113684"],"URL":"https:\/\/doi.org\/10.15252\/embj.2023113684","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"3 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBJ2023113684"}}