{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:31Z","timestamp":1790775751011,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0705"],"award-info":[{"award-number":["01GI0705"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt\u2010Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2017,9,1]]},"DOI":"10.15252\/embr.201744067","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T20:10:39Z","timestamp":1499890239000},"page":"1536-1544","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A\u03b2 seeding potency peaks in the early stages of cerebral \u03b2\u2010amyloidosis"],"prefix":"10.1038","volume":"18","author":[{"given":"Lan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan A","family":"Kaeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Marzesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Oberm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Mahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Schelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Odenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K","family":"Fritschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lary C","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Staufenbiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-1072","authenticated-orcid":false,"given":"Mathias","family":"Jucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"BFEMBR201744067_CR1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","volume":"367","author":"RJ Bateman","year":"2012","unstructured":"Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM et al (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 367: 795\u2013804","journal-title":"N Engl J Med"},{"key":"BFEMBR201744067_CR2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","volume":"80","author":"CR Jack Jr","year":"2013","unstructured":"Jack CR Jr, Holtzman DM (2013) Biomarker modeling of Alzheimer's disease. Neuron 80: 1347\u20131358","journal-title":"Neuron"},{"key":"BFEMBR201744067_CR3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","volume":"12","author":"B Dubois","year":"2016","unstructured":"Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K et al (2016) Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria. Alzheimers Dement 12: 292\u2013323","journal-title":"Alzheimers Dement"},{"key":"BFEMBR201744067_CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00023.2009","volume":"90","author":"B De Strooper","year":"2010","unstructured":"De Strooper B (2010) Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol Rev 90: 465\u2013494","journal-title":"Physiol Rev"},{"key":"BFEMBR201744067_CR5","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neurobiolaging.2004.08.002","volume":"26","author":"M Duering","year":"2005","unstructured":"Duering M, Grimm MO, Grimm HS, Schroder J, Hartmann T (2005) Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42. Neurobiol Aging 26: 785\u2013788","journal-title":"Neurobiol Aging"},{"key":"BFEMBR201744067_CR6","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/humu.20336","volume":"27","author":"S Kumar\u2010Singh","year":"2006","unstructured":"Kumar\u2010Singh S, Theuns J, Van Broeck B, Pirici D, Vennekens K, Corsmit E, Cruts M, Dermaut B, Wang R, Van Broeckhoven C (2006) Mean age\u2010of\u2010onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat 27: 686\u2013695","journal-title":"Hum Mutat"},{"key":"BFEMBR201744067_CR7","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1084\/jem.20150892","volume":"212","author":"M Szaruga","year":"2015","unstructured":"Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda\u2010Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S et al (2015) Qualitative changes in human gamma\u2010secretase underlie familial Alzheimer's disease. J Exp Med 212: 2003\u20132013","journal-title":"J Exp Med"},{"key":"BFEMBR201744067_CR8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","volume":"501","author":"M Jucker","year":"2013","unstructured":"Jucker M, Walker LC (2013) Self\u2010propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 501: 45\u201351","journal-title":"Nature"},{"key":"BFEMBR201744067_CR9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.biochem.66.1.385","volume":"66","author":"JD Harper","year":"1997","unstructured":"Harper JD, Lansbury PT Jr (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time\u2010dependent solubility of amyloid proteins. Annu Rev Biochem 66: 385\u2013407","journal-title":"Annu Rev Biochem"},{"key":"BFEMBR201744067_CR10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-neuro-071714-033828","volume":"38","author":"LC Walker","year":"2015","unstructured":"Walker LC, Jucker M (2015) Neurodegenerative diseases: expanding the prion concept. Annu Rev Neurosci 38: 87\u2013103","journal-title":"Annu Rev Neurosci"},{"key":"BFEMBR201744067_CR11","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","volume":"313","author":"M Meyer\u2010Luehmann","year":"2006","unstructured":"Meyer\u2010Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL et al (2006) Exogenous induction of cerebral beta\u2010amyloidogenesis is governed by agent and host. Science 313: 1781\u20131784","journal-title":"Science"},{"key":"BFEMBR201744067_CR12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1194516","volume":"330","author":"YS Eisele","year":"2010","unstructured":"Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Abeta\u2010containing inoculates induce cerebral beta\u2010amyloidosis. Science 330: 980\u2013982","journal-title":"Science"},{"key":"BFEMBR201744067_CR13","doi-asserted-by":"crossref","first-page":"10329","DOI":"10.1073\/pnas.1408968111","volume":"111","author":"J St\u00f6hr","year":"2014","unstructured":"St\u00f6hr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB (2014) Distinct synthetic Abeta prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci USA 111: 10329\u201310334","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744067_CR14","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/mp.2011.120","volume":"17","author":"R Morales","year":"2012","unstructured":"Morales R, Duran\u2010Aniotz C, Castilla J, Estrada LD, Soto C (2012) De novo induction of amyloid\u2010beta deposition in vivo. Mol Psychiatry 17: 1347\u20131353","journal-title":"Mol Psychiatry"},{"key":"BFEMBR201744067_CR15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","volume":"84","author":"R Sperling","year":"2014","unstructured":"Sperling R, Mormino E, Johnson K (2014) The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron 84: 608\u2013622","journal-title":"Neuron"},{"key":"BFEMBR201744067_CR16","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","volume":"94","author":"C St\u00fcrchler\u2010Pierrat","year":"1997","unstructured":"St\u00fcrchler\u2010Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA et al (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease\u2010like pathology. Proc Natl Acad Sci USA 94: 13287\u201313292","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744067_CR17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","volume":"7","author":"R Radde","year":"2006","unstructured":"Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jaggi F, Wolburg H, Gengler S et al (2006) Abeta42\u2010driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep 7: 940\u2013946","journal-title":"EMBO Rep"},{"key":"BFEMBR201744067_CR18","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1523\/JNEUROSCI.3088-11.2011","volume":"31","author":"F Langer","year":"2011","unstructured":"Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC, Jucker M (2011) Soluble Abeta seeds are potent inducers of cerebral beta\u2010amyloid deposition. J Neurosci 31: 14488\u201314495","journal-title":"J Neurosci"},{"key":"BFEMBR201744067_CR19","doi-asserted-by":"crossref","first-page":"28125","DOI":"10.1038\/srep28125","volume":"6","author":"AM Marzesco","year":"2016","unstructured":"Marzesco AM, Flotenmeyer M, Buhler A, Obermuller U, Staufenbiel M, Jucker M, Baumann F (2016) Highly potent intracellular membrane\u2010associated Abeta seeds. Sci Rep 6: 28125","journal-title":"Sci Rep"},{"key":"BFEMBR201744067_CR20","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/embor.2013.137","volume":"14","author":"G Heilbronner","year":"2013","unstructured":"Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarstrom P, Nilsson KP, Jucker M (2013) Seeded strain\u2010like transmission of beta\u2010amyloid morphotypes in APP transgenic mice. EMBO Rep 14: 1017\u20131022","journal-title":"EMBO Rep"},{"key":"BFEMBR201744067_CR21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","volume":"27","author":"LJ Reed","year":"1938","unstructured":"Reed LJ, Muench H (1938) A simple method of estimating fifty per cent endpoints. Am J Epidemiol 27: 493\u2013497","journal-title":"Am J Epidemiol"},{"key":"BFEMBR201744067_CR22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S0022172400015084","volume":"48","author":"P Armitage","year":"1950","unstructured":"Armitage P, Allen I (1950) Methods of estimating the LD 50 in quantal response data. J Hyg (Lond) 48: 298\u2013322","journal-title":"J Hyg (Lond)"},{"key":"BFEMBR201744067_CR23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","volume":"162","author":"G K\u00e4rber","year":"1931","unstructured":"K\u00e4rber G (1931) Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch Exp Pathol Pharmakol 162: 480\u2013483","journal-title":"Arch Exp Pathol Pharmakol"},{"key":"BFEMBR201744067_CR24","doi-asserted-by":"crossref","first-page":"e89014","DOI":"10.1371\/journal.pone.0089014","volume":"9","author":"C Duran\u2010Aniotz","year":"2014","unstructured":"Duran\u2010Aniotz C, Morales R, Moreno\u2010Gonzalez I, Hu PP, Fedynyshyn J, Soto C (2014) Aggregate\u2010depleted brain fails to induce Abeta deposition in a mouse model of Alzheimer's disease. PLoS One 9: e89014","journal-title":"PLoS One"},{"key":"BFEMBR201744067_CR25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.21-02-00372.2001","volume":"21","author":"T Kawarabayashi","year":"2001","unstructured":"Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age\u2010dependent changes in brain, CSF, and plasma amyloid\u2010beta protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21: 372\u2013381","journal-title":"J Neurosci"},{"key":"BFEMBR201744067_CR26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuroscience.2007.10.054","volume":"151","author":"S Lesne","year":"2008","unstructured":"Lesne S, Kotilinek L, Ashe KH (2008) Plaque\u2010bearing mice with reduced levels of oligomeric amyloid\u2010beta assemblies have intact memory function. Neuroscience 151: 745\u2013749","journal-title":"Neuroscience"},{"key":"BFEMBR201744067_CR27","first-page":"194re192","volume":"5","author":"LF Maia","year":"2013","unstructured":"Maia LF, Kaeser SA, Reichwald J, Hruscha M, Martus P, Staufenbiel M, Jucker M (2013) Changes in amyloid\u2010beta and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. Sci Transl Med 5: 194re192","journal-title":"Sci Transl Med"},{"key":"BFEMBR201744067_CR28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.15252\/emmm.201505026","volume":"7","author":"LF Maia","year":"2015","unstructured":"Maia LF, Kaeser SA, Reichwald J, Lambert M, Obermuller U, Schelle J, Odenthal J, Martus P, Staufenbiel M, Jucker M (2015) Increased CSF Abeta during the very early phase of cerebral Abeta deposition in mouse models. EMBO Mol Med 7: 895\u2013903","journal-title":"EMBO Mol Med"},{"key":"BFEMBR201744067_CR29","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1523\/JNEUROSCI.1608-14.2014","volume":"34","author":"YS Eisele","year":"2014","unstructured":"Eisele YS, Fritschi SK, Hamaguchi T, Obermuller U, Fuger P, Skodras A, Schafer C, Odenthal J, Heikenwalder M, Staufenbiel M et al (2014) Multiple factors contribute to the peripheral induction of cerebral beta\u2010Amyloidosis. J Neurosci 34: 10264\u201310273","journal-title":"J Neurosci"},{"key":"BFEMBR201744067_CR30","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/brain\/awu255","volume":"137","author":"SK Fritschi","year":"2014","unstructured":"Fritschi SK, Langer F, Kaeser SA, Maia LF, Portelius E, Pinotsi D, Kaminski CF, Winkler DT, Maetzler W, Keyvani K et al (2014) Highly potent soluble amyloid\u2010beta seeds in human Alzheimer brain but not cerebrospinal fluid. Brain 137: 2909\u20132915","journal-title":"Brain"},{"key":"BFEMBR201744067_CR31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0896-6273(00)00046-5","volume":"27","author":"E Flechsig","year":"2000","unstructured":"Flechsig E, Shmerling D, Hegyi I, Raeber AJ, Fischer M, Cozzio A, von Mering C, Aguzzi A, Weissmann C (2000) Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron 27: 399\u2013408","journal-title":"Neuron"},{"key":"BFEMBR201744067_CR32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature09768","volume":"470","author":"MK Sandberg","year":"2011","unstructured":"Sandberg MK, Al\u2010Doujaily H, Sharps B, Clarke AR, Collinge J (2011) Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 470: 540\u2013542","journal-title":"Nature"},{"key":"BFEMBR201744067_CR33","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1038\/srep09349","volume":"5","author":"R Morales","year":"2015","unstructured":"Morales R, Bravo\u2010Alegria J, Duran\u2010Aniotz C, Soto C (2015) Titration of biologically active amyloid\u2010beta seeds in a transgenic mouse model of Alzheimer's disease. Sci Rep 5: 9349","journal-title":"Sci Rep"},{"key":"BFEMBR201744067_CR34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ncomms1730","volume":"3","author":"N Makarava","year":"2012","unstructured":"Makarava N, Savtchenko R, Alexeeva I, Rohwer RG, Baskakov IV (2012) Fast and ultrasensitive method for quantitating prion infectivity titre. Nat Commun 3: 741","journal-title":"Nat Commun"},{"key":"BFEMBR201744067_CR35","volume-title":"Subviral pathogens of plants and animals: Viroids and Prions","author":"K Maramorosch","year":"1985","unstructured":"Maramorosch K, McKelvey JJJ (1985) Subviral pathogens of plants and animals: Viroids and Prions. Orlando, FL: Academic Press"},{"key":"BFEMBR201744067_CR36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ana.410110406","volume":"11","author":"SB Prusiner","year":"1982","unstructured":"Prusiner SB, Cochran SP, Groth DF, Downey DE, Bowman KA, Martinez HM (1982) Measurement of the scrapie agent using an incubation time interval assay. Ann Neurol 11: 353\u2013358","journal-title":"Ann Neurol"},{"key":"BFEMBR201744067_CR37","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.celrep.2015.05.021","volume":"11","author":"P Liu","year":"2015","unstructured":"Liu P, Reed MN, Kotilinek LA, Grant MK, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang AC, Jankowsky JL et al (2015) Quaternary structure defines a large class of Amyloid\u2010beta oligomers neutralized by sequestration. Cell Rep 11: 1760\u20131771","journal-title":"Cell Rep"},{"key":"BFEMBR201744067_CR38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(01)02369-2","volume":"315","author":"M Vandermeeren","year":"2001","unstructured":"Vandermeeren M, Geraerts M, Pype S, Dillen L, Van Hove C, Mercken M (2001) The functional gamma\u2010secretase inhibitor prevents production of amyloid beta 1\u201034 in human and murine cell lines. Neurosci Lett 315: 145\u2013148","journal-title":"Neurosci Lett"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201744067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201744067\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201744067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:20:05Z","timestamp":1779110405000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201744067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9,1]]}},"alternative-id":["BFEMBR201744067"],"URL":"https:\/\/doi.org\/10.15252\/embr.201744067","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]},"assertion":[{"value":"13 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}