{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:05:49Z","timestamp":1790723149320,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL63736"],"award-info":[{"award-number":["HL63736"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL55337"],"award-info":[{"award-number":["HL55337"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"crossref","award":["HG007354"],"award-info":[{"award-number":["HG007354"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"crossref","award":["HG007175"],"award-info":[{"award-number":["HG007175"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"crossref","award":["ES024992"],"award-info":[{"award-number":["ES024992"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["RSG\u201014\u2010049\u201001\u2010DMC"],"award-info":[{"award-number":["RSG\u201014\u2010049\u201001\u2010DMC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"crossref","award":["HL119291"],"award-info":[{"award-number":["HL119291"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["11SDG7390074"],"award-info":[{"award-number":["11SDG7390074"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"crossref","award":["#5\u2010FY12\u201044"],"award-info":[{"award-number":["#5\u2010FY12\u201044"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2015,5,1]]},"DOI":"10.15252\/embr.201439939","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T23:02:17Z","timestamp":1427151737000},"page":"654-669","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71\/ETV2"],"prefix":"10.1038","volume":"16","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Yeung Lawrence","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inyoung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ji","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis K","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"BFEMBR201439939_CR1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1242\/dev.125.4.725","volume":"125","author":"K Choi","year":"1998","unstructured":"Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G (1998) A common precursor for hematopoietic and endothelial cells. Development 125: 725\u2013732","journal-title":"Development"},{"key":"BFEMBR201439939_CR2","first-page":"497","volume":"11","author":"PDF Murray","year":"1932","unstructured":"Murray PDF (1932) The development in vitro of the blood of the early chick embryo. Proc Roy Soc London 11: 497\u2013521","journal-title":"Proc Roy Soc London"},{"key":"BFEMBR201439939_CR3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1242\/dev.125.9.1747","volume":"125","author":"SI Nishikawa","year":"1998","unstructured":"Nishikawa SI, Nishikawa S, Hirashima M, Matsuyoshi N, Kodama H (1998) Progressive lineage analysis by cell sorting and culture identifies FLK1+VE\u2010cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development 125: 1747\u20131757","journal-title":"Development"},{"key":"BFEMBR201439939_CR4","first-page":"213","volume":"9","author":"FR Sabin","year":"1920","unstructured":"Sabin FR (1920) Studies on the Origin of Blood\u2010vessels and of Red Blood\u2010corpuscles as Seen in the Living Blastoderm of Chicks During the Second Day of Incubation. Contrib Embryol 9: 213\u2013262","journal-title":"Contrib Embryol"},{"key":"BFEMBR201439939_CR5","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1182\/blood-2013-12-545939","volume":"124","author":"L Padron\u2010Barthe","year":"2014","unstructured":"Padron\u2010Barthe L, Temino S, Villa del Campo C, Carramolino L, Isern J, Torres M (2014) Clonal analysis identifies hemogenic endothelium as the source of the blood\u2010endothelial common lineage in the mouse embryo. Blood 124: 2523\u20132532","journal-title":"Blood"},{"key":"BFEMBR201439939_CR6","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1182\/blood-2013-03-490045","volume":"122","author":"CT Myers","year":"2013","unstructured":"Myers CT, Krieg PA (2013) BMP\u2010mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors. Blood 122: 3929\u20133939","journal-title":"Blood"},{"key":"BFEMBR201439939_CR7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08738","volume":"464","author":"JY Bertrand","year":"2010","unstructured":"Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D (2010) Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 464: 108\u2013111","journal-title":"Nature"},{"key":"BFEMBR201439939_CR8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature08764","volume":"464","author":"JC Boisset","year":"2010","unstructured":"Boisset JC, van Cappellen W, Andrieu\u2010Soler C, Galjart N, Dzierzak E, Robin C (2010) In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464: 116\u2013120","journal-title":"Nature"},{"key":"BFEMBR201439939_CR9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature08761","volume":"464","author":"K Kissa","year":"2010","unstructured":"Kissa K, Herbomel P (2010) Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 464: 112\u2013115","journal-title":"Nature"},{"key":"BFEMBR201439939_CR10","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood-2010-01-264382","volume":"116","author":"EY Lam","year":"2010","unstructured":"Lam EY, Hall CJ, Crosier PS, Crosier KE, Flores MV (2010) Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells. Blood 116: 909\u2013914","journal-title":"Blood"},{"key":"BFEMBR201439939_CR11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.stem.2010.02.001","volume":"6","author":"JM Butler","year":"2010","unstructured":"Butler JM, Nolan DJ, Vertes EL, Varnum\u2010Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M et\u00a0al (2010) Endothelial cells are essential for the self\u2010renewal and repopulation of Notch\u2010dependent hematopoietic stem cells. Cell Stem Cell 6: 251\u2013264","journal-title":"Cell Stem Cell"},{"key":"BFEMBR201439939_CR12","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","volume":"121","author":"MJ Kiel","year":"2005","unstructured":"Kiel MJ, Yilmaz OH, Iwashita T, Terhorst C, Morrison SJ (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121: 1109\u20131121","journal-title":"Cell"},{"key":"BFEMBR201439939_CR13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","volume":"505","author":"SJ Morrison","year":"2014","unstructured":"Morrison SJ, Scadden DT (2014) The bone marrow niche for haematopoietic stem cells. Nature 505: 327\u2013334","journal-title":"Nature"},{"key":"BFEMBR201439939_CR14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/376062a0","volume":"376","author":"F Shalaby","year":"1995","unstructured":"Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC (1995) Failure of blood\u2010island formation and vasculogenesis in Flk\u20101\u2010deficient mice. Nature 376: 62\u201366","journal-title":"Nature"},{"key":"BFEMBR201439939_CR15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/380435a0","volume":"380","author":"P Carmeliet","year":"1996","unstructured":"Carmeliet P, Carver\u2010Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell\u2010Braxton L, Hillan KJ, Moore MW (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435\u2013439","journal-title":"Nature"},{"key":"BFEMBR201439939_CR16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","volume":"380","author":"N Ferrara","year":"1996","unstructured":"Ferrara N, Carver\u2010Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell\u2010Braxton L, Hillan KJ, Moore MW (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439\u2013442","journal-title":"Nature"},{"key":"BFEMBR201439939_CR17","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cell.2008.10.049","volume":"135","author":"S De Val","year":"2008","unstructured":"De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM et\u00a0al (2008) Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell 135: 1053\u20131064","journal-title":"Cell"},{"key":"BFEMBR201439939_CR18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.devcel.2013.06.007","volume":"26","author":"JD Wythe","year":"2013","unstructured":"Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL et\u00a0al (2013) ETS factors regulate Vegf\u2010dependent arterial specification. Dev Cell 26: 45\u201358","journal-title":"Dev Cell"},{"key":"BFEMBR201439939_CR19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(02)01156-3","volume":"303","author":"T Oikawa","year":"2003","unstructured":"Oikawa T, Yamada T (2003) Molecular biology of the Ets family of transcription factors. Gene 303: 11\u201334","journal-title":"Gene"},{"key":"BFEMBR201439939_CR20","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1128\/MCB.20.15.5643-5652.2000","volume":"20","author":"DD Spyropoulos","year":"2000","unstructured":"Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK (2000) Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol 20: 5643\u20135652","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201439939_CR21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ydbio.2006.10.030","volume":"303","author":"VN Pham","year":"2007","unstructured":"Pham VN, Lawson ND, Mugford JW, Dye L, Castranova D, Lo B, Weinstein BM (2007) Combinatorial function of ETS transcription factors in the developing vasculature. Dev Biol 303: 772\u2013783","journal-title":"Dev Biol"},{"key":"BFEMBR201439939_CR22","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1161\/CIRCRESAHA.1134303145","volume":"114","author":"MJ Abedin","year":"2014","unstructured":"Abedin MJ, Nguyen A, Jiang N, Perry CE, Shelton JM, Watson DK, Ferdous A (2014) Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res 114: 1690\u20131699","journal-title":"Circ Res"},{"key":"BFEMBR201439939_CR23","first-page":"298","volume":"1775","author":"E Dejana","year":"2007","unstructured":"Dejana E, Taddei A, Randi AM (2007) Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis. Biochim Biophys Acta 1775: 298\u2013312","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBR201439939_CR24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.stem.2008.03.008","volume":"2","author":"D Lee","year":"2008","unstructured":"Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S et\u00a0al (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497\u2013507","journal-title":"Cell Stem Cell"},{"key":"BFEMBR201439939_CR25","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1073\/pnas.0807583106","volume":"106","author":"A Ferdous","year":"2009","unstructured":"Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN et\u00a0al (2009) Nk2\u20135 transactivates the Ets\u2010related protein 71 gene and specifies an endothelial\/endocardial fate in the developing embryo. Proc Natl Acad Sci USA 106: 814\u2013819","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201439939_CR26","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1182\/blood-2011-05-352658","volume":"118","author":"H Kataoka","year":"2011","unstructured":"Kataoka H, Hayashi M, Nakagawa R, Tanaka Y, Izumi N, Nishikawa S, Jakt ML, Tarui H (2011) Etv2\/ER71 induces vascular mesoderm from Flk1+PDGFRalpha+ primitive mesoderm. Blood 118: 6975\u20136986","journal-title":"Blood"},{"key":"BFEMBR201439939_CR27","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2012-01-403766","volume":"119","author":"F Liu","year":"2012","unstructured":"Liu F, Kang I, Park C, Chang LW, Wang W, Lee D, Lim DS, Vittet D, Nerbonne JM, Choi K (2012) ER71 specifies Flk\u20101+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood 119: 3295\u20133305","journal-title":"Blood"},{"key":"BFEMBR201439939_CR28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","volume":"420","author":"RH Waterston","year":"2002","unstructured":"Waterston RH, Lindblad\u2010Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P et\u00a0al (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420: 520\u2013562","journal-title":"Nature"},{"key":"BFEMBR201439939_CR29","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W et\u00a0al (2008) Model\u2010based analysis of ChIP\u2010Seq (MACS). Genome Biol 9: R137","journal-title":"Genome Biol"},{"key":"BFEMBR201439939_CR30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.stem.2010.07.016","volume":"7","author":"NK Wilson","year":"2010","unstructured":"Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E et\u00a0al (2010) Combinatorial transcriptional control in blood stem\/progenitor cells: genome\u2010wide analysis of ten major transcriptional regulators. Cell Stem Cell 7: 532\u2013544","journal-title":"Cell Stem Cell"},{"key":"BFEMBR201439939_CR31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","volume":"28","author":"CY McLean","year":"2010","unstructured":"McLean CY, Bristor D, Hiller M, Clarke SL, Schaar BT, Lowe CB, Wenger AM, Bejerano G (2010) GREAT improves functional interpretation of cis\u2010regulatory regions. Nat Biotechnol 28: 495\u2013501","journal-title":"Nat Biotechnol"},{"key":"BFEMBR201439939_CR32","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gr.1933104","volume":"14","author":"M Blanchette","year":"2004","unstructured":"Blanchette M, Kent WJ, Riemer C, Elnitski L, Smit AF, Roskin KM, Baertsch R, Rosenbloom K, Clawson H, Green ED et\u00a0al (2004) Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 14: 708\u2013715","journal-title":"Genome Res"},{"key":"BFEMBR201439939_CR33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature10716","volume":"480","author":"MB Stadler","year":"2011","unstructured":"Stadler MB, Murr R, Burger L, Ivanek R, Lienert F, Scholer A, van Nimwegen E, Wirbelauer C, Oakeley EJ, Gaidatzis D et\u00a0al (2011) DNA\u2010binding factors shape the mouse methylome at distal regulatory regions. Nature 480: 490\u2013495","journal-title":"Nature"},{"key":"BFEMBR201439939_CR34","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/ng.2746","volume":"45","author":"GC Hon","year":"2013","unstructured":"Hon GC, Rajagopal N, Shen Y, McCleary DF, Yue F, Dang MD, Ren B (2013) Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues. Nat Genet 45: 1198\u20131206","journal-title":"Nat Genet"},{"key":"BFEMBR201439939_CR35","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1002\/stem.1115","volume":"30","author":"S Wareing","year":"2012","unstructured":"Wareing S, Mazan A, Pearson S, Gottgens B, Lacaud G, Kouskoff V (2012) The Flk1\u2010Cre\u2010mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development. Stem Cells 30: 1521\u20131531","journal-title":"Stem Cells"},{"key":"BFEMBR201439939_CR36","doi-asserted-by":"crossref","first-page":"17692","DOI":"10.1073\/pnas.0707045104","volume":"104","author":"JE Pimanda","year":"2007","unstructured":"Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb\u2010Kokocinski A, Green AR et\u00a0al (2007) Gata2, Fli1, and Scl form a recursively wired gene\u2010regulatory circuit during early hematopoietic development. Proc Natl Acad Sci USA 104: 17692\u201317697","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201439939_CR37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1242\/dev.02731","volume":"134","author":"JJ Lugus","year":"2007","unstructured":"Lugus JJ, Chung YS, Mills JC, Kim SI, Grass J, Kyba M, Doherty JM, Bresnick EH, Choi K (2007) GATA2 functions at multiple steps in hemangioblast development and differentiation. Development 134: 393\u2013405","journal-title":"Development"},{"key":"BFEMBR201439939_CR38","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.exphem.2008.07.005","volume":"36","author":"I Ismailoglu","year":"2008","unstructured":"Ismailoglu I, Yeamans G, Daley GQ, Perlingeiro RC, Kyba M (2008) Mesodermal patterning activity of SCL. Exp Hematol 36: 1593\u20131603","journal-title":"Exp Hematol"},{"key":"BFEMBR201439939_CR39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stemcr.2013.06.005","volume":"1","author":"F Liu","year":"2013","unstructured":"Liu F, Bhang SH, Arentson E, Sawada A, Kim CK, Kang I, Yu J, Sakurai N, Kim SH, Yoo JJ et\u00a0al (2013) Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors. Stem Cell Rep 1: 166\u2013182","journal-title":"Stem Cell Rep"},{"key":"BFEMBR201439939_CR40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2014.02.018","volume":"389","author":"X Shi","year":"2014","unstructured":"Shi X, Richard J, Zirbes KM, Gong W, Lin G, Kyba M, Thomson JA, Koyano\u2010Nakagawa N, Garry DJ (2014) Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol 389: 208\u2013218","journal-title":"Dev Biol"},{"key":"BFEMBR201439939_CR41","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1182\/blood-2011-12-398156","volume":"120","author":"H Takase","year":"2012","unstructured":"Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S et\u00a0al (2012) Genome\u2010wide identification of endothelial cell\u2010enriched genes in the mouse embryo. Blood 120: 914\u2013923","journal-title":"Blood"},{"key":"BFEMBR201439939_CR42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2005-05-1970","volume":"107","author":"M Ema","year":"2006","unstructured":"Ema M, Takahashi S, Rossant J (2006) Deletion of the selection cassette, but not cis\u2010acting elements, in targeted Flk1\u2010lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 107: 111\u2013117","journal-title":"Blood"},{"key":"BFEMBR201439939_CR43","doi-asserted-by":"crossref","first-page":"e50103","DOI":"10.1371\/journal.pone.0050103","volume":"7","author":"TL Rasmussen","year":"2012","unstructured":"Rasmussen TL, Shi X, Wallis A, Kweon J, Zirbes KM, Koyano\u2010Nakagawa N, Garry DJ (2012) VEGF\/Flk1 signaling cascade transactivates Etv2 gene expression. PLoS ONE 7: e50103","journal-title":"PLoS ONE"},{"key":"BFEMBR201439939_CR44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.exphem.2013.02.009","volume":"41","author":"H Kataoka","year":"2013","unstructured":"Kataoka H, Hayashi M, Kobayashi K, Ding G, Tanaka Y, Nishikawa S (2013) Region\u2010specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6\u2010positive caudal\u2010lateral primitive mesoderm. Exp Hematol 41: 567\u2013581 e569","journal-title":"Exp Hematol"},{"key":"BFEMBR201439939_CR45","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1101\/gr.156539.113","volume":"23","author":"B Zhang","year":"2013","unstructured":"Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ et\u00a0al (2013) Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res 23: 1522\u20131540","journal-title":"Genome Res"},{"key":"BFEMBR201439939_CR46","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1128\/MCB.01033-06","volume":"26","author":"JA Grass","year":"2006","unstructured":"Grass JA, Jing H, Kim SI, Martowicz ML, Pal S, Blobel GA, Bresnick EH (2006) Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol 26: 7056\u20137067","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201439939_CR47","doi-asserted-by":"crossref","first-page":"31087","DOI":"10.1074\/jbc.R110.159079","volume":"285","author":"EH Bresnick","year":"2010","unstructured":"Bresnick EH, Lee HY, Fujiwara T, Johnson KD, Keles S (2010) GATA switches as developmental drivers. J Biol Chem 285: 31087\u201331093","journal-title":"J Biol Chem"},{"key":"BFEMBR201439939_CR48","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1182\/blood-2014-03-556332","volume":"124","author":"JY Kim","year":"2014","unstructured":"Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K et\u00a0al (2014) OVOL2 is a critical regulator of ER71\/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells. Blood 124: 2948\u20132952","journal-title":"Blood"},{"key":"BFEMBR201439939_CR49","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.exphem.2012.05.012","volume":"40","author":"M Hayashi","year":"2012","unstructured":"Hayashi M, Pluchinotta M, Momiyama A, Tanaka Y, Nishikawa S, Kataoka H (2012) Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp Hematol 40: 738\u2013750 e711","journal-title":"Exp Hematol"},{"key":"BFEMBR201439939_CR50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1073\/pnas.1413234112","volume":"112","author":"R Morita","year":"2015","unstructured":"Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A et\u00a0al (2015) ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. Proc Natl Acad Sci USA 112: 160\u2013165","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201439939_CR51","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cell.2012.09.032","volume":"151","author":"M Ginsberg","year":"2012","unstructured":"Ginsberg M, James D, Ding BS, Nolan D, Geng F, Butler JM, Schachterle W, Pulijaal VR, Mathew S, Chasen ST et\u00a0al (2012) Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFbeta suppression. Cell 151: 559\u2013575","journal-title":"Cell"},{"key":"BFEMBR201439939_CR52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/gene.10175","volume":"35","author":"T Motoike","year":"2003","unstructured":"Motoike T, Markham DW, Rossant J, Sato TN (2003) Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis 35: 153\u2013159","journal-title":"Genesis"},{"key":"BFEMBR201439939_CR53","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/stem.597","volume":"29","author":"D Lee","year":"2011","unstructured":"Lee D, Kim T, Lim DS (2011) The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells 29: 539\u2013548","journal-title":"Stem Cells"},{"key":"BFEMBR201439939_CR54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2174\/1566523023347742","volume":"2","author":"P de Felipe","year":"2002","unstructured":"de Felipe P (2002) Polycistronic viral vectors. Curr Gene Ther 2: 355\u2013378","journal-title":"Curr Gene Ther"},{"key":"BFEMBR201439939_CR55","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows\u2010Wheeler transform. Bioinformatics 25: 1754\u20131760","journal-title":"Bioinformatics"},{"key":"BFEMBR201439939_CR56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ymeth.2014.10.032","volume":"72","author":"D Li","year":"2015","unstructured":"Li D, Zhang B, Xing X, Wang T (2015) Combining MeDIP\u2010seq and MRE\u2010seq to investigate genome\u2010wide CpG methylation. Methods 72: 29\u201340","journal-title":"Methods"},{"key":"BFEMBR201439939_CR57","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK (2010) Simple combinations of lineage\u2010determining transcription factors prime cis\u2010regulatory elements required for macrophage and B cell identities. Mol Cell 38: 576\u2013589","journal-title":"Mol Cell"},{"key":"BFEMBR201439939_CR58","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/bib\/bbq086","volume":"12","author":"HE Lockstone","year":"2011","unstructured":"Lockstone HE (2011) Exon array data analysis using Affymetrix power tools and R statistical software. Brief Bioinform 12: 634\u2013644","journal-title":"Brief Bioinform"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201439939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201439939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201439939\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201439939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201439939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:58:15Z","timestamp":1779109095000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201439939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,23]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5,1]]}},"alternative-id":["BFEMBR201439939"],"URL":"https:\/\/doi.org\/10.15252\/embr.201439939","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,23]]},"assertion":[{"value":"2 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}