{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:36:46Z","timestamp":1792647406628,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["432291016"],"award-info":[{"award-number":["432291016"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gouvernement du Canada | Canadian Institutes of Health Research","award":["PJT162186"],"award-info":[{"award-number":["PJT162186"]}]},{"name":"Ontario Graduate Scholarship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2023,8,1]]},"DOI":"10.15252\/embj.2023113687","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T06:00:16Z","timestamp":1687932016000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines"],"prefix":"10.1038","volume":"42","author":[{"given":"Gautier M","family":"Courbon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Palme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-3887","authenticated-orcid":false,"given":"Peter","family":"Imming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-2209","authenticated-orcid":false,"given":"John L","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"BFEMBJ2023113687_CR1","first-page":"531","volume":"D74","author":"PV Afonine","year":"2018","unstructured":"Afonine PV, Poon BK, Read RJ, Sobolev OV, Terwilliger TC, Urzhumtsev A,\u00a0Adamsa PD (2018) Real\u2010space refinement in PHENIX for cryo\u2010EM and\u00a0crystallography research papers. Acta Crystallogr D74: 531\u2013544","journal-title":"Acta Crystallogr"},{"key":"BFEMBJ2023113687_CR2","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1164\/rccm.201909-1819LE","volume":"201","author":"S Andres","year":"2020","unstructured":"Andres S, Merker M, Heyckendorf J, Kalsdorf B, Rumetshofer R, Indra A, Hofmann\u2010Thiel S, Hoffmann H, Lange C, Niemann S et\u00a0al (2020) Bedaquiline\u2010resistant tuberculosis: dark clouds on the horizon. Am J Respir Crit Care Med 201: 1564\u20131568","journal-title":"Am J Respir Crit Care Med"},{"key":"BFEMBJ2023113687_CR3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1106753","volume":"307","author":"K Andries","year":"2005","unstructured":"Andries K, Verhasselt P, Guillemont J, G\u00f6hlmann HWH, Neefs J\u2010M, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E et\u00a0al (2005) A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307: 223\u2013227","journal-title":"Science"},{"key":"BFEMBJ2023113687_CR4","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nmeth.3541","volume":"12","author":"BA Barad","year":"2015","unstructured":"Barad BA, Echols N, Wang RYR, Cheng Y, Dimaio F, Adams PD, Fraser JS (2015) EMRinger: side chain\u2010directed model and map validation for 3D cryo\u2010electron microscopy. Nat Methods 12: 943\u2013946","journal-title":"Nat Methods"},{"key":"BFEMBJ2023113687_CR5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0003-2697(88)90484-8","volume":"171","author":"AA Baykov","year":"1988","unstructured":"Baykov AA, Evtushenko OA, Avaeva SM (1988) A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase\u2010based enzyme immunoassay. Anal Biochem 171: 266\u2013270","journal-title":"Anal Biochem"},{"key":"BFEMBJ2023113687_CR6","first-page":"12","volume":"D66","author":"VB Chen","year":"2010","unstructured":"Chen VB, Arendall WB, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC (2010) MolProbity: all\u2010atom structure validation for macromolecular crystallography. Acta Crystallogr D66: 12\u201321","journal-title":"Acta Crystallogr"},{"key":"BFEMBJ2023113687_CR7","volume":"5","author":"GM Cook","year":"2017","unstructured":"Cook GM, Hards K, Dunn E, Heikal A, Nakatani Y, Greening C, Crick DC, Fontes FL, Pethe K, Hasenoehrl E et\u00a0al (2017) Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions. Microbiol Spectr 5: 5.3.14","journal-title":"Microbiol Spectr"},{"key":"BFEMBJ2023113687_CR8","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.864006","volume":"13","author":"GM Courbon","year":"2022","unstructured":"Courbon GM, Rubinstein JL (2022) CryoEM reveals the complexity and diversity of ATP synthases. Front Microbiol 13: 864006","journal-title":"Front Microbiol"},{"key":"BFEMBJ2023113687_CR9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1107\/S2059798318002425","volume":"74","author":"TI Croll","year":"2018","unstructured":"Croll TI (2018) ISOLDE: a physically realistic environment for model building into low\u2010resolution electron\u2010density maps. Acta Crystallogr D Struct Biol 74: 519\u2013530","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"BFEMBJ2023113687_CR10","first-page":"2126","volume":"D60","author":"P Emsley","year":"2004","unstructured":"Emsley P, Cowtan K (2004) Coot: model\u2010building tools for molecular graphics. Acta Crystallogr D60: 2126\u20132132","journal-title":"Acta Crystallogr"},{"key":"BFEMBJ2023113687_CR11","doi-asserted-by":"crossref","first-page":"E7073","DOI":"10.1073\/pnas.1500791112","volume":"112","author":"X Feng","year":"2015","unstructured":"Feng X, Zhu W, Schurig\u2010Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T et\u00a0al (2015) Antiinfectives targeting enzymes and the proton motive force. Proc Natl Acad Sci USA 112: E7073\u2013E7082","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2023113687_CR12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsb.2006.06.010","volume":"157","author":"TD Goddard","year":"2007","unstructured":"Goddard TD, Huang CC, Ferrin TE (2007) Visualizing density maps with UCSF Chimera. J Struct Biol 157: 281\u2013287","journal-title":"J Struct Biol"},{"key":"BFEMBJ2023113687_CR13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","volume":"27","author":"TD Goddard","year":"2018","unstructured":"Goddard TD, Huang CC, Meng EC, Pettersen EF, Couch GS, Morris JH, Ferrin TE (2018) UCSF ChimeraX: meeting modern challenges in visualization and analysis. Protein Sci 27: 14\u201325","journal-title":"Protein Sci"},{"key":"BFEMBJ2023113687_CR14","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.aao4815","volume":"358","author":"H Guo","year":"2017","unstructured":"Guo H, Bueler SA, Rubinstein JL (2017) Atomic model for the dimeric FO region of mitochondrial ATP synthase. Science 358: 936\u2013940","journal-title":"Science"},{"key":"BFEMBJ2023113687_CR15","volume":"8","author":"H Guo","year":"2019","unstructured":"Guo H, Suzuki T, Rubinstein JL (2019) Structure of a bacterial ATP synthase. Elife 8: e43128","journal-title":"Elife"},{"key":"BFEMBJ2023113687_CR16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-020-3004-3","volume":"589","author":"H Guo","year":"2021","unstructured":"Guo H, Courbon GM, Bueler SA, Mai J, Liu J, Rubinstein JL (2021) Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature 589: 143\u2013147","journal-title":"Nature"},{"key":"BFEMBJ2023113687_CR17","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/jac\/dkv054","volume":"70","author":"K Hards","year":"2015","unstructured":"Hards K, Robson JR, Berney M, Shaw L, Bald D, Koul A, Andries K, Cook GM (2015) Bactericidal mode of action of bedaquiline. J Antimicrob Chemother 70: 2028\u20132037","journal-title":"J Antimicrob Chemother"},{"key":"BFEMBJ2023113687_CR18","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.1803723115","volume":"115","author":"K Hards","year":"2018","unstructured":"Hards K, McMillan DGG, Schurig\u2010Briccio LA, Gennis RB, Lill H, Bald D, Cook GM (2018) Ionophoric effects of the antitubercular drug bedaquiline. Proc Natl Acad Sci USA 115: 7326\u20137331","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2023113687_CR19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101859","volume":"298","author":"LK Harold","year":"2022","unstructured":"Harold LK, Jinich A, Hards K, Cordeiro A, Keighley LM, Cross A, McNeil MB, Rhee K, Cook GM (2022) Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. J Biol Chem 298: 101859","journal-title":"J Biol Chem"},{"key":"BFEMBJ2023113687_CR20","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0003-2697(75)90388-7","volume":"63","author":"HH Hess","year":"1975","unstructured":"Hess HH, Derr JE (1975) Assay of inorganic and organic phosphorus in the 0.1\u20135 nanomole range. Anal Biochem 63: 607\u2013613","journal-title":"Anal Biochem"},{"key":"BFEMBJ2023113687_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1472-6807-8-49","volume":"8","author":"BK Ho","year":"2008","unstructured":"Ho BK, Gruswitz F (2008) HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures. BMC Struct Biol 8: 49","journal-title":"BMC Struct Biol"},{"key":"BFEMBJ2023113687_CR22","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1128\/AAC.01611-09","volume":"54","author":"E Huitric","year":"2010","unstructured":"Huitric E, Verhasselt P, Koul A, Andries K, Hoffner S, Andersson DI (2010) Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor. Antimicrob Agents Chemother 54: 1022\u20131028","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0021-9258(18)50904-2","volume":"193","author":"A Kornberg","year":"1951","unstructured":"Kornberg A, Pricer WE (1951) Enzymatic phosphorylation of adenosine and 2,6\u2010diaminopurine riboside. J Biol Chem 193: 481\u2013496","journal-title":"J Biol Chem"},{"key":"BFEMBJ2023113687_CR24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nchembio884","volume":"3","author":"A Koul","year":"2007","unstructured":"Koul A, Dendouga N, Vergauwen K, Molenberghs B, Vranckx L, Willebrords R, Ristic Z, Lill H, Dorange I, Guillemont J et\u00a0al (2007) Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat Chem Biol 3: 323\u2013324","journal-title":"Nat Chem Biol"},{"key":"BFEMBJ2023113687_CR25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4369","volume":"5","author":"A Koul","year":"2014","unstructured":"Koul A, Vranckx L, Dhar N, G\u00f6hlmann HWH, \u00d6zdemir E, Neefs J\u2010M, Schulz M, Lu P, M\u00f8rtz E, McKinney JD et\u00a0al (2014) Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism. Nat Commun 5: 3369","journal-title":"Nat Commun"},{"key":"BFEMBJ2023113687_CR26","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1128\/AAC.01291-16","volume":"60","author":"S Kundu","year":"2016","unstructured":"Kundu S, Biukovic G, Gr\u00fcber G, Dick T (2016) Bedaquiline targets the \u03b5 subunit of mycobacterial F\u2010ATP synthase. Antimicrob Agents Chemother 60: 6977\u20136979","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-2697(79)90115-5","volume":"100","author":"PA Lanzetta","year":"1979","unstructured":"Lanzetta PA, Alvarez LJ, Reinach PS, Candia OA (1979) An improved assay for nanomole amounts of inorganic phosphate. Anal Biochem 100: 95\u201397","journal-title":"Anal Biochem"},{"key":"BFEMBJ2023113687_CR28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0076-6879(78)57006-7","volume-title":"Methods in Enzymology, Bioluminescence and Chemiluminescence","author":"JJ Lemasters","year":"1978","unstructured":"Lemasters JJ, Hackenbrock CR (1978) [4] Firefly luciferase assay for ATP production by mitochondria. In Methods in Enzymology, Bioluminescence and Chemiluminescence, Richard JP, Moran GR (eds), pp 36\u201350. Cambridge, MA: Academic Press"},{"key":"BFEMBJ2023113687_CR29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsb.2013.11.002","volume":"185","author":"CR Marr","year":"2014","unstructured":"Marr CR, Benlekbir S, Rubinstein JL (2014) Fabrication of carbon films with approximately 500 nm holes for cryo\u2010EM with a direct detector device. J Struct Biol 185: 42\u201347","journal-title":"J Struct Biol"},{"key":"BFEMBJ2023113687_CR30","first-page":"1","volume":"62","author":"S Mase","year":"2013","unstructured":"Mase S, Chorba T, Lobue P, Castro K (2013) Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug\u2010resistant tuberculosis. Morb Mortal Wkly Rep Recomm Rep 62: 1\u201312","journal-title":"Morb Mortal Wkly Rep Recomm Rep"},{"key":"BFEMBJ2023113687_CR31","volume":"118","author":"MG Montgomery","year":"2021","unstructured":"Montgomery MG, Petri J, Spikes TE, Walker JE (2021) Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc Natl Acad Sci USA 118: e2111899118","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2023113687_CR32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJ Murray","year":"2022","unstructured":"Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, Han C, Bisignano C, Rao P, Wool E et\u00a0al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399: 629\u2013655","journal-title":"Lancet"},{"key":"BFEMBJ2023113687_CR33","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500106","volume":"1","author":"L Preiss","year":"2015","unstructured":"Preiss L, Langer JD, Yildiz \u00d6, Eckhardt\u2010Strelau L, Guillemont JEG, Koul A, Meier T (2015) Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti\u2010TB drug bedaquiline. Sci Adv 1: e1500106","journal-title":"Sci Adv"},{"key":"BFEMBJ2023113687_CR34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","volume":"14","author":"A Punjani","year":"2017","unstructured":"Punjani A, Rubinstein JL, Fleet DJ, Brubaker MA (2017) cryoSPARC: algorithms for rapid unsupervised cryo\u2010EM structure determination. Nat Methods 14: 290\u2013296","journal-title":"Nat Methods"},{"key":"BFEMBJ2023113687_CR35","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/s41592-020-00990-8","volume":"17","author":"A Punjani","year":"2020","unstructured":"Punjani A, Zhang H, Fleet DJ (2020) Non\u2010uniform refinement: adaptive regularization improves single\u2010particle cryo\u2010EM reconstruction. Nat Methods 17: 1214\u20131221","journal-title":"Nat Methods"},{"key":"BFEMBJ2023113687_CR36","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.1073\/pnas.0711697105","volume":"105","author":"SPS Rao","year":"2008","unstructured":"Rao SPS, Alonso S, Rand L, Dick T, Pethe K (2008) The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Natl Acad Sci USA 105: 11945\u201311950","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ2023113687_CR37","doi-asserted-by":"crossref","first-page":"e00828-18","DOI":"10.1128\/AAC.00828-18","volume":"62","author":"A Richter","year":"2018","unstructured":"Richter A, Strauch A, Chao J, Ko M, Av-Gay Y (2018) Screening of preselected libraries targeting Mycobacterium abscessus for drug discovery. Antimicrob Agents Chemother 62: e00828-18","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR38","volume":"63","author":"JP Sarathy","year":"2019","unstructured":"Sarathy JP, Ragunathan P, Shin J, Cooper CB, Upton AM, Gr\u00fcber G, Dick T (2019) TBAJ\u2010876 retains bedaquiline's activity against subunits c and \u03b5 of Mycobacterium tuberculosis F\u2010ATP synthase. Antimicrob Agents Chemother 63: e01191\u201019","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR39","volume":"64","author":"JP Sarathy","year":"2020","unstructured":"Sarathy JP, Ragunathan P, Cooper CB, Upton AM, Gr\u00fcber G, Dick T (2020) TBAJ\u2010876 displays bedaquiline\u2010like mycobactericidal potency without retaining the parental drug's uncoupler activity. Antimicrob Agents Chemother 64: e01540\u201019","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR40","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.bmc.2019.02.026","volume":"27","author":"HS Sutherland","year":"2019","unstructured":"Sutherland HS, Tong AST, Choi PJ, Blaser A, Conole D, Franzblau SG, Lotlikar MU, Cooper CB, Upton AM, Denny WA et\u00a0al (2019) 3,5\u2010Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorg Med Chem 27: 1292\u20131307","journal-title":"Bioorg Med Chem"},{"key":"BFEMBJ2023113687_CR41","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nprot.2013.068","volume":"8","author":"K Takaki","year":"2013","unstructured":"Takaki K, Davis JM, Winglee K, Ramakrishnan L (2013) Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish. Nat Protoc 8: 1114\u20131124","journal-title":"Nat Protoc"},{"key":"BFEMBJ2023113687_CR42","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/acs.jmedchem.6b01358","volume":"60","author":"SJ Tantry","year":"2017","unstructured":"Tantry SJ, Markad SD, Shinde V, Bhat J, Balakrishnan G, Gupta AK, Ambady A, Raichurkar A, Kedari C, Sharma S et\u00a0al (2017) Discovery of Imidazo[1,2\u2010a]pyridine ethers and squaramides as selective and potent inhibitors of mycobacterial adenosine triphosphate (ATP) synthesis. J Med Chem 60: 1379\u20131399","journal-title":"J Med Chem"},{"key":"BFEMBJ2023113687_CR43","first-page":"684","volume":"72","author":"C Villellas","year":"2017","unstructured":"Villellas C, Coeck N, Meehan CJ, Lounis N, de Jong B, Rigouts L, Andries K (2017) Unexpected high prevalence of resistance\u2010associated Rv0678 variants in MDR\u2010TB patients without documented prior use of clofazimine or bedaquiline. J Antimicrob Chemother 72: 684\u2013690","journal-title":"J Antimicrob Chemother"},{"key":"BFEMBJ2023113687_CR44","volume-title":"The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019","author":"World Health Organization","year":"2019","unstructured":"World Health Organization (2019) The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO model list of essential medicines and the 7th WHO model list of essential medicines for children), WHO technical report series; 1021. Geneva: World Health Organization"},{"key":"BFEMBJ2023113687_CR45","volume-title":"World health statistics 2023: monitoring health for the SDGs, sustainable development goals","author":"World Health Organization","year":"2023","unstructured":"World Health Organization (2023) World health statistics 2023: monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization"},{"key":"BFEMBJ2023113687_CR46","volume":"65","author":"J Xu","year":"2021","unstructured":"Xu J, Converse PJ, Upton AM, Mdluli K, Fotouhi N, Nuermberger EL (2021) Comparative efficacy of the novel diarylquinoline TBAJ\u2010587 and bedaquiline against a resistant Rv0678 mutant in a mouse model of tuberculosis. Antimicrob Agents Chemother 65: e02418\u201020","journal-title":"Antimicrob Agents Chemother"},{"key":"BFEMBJ2023113687_CR47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","volume":"14","author":"SQ Zheng","year":"2017","unstructured":"Zheng SQ, Palovcak E, Armache J\u2010P, Verba KA, Cheng Y, Agard DA (2017) MotionCor2: anisotropic correction of beam\u2010induced motion for improved cryo\u2010electron microscopy. Nat Methods 14: 331\u2013332","journal-title":"Nat Methods"},{"key":"BFEMBJ2023113687_CR48","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/jac\/dkx094","volume":"72","author":"DV Zimenkov","year":"2017","unstructured":"Zimenkov DV, Nosova EY, Kulagina EV, Antonova OV, Arslanbaeva LR, Isakova AI, Krylova LY, Peretokina IV, Makarova MV, Safonova SG et\u00a0al (2017) Examination of bedaquiline\u2010 and linezolid\u2010resistant Mycobacterium tuberculosis isolates from the Moscow region. J Antimicrob Chemother 72: 1901\u20131906","journal-title":"J Antimicrob Chemother"},{"key":"BFEMBJ2023113687_CR49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1107\/S205225251801463X","volume":"6","author":"J Zivanov","year":"2019","unstructured":"Zivanov J, Nakane T, Scheres SHW (2019) A Bayesian approach to beam\u2010induced motion correction in cryo\u2010EM single\u2010particle analysis. IUCrJ 6: 5\u201317","journal-title":"IUCrJ"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2023113687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embj.2023113687\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embj.2023113687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embj.2023113687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:37:51Z","timestamp":1779309471000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embj.2023113687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":49,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["BFEMBJ2023113687"],"URL":"https:\/\/doi.org\/10.15252\/embj.2023113687","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.02.03.527018","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"6 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBJ2023113687"}}