{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:55:19Z","timestamp":1790279719052,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003837","name":"The Ichiro Kanehara Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["17K16332"],"award-info":[{"award-number":["17K16332"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["80292423"],"award-info":[{"award-number":["80292423"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.15252\/embr.201744523","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T20:10:53Z","timestamp":1512677453000},"page":"73-88","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["ROCK\u2010dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation"],"prefix":"10.1038","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-9016","authenticated-orcid":false,"given":"Masaharu","family":"Hazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firli Rahmah Primula","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Shaaban","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Hartono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Meguro\u2010Horike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Horike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Phillip","family":"Koeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-6595","authenticated-orcid":false,"given":"Richard W","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"BFEMBR201744523_CR1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","volume":"517","author":"Cancer Genome Atlas Network","year":"2015","unstructured":"Cancer Genome Atlas Network (2015) Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517: 576\u2013582","journal-title":"Nature"},{"key":"BFEMBR201744523_CR2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ng.2935","volume":"46","author":"DC Lin","year":"2014","unstructured":"Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW et al (2014) Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet 46: 467\u2013473","journal-title":"Nat Genet"},{"key":"BFEMBR201744523_CR3","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/ng.3091","volume":"46","author":"CS Lee","year":"2014","unstructured":"Lee CS, Bhaduri A, Mah A, Johnson WL, Ungewickell A, Aros CJ, Nguyen CB, Rios EJ, Siprashvili Z, Straight A et al (2014) Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat Genet 46: 1060\u20131062","journal-title":"Nat Genet"},{"key":"BFEMBR201744523_CR4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","volume":"541","author":"Cancer Genome Atlas Research Network, Analysis Working Group: Asan University, BC Cancer Agency, Brigham and Women's Hospital, Broad Institute, Brown University, Case Western Reserve University, Dana\u2010Farber Cancer Institute, Duke University, Greater Poland Cancer Centre","year":"2017","unstructured":"Cancer Genome Atlas Research Network, Analysis Working Group: Asan University, BC Cancer Agency, Brigham and Women's Hospital, Broad Institute, Brown University, Case Western Reserve University, Dana\u2010Farber Cancer Institute, Duke University, Greater Poland Cancer Centre et al (2017) Integrated genomic characterization of oesophageal carcinoma. Nature 541: 169\u2013175","journal-title":"Nature"},{"key":"BFEMBR201744523_CR5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/19531","volume":"398","author":"AA Mills","year":"1999","unstructured":"Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398: 708\u2013713","journal-title":"Nature"},{"key":"BFEMBR201744523_CR6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","volume":"398","author":"A Yang","year":"1999","unstructured":"Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C et al (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714\u2013718","journal-title":"Nature"},{"key":"BFEMBR201744523_CR7","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1101\/gad.342305","volume":"19","author":"WM Keyes","year":"2005","unstructured":"Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW, Mills AA (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19: 1986\u20131999","journal-title":"Genes Dev"},{"key":"BFEMBR201744523_CR8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2007.02.045","volume":"129","author":"M Senoo","year":"2007","unstructured":"Senoo M, Pint F, Crum CP, Mckeon F (2007) p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129: 523\u2013536","journal-title":"Cell"},{"key":"BFEMBR201744523_CR9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35043127","volume":"1","author":"A Yang","year":"2000","unstructured":"Yang A, McKeon F (2000) P63 and P73: P53 mimics, menaces and more. Nat Rev Mol Cell Biol 1: 199\u2013207","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201744523_CR10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nrc3446","volume":"13","author":"X Su","year":"2013","unstructured":"Su X, Chakravarti D, Flores ER (2013) p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer 13: 136\u2013143","journal-title":"Nat Rev Cancer"},{"key":"BFEMBR201744523_CR11","doi-asserted-by":"crossref","first-page":"pii: a015248","DOI":"10.1101\/cshperspect.a015248","volume":"4","author":"VA Botchkarev","year":"2014","unstructured":"Botchkarev VA, Flores ER (2014) p53\/p63\/p73 in the epidermis in health and disease. Cold Spring Harb Perspect Med 4: pii: a015248","journal-title":"Cold Spring Harb Perspect Med"},{"key":"BFEMBR201744523_CR12","doi-asserted-by":"crossref","first-page":"re9","DOI":"10.1126\/scisignal.aaa1033","volume":"8","author":"G Melino","year":"2015","unstructured":"Melino G, Memmi EM, Pelicci PG, Bernassola F (2015) Maintaining epithelial stemness with p63. Sci Signal 8: re9","journal-title":"Sci Signal"},{"key":"BFEMBR201744523_CR13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1097-2765(00)80275-0","volume":"2","author":"A Yang","year":"1998","unstructured":"Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, D\u00f6tsch V, Andrews NC, Caput D, McKeon F (1998) p63 is the molecular switch for initiation of an epithelial stratification program. Mol Cell 2: 305\u2013316","journal-title":"Mol Cell"},{"key":"BFEMBR201744523_CR14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.15252\/embr.201439941","volume":"16","author":"EN Kouwenhoven","year":"2015","unstructured":"Kouwenhoven EN, Oti M, Niehues H, van Heeringen SJ, Schalkwijk J, Stunnenberg HG, van Bokhoven H, Zhou H (2015) Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation. EMBO Rep 16: 863\u2013878","journal-title":"EMBO Rep"},{"key":"BFEMBR201744523_CR15","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1073\/pnas.061032098","volume":"98","author":"G Pellegrini","year":"2001","unstructured":"Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M (2001) p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98: 3156\u20133161","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR16","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1038\/cdd.2011.73","volume":"18","author":"MK Leonard","year":"2011","unstructured":"Leonard MK, Kommagani R, Payal V, Mayo LD, Shamma HN, Kadakia MP (2011) \u2206Np63\u03b1 regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ 18: 1924\u20131933","journal-title":"Cell Death Differ"},{"key":"BFEMBR201744523_CR17","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1073\/pnas.0603449103","volume":"103","author":"M Rossi","year":"2006","unstructured":"Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, Croce CM, Melino G (2006) The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci USA 103: 12753\u201312758","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR18","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1128\/MCB.00577-13","volume":"33","author":"T Yugawa","year":"2013","unstructured":"Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T (2013) Noncanonical NOTCH signaling limits self\u2010renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Mol Cell Biol 33: 4434\u20134447","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201744523_CR19","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cub.2003.11.050","volume":"13","author":"R McMullan","year":"2003","unstructured":"McMullan R, Lax S, Robertson VH, Radford DJ, Broad S, Watt FM, Rowles A, Croft DR, Olson MF, Hotchin NA (2003) Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol 13: 2185\u20132189","journal-title":"Curr Biol"},{"key":"BFEMBR201744523_CR20","doi-asserted-by":"crossref","first-page":"20035","DOI":"10.1073\/pnas.1213241109","volume":"109","author":"FA Suprynowicz","year":"2012","unstructured":"Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu X, Yuan H, Cheluvaraju C, Clapp PW, Boucher RC Jr et al (2012) Conditionally reprogrammed cells represent a stem\u2010like state of adult epithelial cells. Proc Natl Acad Sci USA 109: 20035\u201320040","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR21","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1158\/0008-5472.CAN-09-4063","volume":"70","author":"T Yugawa","year":"2010","unstructured":"Yugawa T, Narisawa\u2010Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T (2010) DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells. Cancer Res 70: 4034\u20134044","journal-title":"Cancer Res"},{"key":"BFEMBR201744523_CR22","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1158\/0008-5472.CAN-11-0046","volume":"71","author":"MR Ramsey","year":"2011","unstructured":"Ramsey MR, He L, Forster N, Ory B, Ellisen LW (2011) Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res 71: 4373\u20134379","journal-title":"Cancer Res"},{"key":"BFEMBR201744523_CR23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.stem.2010.12.009","volume":"8","author":"WM Keyes","year":"2011","unstructured":"Keyes WM, Pecoraro M, Aranda V, Vernersson\u2010Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G et al (2011) \u2206Np63\u03b1 is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 8: 164\u2013176","journal-title":"Cell Stem Cell"},{"key":"BFEMBR201744523_CR24","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1172\/JCI68899","volume":"123","author":"MR Ramsey","year":"2013","unstructured":"Ramsey MR, Wilson C, Ory B, Rothenberg SM, Faquin W, Mills AA, Ellisen LW (2013) FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest 123: 3525\u20133538","journal-title":"J Clin Invest"},{"key":"BFEMBR201744523_CR25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccell.2016.12.001","volume":"31","author":"SV Saladi","year":"2017","unstructured":"Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW (2017) ACTL6A is co\u2010amplified with p63 in squamous cell carcinoma to drive YAP activation, regenerative proliferation, and poor prognosis. Cancer Cell 31: 35\u201349","journal-title":"Cancer Cell"},{"key":"BFEMBR201744523_CR26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ncb1420","volume":"8","author":"DK Carroll","year":"2006","unstructured":"Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW et al (2006) p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol 8: 551\u2013561","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201744523_CR27","doi-asserted-by":"crossref","first-page":"17969","DOI":"10.1073\/pnas.1309362110","volume":"110","author":"L Tordella","year":"2013","unstructured":"Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G et al (2013) ASPP2 suppresses squamous cell carcinoma via RelA\/p65\u2010mediated repression of p63. Proc Natl Acad Sci USA 110: 17969\u201317974","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10555-011-9287-y","volume":"30","author":"T Funasaka","year":"2011","unstructured":"Funasaka T, Wong RW (2011) The role of nuclear pore complex in tumor microenvironment and metastasis. Cancer Metastasis Rev 30: 239\u2013251","journal-title":"Cancer Metastasis Rev"},{"key":"BFEMBR201744523_CR29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-4899-8032-8_13","volume":"773","author":"DN Simon","year":"2014","unstructured":"Simon DN, Rout MP (2014) Cancer and the nuclear pore complex. Adv Exp Med Biol 773: 285\u2013307","journal-title":"Adv Exp Med Biol"},{"key":"BFEMBR201744523_CR30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.chembiol.2015.10.001","volume":"22","author":"RW Wong","year":"2015","unstructured":"Wong RW (2015) Nuclear pore complex: from structural view to chemical tools. Chem Biol 22: 1285\u20131287","journal-title":"Chem Biol"},{"key":"BFEMBR201744523_CR31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1101\/gad.256495.114","volume":"29","author":"A Ibarra","year":"2015","unstructured":"Ibarra A, Hetzer MW (2015) Nuclear pore proteins and the control of genome functions. Genes Dev 29: 337\u2013349","journal-title":"Genes Dev"},{"key":"BFEMBR201744523_CR32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nsmb.3244","volume":"23","author":"A Hoelz","year":"2016","unstructured":"Hoelz A, Glavy JS, Beck M (2016) Toward the atomic structure of the nuclear pore complex: when top down meets bottom up. Nat Struct Mol Biol 23: 624\u2013630","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBR201744523_CR33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.semcdb.2017.05.006","volume":"68","author":"S Sakuma","year":"2017","unstructured":"Sakuma S, D'Angelo MA (2017) The roles of the nuclear pore complex in cellular dysfunction, aging and disease. Semin Cell Dev Biol 68: 72\u201384","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMBR201744523_CR34","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1128\/EC.00225-09","volume":"8","author":"LJ Terry","year":"2009","unstructured":"Terry LJ, Wente SR (2009) Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport. Eukaryot Cell 8: 1814\u20131827","journal-title":"Eukaryot Cell"},{"key":"BFEMBR201744523_CR35","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1021\/acsnano.7b00906","volume":"11","author":"MS Mohamed","year":"2017","unstructured":"Mohamed MS, Kobayashi A, Taoka A, Watanabe\u2010Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T et al (2017) High\u2010speed atomic force microscopy reveals loss of nuclear pore resilience as a dying code in colorectal cancer cells. ACS Nano 11: 5567\u20135578","journal-title":"ACS Nano"},{"key":"BFEMBR201744523_CR36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2008.03.011","volume":"14","author":"F Lupu","year":"2008","unstructured":"Lupu F, Alves A, Anderson K, Doye V, Lacy E (2008) Nuclear pore composition regulates neural stem\/progenitor cell differentiation in the mouse embryo. Dev Cell 14: 831\u2013842","journal-title":"Dev Cell"},{"key":"BFEMBR201744523_CR37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.devcel.2011.11.021","volume":"22","author":"MA D'Angelo","year":"2012","unstructured":"D'Angelo MA, Gomez\u2010Cavazos JS, Mei A, Lackner DH, Hetzer MW (2012) A change in nuclear pore complex composition regulates cell differentiation. Dev Cell 22: 446\u2013458","journal-title":"Dev Cell"},{"key":"BFEMBR201744523_CR38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1083\/jcb.201410047","volume":"208","author":"JS Gomez\u2010Cavazos","year":"2015","unstructured":"Gomez\u2010Cavazos JS, Hetzer MW (2015) The nucleoporin gp210\/Nup210 controls muscle differentiation by regulating nuclear envelope\/ER homeostasis. J Cell Biol 208: 671\u2013681","journal-title":"J Cell Biol"},{"key":"BFEMBR201744523_CR39","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.260919.115","volume":"29","author":"FV Jacinto","year":"2015","unstructured":"Jacinto FV, Benner C, Hetzer MW (2015) The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev 29: 1224\u20131238","journal-title":"Genes Dev"},{"key":"BFEMBR201744523_CR40","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1101\/gad.287417.116","volume":"30","author":"A Ibarra","year":"2016","unstructured":"Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW (2016) Nucleoporin\u2010mediated regulation of cell identity genes. Genes Dev 30: 2253\u20132258","journal-title":"Genes Dev"},{"key":"BFEMBR201744523_CR41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.devcel.2017.05.007","volume":"41","author":"M Raices","year":"2017","unstructured":"Raices M, Bukata L, Sakuma S, Borlido J, Hernandez LS, Hart DO, D'Angelo MA (2017) Nuclear pores regulate muscle development and maintenance by assembling a localized Mef2C complex. Dev Cell 41: 540\u2013554","journal-title":"Dev Cell"},{"key":"BFEMBR201744523_CR42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm3461","volume":"13","author":"M Raices","year":"2012","unstructured":"Raices M, D'Angelo MA (2012) Nuclear pore complex composition: a new regulator of tissue\u2010specific and developmental functions. Nat Rev Mol Cell Biol 13: 687\u2013699","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201744523_CR43","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4161\/cc.5.23.3525","volume":"5","author":"B Testoni","year":"2006","unstructured":"Testoni B, Borrelli S, Tenedini E, Alotto D, Castagnoli C, Piccolo S, Tagliafico E, Ferrari S, Vigan\u00f2 MA, Mantovani R (2006) Identification of new p63 targets in human keratinocytes. Cell Cycle 5: 2805\u20132811","journal-title":"Cell Cycle"},{"key":"BFEMBR201744523_CR44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4161\/cc.5.2.2361","volume":"5","author":"E Sbisa","year":"2006","unstructured":"Sbisa E, Mastropasqua G, Lefkimmiatis K, Caratozzolo MF, D'Erchia AM, Tullo A (2006) Connecting p63 to cellular proliferation: the example of the adenosine deaminase target gene. Cell Cycle 5: 205\u2013212","journal-title":"Cell Cycle"},{"key":"BFEMBR201744523_CR45","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cell.2005.01.008","volume":"120","author":"RA Ihrie","year":"2005","unstructured":"Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD (2005) Perp is a p63\u2010regulated gene essential for epithelial integrity. Cell 120: 843\u2013856","journal-title":"Cell"},{"key":"BFEMBR201744523_CR46","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/dev.02325","volume":"133","author":"J Laurikkala","year":"2006","unstructured":"Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I (2006) p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development 133: 1553\u20131563","journal-title":"Development"},{"key":"BFEMBR201744523_CR47","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.devcel.2011.12.001","volume":"22","author":"GL Sen","year":"2012","unstructured":"Sen GL, Boxer LD, Webster DE, Bussat RT, Qu K, Zarnegar BJ, Johnston D, Siprashvili Z, Khavari PA (2012) ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell 22: 669\u2013677","journal-title":"Dev Cell"},{"key":"BFEMBR201744523_CR48","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1038\/onc.2016.377","volume":"36","author":"M Hazawa","year":"2017","unstructured":"Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A et al (2017) ZNF750 is a lineage\u2010specific tumour suppressor in squamous cell carcinoma. Oncogene 36: 2243\u20132254","journal-title":"Oncogene"},{"key":"BFEMBR201744523_CR49","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1128\/MCB.23.7.2264-2276.2003","volume":"23","author":"MD Westfall","year":"2003","unstructured":"Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA (2003) The Delta Np63 alpha phosphoprotein binds the p21 and 14\u20103\u20103 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay\u2010Wells syndrome\u2010derived mutations. Mol Cell Biol 23: 2264\u20132276","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201744523_CR50","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1634\/stemcells.2007-0691","volume":"26","author":"N Li","year":"2008","unstructured":"Li N, Singh S, Cherukuri P, Li H, Yuan Z, Ellisen LW, Wang B, Robbins D, DiRenzo J (2008) Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells 26: 1253\u20131264","journal-title":"Stem Cells"},{"key":"BFEMBR201744523_CR51","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1073\/pnas.1500762112","volume":"112","author":"EM Memmi","year":"2015","unstructured":"Memmi EM, Sanarico AG, Giacobbe A, Peschiaroli A, Frezza V, Cicalese A, Pisati F, Tosoni D, Zhou H, Tonon G et al (2015) p63 Sustains self\u2010renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. Proc Natl Acad Sci USA 112: 3499\u20133504","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR52","doi-asserted-by":"crossref","first-page":"30574","DOI":"10.1074\/jbc.M109.049619","volume":"284","author":"L De Rosa","year":"2009","unstructured":"De Rosa L, Antonini D, Ferone G, Russo MT, Yu PB, Han R, Missero C (2009) p63 Suppresses non\u2010epidermal lineage markers in a bone morphogenetic protein\u2010dependent manner via repression of Smad7. J Biol Chem 284: 30574\u201330582","journal-title":"J Biol Chem"},{"key":"BFEMBR201744523_CR53","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cmet.2012.09.006","volume":"16","author":"X Su","year":"2012","unstructured":"Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER (2012) TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab 16: 511\u2013525","journal-title":"Cell Metab"},{"key":"BFEMBR201744523_CR54","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nsmb.1656","volume":"16","author":"H Kosako","year":"2009","unstructured":"Kosako H, Yamaguchi N, Aranami C, Ushiyama M, Kose S, Imamoto N, Taniguchi H, Nishida E, Hattori S (2009) Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin\u2010mediated nuclear transport. Nat Struct Mol Biol 16: 1026\u20131035","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBR201744523_CR55","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1242\/jcs.020941","volume":"121","author":"MP Iwanicki","year":"2008","unstructured":"Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT (2008) FAK, PDZ\u2010RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing\u2010edge retraction in fibroblasts. J Cell Sci 121: 895\u2013905","journal-title":"J Cell Sci"},{"key":"BFEMBR201744523_CR56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0014-5793(97)00107-5","volume":"404","author":"T Ishizaki","year":"1997","unstructured":"Ishizaki T, Naito M, Fujisawa K, Maekawa M, Watanabe N, Saito Y, Narumiya S (1997) p160ROCK, a Rho\u2010associated coiled\u2010coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett 404: 118\u2013124","journal-title":"FEBS Lett"},{"key":"BFEMBR201744523_CR57","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.jmb.2015.10.023","volume":"428","author":"M Christie","year":"2016","unstructured":"Christie M, Chang CW, R\u00f3na G, Smith KM, Stewart AG, Takeda AA, Fontes MR, Stewart M, V\u00e9rtessy BG, Forwood JK et al (2016) Structural biology and regulation of protein import into the nucleus. J Mol Biol 428: 2060\u20132090","journal-title":"J Mol Biol"},{"key":"BFEMBR201744523_CR58","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/sj.onc.1202350","volume":"18","author":"SH Liang","year":"1999","unstructured":"Liang SH, Clarke MF (1999) The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal. Oncogene 18: 2163\u20132166","journal-title":"Oncogene"},{"key":"BFEMBR201744523_CR59","doi-asserted-by":"crossref","first-page":"32699","DOI":"10.1074\/jbc.274.46.32699","volume":"274","author":"SH Liang","year":"1999","unstructured":"Liang SH, Clarke MF (1999) A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl\u2010terminal domain. J Biol Chem 274: 32699\u201332703","journal-title":"J Biol Chem"},{"key":"BFEMBR201744523_CR60","doi-asserted-by":"crossref","first-page":"15053","DOI":"10.1074\/jbc.M200248200","volume":"277","author":"T Inoue","year":"2002","unstructured":"Inoue T, Stuart J, Leno R, Maki CG (2002) Nuclear import and export signals in control of the p53\u2010related protein p73. J Biol Chem 277: 15053\u201315060","journal-title":"J Biol Chem"},{"key":"BFEMBR201744523_CR61","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2011.09.034","volume":"147","author":"SR Solmaz","year":"2011","unstructured":"Solmaz SR, Chauhan R, Blobel G, Mel\u010d\u00e1k I (2011) Molecular architecture of the transport channel of the nuclear pore complex. Cell 147: 590\u2013602 l","journal-title":"Cell"},{"key":"BFEMBR201744523_CR62","doi-asserted-by":"crossref","first-page":"241","DOI":"10.15252\/embr.201642386","volume":"18","author":"MR Sahoo","year":"2017","unstructured":"Sahoo MR, Gaikwad S, Khuperkar D, Ashok M, Helen M, Yadav SK, Singh A, Magre I, Deshmukh P, Dhanvijay S et al (2017) Nup358 binds to AGO proteins through its SUMO\u2010interacting motifs and promotes the association of target mRNA with miRISC. EMBO Rep 18: 241\u2013263","journal-title":"EMBO Rep"},{"key":"BFEMBR201744523_CR63","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.stem.2017.08.012","volume":"21","author":"T Toda","year":"2017","unstructured":"Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH (2017) Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell 21: 618\u2013634.e7","journal-title":"Cell Stem Cell"},{"key":"BFEMBR201744523_CR64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2005.12.013","volume":"9","author":"JW Rocco","year":"2006","unstructured":"Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW (2006) p63 mediates survival in squamous cell carcinoma by suppression of p73\u2010dependent apoptosis. Cancer Cell 9: 45\u201356","journal-title":"Cancer Cell"},{"key":"BFEMBR201744523_CR65","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/cdd.2016.83","volume":"23","author":"J Gebel","year":"2016","unstructured":"Gebel J, Luh LM, Coutandin D, Osterburg C, L\u00f6hr F, Sch\u00e4fer B, Frombach AS, Sumyk M, Buchner L, Krojer T et al (2016) Mechanism of TAp73 inhibition by \u0394Np63 and structural basis of p63\/p73 hetero\u2010tetramerization. Cell Death Differ 23: 1930\u20131940","journal-title":"Cell Death Differ"},{"key":"BFEMBR201744523_CR66","doi-asserted-by":"crossref","first-page":"16911","DOI":"10.1073\/pnas.1208440109","volume":"109","author":"RL Schoch","year":"2012","unstructured":"Schoch RL, Kapinos LE, Lim RY (2012) Nuclear transport receptor binding avidity triggers a self\u2010healing collapse transition in FG\u2010nucleoporin molecular brushes. Proc Natl Acad Sci USA 109: 16911\u201316916","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744523_CR67","doi-asserted-by":"crossref","first-page":"30604","DOI":"10.1074\/jbc.M503352200","volume":"280","author":"M MacPartlin","year":"2005","unstructured":"MacPartlin M, Zeng S, Lee H, Stauffer D, Jin Y, Thayer M, Lu H (2005) p300 regulates p63 transcriptional activity. J Biol Chem 280: 30604\u201330610","journal-title":"J Biol Chem"},{"key":"BFEMBR201744523_CR68","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.4161\/cc.26671","volume":"12","author":"C Hashizume","year":"2013","unstructured":"Hashizume C, Moyori A, Kobayashi A, Yamakoshi N, Endo A, Wong RW (2013) Nucleoporin Nup62 maintains centrosome homeostasis. Cell Cycle 12: 3804\u20133816","journal-title":"Cell Cycle"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744523.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201744523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201744523\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201744523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744523.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:23:00Z","timestamp":1779110580000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201744523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,1]]}},"alternative-id":["BFEMBR201744523"],"URL":"https:\/\/doi.org\/10.15252\/embr.201744523","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]},"assertion":[{"value":"23 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}