{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:54:10Z","timestamp":1790736850227,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"LNCC"},{"name":"Odyssey\u2010RE"},{"DOI":"10.13039\/501100006364","name":"INCa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ANR"},{"name":"ERC"},{"name":"RUBICON"},{"DOI":"10.13039\/100009060","name":"Sidaction","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.15252\/embr.201338386","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T23:26:56Z","timestamp":1407281216000},"page":"965-972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Sumoylation controls host anti\u2010bacterial response to the gut invasive pathogen Shigella flexneri"],"prefix":"10.1038","volume":"15","author":[{"given":"Sabrina","family":"Fritah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouara","family":"Lhocine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Golebiowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Mounier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Andrieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sansonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dejean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"BFEMBR201338386_CR1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nrm2293","volume":"8","author":"R Geiss\u2010Friedlander","year":"2007","unstructured":"Geiss\u2010Friedlander R, Melchior F (2007) Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947\u2013956","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201338386_CR2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.tox.2010.07.013","volume":"278","author":"Z Hannoun","year":"2010","unstructured":"Hannoun Z, Greenhough S, Jaffray E, Hay RT, Hay DC (2010) Post\u2010translational modification by SUMO. Toxicology 278: 288\u2013293","journal-title":"Toxicology"},{"key":"BFEMBR201338386_CR3","doi-asserted-by":"crossref","first-page":"35368","DOI":"10.1074\/jbc.M104214200","volume":"276","author":"MH Tatham","year":"2001","unstructured":"Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT (2001) Polymeric chains of SUMO\u20102 and SUMO\u20103 are conjugated to protein substrates by SAE1\/SAE2 and Ubc9. J Biol Chem 276: 35368\u201335374","journal-title":"J Biol Chem"},{"key":"BFEMBR201338386_CR4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.devcel.2005.10.007","volume":"9","author":"K Nacerddine","year":"2005","unstructured":"Nacerddine K, Lehembre F, Bhaumik M, Artus J, Cohen\u2010Tannoudji M, Babinet C, Pandolfi PP, Dejean A (2005) The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell 9: 769\u2013779","journal-title":"Dev Cell"},{"key":"BFEMBR201338386_CR5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000335027","volume":"4","author":"M B\u00e9k\u00e9s","year":"2012","unstructured":"B\u00e9k\u00e9s M, Drag M (2012) Trojan horse strategies used by pathogens to influence the small ubiquitin\u2010like modifier (SUMO) system of host eukaryotic cells. J Innate Immun 4: 159\u2013167","journal-title":"J Innate Immun"},{"key":"BFEMBR201338386_CR6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molcel.2004.11.007","volume":"16","author":"R Boggio","year":"2004","unstructured":"Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S (2004) A mechanism for inhibiting the SUMO pathway. Mol Cell 16: 549\u2013561","journal-title":"Mol Cell"},{"key":"BFEMBR201338386_CR7","doi-asserted-by":"crossref","first-page":"15376","DOI":"10.1074\/jbc.M700889200","volume":"282","author":"R Boggio","year":"2007","unstructured":"Boggio R, Passafaro A, Chiocca S (2007) Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J Biol Chem 282: 15376\u201315382","journal-title":"J Biol Chem"},{"key":"BFEMBR201338386_CR8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nature08963","volume":"464","author":"D Ribet","year":"2010","unstructured":"Ribet D, Hamon M, Gouin E, Nahori M\u2010A, Impens F, Neyret\u2010Kahn H, Gevaert K, Vandekerckhove J, Dejean A, Cossart P (2010) Listeria monocytogenes impairs SUMOylation for efficient infection. Nature 464: 1192\u20131195","journal-title":"Nature"},{"key":"BFEMBR201338386_CR9","first-page":"651","volume":"77","author":"KL Kotloff","year":"1999","unstructured":"Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM (1999) Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ 77: 651\u2013666","journal-title":"Bull World Health Organ"},{"key":"BFEMBR201338386_CR10","first-page":"3","volume":"25","author":"PJ Sansonetti","year":"2001","unstructured":"Sansonetti PJ (2001) Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella, making sense of prokaryote\u2010eukaryote cross\u2010talks. FEMS Microbiol Rev 25: 3\u201314","journal-title":"FEMS Microbiol Rev"},{"key":"BFEMBR201338386_CR11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1086\/515150","volume":"28","author":"PJ Sansonetti","year":"1999","unstructured":"Sansonetti PJ, Tran Van Nhieu G, Egile C (1999) Rupture of the intestinal epithelial barrier and mucosal invasion by Shigella flexneri. Clin Infect Dis 28: 466\u2013475","journal-title":"Clin Infect Dis"},{"key":"BFEMBR201338386_CR12","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.180.4.1307","volume":"180","author":"OJ Perdomo","year":"1994","unstructured":"Perdomo OJ, Cavaillon JM, Huerre M, Ohayon H, Gounon P, Sansonetti PJ (1994) Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis. J Exp Med 180: 1307\u20131319","journal-title":"J Exp Med"},{"key":"BFEMBR201338386_CR13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1749-6632.1994.tb44249.x","volume":"730","author":"A Zychlinsky","year":"1994","unstructured":"Zychlinsky A, Perdomo JJ, Sansonetti PJ (1994) Molecular and cellular mechanisms of tissue invasion by Shigella flexneri. Ann N Y Acad Sci 730: 197\u2013208","journal-title":"Ann N Y Acad Sci"},{"key":"BFEMBR201338386_CR14","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1090124","volume":"304","author":"P Cossart","year":"2004","unstructured":"Cossart P, Sansonetti PJ (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304: 242\u2013248","journal-title":"Science"},{"key":"BFEMBR201338386_CR15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1462-5822.2003.00295.x","volume":"5","author":"MI Fernandez","year":"2003","unstructured":"Fernandez MI, Thuizat A, Pedron T, Neutra M, Phalipon A, Sansonetti PJ (2003) A newborn mouse model for the study of intestinal pathogenesis of shigellosis. Cell Microbiol 5: 481\u2013491","journal-title":"Cell Microbiol"},{"key":"BFEMBR201338386_CR16","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1084\/jem.20061929","volume":"204","author":"G An","year":"2007","unstructured":"An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L (2007) Increased susceptibility to colitis and colorectal tumors in mice lacking core 3\u2010derived O\u2010glycans. J Exp Med 204: 1417\u20131429","journal-title":"J Exp Med"},{"key":"BFEMBR201338386_CR17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1053\/j.gastro.2010.10.002","volume":"140","author":"MD Demarque","year":"2011","unstructured":"Demarque MD, Nacerddine K, Neyret\u2010Kahn H, Andrieux A, Danenberg E, Jouvion G, Bomme P, Hamard G, Romagnolo B, Terris B et\u00a0al (2011) Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology 140: 286\u2013296","journal-title":"Gastroenterology"},{"key":"BFEMBR201338386_CR18","doi-asserted-by":"crossref","first-page":"ra24","DOI":"10.1126\/scisignal.2000282","volume":"2","author":"F Golebiowski","year":"2009","unstructured":"Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT (2009) System\u2010wide changes to SUMO modifications in response to heat shock. Sci Signal. 2: ra24","journal-title":"Sci Signal"},{"key":"BFEMBR201338386_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","volume":"32","author":"JA Vizca\u00edno","year":"2014","unstructured":"Vizca\u00edno JA, Deutsch EW, Wang R, Csordas A, Reisinger F, R\u00edos D, Dianes JA, Sun Z, Farrah T, Bandeira N et\u00a0al (2014) ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat Biotechnol 32: 223\u2013226","journal-title":"Nat Biotechnol"},{"key":"BFEMBR201338386_CR20","doi-asserted-by":"crossref","first-page":"rs4","DOI":"10.1126\/scisignal.2001484","volume":"4","author":"MH Tatham","year":"2011","unstructured":"Tatham MH, Matic I, Mann M, Hay RT (2011) Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal. 4: rs4","journal-title":"Sci Signal"},{"key":"BFEMBR201338386_CR21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.gde.2005.07.004","volume":"15","author":"G Gill","year":"2005","unstructured":"Gill G (2005) Something about SUMO inhibits transcription. Curr Opin Genet Dev 15: 536\u2013541","journal-title":"Curr Opin Genet Dev"},{"key":"BFEMBR201338386_CR22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.semcdb.2003.12.001","volume":"15","author":"DWH Girdwood","year":"2004","unstructured":"Girdwood DWH, Tatham MH, Hay RT (2004) SUMO and transcriptional regulation. Semin Cell Dev Biol 15: 201\u2013210","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMBR201338386_CR23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/epi.4.7.9807","volume":"4","author":"J Ouyang","year":"2009","unstructured":"Ouyang J, Gill G (2009) SUMO engages multiple corepressors to regulate chromatin structure and transcription. Epigenetics 4: 440\u2013444","journal-title":"Epigenetics"},{"key":"BFEMBR201338386_CR24","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1128\/MCB.25.16.6964-6979.2005","volume":"25","author":"G Bossis","year":"2005","unstructured":"Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel\u2010Encontre I, Piechaczyk M (2005) Down\u2010regulation of c\u2010Fos\/c\u2010Jun AP\u20101 dimer activity by sumoylation. Mol Cell Biol 25: 6964\u20136979","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201338386_CR25","doi-asserted-by":"crossref","first-page":"30669","DOI":"10.1074\/jbc.M604033200","volume":"281","author":"SJ Choi","year":"2006","unstructured":"Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi H\u2010S, Seol JH, Baek SH, Bang OS, Chung CH (2006) Negative modulation of RXRalpha transcriptional activity by small ubiquitin\u2010related modifier (SUMO) modification and its reversal by SUMO\u2010specific protease SUSP1. J Biol Chem 281: 30669\u201330677","journal-title":"J Biol Chem"},{"key":"BFEMBR201338386_CR26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nature03988","volume":"437","author":"G Pascual","year":"2005","unstructured":"Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK (2005) A SUMOylation\u2010dependent pathway mediates transrepression of inflammatory response genes by PPAR\u2010gamma. Nature 437: 759\u2013763","journal-title":"Nature"},{"key":"BFEMBR201338386_CR27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/iai.48.1.124-129.1985","volume":"48","author":"EV Oaks","year":"1985","unstructured":"Oaks EV, Wingfield ME, Formal SB (1985) Plaque formation by virulent Shigella flexneri. Infect Immun 48: 124\u2013129","journal-title":"Infect Immun"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201338386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201338386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201338386\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201338386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201338386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:41:49Z","timestamp":1779108109000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201338386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,1]]}},"alternative-id":["BFEMBR201338386"],"URL":"https:\/\/doi.org\/10.15252\/embr.201338386","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]},"assertion":[{"value":"19 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}