{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:49:10Z","timestamp":1787503750193,"version":"build-2736575974"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute NHLBI","doi-asserted-by":"publisher","award":["HL072016"],"award-info":[{"award-number":["HL072016"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute NHLBI","doi-asserted-by":"publisher","award":["HL097768"],"award-info":[{"award-number":["HL097768"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute NHLBI","doi-asserted-by":"publisher","award":["HL102478"],"award-info":[{"award-number":["HL102478"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute NHLBI","doi-asserted-by":"publisher","award":["1U54HD087351"],"award-info":[{"award-number":["1U54HD087351"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases NIDDK","doi-asserted-by":"publisher","award":["DK104789"],"award-info":[{"award-number":["DK104789"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["11POST7950051"],"award-info":[{"award-number":["11POST7950051"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13POST16520009"],"award-info":[{"award-number":["13POST16520009"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council NHMRC","doi-asserted-by":"publisher","award":["APP1088737"],"award-info":[{"award-number":["APP1088737"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"National Fund for Scientific and Technological Development in Chile","doi-asserted-by":"publisher","award":["FONDECYT 11150282"],"award-info":[{"award-number":["FONDECYT 11150282"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"National Fund for Scientific and Technological Development in Chile","doi-asserted-by":"publisher","award":["PAI 79150007"],"award-info":[{"award-number":["PAI 79150007"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","award":["Y16G\u2010KEAD"],"award-info":[{"award-number":["Y16G\u2010KEAD"]}],"id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.15252\/embr.201744706","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T06:55:22Z","timestamp":1541141722000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Regulator of Calcineurin 1 helps coordinate whole\u2010body metabolism and thermogenesis"],"prefix":"10.1038","volume":"19","author":[{"given":"David","family":"Rotter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heshan","family":"Peiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Bennett","family":"Grinsfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyce M","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Burchfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyndi R","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire F","family":"Jessup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusan","family":"Matusica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldons J","family":"Lusis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Uyen Nhi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Iyoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Jakkampudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Randy","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham A","family":"Sadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana K","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-8305","authenticated-orcid":false,"given":"Damien J","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-6703","authenticated-orcid":false,"given":"Beverly A","family":"Rothermel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"BFEMBR201744706_CR1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00007.2014","volume":"95","author":"S Bouret","year":"2014","unstructured":"Bouret S, Levin BE, Ozanne SE (2014) Gene\u2010environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev 95: 47\u201382","journal-title":"Physiol Rev"},{"key":"BFEMBR201744706_CR2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","volume":"19","author":"M Harms","year":"2013","unstructured":"Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nat Med 19: 1252\u20131263","journal-title":"Nat Med"},{"key":"BFEMBR201744706_CR3","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","volume":"77","author":"DF Rolfe","year":"1997","unstructured":"Rolfe DF, Brown GC (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77: 731\u2013758","journal-title":"Physiol Rev"},{"key":"BFEMBR201744706_CR4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yjmcc.2015.12.030","volume":"91","author":"SA Shaikh","year":"2016","unstructured":"Shaikh SA, Sahoo SK, Periasamy M (2016) Phospholamban and sarcolipin: are they functionally redundant or distinct regulators of the sarco(endo)plasmic reticulum calcium ATPase? J Mol Cell Cardiol 91: 81\u201391","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMBR201744706_CR5","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/nm.2897","volume":"18","author":"NC Bal","year":"2012","unstructured":"Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Goonasekera SA, Molkentin JD et al (2012) Sarcolipin is a newly identified regulator of muscle\u2010based thermogenesis in mammals. Nat Med 18: 1575\u20131579","journal-title":"Nat Med"},{"key":"BFEMBR201744706_CR6","doi-asserted-by":"crossref","first-page":"e12549","DOI":"10.14814\/phy2.12549","volume":"3","author":"D Gamu","year":"2015","unstructured":"Gamu D, Trinh A, Bombardier E, Tupling AR (2015) Persistence of diet\u2010induced obesity despite access to voluntary activity in mice lacking sarcolipin. Physiol Rep 3: e12549","journal-title":"Physiol Rep"},{"key":"BFEMBR201744706_CR7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.phrs.2015.10.020","volume":"102","author":"SK Maurya","year":"2015","unstructured":"Maurya SK, Periasamy M (2015) Sarcolipin is a novel regulator of muscle metabolism and obesity. Pharmacol Res 102: 270\u2013275","journal-title":"Pharmacol Res"},{"key":"BFEMBR201744706_CR8","doi-asserted-by":"crossref","first-page":"12282","DOI":"10.1074\/jbc.M115.637603","volume":"290","author":"LA Rowland","year":"2015","unstructured":"Rowland LA, Bal NC, Kozak LP, Periasamy M (2015) Uncoupling protein 1 and sarcolipin are required to maintain optimal thermogenesis, and loss of both systems compromises survival of mice under cold stress. J Biol Chem 290: 12282\u201312289","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR9","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/hmg\/9.11.1681","volume":"9","author":"JJ Fuentes","year":"2000","unstructured":"Fuentes JJ, Genesc\u00e0 L, Kingsbury TJ, Cunningham KW, P\u00e9rez\u2010Riba M, Estivill X, la Luna de S (2000) DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin\u2010mediated signaling pathways. Hum Mol Genet 9: 1681\u20131690","journal-title":"Hum Mol Genet"},{"key":"BFEMBR201744706_CR10","doi-asserted-by":"crossref","first-page":"8719","DOI":"10.1074\/jbc.275.12.8719","volume":"275","author":"B Rothermel","year":"2000","unstructured":"Rothermel B, Vega RB, Yang J, Wu H, Bassel\u2010Duby R, Williams RS (2000) A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 275: 8719\u20138725","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.1600-6143.2003.00372.x","volume":"4","author":"O Heisel","year":"2004","unstructured":"Heisel O, Heisel R, Balshaw R, Keown P (2004) New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta\u2010analysis. Am J Transplant 4: 583\u2013595","journal-title":"Am J Transplant"},{"key":"BFEMBR201744706_CR12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.transproceed.2014.11.025","volume":"47","author":"R L\u00f3pez\u2010Vilella","year":"2015","unstructured":"L\u00f3pez\u2010Vilella R, S\u00e1nchez\u2010L\u00e1zaro IJ, Mart\u00ednez\u2010Dolz L, Almenar\u2010Bonet L, Marqu\u00e9s\u2010Sul\u00e9 E, Melero\u2010Ferrer J, Portol\u00e9s\u2010Sanz M, Rivera\u2010Otero M, Domingo\u2010Valero D, Montero\u2010Argudo A (2015) Incidence of development of obesity after heart transplantation according to the calcineurin inhibitor. Transplant Proc 47: 127\u2013129","journal-title":"Transplant Proc"},{"key":"BFEMBR201744706_CR13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ejhg.2013.96","volume":"22","author":"EM Ramos","year":"2013","unstructured":"Ramos EM, Hoffman D, Junkins HA, Maglott D, Phan L, Sherry ST, Feolo M, Hindorff LA (2013) Phenotype\u2010genotype integrator (PheGenI): synthesizing genome\u2010wide association study (GWAS) data with existing genomic resources. Eur J Hum Genet 22: 144\u2013147","journal-title":"Eur J Hum Genet"},{"key":"BFEMBR201744706_CR14","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1128\/MCB.00580-06","volume":"26","author":"TTC Yang","year":"2006","unstructured":"Yang TTC, Suk HY, Yang X, Olabisi O, Yu RYL, Durand J, Jelicks LA, Kim J\u2010Y, Scherer PE, Wang Y et al (2006) Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol 26: 7372\u20137387","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201744706_CR15","doi-asserted-by":"crossref","first-page":"40050","DOI":"10.1074\/jbc.M110.154955","volume":"285","author":"SA Soleimanpour","year":"2010","unstructured":"Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Lu T, Rankin MM, Liu C, De Le\u00f3n DD, Naji A, Kushner JA et al (2010) Calcineurin signaling regulates human islet {beta}\u2010cell survival. J Biol Chem 285: 40050\u201340059","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2337\/diabetes.51.3.691","volume":"51","author":"MC Lawrence","year":"2002","unstructured":"Lawrence MC, Bhatt HS, Easom RA (2002) NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon\u2010like peptide\u20101. Diabetes 51: 691\u2013698","journal-title":"Diabetes"},{"key":"BFEMBR201744706_CR17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/TP.0b013e31823f7f26","volume":"93","author":"Y Chen","year":"2012","unstructured":"Chen Y, Sampaio MS, Yang JW, Min D, Hutchinson IV (2012) Genetic polymorphisms of the transcription factor NFATc4 and development of new\u2010onset diabetes after transplantation in Hispanic kidney transplant recipients. Transplantation 93: 325\u2013330","journal-title":"Transplantation"},{"key":"BFEMBR201744706_CR18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","volume":"12","author":"JY Altarejos","year":"2011","unstructured":"Altarejos JY, Montminy M (2011) CREB and the CRTC co\u2010activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12: 141\u2013151","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR201744706_CR19","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1001\/jamapsychiatry.2013.187","volume":"70","author":"E Choong","year":"2013","unstructured":"Choong E (2013) Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population. JAMA Psychiatry 70: 1011","journal-title":"JAMA Psychiatry"},{"key":"BFEMBR201744706_CR20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/tpj.2015.82","volume":"17","author":"L Quteineh","year":"2015","unstructured":"Quteineh L, Bochud P\u2010Y, Golshayan D, Crettol S, Venetz J\u2010P, Manuel O, Kutalik Z, Treyer A, Lehmann R, Mueller NJ et al (2015) CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation. Pharmacogenomics J 17: 69\u201375","journal-title":"Pharmacogenomics J"},{"key":"BFEMBR201744706_CR21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nature09564","volume":"468","author":"Y Song","year":"2010","unstructured":"Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim J\u2010H, Goode J, Igata M, Paz JC et al (2010) CRTC3 links catecholamine signalling to energy balance. Nature 468: 933\u2013939","journal-title":"Nature"},{"key":"BFEMBR201744706_CR22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11033-013-2844-4","volume":"41","author":"Z Ou","year":"2014","unstructured":"Ou Z, Wang G, Li Q, Ma Z, Dai M, Zou F (2014) CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population. Mol Biol Rep 41: 125\u2013130","journal-title":"Mol Biol Rep"},{"key":"BFEMBR201744706_CR23","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1096\/fj.06-7246com","volume":"21","author":"KJA Davies","year":"2007","unstructured":"Davies KJA, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique\u2010Silva F, Crawford D, Canaider S, Strippoli P et al (2007) Renaming the DSCR1\/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J 21: 3023\u20133028","journal-title":"FASEB J"},{"key":"BFEMBR201744706_CR24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/geno.1997.4866","volume":"44","author":"JJ Fuentes","year":"1997","unstructured":"Fuentes JJ, Pritchard MA, Estivill X (1997) Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44: 358\u2013361","journal-title":"Genomics"},{"key":"BFEMBR201744706_CR25","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1161\/01.RES.87.12.e61","volume":"87","author":"J Yang","year":"2000","unstructured":"Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel\u2010Duby R, Williams RS (2000) Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res 87: E61\u2013E68","journal-title":"Circ Res"},{"key":"BFEMBR201744706_CR26","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1210\/en.2011-2149","volume":"153","author":"H Peiris","year":"2012","unstructured":"Peiris H, Raghupathi R, Jessup CF, Zanin MP, Mohanasundaram D, Mackenzie KD, Chataway T, Clarke JN, Brealey J, Coates PT et al (2012) Increased expression of the glucose\u2010responsive gene, RCAN1, causes hypoinsulinemia, \u03b2\u2010cell dysfunction, and diabetes. Endocrinology 153: 5212\u20135221","journal-title":"Endocrinology"},{"key":"BFEMBR201744706_CR27","doi-asserted-by":"crossref","first-page":"e1006033","DOI":"10.1371\/journal.pgen.1006033","volume":"12","author":"H Peiris","year":"2016","unstructured":"Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N et al (2016) A syntenic cross species aneuploidy genetic screen links RCAN1 expression to \u03b2\u2010cell mitochondrial dysfunction in type 2 diabetes. PLoS Genet 12: e1006033","journal-title":"PLoS Genet"},{"key":"BFEMBR201744706_CR28","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1371\/journal.pgen.0040032","volume":"4","author":"AM Hancock","year":"2008","unstructured":"Hancock AM, Witonsky DB, Gordon AS, Eshel G, Pritchard JK, Coop G, Di Rienzo A (2008) Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet 4: e32","journal-title":"PLoS Genet"},{"key":"BFEMBR201744706_CR29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.7150\/ijbs.6.691","volume":"6","author":"MV Dodson","year":"2010","unstructured":"Dodson MV, Hausman GJ, Guan L, Du M, Rasmussen TP, Poulos SP, Mir P, Bergen WG, Fernyhough ME, McFarland DC et al (2010) Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research. Int J Biol Sci 6: 691\u2013699","journal-title":"Int J Biol Sci"},{"key":"BFEMBR201744706_CR30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5483\/BMBRep.2009.42.1.006","volume":"42","author":"J Park","year":"2009","unstructured":"Park J, Oh Y, Chung KC (2009) Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep 42: 6\u201315","journal-title":"BMB Rep"},{"key":"BFEMBR201744706_CR31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1472-6823-12-22","volume":"12","author":"S Yahia","year":"2012","unstructured":"Yahia S, El\u2010Farahaty RM, El\u2010Hawary AK, El\u2010Hussiny MA, Abdel\u2010Maseih H, El\u2010Dahtory F, El\u2010Gilany A\u2010H (2012) Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study. BMC Endocr Disord 12: 22","journal-title":"BMC Endocr Disord"},{"key":"BFEMBR201744706_CR32","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"SE Shoelson","year":"2006","unstructured":"Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116: 1793\u20131801","journal-title":"J Clin Invest"},{"key":"BFEMBR201744706_CR33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"P Puigserver","year":"1998","unstructured":"Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold\u2010inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829\u2013839","journal-title":"Cell"},{"key":"BFEMBR201744706_CR34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bbrc.2009.02.077","volume":"381","author":"T Yoshioka","year":"2009","unstructured":"Yoshioka T, Inagaki K, Noguchi T, Sakai M, Ogawa W, Hosooka T, Iguchi H, Watanabe E, Matsuki Y, Hiramatsu R et al (2009) Identification and characterization of an alternative promoter of the human PGC\u20101alpha gene. Biochem Biophys Res Commun 381: 537\u2013543","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBR201744706_CR35","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00125-015-3671-z","volume":"58","author":"V Martinez\u2010Redondo","year":"2015","unstructured":"Martinez\u2010Redondo V, Pettersson AT, Ruas JL (2015) The hitchhiker's guide to PGC\u20101\u03b1 isoform structure and biological functions. Diabetologia 58: 1969\u20131977","journal-title":"Diabetologia"},{"key":"BFEMBR201744706_CR36","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.1074\/jbc.M111.320200","volume":"287","author":"JS Chang","year":"2012","unstructured":"Chang JS, Fernand V, Zhang Y, Shin J, Jun H\u2010J, Joshi Y, Gettys TW (2012) NT\u2010PGC\u20101\u03b1 protein is sufficient to link \u03b23\u2010adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J Biol Chem 287: 9100\u20139111","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR37","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1073\/pnas.0606714103","volume":"103","author":"Z Wu","year":"2006","unstructured":"Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (2006) Transducer of regulated CREB\u2010binding proteins (TORCs) induce PGC\u20101alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci USA 103: 14379\u201314384","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744706_CR38","doi-asserted-by":"crossref","first-page":"e68924","DOI":"10.1371\/journal.pone.0068924","volume":"8","author":"IC Smith","year":"2013","unstructured":"Smith IC, Bombardier E, Vigna C, Tupling AR (2013) ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 40\u201350% of resting metabolic rate in mouse fast and slow twitch skeletal muscle. PLoS ONE 8: e68924","journal-title":"PLoS ONE"},{"key":"BFEMBR201744706_CR39","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1128\/MCB.25.15.6629-6638.2005","volume":"25","author":"M Oh","year":"2005","unstructured":"Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, van Rooij E, Richardson JA, Hill JA, De Windt LJ, Bassel\u2010Duby R et al (2005) Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol 25: 6629\u20136638","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201744706_CR40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/10520299009105613","volume":"65","author":"RW Ogilvie","year":"1990","unstructured":"Ogilvie RW, Feeback DL (1990) A metachromatic dye\u2010ATPase method for the simultaneous identification of skeletal muscle fiber types I, IIA, IIB and IIC. Stain Technol 65: 231\u2013241","journal-title":"Stain Technol"},{"key":"BFEMBR201744706_CR41","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1152\/jappl.1993.75.5.2337","volume":"75","author":"RJ Talmadge","year":"1993","unstructured":"Talmadge RJ, Roy RR (1993) Electrophoretic separation of rat skeletal muscle myosin heavy\u2010chain isoforms. J Appl Physiol 75: 2337\u20132340","journal-title":"J Appl Physiol"},{"key":"BFEMBR201744706_CR42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yjmcc.2007.05.009","volume":"43","author":"GJ Babu","year":"2007","unstructured":"Babu GJ, Bhupathy P, Carnes CA, Billman GE, Periasamy M (2007) Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology. J Mol Cell Cardiol 43: 215\u2013222","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMBR201744706_CR43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cmet.2015.01.002","volume":"21","author":"BW Parks","year":"2015","unstructured":"Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J et al (2015) Genetic architecture of insulin resistance in the mouse. Cell Metab 21: 334\u2013346","journal-title":"Cell Metab"},{"key":"BFEMBR201744706_CR44","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1101\/gr.074914.107","volume":"18","author":"MP Keller","year":"2008","unstructured":"Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S et al (2008) A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res 18: 706\u2013716","journal-title":"Genome Res"},{"key":"BFEMBR201744706_CR45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7326\/0003-4819-138-1-200301070-00008","volume":"138","author":"A Peeters","year":"2003","unstructured":"Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Mamun Al A, Bonneux L, NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group (2003) Obesity in adulthood and its consequences for life expectancy: a life\u2010table analysis. Ann Intern Med 138: 24\u201332","journal-title":"Ann Intern Med"},{"key":"BFEMBR201744706_CR46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","volume":"387","author":"S Enerb\u00e4ck","year":"1997","unstructured":"Enerb\u00e4ck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP (1997) Mice lacking mitochondrial uncoupling protein are cold\u2010sensitive but not obese. Nature 387: 90\u201394","journal-title":"Nature"},{"key":"BFEMBR201744706_CR47","first-page":"31894","volume":"281","author":"J Ukropec","year":"2006","unstructured":"Ukropec J, Anunciado RP, Ravussin Y, Hulver MW, Kozak LP (2006) UCP1\u2010independent thermogenesis in white adipose tissue of cold\u2010acclimated Ucp1\u2010\/\u2010 mice. J Biol Chem 281: 31894\u201331908","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR48","doi-asserted-by":"crossref","first-page":"17247","DOI":"10.1074\/jbc.M116.728188","volume":"291","author":"NC Bal","year":"2016","unstructured":"Bal NC, Maurya SK, Singh S, Wehrens XHT, Periasamy M (2016) Increased reliance on muscle\u2010based thermogenesis upon acute minimization of brown adipose tissue function. J Biol Chem 291: 17247\u201317257","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR49","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.2337\/db15-0146","volume":"64","author":"MJ Betz","year":"2015","unstructured":"Betz MJ, Enerb\u00e4ck S (2015) Human brown adipose tissue: what we have learned so far. Diabetes 64: 2352\u20132360","journal-title":"Diabetes"},{"key":"BFEMBR201744706_CR50","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","volume":"360","author":"AM Cypess","year":"2009","unstructured":"Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng Y\u2010H, Doria A et al (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360: 1509\u20131517","journal-title":"N Engl J Med"},{"key":"BFEMBR201744706_CR51","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nm.3017","volume":"19","author":"ME Lidell","year":"2013","unstructured":"Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P et al (2013) Evidence for two types of brown adipose tissue in humans. Nat Med 19: 631\u2013634","journal-title":"Nat Med"},{"key":"BFEMBR201744706_CR52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","volume":"119","author":"J Lin","year":"2004","unstructured":"Lin J, Wu P\u2010H, Tarr PT, Lindenberg KS, St\u2010Pierre J, Zhang C\u2010Y, Mootha VK, J\u00e4ger S, Vianna CR, Reznick RM et al (2004) Defects in adaptive energy metabolism with CNS\u2010linked hyperactivity in PGC\u20101alpha null mice. Cell 119: 121\u2013135","journal-title":"Cell"},{"key":"BFEMBR201744706_CR53","first-page":"1","volume":"7","author":"T Shan","year":"2016","unstructured":"Shan T, Xiong Y, Zhang P, Li Z, Jiang Q, Bi P, Yue F, Yang G, Wang Y, Liu X et al (2016) Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nat Commun 7: 1\u201311","journal-title":"Nat Commun"},{"key":"BFEMBR201744706_CR54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molmet.2015.10.004","volume":"5","author":"M Nixon","year":"2016","unstructured":"Nixon M, Stewart\u2010Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza\u2010Rodriguez MG, Rivera\u2010Molina YA, Gibson M, Berglund ED, Justice NJ et al (2016) Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Mol Metab 5: 34\u201346","journal-title":"Mol Metab"},{"key":"BFEMBR201744706_CR55","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1101\/gad.12.16.2499","volume":"12","author":"ER Chin","year":"1998","unstructured":"Chin ER, Olson EN, Richardson JA, Yang Q, Humphries C, Shelton JM, Wu H, Zhu W, Bassel\u2010Duby R, Williams RS (1998) A calcineurin\u2010dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev 12: 2499\u20132509","journal-title":"Genes Dev"},{"key":"BFEMBR201744706_CR56","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1006\/geno.1997.4967","volume":"45","author":"A Odermatt","year":"1997","unstructured":"Odermatt A, Taschner PE, Scherer SW, Beatty B, Khanna VK, Cornblath DR, Chaudhry V, Yee WC, Schrank B, Karpati G et al (1997) Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. Genomics 45: 541\u2013553","journal-title":"Genomics"},{"key":"BFEMBR201744706_CR57","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1074\/jbc.M115.636878","volume":"290","author":"SK Maurya","year":"2015","unstructured":"Maurya SK, Bal NC, Sopariwala DH, Pant M, Rowland LA, Shaikh SA, Periasamy M (2015) Sarcolipin is a key determinant of the basal metabolic rate, and its overexpression enhances energy expenditure and resistance against diet\u2010induced obesity. J Biol Chem 290: 10840\u201310849","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR58","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1113\/jphysiol.2011.212860","volume":"589","author":"P Tavi","year":"2011","unstructured":"Tavi P, Westerblad H (2011) The role of in vivo Ca\u00b2\u207a signals acting on Ca\u00b2\u207a\u2010calmodulin\u2010dependent proteins for skeletal muscle plasticity. J Physiol 589: 5021\u20135031","journal-title":"J Physiol"},{"key":"BFEMBR201744706_CR59","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature05097","volume":"443","author":"JJ Heit","year":"2006","unstructured":"Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, Kim SK (2006) Calcineurin\/NFAT signalling regulates pancreatic beta\u2010cell growth and function. Nature 443: 345\u2013349","journal-title":"Nature"},{"key":"BFEMBR201744706_CR60","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/hmg\/ddm374","volume":"17","author":"DJ Keating","year":"2008","unstructured":"Keating DJ, Dubach D, Zanin MP, Yu Y, Martin K, Zhao Y\u2010F, Chen C, Porta S, Arbon\u00e9s ML, Mittaz L et al (2008) DSCR1\/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Hum Mol Genet 17: 1020\u20131030","journal-title":"Hum Mol Genet"},{"key":"BFEMBR201744706_CR61","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/jnc.12086","volume":"124","author":"MP Zanin","year":"2013","unstructured":"Zanin MP, Mackenzie KD, Peiris H, Pritchard MA, Keating DJ (2013) RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity. J Neurochem 124: 290\u2013299","journal-title":"J Neurochem"},{"key":"BFEMBR201744706_CR62","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1053\/j.gastro.2010.04.050","volume":"139","author":"GT Gurda","year":"2010","unstructured":"Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, Williams JA (2010) Regulator of calcineurin 1 controls growth plasticity of adult pancreas. Gastroenterology 139: 609\u2013619.e6","journal-title":"Gastroenterology"},{"key":"BFEMBR201744706_CR63","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ni.3003","volume":"15","author":"R Valdor","year":"2014","unstructured":"Valdor R, Mocholi E, Botbol Y, Guerrero\u2010Ros I, Chandra D, Koga H, Gravekamp C, Cuervo AM, Macian F (2014) Chaperone\u2010mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol 15: 1046\u20131054","journal-title":"Nat Immunol"},{"key":"BFEMBR201744706_CR64","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-695X.2010.00753.x","volume":"61","author":"DL Bhoiwala","year":"2011","unstructured":"Bhoiwala DL, Kannabiran V, Hushmendy SF, Hahn A, Bhoiwala DL, Heuring JM, Crawford DR (2011) The calcineurin inhibitor RCAN1 is involved in cultured macrophage and in vivo immune response. FEMS Immunol Med Microbiol 61: 103\u2013113","journal-title":"FEMS Immunol Med Microbiol"},{"key":"BFEMBR201744706_CR65","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molimm.2016.07.009","volume":"77","author":"Q\u2010Q Lei","year":"2016","unstructured":"Lei Q\u2010Q, Hu G\u2010Q, Chen W, Yu S\u2010X, Qi S, Du C\u2010T, Gu J\u2010M, Lin T\u2010J, Yang Y\u2010J (2016) Molecular immunology. Mol Immunol 77: 26\u201333","journal-title":"Mol Immunol"},{"key":"BFEMBR201744706_CR66","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.4049\/jimmunol.1301271","volume":"191","author":"Z Wu","year":"2013","unstructured":"Wu Z, Li Y, MacNeil AJ, Junkins RD, Berman JN, Lin TJ (2013) Calcineurin\u2010Rcan1 interaction contributes to stem cell factor\u2010mediated mast cell activation. J Immunol 191: 5885\u20135894","journal-title":"J Immunol"},{"key":"BFEMBR201744706_CR67","doi-asserted-by":"crossref","first-page":"39051","DOI":"10.1074\/jbc.M604659200","volume":"281","author":"YS Kim","year":"2006","unstructured":"Kim YS, Cho K\u2010O, Lee HJ, Kim SY, Sato Y, Cho Y\u2010J (2006) Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti\u2010inflammatory effects. J Biol Chem 281: 39051\u201339061","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR68","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.4049\/jimmunol.1203196","volume":"190","author":"RD Junkins","year":"2013","unstructured":"Junkins RD, MacNeil AJ, Wu Z, McCormick C, Lin TJ (2013) Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol 190: 5178\u20135186","journal-title":"J Immunol"},{"key":"BFEMBR201744706_CR69","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.phrs.2018.01.001","volume":"133","author":"AB Garc\u00eda\u2010Redondo","year":"2018","unstructured":"Garc\u00eda\u2010Redondo AB, Esteban V, Briones AM, del Campo LSD, Gonz\u00e1lez\u2010Amor M, M\u00e9ndez\u2010Barbero N, Campanero MR, Redondo JM, Salaices M (2018) Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX\u20102\u2010derived prostanoids. Pharmacol Res 133: 236\u2013249","journal-title":"Pharmacol Res"},{"key":"BFEMBR201744706_CR70","doi-asserted-by":"crossref","first-page":"S285","DOI":"10.2337\/dc11-s239","volume":"34","author":"A Avogaro","year":"2011","unstructured":"Avogaro A, Albiero M, Menegazzo L, de Kreutzenberg S, Fadini GP (2011) Endothelial dysfunction in diabetes: the role of reparatory mechanisms. Diabetes Care 34: S285\u2013S290","journal-title":"Diabetes Care"},{"key":"BFEMBR201744706_CR71","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3389\/fimmu.2017.01323","volume":"8","author":"C Ballesteros\u2010Martinez","year":"2017","unstructured":"Ballesteros\u2010Martinez C, M\u00e9ndez\u2010Barbero N, Montalvo\u2010Yuste A, Jensen BM, Gomez\u2010Cardenosa A, Klitfod L, Garrido\u2010Arandia M, Alvarez\u2010Llamas G, Pastor\u2010Vargas C, Vivanco F et al (2017) Endothelial regulator of calcineurin 1 promotes barrier integrity and modulates histamine\u2010induced barrier dysfunction in anaphylaxis. Front Immunol 8: 1323","journal-title":"Front Immunol"},{"key":"BFEMBR201744706_CR72","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molmet.2015.09.004","volume":"4","author":"KA Dyar","year":"2015","unstructured":"Dyar KA, Ciciliot S, Tagliazucchi GM, Pallafacchina G, Tothova J, Argentini C, Agatea L, Abraham R, Ahdesm\u00e4ki M, Forcato M et al (2015) The calcineurin\u2010NFAT pathway controls activity\u2010dependent circadian gene expression in slow skeletal muscle. Mol Metab 4: 823\u2013833","journal-title":"Mol Metab"},{"key":"BFEMBR201744706_CR73","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/CIRCRESAHA.110.235309","volume":"108","author":"N Sachan","year":"2011","unstructured":"Sachan N, Dey A, Rotter D, Grinsfelder DB, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM et al (2011) Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin\u2010dependent signaling and protein phosphorylation in the heart. Circ Res 108: 437\u2013445","journal-title":"Circ Res"},{"key":"BFEMBR201744706_CR74","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2014.05.004","volume":"74C","author":"D Rotter","year":"2014","unstructured":"Rotter D, Grinsfelder DB, Parra V, Pedrozo Z, Singh S, Sachan N, Rothermel BA (2014) Calcineurin and its regulator, RCAN1, confer time\u2010of\u2010day changes in susceptibility of the heart to ischemia\/reperfusion. J Mol Cell Cardiol 74C: 103\u2013111","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMBR201744706_CR75","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiolgenomics.00108.2014","volume":"47","author":"KL Vermillion","year":"2015","unstructured":"Vermillion KL, Anderson KJ, Hampton M, Andrews MT (2015) Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal. Physiol Genomics 47: 58\u201374","journal-title":"Physiol Genomics"},{"key":"BFEMBR201744706_CR76","doi-asserted-by":"crossref","first-page":"48098","DOI":"10.18632\/oncotarget.18259","volume":"8","author":"L\u2010C Ding","year":"2017","unstructured":"Ding L\u2010C, Gong Q\u2010Q, Li S\u2010W, Fu X\u2010L, Jin Y\u2010C, Zhang J, Gao J\u2010G, Sun X\u2010Y (2017) Rcan2 and estradiol independently regulate body weight in female mice. Oncotarget 8: 48098\u201348109","journal-title":"Oncotarget"},{"key":"BFEMBR201744706_CR77","doi-asserted-by":"crossref","first-page":"e14605","DOI":"10.1371\/journal.pone.0014605","volume":"6","author":"X\u2010Y Sun","year":"2011","unstructured":"Sun X\u2010Y, Hayashi Y, Xu S, Kanou Y, Takagishi Y, Tang Y\u2010P, Murata Y (2011) Inactivation of the Rcan2 gene in mice ameliorates the age\u2010 and diet\u2010induced obesity by causing a reduction in food intake. PLoS ONE 6: e14605","journal-title":"PLoS ONE"},{"key":"BFEMBR201744706_CR78","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1161\/CIRCRESAHA.117.311522","volume":"122","author":"V Parra","year":"2018","unstructured":"Parra V, Altamirano F, Hern\u00e1ndez\u2010Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S et al (2018) Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused mitochondrial network. Circ Res 122: e20\u2013e33","journal-title":"Circ Res"},{"key":"BFEMBR201744706_CR79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molmet.2017.11.007","volume":"7","author":"DF Pisani","year":"2018","unstructured":"Pisani DF, Barquissau V, Chambard J\u2010C, Beuzelin D, Ghandour RA, Giroud M, Mairal A, Pagnotta S, Cinti S, Langin D et al (2018) Mitochondrial fission is associated with UCP1 activity in human brite\/beige adipocytes. Mol Metab 7: 35\u201344","journal-title":"Mol Metab"},{"key":"BFEMBR201744706_CR80","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpeds.2016.02.046","volume":"173","author":"JS Basil","year":"2016","unstructured":"Basil JS, Santoro SL, Martin LJ, Healy KW, Chini BA, Saal HM (2016) Retrospective study of obesity in children with Down syndrome. J Pediatr 173: 143\u2013148","journal-title":"J Pediatr"},{"key":"BFEMBR201744706_CR81","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/HJR.0b013e3282f2bff3","volume":"15","author":"P Flore","year":"2008","unstructured":"Flore P, Bricout V\u2010A, van Biesen D, Guinot M, Laporte F, P\u00e9pin J\u2010L, Eberhard Y, Favre\u2010Juvin A, Wuyam B, van de Vliet P et al (2008) Oxidative stress and metabolism at rest and during exercise in persons with Down syndrome. Eur J Cardiovasc Prev Rehabil 15: 35\u201342","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"BFEMBR201744706_CR82","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ejcn.2013.137","volume":"67","author":"DL Hill","year":"2013","unstructured":"Hill DL, Parks EP, Zemel BS, Shults J, Stallings VA, Stettler N (2013) Resting energy expenditure and adiposity accretion among children with Down syndrome: a 3\u2010year prospective study. Eur J Clin Nutr 67: 1087\u20131091","journal-title":"Eur J Clin Nutr"},{"key":"BFEMBR201744706_CR83","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1073\/pnas.0237225100","volume":"100","author":"RB Vega","year":"2003","unstructured":"Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel\u2010Duby R, Williams RS, Olson EN (2003) Dual roles of modulatory calcineurin\u2010interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci USA 100: 669\u2013674","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201744706_CR84","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/hmg\/ddm049","volume":"16","author":"S Porta","year":"2007","unstructured":"Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbon\u00e9s ML, Mart\u00ed E (2007) RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet 16: 1039\u20131050","journal-title":"Hum Mol Genet"},{"key":"BFEMBR201744706_CR85","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1038\/oby.2009.477","volume":"18","author":"A Nicholson","year":"2009","unstructured":"Nicholson A, Reifsnyder PC, Malcolm RD, Lucas CA, MacGregor GR, Zhang W, Leiter EH (2009) Diet\u2010induced obesity in Two C57BL\/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity 18: 1902\u20131905","journal-title":"Obesity"},{"key":"BFEMBR201744706_CR86","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bbabio.2009.06.005","volume":"1787","author":"N Parker","year":"2009","unstructured":"Parker N, Vidal\u2010Puig AJ, Azzu V, Brand MD (2009) Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. Biochim Biophys Acta 1787: 1451\u20131457","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBR201744706_CR87","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1083\/jcb.17.2.299","volume":"17","author":"GJ Todaro","year":"1963","unstructured":"Todaro GJ, Green H (1963) Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17: 299\u2013313","journal-title":"J Cell Biol"},{"key":"BFEMBR201744706_CR88","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cmet.2015.10.018","volume":"23","author":"L Vishvanath","year":"2016","unstructured":"Vishvanath L, MacPherson KA, Hepler C, Wang QA, Shao M, Spurgin SB, Wang MY, Kusminski CM, Morley TS, Gupta RK (2016) Mural preadipocytes contribute to adipocyte hyperplasia induced by high\u2010fat\u2010diet feeding and prolonged cold exposure in adult mice. Cell Metab 23: 350\u2013359","journal-title":"Cell Metab"},{"key":"BFEMBR201744706_CR89","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497\u2013509","journal-title":"J Biol Chem"},{"key":"BFEMBR201744706_CR90","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","volume":"31","author":"PA Yushkevich","year":"2006","unstructured":"Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, Gerig G (2006) User\u2010guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. NeuroImage 31: 1116\u20131128","journal-title":"NeuroImage"},{"key":"BFEMBR201744706_CR91","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0248-4900(03)00087-X","volume":"95","author":"O Agbulut","year":"2012","unstructured":"Agbulut O, Noirez P, Beaumont F, Butler\u2010Browne G (2012) Myosin heavy chain isoforms in postnatal muscle development of mice. Biol Cell 95: 399\u2013406","journal-title":"Biol Cell"},{"key":"BFEMBR201744706_CR92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nprot.2006.4","volume":"1","author":"H Sch\u00e4gger","year":"2006","unstructured":"Sch\u00e4gger H (2006) Tricine\u2010SDS\u2010PAGE. Nat Protoc 1: 16\u201322","journal-title":"Nat Protoc"},{"key":"BFEMBR201744706_CR93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuropharm.2017.04.010","volume":"123","author":"A Stefanidis","year":"2017","unstructured":"Stefanidis A, Watt MJ, Cowley MA, Oldfield BJ (2017) Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide. Neuropharmacology 123: 55\u201366","journal-title":"Neuropharmacology"},{"key":"BFEMBR201744706_CR94","doi-asserted-by":"crossref","first-page":"16623","DOI":"10.1074\/jbc.M109.098236","volume":"285","author":"M Oh","year":"2010","unstructured":"Oh M, Dey A, Gerard RD, Hill JA, Rothermel BA (2010) The CCAAT\/enhancer binding protein beta (C\/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1\u20104. J Biol Chem 285: 16623\u201316631","journal-title":"J Biol Chem"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201744706","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201744706\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201744706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201744706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:27:26Z","timestamp":1779110846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201744706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":94,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12,1]]}},"alternative-id":["BFEMBR201744706"],"URL":"https:\/\/doi.org\/10.15252\/embr.201744706","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,2]]},"assertion":[{"value":"26 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR201744706"}}