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By using xenograft orthotopic implantation of prostate cancer PC3 cells and subsequently comparing bone metastatic with primary tumor\u2010derived cancer cells, we find that H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing\u00a0enzyme cystathionine \u03b3\u2010lyase (CTH) is upregulated in bone\u2010metastatic PC3 cells. Clinical data further reveal that the expression of CTH is elevated in late\u2010stage prostate cancer patients, and higher CTH expression correlates with poor survival from The Cancer Genome Atlas (TCGA) prostate cancer RNA\u2010seq datasets. CTH promotes NF\u2010\u03baB nuclear translocation through H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010mediated sulfhydration on cysteine\u201038 of the NF\u2010\u03baB p65 subunit, resulting in increased IL\u20101\u03b2 expression and H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010induced cell invasion. Knockdown of CTH in PC3 cells results in the suppression of tumor growth and distant metastasis, while overexpression of CTH in DU145 cells promotes primary tumor growth and lymph node metastasis in the orthotopic implanted xenograft mouse model. Together, our findings provide evidence that CTH generated H\n                    <jats:sub>2<\/jats:sub>\n                    S promotes prostate cancer progression and metastasis through IL\u20101\u03b2\/NF\u2010\u03baB signaling pathways.\n                  <\/jats:p>","DOI":"10.15252\/embr.201845986","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T20:43:12Z","timestamp":1567111392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Dysregulation of cystathionine \u03b3\u2010lyase promotes prostate cancer progression and metastasis"],"prefix":"10.1038","volume":"20","author":[{"given":"Yi\u2010Hsiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Hsuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chien","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ru","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hsuan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Wang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing\u2010Jien","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-5755","authenticated-orcid":false,"given":"Kai\u2010Ti","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-8560","authenticated-orcid":false,"given":"Lu\u2010Hai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"BFEMBR201845986_CR1","first-page":"5","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel RL, Miller KD, Jemal A (2015) Cancer statistics, 2015. 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