{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:38:24Z","timestamp":1791279504487,"version":"4.1.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["Pest\u2010OE\/EQB\/LA0004\/2013\u20102014"],"award-info":[{"award-number":["Pest\u2010OE\/EQB\/LA0004\/2013\u20102014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["INOVA4HEALTH \u2010 UID\/Multi\/04462\/2013"],"award-info":[{"award-number":["INOVA4HEALTH \u2010 UID\/Multi\/04462\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["01\u20100145_FEDER\u2010007344"],"award-info":[{"award-number":["01\u20100145_FEDER\u2010007344"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["IF\/00998\/2012\/CP0182\/CT0004"],"award-info":[{"award-number":["IF\/00998\/2012\/CP0182\/CT0004"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["RECI\/BEX\u2010BCM\/0083\/2012"],"award-info":[{"award-number":["RECI\/BEX\u2010BCM\/0083\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia ea Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/94186\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/94186\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Curie Integration Grant","award":["PCIG\u2010GA\u20102012\u2010334366\u2010trafficinAD"],"award-info":[{"award-number":["PCIG\u2010GA\u20102012\u2010334366\u2010trafficinAD"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPE20130326599"],"award-info":[{"award-number":["SPE20130326599"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PT2020"],"award-info":[{"award-number":["PT2020"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2017,1,1]]},"DOI":"10.15252\/embr.201642738","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T20:30:32Z","timestamp":1480365032000},"page":"102-122","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":174,"title":["Bin1 and CD2AP polarise the endocytic generation of beta\u2010amyloid"],"prefix":"10.1038","volume":"18","author":[{"given":"Florent","family":"Ubelmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Burrinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Salavessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9384-2896","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Guimas Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"BFEMBR201642738_CR1","doi-asserted-by":"crossref","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","volume":"2","author":"L Mucke","year":"2012","unstructured":"Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid \u03b2\u2010protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2: a006338","journal-title":"Cold Spring Harb Perspect Med"},{"key":"BFEMBR201642738_CR2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000095267","volume":"3","author":"C Kaether","year":"2006","unstructured":"Kaether C, Haass C, Steiner H (2006) Assembly, trafficking and function of gamma\u2010secretase. Neurodegener Dis 3: 275\u2013283","journal-title":"Neurodegener Dis"},{"key":"BFEMBR201642738_CR3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1600-0854.2012.01332.x","volume":"13","author":"L Rajendran","year":"2012","unstructured":"Rajendran L, Annaert W (2012) Membrane trafficking pathways in Alzheimer's disease. Traffic 13: 759\u2013770","journal-title":"Traffic"},{"key":"BFEMBR201642738_CR4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00401-014-1379-7","volume":"129","author":"A Peric","year":"2015","unstructured":"Peric A, Annaert W (2015) Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathol (Berl) 129: 363\u2013381","journal-title":"Acta Neuropathol (Berl)"},{"key":"BFEMBR201642738_CR5","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1523\/JNEUROSCI.5078-05.2006","volume":"26","author":"CG Almeida","year":"2006","unstructured":"Almeida CG, Takahashi RH, Gouras GK (2006) \u03b2\u2010Amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin\u2010proteasome system. J Neurosci 26: 4277\u20134288","journal-title":"J Neurosci"},{"key":"BFEMBR201642738_CR6","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","volume":"161","author":"RH Takahashi","year":"2002","unstructured":"Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161: 1869\u20131879","journal-title":"Am J Pathol"},{"key":"BFEMBR201642738_CR7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2008.02.003","volume":"58","author":"JR Cirrito","year":"2008","unstructured":"Cirrito JR, Kang J\u2010E, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM (2008) Endocytosis is required for synaptic activity\u2010dependent release of amyloid\u2010beta in vivo. Neuron 58: 42\u201351","journal-title":"Neuron"},{"key":"BFEMBR201642738_CR8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1126\/science.1156609","volume":"320","author":"L Rajendran","year":"2008","unstructured":"Rajendran L, Schneider A, Schlechtingen G, Weidlich S, Ries J, Braxmeier T, Schwille P, Schulz JB, Schroeder C, Simons M et al (2008) Efficient inhibition of the Alzheimer's disease beta\u2010secretase by membrane targeting. Science 320: 520\u2013523","journal-title":"Science"},{"key":"BFEMBR201642738_CR9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/cr.2007.5","volume":"17","author":"L Zou","year":"2007","unstructured":"Zou L, Wang Z, Shen L, Bao GB, Wang T, Kang JH, Pei G (2007) Receptor tyrosine kinases positively regulate BACE activity and Amyloid\u2010\u03b2 production through enhancing BACE internalization. Cell Res 17: 389\u2013401","journal-title":"Cell Res"},{"key":"BFEMBR201642738_CR10","doi-asserted-by":"crossref","first-page":"E559","DOI":"10.1073\/pnas.1100745108","volume":"108","author":"R Sannerud","year":"2011","unstructured":"Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B et al (2011) ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci 108: E559\u2013E568","journal-title":"Proc Natl Acad Sci"},{"key":"BFEMBR201642738_CR11","doi-asserted-by":"crossref","first-page":"31261","DOI":"10.1074\/jbc.M304122200","volume":"278","author":"OM Grbovic","year":"2003","unstructured":"Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers\u2010Terio NB, Ceresa BP, Nixon RA, Cataldo AM (2003) Rab5\u2010stimulated up\u2010regulation of the endocytic pathway increases intracellular beta\u2010cleaved amyloid precursor protein carboxyl\u2010terminal fragment levels and Abeta production. J Biol Chem 278: 31261\u201331268","journal-title":"J Biol Chem"},{"key":"BFEMBR201642738_CR12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/tra.12088","volume":"14","author":"PZC Chia","year":"2013","unstructured":"Chia PZC, Toh WH, Sharples R, Gasnereau I, Hill AF, Gleeson PA (2013) Intracellular itinerary of internalised \u03b2\u2010Secretase, BACE1, and its potential impact on \u03b2\u2010Amyloid peptide biogenesis. Traffic 14: 997\u20131013","journal-title":"Traffic"},{"key":"BFEMBR201642738_CR13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuron.2013.05.035","volume":"79","author":"U Das","year":"2013","unstructured":"Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S (2013) Activity\u2010induced convergence of APP and BACE\u20101 in acidic microdomains via an endocytosis\u2010dependent pathway. Neuron 79: 447\u2013460","journal-title":"Neuron"},{"key":"BFEMBR201642738_CR14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"C Haass","year":"1992","unstructured":"Haass C, Schlossmacher MG, Hung AY, Vigo\u2010Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB (1992) Amyloid beta\u2010peptide is produced by cultured cells during normal metabolism. Nature 359: 322\u2013325","journal-title":"Nature"},{"key":"BFEMBR201642738_CR15","first-page":"2520","volume":"128","author":"JR Edgar","year":"2015","unstructured":"Edgar JR, Will\u00e9n K, Gouras GK, Futter CE (2015) ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid\u2010\u03b2 accumulation. J Cell Sci 128: 2520\u20132528","journal-title":"J Cell Sci"},{"key":"BFEMBR201642738_CR16","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1038\/ncomms3250","volume":"4","author":"E Morel","year":"2013","unstructured":"Morel E, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall'Armi C, Simoes S, Point Du Jour KS, McCabe BD et al (2013) Phosphatidylinositol\u20103\u2010phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun 4: 2250","journal-title":"Nat Commun"},{"key":"BFEMBR201642738_CR17","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.celrep.2013.12.006","volume":"5","author":"V Buggia\u2010Pr\u00e9vot","year":"2013","unstructured":"Buggia\u2010Pr\u00e9vot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S et al (2013) A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease A\u03b2 production. Cell Rep 5: 1552\u20131563","journal-title":"Cell Rep"},{"key":"BFEMBR201642738_CR18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1034\/j.1600-0854.2003.40205.x","volume":"4","author":"M Cormont","year":"2003","unstructured":"Cormont M, Meton I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand\u2010Brustel Y (2003) CD2AP\/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c\u2010Cbl. Traffic Cph Den 4: 97\u2013112","journal-title":"Traffic Cph Den"},{"key":"BFEMBR201642738_CR19","doi-asserted-by":"crossref","first-page":"21805","DOI":"10.1074\/jbc.M211407200","volume":"278","author":"DK Lynch","year":"2003","unstructured":"Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ (2003) A cortactin\u2010CD2\u2010associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem 278: 21805\u201321813","journal-title":"J Biol Chem"},{"key":"BFEMBR201642738_CR20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1083\/jcb.200609061","volume":"177","author":"NC Gauthier","year":"2007","unstructured":"Gauthier NC, Monzo P, Gonzalez T, Doye A, Oldani A, Gounon P, Ricci V, Cormont M, Boquet P (2007) Early endosomes associated with dynamic F\u2010actin structures are required for late trafficking of H. pylori VacA toxin. J Cell Biol 177: 343\u2013354","journal-title":"J Cell Biol"},{"key":"BFEMBR201642738_CR21","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ncb1986","volume":"11","author":"S Pant","year":"2009","unstructured":"Pant S, Sharma M, Patel K, Caplan S, Carr CM, Grant BD (2009) AMPH\u20101\/Amphiphysin\/Bin1 functions with RME\u20101\/Ehd1 in endocytic recycling. Nat Cell Biol 11: 1399\u20131410","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201642738_CR22","doi-asserted-by":"crossref","first-page":"15101","DOI":"10.1074\/jbc.272.24.15101","volume":"272","author":"C Leprince","year":"1997","unstructured":"Leprince C, Romero F, Cussac D, Vayssiere B, Berger R, Tavitian A, Camonis JH (1997) A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. J Biol Chem 272: 15101\u201315105","journal-title":"J Biol Chem"},{"key":"BFEMBR201642738_CR23","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1242\/jcs.00403","volume":"116","author":"C Leprince","year":"2003","unstructured":"Leprince C, Scolan EL, Meunier B, Fraisier V, Brandon N, Gunzburg JD, Camonis J (2003) Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci 116: 1937\u20131948","journal-title":"J Cell Sci"},{"key":"BFEMBR201642738_CR24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nrn2516","volume":"9","author":"TE Willnow","year":"2008","unstructured":"Willnow TE, Petersen CM, Nykjaer A (2008) VPS10P\u2010domain receptors [mdash] regulators of neuronal viability and function. Nat Rev Neurosci 9: 899\u2013909","journal-title":"Nat Rev Neurosci"},{"key":"BFEMBR201642738_CR25","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1091\/mbc.10.8.2687","volume":"10","author":"F Tebar","year":"1999","unstructured":"Tebar F, Bohlander SK, Sorkin A (1999) Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic\u2010coated pits, interactions with clathrin, and the impact of overexpression on clathrin\u2010mediated traffic. Mol Biol Cell 10: 2687\u20132702","journal-title":"Mol Biol Cell"},{"key":"BFEMBR201642738_CR26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","volume":"39","author":"L Bertram","year":"2007","unstructured":"Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta\u2010analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39: 17\u201323","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","volume":"41","author":"D Harold","year":"2009","unstructured":"Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A et al (2009) Genome\u2010wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41: 1088\u20131093","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","volume":"43","author":"P Hollingworth","year":"2011","unstructured":"Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J\u2010C, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V et al (2011) Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 43: 429\u2013435","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR29","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","volume":"43","author":"AC Naj","year":"2011","unstructured":"Naj AC, Jun G, Beecham GW, Wang L\u2010S, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK et al (2011) Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late\u2010onset Alzheimer's disease. Nat Genet 43: 436\u2013441","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1943","volume":"39","author":"E Rogaeva","year":"2007","unstructured":"Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H et al (2007) The neuronal sortilin\u2010related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39: 168\u2013177","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR31","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archneur.61.8.1200","volume":"61","author":"CR Scherzer","year":"2004","unstructured":"Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ (2004) Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 61: 1200\u20131205","journal-title":"Arch Neurol"},{"key":"BFEMBR201642738_CR32","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nn.4025","volume":"18","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G et al (2015) Central role for PICALM in amyloid\u2010\u03b2 blood\u2010brain barrier transcytosis and clearance. Nat Neurosci 18: 978\u2013987","journal-title":"Nat Neurosci"},{"key":"BFEMBR201642738_CR33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00401-013-1111-z","volume":"125","author":"K Ando","year":"2013","unstructured":"Ando K, Brion J\u2010P, Stygelbout V, Suain V, Authelet M, Dedecker R, Chanut A, Lacor P, Lavaur J, Sazdovitch V et al (2013) Clathrin adaptor CALM\/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol (Berl) 125: 861\u2013878","journal-title":"Acta Neuropathol (Berl)"},{"key":"BFEMBR201642738_CR34","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/bi052120v","volume":"45","author":"OM Andersen","year":"2006","unstructured":"Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT et al (2006) Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA\/LR11. Biochemistry (Mosc) 45: 2618\u20132628","journal-title":"Biochemistry (Mosc)"},{"key":"BFEMBR201642738_CR35","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/mp.2013.1","volume":"18","author":"J Chapuis","year":"2013","unstructured":"Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P et al (2013) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 18: 1225\u20131234","journal-title":"Mol Psychiatry"},{"key":"BFEMBR201642738_CR36","doi-asserted-by":"crossref","first-page":"e78806","DOI":"10.1371\/journal.pone.0078806","volume":"8","author":"EBC Glennon","year":"2013","unstructured":"Glennon EBC, Whitehouse IJ, Miners JS, Kehoe PG, Love S, Kellett KAB, Hooper NM (2013) BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One 8: e78806","journal-title":"PLoS One"},{"key":"BFEMBR201642738_CR37","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3233\/JAD-132450","volume":"42","author":"CJ Holler","year":"2014","unstructured":"Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP (2014) Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis JAD 42: 1221\u20131227","journal-title":"J Alzheimers Dis JAD"},{"key":"BFEMBR201642738_CR38","doi-asserted-by":"crossref","first-page":"e50976","DOI":"10.1371\/journal.pone.0050976","volume":"7","author":"CM Karch","year":"2012","unstructured":"Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM (2012) Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One 7: e50976","journal-title":"PLoS One"},{"key":"BFEMBR201642738_CR39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/JAD-130392","volume":"37","author":"L Sun","year":"2013","unstructured":"Sun L, Tan M\u2010S, Hu N, Yu J\u2010T, Tan L (2013) Exploring the value of plasma BIN1 as a potential biomarker for Alzheimer's disease. J Alzheimers Dis JAD 37: 291\u2013295","journal-title":"J Alzheimers Dis JAD"},{"key":"BFEMBR201642738_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/jamaneurol.2014.3049","volume":"72","author":"L Yu","year":"2015","unstructured":"Yu L, Chibnik LB, Srivastava GP, Pochet N, Yang J, Xu J, Kozubek J, Obholzer N, Leurgans SE, Schneider JA et al (2015) Association of brain DNA methylation in SORL1, ABCA7, HLA\u2010DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. JAMA Neurol 72: 15\u201324","journal-title":"JAMA Neurol"},{"key":"BFEMBR201642738_CR41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-016-0124-1","volume":"11","author":"P De Rossi","year":"2016","unstructured":"De Rossi P, Buggia\u2010Pr\u00e9vot V, Clayton BLL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Bott\u00e9 A, Deyts C, Salem S et al (2016) Predominant expression of Alzheimer's disease\u2010associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol Neurodegener 11: 59","journal-title":"Mol Neurodegener"},{"key":"BFEMBR201642738_CR42","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1212\/WNL.0b013e3182553c48","volume":"78","author":"S Barral","year":"2012","unstructured":"Barral S, Bird T, Goate A, Farlow MR, Diaz\u2010Arrastia R, Bennett DA, Graff\u2010Radford N, Boeve BF, Sweet RA, Stern Y et al (2012) Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology 78: 1464\u20131471","journal-title":"Neurology"},{"key":"BFEMBR201642738_CR43","doi-asserted-by":"crossref","first-page":"15307","DOI":"10.1073\/pnas.1201632109","volume":"109","author":"J Bali","year":"2012","unstructured":"Bali J, Gheinani AH, Zurbriggen S, Rajendran L (2012) Role of genes linked to sporadic Alzheimer's disease risk in the production of \u03b2\u2010amyloid peptides. Proc Natl Acad Sci 109: 15307\u201315311","journal-title":"Proc Natl Acad Sci"},{"key":"BFEMBR201642738_CR44","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamaneurol.2013.2815","volume":"70","author":"JM Shulman","year":"2013","unstructured":"Shulman JM, Chen K, Keenan BT, Chibnik LB, Fleisher A, Thiyyagura P, Roontiva A, McCabe C, Patsopoulos NA, Corneveaux JJ et al (2013) Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol 70: 1150\u20131157","journal-title":"JAMA Neurol"},{"key":"BFEMBR201642738_CR45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13024-015-0006-y","volume":"10","author":"F Liao","year":"2015","unstructured":"Liao F, Jiang H, Srivatsan S, Xiao Q, Lefton KB, Yamada K, Mahan TE, Lee J\u2010M, Shaw AS, Holtzman DM (2015) Effects of CD2\u2010associated protein deficiency on amyloid\u2010\u03b2 in neuroblastoma cells and in an APP transgenic mouse model. Mol Neurodegener 10: 12","journal-title":"Mol Neurodegener"},{"key":"BFEMBR201642738_CR46","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1523\/JNEUROSCI.5167-03.2004","volume":"24","author":"RH Takahashi","year":"2004","unstructured":"Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK (2004) Oligomerization of Alzheimer's beta\u2010amyloid within processes and synapses of cultured neurons and brain. J Neurosci Off J Soc Neurosci 24: 3592\u20133599","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"BFEMBR201642738_CR47","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1523\/JNEUROSCI.2292-09.2009","volume":"29","author":"D Tampellini","year":"2009","unstructured":"Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo\u2010Zarate E, Ma T, Zheng R, Lu B, Nanus DM et al (2009) Synaptic activity reduces intraneuronal A\u03b2, promotes APP transport to synapses, and protects against A\u03b2\u2010related synaptic alterations. J Neurosci 29: 9704","journal-title":"J Neurosci"},{"key":"BFEMBR201642738_CR48","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.15252\/emmm.201404436","volume":"6","author":"S Falcone","year":"2014","unstructured":"Falcone S, Roman W, Hnia K, Gache V, Didier N, Lain\u00e9 J, Aurad\u00e9 F, Marty I, Nishino I, Charlet\u2010Berguerand N et al (2014) N\u2010WASP is required for Amphiphysin\u20102\/BIN1\u2010dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy. EMBO Mol Med 6: 1455\u20131475","journal-title":"EMBO Mol Med"},{"key":"BFEMBR201642738_CR49","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1091\/mbc.e04-09-0773","volume":"16","author":"P Monzo","year":"2005","unstructured":"Monzo P, Gauthier NC, Keslair F, Loubat A, Field CM, Marchand\u2010Brustel YL, Cormont M (2005) Clues to CD2\u2010associated protein involvement in cytokinesis. Mol Biol Cell 16: 2891\u20132902","journal-title":"Mol Biol Cell"},{"key":"BFEMBR201642738_CR50","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/MCB.06106-11","volume":"32","author":"I Tossidou","year":"2012","unstructured":"Tossidou I, Niedenthal R, Klaus M, Teng B, Worthmann K, King BL, Peterson KJ, Haller H, Schiffer M (2012) CD2AP regulates SUMOylation of CIN85 in podocytes. Mol Cell Biol 32: 1068\u20131079","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201642738_CR51","doi-asserted-by":"crossref","first-page":"e1000604","DOI":"10.1371\/journal.pbio.1000604","volume":"9","author":"MJ Taylor","year":"2011","unstructured":"Taylor MJ, Perrais D, Merrifield CJ (2011) A high precision survey of the molecular dynamics of mammalian clathrin\u2010mediated endocytosis. PLoS Biol 9: e1000604","journal-title":"PLoS Biol"},{"key":"BFEMBR201642738_CR52","doi-asserted-by":"crossref","unstructured":"Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S et al (2016) BIN1 regulates BACE1 intracellular trafficking and amyloid\u2010\u03b2 production. Hum Mol Genet ddw146","DOI":"10.1093\/hmg\/ddw146"},{"key":"BFEMBR201642738_CR53","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1523\/JNEUROSCI.0602-12.2012","volume":"32","author":"J Chaufty","year":"2012","unstructured":"Chaufty J, Sullivan SE, Ho A (2012) Intracellular amyloid precursor protein sorting and amyloid\u2010\u03b2 secretion are regulated by Src\u2010mediated phosphorylation of Mint2. J Neurosci 32: 9613\u20139625","journal-title":"J Neurosci"},{"key":"BFEMBR201642738_CR54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1326-5-40","volume":"5","author":"SI Vieira","year":"2010","unstructured":"Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz e Silva EF, da Cruz e Silva OA (2010) Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state\u2010dependent and retromer\u2010mediated. Mol Neurodegener 5: 40","journal-title":"Mol Neurodegener"},{"key":"BFEMBR201642738_CR55","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/357500a0","volume":"357","author":"C Haass","year":"1992","unstructured":"Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992) Targeting of cell\u2010surface beta\u2010amyloid precursor protein to lysosomes: alternative processing into amyloid\u2010bearing fragments. Nature 357: 500\u2013503","journal-title":"Nature"},{"key":"BFEMBR201642738_CR56","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.neurobiolaging.2009.08.005","volume":"32","author":"S Matsuda","year":"2011","unstructured":"Matsuda S, Matsuda Y, Snapp EL, D'Adamio L (2011) Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles. Neurobiol Aging 32: 1400\u20131408","journal-title":"Neurobiol Aging"},{"key":"BFEMBR201642738_CR57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-9-1","volume":"9","author":"V Buggia\u2010Pr\u00e9vot","year":"2014","unstructured":"Buggia\u2010Pr\u00e9vot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G (2014) Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener 9: 1","journal-title":"Mol Neurodegener"},{"key":"BFEMBR201642738_CR58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1937-6448(08)01607-9","volume":"272","author":"ZM Lasiecka","year":"2008","unstructured":"Lasiecka ZM, Yap CC, Vakulenko M, Winckler B (2008) Chapter 7 Compartmentalizing the neuronal plasma membrane: from axon initial segments to synapses. Int Rev Cell Mol Biol 272: 303\u2013389","journal-title":"Int Rev Cell Mol Biol"},{"key":"BFEMBR201642738_CR59","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0896-6273(02)00601-3","volume":"33","author":"G Di Paolo","year":"2002","unstructured":"Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O et al (2002) Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron 33: 789\u2013804","journal-title":"Neuron"},{"key":"BFEMBR201642738_CR60","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrm2755","volume":"10","author":"BD Grant","year":"2009","unstructured":"Grant BD, Donaldson JG (2009) Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol 10: 597\u2013608","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201642738_CR61","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","volume":"103","author":"L Rajendran","year":"2006","unstructured":"Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K (2006) Alzheimer's disease \u03b2\u2010amyloid peptides are released in association with exosomes. Proc Natl Acad Sci 103: 11172\u201311177","journal-title":"Proc Natl Acad Sci"},{"key":"BFEMBR201642738_CR62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00418-009-0643-8","volume":"133","author":"CS Wegener","year":"2010","unstructured":"Wegener CS, Maler\u00f8d L, Pedersen NM, Prodiga C, Bakke O, Stenmark H, Brech A (2010) Ultrastructural characterization of giant endosomes induced by GTPase\u2010deficient Rab5. Histochem Cell Biol 133: 41\u201355","journal-title":"Histochem Cell Biol"},{"key":"BFEMBR201642738_CR63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nn.4188","volume":"19","author":"U Das","year":"2016","unstructured":"Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S (2016) Visualizing APP and BACE\u20101 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci 19: 55\u201364","journal-title":"Nat Neurosci"},{"key":"BFEMBR201642738_CR64","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cell.2016.05.020","volume":"166","author":"R Sannerud","year":"2016","unstructured":"Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V et al (2016) Restricted location of PSEN2\/\u03b3\u2010secretase determines substrate specificity and generates an intracellular A\u03b2 Pool. Cell 166: 193\u2013208","journal-title":"Cell"},{"key":"BFEMBR201642738_CR65","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neurobiolaging.2005.05.022","volume":"26","author":"GK Gouras","year":"2005","unstructured":"Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26: 1235\u20131244","journal-title":"Neurobiol Aging"},{"key":"BFEMBR201642738_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.490360102","volume":"36","author":"RG Parton","year":"1993","unstructured":"Parton RG, Dotti CG (1993) Cell biology of neuronal endocytosis. J Neurosci Res 36: 1\u20139","journal-title":"J Neurosci Res"},{"key":"BFEMBR201642738_CR67","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrm1593","volume":"6","author":"E Rodriguez\u2010Boulan","year":"2005","unstructured":"Rodriguez\u2010Boulan E, Kreitzer G, M\u00fcsch A (2005) Organization of vesicular trafficking in epithelia. Nat Rev Mol Cell Biol 6: 233\u2013247","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201642738_CR68","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1091\/mbc.8.10.2003","volume":"8","author":"P Wigge","year":"1997","unstructured":"Wigge P, K\u00f6hler K, Vallis Y, Doyle CA, Owen D, Hunt SP, McMahon HT (1997) Amphiphysin heterodimers: potential role in clathrin\u2010mediated endocytosis. Mol Biol Cell 8: 2003\u20132015","journal-title":"Mol Biol Cell"},{"key":"BFEMBR201642738_CR69","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1046\/j.1471-4159.1998.70062369.x","volume":"70","author":"AR Ramjaun","year":"1998","unstructured":"Ramjaun AR, McPherson PS (1998) Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin\u2010binding sites. J Neurochem 70: 2369\u20132376","journal-title":"J Neurochem"},{"key":"BFEMBR201642738_CR70","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.132.1.21","volume":"132","author":"W Stoorvogel","year":"1996","unstructured":"Stoorvogel W, Oorschot V, Geuze HJ (1996) A novel class of clathrin\u2010coated vesicles budding from endosomes. J Cell Biol 132: 21\u201333","journal-title":"J Cell Biol"},{"key":"BFEMBR201642738_CR71","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1111\/j.1600-0854.2008.00819.x","volume":"9","author":"Y Zhao","year":"2008","unstructured":"Zhao Y, Keen JH (2008) Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling. Traffic Cph Den 9: 2253\u20132264","journal-title":"Traffic Cph Den"},{"key":"BFEMBR201642738_CR72","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.devcel.2009.11.005","volume":"17","author":"SM Ferguson","year":"2009","unstructured":"Ferguson SM, Raimondi A, Paradise S, Shen H, Mesaki K, Ferguson A, Destaing O, Ko G, Takasaki J, Cremona O et al (2009) Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin\u2010coated pits. Dev Cell 17: 811\u2013822","journal-title":"Dev Cell"},{"key":"BFEMBR201642738_CR73","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ng2086","volume":"39","author":"A\u2010S Nicot","year":"2007","unstructured":"Nicot A\u2010S, Toussaint A, Tosch V, Kretz C, Wallgren\u2010Pettersson C, Iwarsson E, Kingston H, Garnier J\u2010M, Biancalana V, Oldfors A et al (2007) Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. Nat Genet 39: 1134\u20131139","journal-title":"Nat Genet"},{"key":"BFEMBR201642738_CR74","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1038\/ncomms6647","volume":"5","author":"L Picas","year":"2014","unstructured":"Picas L, Viaud J, Schauer K, Vanni S, Hnia K, Fraisier V, Roux A, Bassereau P, Gaits\u2010Iacovoni F, Payrastre B et al (2014) BIN1\/M\u2010Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin. Nat Commun 5: 5647","journal-title":"Nat Commun"},{"key":"BFEMBR201642738_CR75","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1126\/science.1081068","volume":"300","author":"JM Kim","year":"2003","unstructured":"Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS (2003) CD2\u2010associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science 300: 1298\u20131300","journal-title":"Science"},{"key":"BFEMBR201642738_CR76","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.201304143","volume":"203","author":"VW Tang","year":"2013","unstructured":"Tang VW, Brieher WM (2013) FSGS3\/CD2AP is a barbed\u2010end capping protein that stabilizes actin and strengthens adherens junctions. J Cell Biol 203: 815\u2013833","journal-title":"J Cell Biol"},{"key":"BFEMBR201642738_CR77","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.devcel.2009.01.007","volume":"16","author":"E Morel","year":"2009","unstructured":"Morel E, Parton RG, Gruenberg J (2009) Annexin A2\u2010dependent polymerization of actin mediates endosome biogenesis. Dev Cell 16: 445\u2013457","journal-title":"Dev Cell"},{"key":"BFEMBR201642738_CR78","doi-asserted-by":"crossref","first-page":"e73018","DOI":"10.1371\/journal.pone.0073018","volume":"8","author":"JL Ortega Roldan","year":"2013","unstructured":"Ortega Roldan JL, Casares S, Ringkj\u00f8bing Jensen M, C\u00e1rdenes N, Bravo J, Blackledge M, Azuaga AI, van Nuland NAJ (2013) Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications. PLoS One 8: e73018","journal-title":"PLoS One"},{"key":"BFEMBR201642738_CR79","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1038\/sj.emboj.7601850","volume":"26","author":"E Morita","year":"2007","unstructured":"Morita E, Sandrin V, Chung H\u2010Y, Morham SG, Gygi SP, Rodesch CK, Sundquist WI (2007) Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J 26: 4215\u20134227","journal-title":"EMBO J"},{"key":"BFEMBR201642738_CR80","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9440(10)64538-5","volume":"157","author":"AM Cataldo","year":"2000","unstructured":"Cataldo AM, Peterhoff CM, Troncoso JC, Gomez\u2010Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid \u03b2 deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157: 277\u2013286","journal-title":"Am J Pathol"},{"key":"BFEMBR201642738_CR81","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ana.24466","volume":"78","author":"BN Vardarajan","year":"2015","unstructured":"Vardarajan BN, Ghani M, Kahn A, Sheikh S, Sato C, Barral S, Lee JH, Cheng R, Reitz C, Lantigua R et al (2015) Rare coding mutations identified by sequencing of Alzheimer disease genome\u2010wide association studies loci. Ann Neurol 78: 487\u2013498","journal-title":"Ann Neurol"},{"key":"BFEMBR201642738_CR82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nbd.2005.02.008","volume":"20","author":"CG Almeida","year":"2005","unstructured":"Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK (2005) Beta\u2010amyloid accumulation in APP mutant neurons reduces PSD\u201095 and GluR1 in synapses. Neurobiol Dis 20: 187\u2013198","journal-title":"Neurobiol Dis"},{"key":"BFEMBR201642738_CR83","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.6412-10.2011","volume":"31","author":"S Lee","year":"2011","unstructured":"Lee S, Sato Y, Nixon RA (2011) Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's\u2010like axonal dystrophy. J Neurosci 31: 7817","journal-title":"J Neurosci"},{"key":"BFEMBR201642738_CR84","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.febslet.2008.01.003","volume":"582","author":"VA Morais","year":"2008","unstructured":"Morais VA, Leight S, Pijak DS, Lee VM\u2010Y, Costa J (2008) Cellular localization of Nicastrin affects amyloid beta species production. FEBS Lett 582: 427\u2013433","journal-title":"FEBS Lett"},{"key":"BFEMBR201642738_CR85","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1091\/mbc.e10-09-0796","volume":"22","author":"D Chirivino","year":"2011","unstructured":"Chirivino D, Del Maestro L, Formstecher E, Hup\u00e9 P, Raposo G, Louvard D, Arpin M (2011) The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes. Mol Biol Cell 22: 375\u2013385","journal-title":"Mol Biol Cell"},{"key":"BFEMBR201642738_CR86","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/ncb2262","volume":"13","author":"CG Almeida","year":"2011","unstructured":"Almeida CG, Yamada A, Tenza D, Louvard D, Raposo G, Coudrier E (2011) Myosin 1b promotes the formation of post\u2010Golgi carriers by regulating actin assembly and membrane remodelling at the trans\u2010Golgi network. Nat Cell Biol 13: 779\u2013789","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201642738_CR87","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1084\/jem.20130150","volume":"210","author":"H Soares","year":"2013","unstructured":"Soares H, Henriques R, Sachse M, Ventimiglia L, Alonso MA, Zimmer C, Thoulouze M\u2010I, Alcover A (2013) Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse. J Exp Med 210: 2415\u20132433","journal-title":"J Exp Med"},{"key":"BFEMBR201642738_CR88","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1093\/bioinformatics\/btu202","volume":"30","author":"M Ovesn\u00fd","year":"2014","unstructured":"Ovesn\u00fd M, K\u0159\u00ed\u017eek P, Borkovec J, Svindrych Z, Hagen GM (2014) ThunderSTORM: a comprehensive ImageJ plug\u2010in for PALM and STORM data analysis and super\u2010resolution imaging. Bioinforma Oxf Engl 30: 2389\u20132390","journal-title":"Bioinforma Oxf Engl"},{"key":"BFEMBR201642738_CR89","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.celrep.2013.12.005","volume":"5","author":"V Udayar","year":"2013","unstructured":"Udayar V, Buggia\u2010Pr\u00e9vot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J, AESG et al (2013) A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of \u03b2\u2010Amyloid production. Cell Rep 5: 1536\u20131551","journal-title":"Cell Rep"},{"key":"BFEMBR201642738_CR90","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1124\/jpet.102.048280","volume":"305","author":"TA Lanz","year":"2003","unstructured":"Lanz TA, Himes CS, Pallante G, Adams L, Yamazaki S, Amore B, Merchant KM (2003) The gamma\u2010secretase inhibitor N\u2010[N\u2010(3,5\u2010difluorophenacetyl)\u2010L\u2010alanyl]\u2010S\u2010phenylglycine t\u2010butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque\u2010free) and aged (plaque\u2010bearing) Tg2576 mice. J Pharmacol Exp Ther 305: 864\u2013871","journal-title":"J Pharmacol Exp Ther"},{"key":"BFEMBR201642738_CR91","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1021\/jm049379g","volume":"47","author":"SJ Stachel","year":"2004","unstructured":"Stachel SJ, Coburn CA, Steele TG, Jones KG, Loutzenhiser EF, Gregro AR, Rajapakse HA, Lai M\u2010T, Crouthamel M\u2010C, Xu M et al (2004) Structure\u2010based design of potent and selective cell\u2010permeable inhibitors of human beta\u2010secretase (BACE\u20101). J Med Chem 47: 6447\u20136450","journal-title":"J Med Chem"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201642738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201642738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201642738\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201642738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201642738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:18:16Z","timestamp":1779110296000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201642738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,1]]}},"alternative-id":["BFEMBR201642738"],"URL":"https:\/\/doi.org\/10.15252\/embr.201642738","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"18 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}