{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:29:56Z","timestamp":1791563396593,"version":"4.3.4"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["SL220120605303"],"award-info":[{"award-number":["SL220120605303"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO15\u2010057"],"award-info":[{"award-number":["PLBIO15\u2010057"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO16\u2010161"],"award-info":[{"award-number":["PLBIO16\u2010161"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO16\u2010143"],"award-info":[{"award-number":["PLBIO16\u2010143"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO17\u2010183"],"award-info":[{"award-number":["PLBIO17\u2010183"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SIRIC Montpellier Cancer Grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.15252\/embr.201846589","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T03:19:24Z","timestamp":1540178364000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Mixed signals from the cell's antennae: primary cilia in cancer"],"prefix":"10.1038","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1891-9253","authenticated-orcid":false,"given":"Thibaut","family":"Eguether","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-6430","authenticated-orcid":false,"given":"Michael","family":"Hahne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"BFEMBR201846589_CR1","first-page":"391","volume":"1","author":"JE Purkinje","year":"1834","unstructured":"Purkinje JE, Valentin GG (1834) Entdeckung continuierlicher durch Wimperhaare erzeugter Flimmerbewegungen. Arch Anat Physiol 1: 391\u2013400","journal-title":"Arch Anat Physiol"},{"key":"BFEMBR201846589_CR2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1289\/ehp.803577","volume":"35","author":"P Satir","year":"1980","unstructured":"Satir P (1980) Structural basis of ciliary movement. Environ Health Perspect 35: 77\u201382","journal-title":"Environ Health Perspect"},{"key":"BFEMBR201846589_CR3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF02975837","volume":"52","author":"KW Zimmerman","year":"1898","unstructured":"Zimmerman KW (1898) Beitrage zur kenntnis einiger drusen und epithelien. Arch Mikrosk Anat 52: 552\u2013706","journal-title":"Arch Mikrosk Anat"},{"key":"BFEMBR201846589_CR4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0022-5320(61)80019-1","volume":"5","author":"BG Barnes","year":"1961","unstructured":"Barnes BG (1961) Ciliated secretory cells in the pars distalis of the mouse hypophysis. J Ultrastruct Res 5: 453\u2013467","journal-title":"J Ultrastruct Res"},{"key":"BFEMBR201846589_CR5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.15.2.363","volume":"15","author":"S Sorokin","year":"1962","unstructured":"Sorokin S (1962) Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol 15: 363\u2013377","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR6","volume-title":"The cell","author":"DW Fawcett","year":"1981","unstructured":"Fawcett DW (1981) The cell. Philadelphia, PA: Saunders"},{"key":"BFEMBR201846589_CR7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","volume":"151","author":"GJ Pazour","year":"2000","unstructured":"Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151: 709\u2013718","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","volume":"426","author":"D Huangfu","year":"2003","unstructured":"Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426: 83\u201387","journal-title":"Nature"},{"key":"BFEMBR201846589_CR9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","volume":"11","author":"SC Goetz","year":"2010","unstructured":"Goetz SC, Anderson KV (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11: 331\u2013344","journal-title":"Nat Rev Genet"},{"key":"BFEMBR201846589_CR10","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","volume":"364","author":"F Hildebrandt","year":"2011","unstructured":"Hildebrandt F, Benzing T, Katsanis N (2011) Ciliopathies. N Engl J Med 364: 1533\u20131543","journal-title":"N Engl J Med"},{"key":"BFEMBR201846589_CR11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ceb.2010.03.010","volume":"22","author":"R Rohatgi","year":"2010","unstructured":"Rohatgi R, Snell WJ (2010) The ciliary membrane. Curr Opin Cell Biol 22: 541\u2013546","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBR201846589_CR12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-679X(08)94007-3","volume":"94","author":"OV Plotnikova","year":"2009","unstructured":"Plotnikova OV, Pugacheva EN, Golemis EA (2009) Primary cilia and the cell cycle. Methods Cell Biol 94: 137\u2013160","journal-title":"Methods Cell Biol"},{"key":"BFEMBR201846589_CR13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.gene.2014.06.050","volume":"547","author":"Y\u2010N Ke","year":"2014","unstructured":"Ke Y\u2010N, Yang W\u2010X (2014) Primary cilium: an elaborate structure that blocks cell division? Gene 547: 175\u2013185","journal-title":"Gene"},{"key":"BFEMBR201846589_CR14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2046-2530-2-9","volume":"2","author":"WY Tsang","year":"2013","unstructured":"Tsang WY, Dynlacht BD (2013) CP110 and its network of partners coordinately regulate cilia assembly. Cilia 2: 9","journal-title":"Cilia"},{"key":"BFEMBR201846589_CR15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.201106101","volume":"197","author":"A Inoko","year":"2012","unstructured":"Inoko A, Matsuyama M, Goto H, Ohmuro\u2010Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T et al (2012) Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells. J Cell Biol 197: 391\u2013405","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR16","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1242\/jcs.135178","volume":"126","author":"G Wang","year":"2013","unstructured":"Wang G, Chen Q, Zhang X, Zhang B, Zhuo X, Liu J, Jiang Q, Zhang C (2013) PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. J Cell Sci 126: 1355\u20131365","journal-title":"J Cell Sci"},{"key":"BFEMBR201846589_CR17","doi-asserted-by":"crossref","first-page":"8087","DOI":"10.1038\/ncomms9087","volume":"6","author":"S Kim","year":"2015","unstructured":"Kim S, Lee K, Choi J\u2010H, Ringstad N, Dynlacht BD (2015) Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. Nat Commun 6: 8087","journal-title":"Nat Commun"},{"key":"BFEMBR201846589_CR18","first-page":"222","volume":"63","author":"DN Wheatley","year":"1995","unstructured":"Wheatley DN (1995) Primary cilia in normal and pathological tissues. Pathobiology 63: 222\u2013238","journal-title":"Pathobiology"},{"key":"BFEMBR201846589_CR19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/cbin.10500","volume":"39","author":"TJ Kowal","year":"2015","unstructured":"Kowal TJ, Falk MM (2015) Primary cilia found on HeLa and other cancer cells. Cell Biol Int 39: 1341\u20131347","journal-title":"Cell Biol Int"},{"key":"BFEMBR201846589_CR20","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1038\/onc.2017.117","volume":"36","author":"N Yang","year":"2017","unstructured":"Yang N, Leung EL\u2010H, Liu C, Li L, Eguether T, Jun Yao X\u2010J, Jones EC, Norris DA, Liu A, Clark RA et al (2017) INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene 36: 4997\u20135005","journal-title":"Oncogene"},{"key":"BFEMBR201846589_CR21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nm.2020","volume":"15","author":"Y\u2010G Han","year":"2009","unstructured":"Han Y\u2010G, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez\u2010Buylla A (2009) Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 15: 1062\u20131065","journal-title":"Nat Med"},{"key":"BFEMBR201846589_CR22","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nm.2011","volume":"15","author":"SY Wong","year":"2009","unstructured":"Wong SY, Seol AD, So P\u2010L, Ermilov AN, Bichakjian CK, Epstein EH, Dlugosz AA, Reiter JF (2009) Primary cilia can both mediate and suppress Hedgehog pathway\u2013dependent tumorigenesis. Nat Med 15: 1055\u20131061","journal-title":"Nat Med"},{"key":"BFEMBR201846589_CR23","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1091\/mbc.E17-10-0600","volume":"29","author":"T Eguether","year":"2018","unstructured":"Eguether T, Cordelieres FP, Pazour GJ (2018) Intraflagellar transport is deeply integrated in hedgehog signaling. Mol Biol Cell 29: 1178\u20131189","journal-title":"Mol Biol Cell"},{"key":"BFEMBR201846589_CR24","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1158\/1078-0432.CCR-11-0755","volume":"18","author":"NB Hassounah","year":"2012","unstructured":"Hassounah NB, Bunch TA, McDermott KM (2012) Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on hedgehog signaling. Clin Cancer Res 18: 2429\u20132435","journal-title":"Clin Cancer Res"},{"key":"BFEMBR201846589_CR25","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","volume":"437","author":"KC Corbit","year":"2005","unstructured":"Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DYR, Reiter JF (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018\u20131021","journal-title":"Nature"},{"key":"BFEMBR201846589_CR26","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pgen.0010053","volume":"1","author":"CJ Haycraft","year":"2005","unstructured":"Haycraft CJ, Banizs B, Aydin\u2010Son Y, Zhang Q, Michaud EJ, Yoder BK (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53","journal-title":"PLoS Genet"},{"key":"BFEMBR201846589_CR27","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ncb435","volume":"9","author":"R Rohatgi","year":"2007","unstructured":"Rohatgi R, Scott MP (2007) Patching the gaps in Hedgehog signalling. Nat Cell Biol 9: 1005\u20131009","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201846589_CR28","doi-asserted-by":"crossref","first-page":"e6839","DOI":"10.1371\/journal.pone.0006839","volume":"4","author":"PJR Ocbina","year":"2009","unstructured":"Ocbina PJR, Tuson M, Anderson KV (2009) Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One 4: e6839","journal-title":"PLoS One"},{"key":"BFEMBR201846589_CR29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.devcel.2016.07.026","volume":"38","author":"E Pak","year":"2016","unstructured":"Pak E, Segal RA (2016) Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy. Dev Cell 38: 333\u2013344","journal-title":"Dev Cell"},{"key":"BFEMBR201846589_CR30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chembiol.2017.02.010","volume":"24","author":"F Wu","year":"2017","unstructured":"Wu F, Zhang Y, Sun B, McMahon AP, Wang Y (2017) Hedgehog signaling: from basic biology to cancer therapy. Cell Chem Biol 24: 252\u2013280","journal-title":"Cell Chem Biol"},{"key":"BFEMBR201846589_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.201004108","volume":"191","author":"H Tukachinsky","year":"2010","unstructured":"Tukachinsky H, Lopez LV, Salic A (2010) A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu\u2010Gli protein complexes. J Cell Biol 191: 415\u2013428","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ncb2988","volume":"16","author":"M He","year":"2014","unstructured":"He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (2014) The kinesin\u20104 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. Nat Cell Biol 16: 663\u2013672","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201846589_CR33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-cellbio-092910-154048","volume":"27","author":"C\u2010C Hui","year":"2011","unstructured":"Hui C\u2010C, Angers S (2011) Gli proteins in development and disease. Annu Rev Cell Dev Biol 27: 513\u2013537","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBR201846589_CR34","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/ajmg.a.32909","volume":"152A","author":"MM Cohen","year":"2010","unstructured":"Cohen MM (2010) Hedgehog signaling update. Am J Med Genet A 152A: 1875\u20131914","journal-title":"Am J Med Genet A"},{"key":"BFEMBR201846589_CR35","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2012.12.026","volume":"152","author":"S Mukhopadhyay","year":"2013","unstructured":"Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK (2013) The ciliary G\u2010protein\u2010coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell 152: 210\u2013223","journal-title":"Cell"},{"key":"BFEMBR201846589_CR36","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.devcel.2012.04.009","volume":"22","author":"BT Keady","year":"2012","unstructured":"Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ (2012) IFT25 links the signal\u2010dependent movement of Hedgehog components to intraflagellar transport. Dev Cell 22: 940\u2013951","journal-title":"Dev Cell"},{"key":"BFEMBR201846589_CR37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.devcel.2014.09.011","volume":"31","author":"T Eguether","year":"2014","unstructured":"Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW et al (2014) IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell 31: 279\u2013290","journal-title":"Dev Cell"},{"key":"BFEMBR201846589_CR38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.devcel.2015.06.016","volume":"34","author":"M Ch\u00e1vez","year":"2015","unstructured":"Ch\u00e1vez M, Ena S, Van Sande J, de Kerchove d'Exaerde A, Schurmans S, Schiffmann SN (2015) Modulation of ciliary phosphoinositide content regulates trafficking and sonic hedgehog signaling output. Dev Cell 34: 338\u2013350","journal-title":"Dev Cell"},{"key":"BFEMBR201846589_CR39","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.devcel.2015.08.001","volume":"34","author":"FR Garcia\u2010Gonzalo","year":"2015","unstructured":"Garcia\u2010Gonzalo FR, Phua SC, Roberson EC, Garcia G, Abedin M, Schurmans S, Inoue T, Reiter JF (2015) Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling. Dev Cell 34: 400\u2013409","journal-title":"Dev Cell"},{"key":"BFEMBR201846589_CR40","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.3390\/cancers7030857","volume":"7","author":"D Gu","year":"2015","unstructured":"Gu D, Xie J (2015) Non\u2010canonical hh signaling in cancer\u2010current understanding and future directions. Cancers (Basel) 7: 1684\u20131698","journal-title":"Cancers (Basel)"},{"key":"BFEMBR201846589_CR41","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.18632\/oncotarget.4224","volume":"6","author":"A Gonnissen","year":"2015","unstructured":"Gonnissen A, Isebaert S, Haustermans K (2015) Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. Oncotarget 6: 13899\u201313913","journal-title":"Oncotarget"},{"key":"BFEMBR201846589_CR42","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1242\/dev.00821","volume":"130","author":"R Nusse","year":"2003","unstructured":"Nusse R (2003) Wnts and Hedgehogs: lipid\u2010modified proteins and similarities in signaling mechanisms at the cell surface. Development 130: 5297\u20135305","journal-title":"Development"},{"key":"BFEMBR201846589_CR43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.trecan.2017.01.001","volume":"3","author":"AM Daulat","year":"2017","unstructured":"Daulat AM, Borg J\u2010P (2017) Wnt\/Planar cell polarity signaling: new opportunities for cancer treatment. Trends Cancer 3: 113\u2013125","journal-title":"Trends Cancer"},{"key":"BFEMBR201846589_CR44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1097-2765(00)80446-3","volume":"5","author":"A Salic","year":"2000","unstructured":"Salic A, Lee E, Mayer L, Kirschner MW (2000) Control of beta\u2010catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell 5: 523\u2013532","journal-title":"Mol Cell"},{"key":"BFEMBR201846589_CR45","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ng1552","volume":"37","author":"M Simons","year":"2005","unstructured":"Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Kr\u00f6nig C, Schermer B, Benzing T, Cabello OA, Jenny A et al (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 37: 537\u2013543","journal-title":"Nat Genet"},{"key":"BFEMBR201846589_CR46","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1093\/hmg\/11.26.3345","volume":"11","author":"D Morgan","year":"2002","unstructured":"Morgan D, Eley L, Sayer J, Strachan T, Yates LM, Craighead AS, Goodship JA (2002) Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum Mol Genet 11: 3345\u20133350","journal-title":"Hum Mol Genet"},{"key":"BFEMBR201846589_CR47","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/ng1644","volume":"37","author":"AJ Ross","year":"2005","unstructured":"Ross AJ, May\u2010Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S et al (2005) Disruption of Bardet\u2010Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet 37: 1135\u20131140","journal-title":"Nat Genet"},{"key":"BFEMBR201846589_CR48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000208212","volume":"111","author":"IR Veland","year":"2009","unstructured":"Veland IR, Awan A, Pedersen LB, Yoder BK, Christensen ST (2009) Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol 111: 39\u201353","journal-title":"Nephron Physiol"},{"key":"BFEMBR201846589_CR49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1670","volume":"10","author":"KC Corbit","year":"2008","unstructured":"Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen M\u2010H, Chuang P\u2010T, Reiter JF (2008) Kif3a constrains beta\u2010catenin\u2010dependent Wnt signalling through dual ciliary and non\u2010ciliary mechanisms. Nat Cell Biol 10: 70\u201376","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201846589_CR50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.2008011","volume":"25","author":"JB Wallingford","year":"2011","unstructured":"Wallingford JB, Mitchell B (2011) Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev 25: 201\u2013213","journal-title":"Genes Dev"},{"key":"BFEMBR201846589_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.03.007","author":"KH Elliott","year":"2018","unstructured":"Elliott KH, Brugmann SA (2018) Sending mixed signals: Cilia\u2010dependent signaling during development and disease. Dev Biol https:\/\/doi.org\/10.1016\/j.ydbio.2018.03.007","journal-title":"Dev Biol"},{"key":"BFEMBR201846589_CR52","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1242\/dev.041343","volume":"136","author":"P Huang","year":"2009","unstructured":"Huang P, Schier AF (2009) Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136: 3089\u20103098","journal-title":"Development"},{"key":"BFEMBR201846589_CR53","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2011.05.030","volume":"145","author":"EJ Ezratty","year":"2011","unstructured":"Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145: 1129\u20131141","journal-title":"Cell"},{"key":"BFEMBR201846589_CR54","first-page":"2407","volume":"127","author":"CC Leitch","year":"2014","unstructured":"Leitch CC, Lodh S, Prieto\u2010Echag\u00fce V, Badano JL, Zaghloul NA (2014) Basal body proteins regulate Notch signaling through endosomal trafficking. J Cell Sci 127: 2407\u20132419","journal-title":"J Cell Sci"},{"key":"BFEMBR201846589_CR55","first-page":"2160","volume":"143","author":"L Grisanti","year":"2016","unstructured":"Grisanti L, Revenkova E, Gordon RE, Iomini C (2016) Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway. Development 143: 2160\u20132171","journal-title":"Development"},{"key":"BFEMBR201846589_CR56","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1073\/pnas.0909900107","volume":"107","author":"S Cervantes","year":"2010","unstructured":"Cervantes S, Lau J, Cano DA, Borromeo\u2010Austin C, Hebrok M (2010) Primary cilia regulate Gli\/Hedgehog activation in pancreas. Proc Natl Acad Sci USA 107: 10109\u201310114","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR57","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1172\/JCI71898","volume":"124","author":"YP Liu","year":"2014","unstructured":"Liu YP, Tsai I\u2010C, Morleo M, Oh EC, Leitch CC, Massa F, Lee B\u2010H, Parker DS, Finley D, Zaghloul NA et al (2014) Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest 124: 2059\u20132070","journal-title":"J Clin Invest"},{"key":"BFEMBR201846589_CR58","doi-asserted-by":"crossref","first-page":"a028167","DOI":"10.1101\/cshperspect.a028167","volume":"9","author":"ST Christensen","year":"2017","unstructured":"Christensen ST, Morthorst SK, Mogensen JB, Pedersen LB (2017) Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor \u03b2 (TGF\u2010\u03b2) signaling. Cold Spring Harb Perspect Biol 9: a028167","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"BFEMBR201846589_CR59","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.cub.2005.09.012","volume":"15","author":"L Schneider","year":"2005","unstructured":"Schneider L, Clement CA, Teilmann SC, Pazour GJ, Hoffmann EK, Satir P, Christensen ST (2005) PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol 15: 1861\u20131866","journal-title":"Curr Biol"},{"key":"BFEMBR201846589_CR60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.201611050","volume":"217","author":"FM Schmid","year":"2018","unstructured":"Schmid FM, Schou KB, Vilhelm MJ, Holm MS, Breslin L, Farinelli P, Larsen LA, Andersen JS, Pedersen LB, Christensen ST (2018) IFT20 modulates ciliary PDGFR\u03b1 signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biol 217: 151\u2013161","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR61","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrc3143","volume":"11","author":"CL Corless","year":"2011","unstructured":"Corless CL, Barnett CM, Heinrich MC (2011) Gastrointestinal stromal tumours: origin and molecular oncology. Nat Rev Cancer 11: 865\u2013878","journal-title":"Nat Rev Cancer"},{"key":"BFEMBR201846589_CR62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.trecan.2016.11.008","volume":"3","author":"S Colak","year":"2017","unstructured":"Colak S, Ten Dijke P (2017) Targeting TGF\u2010\u03b2 signaling in cancer. Trends Cancer 3: 56\u201371","journal-title":"Trends Cancer"},{"key":"BFEMBR201846589_CR63","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.celrep.2013.05.020","volume":"3","author":"CA Clement","year":"2013","unstructured":"Clement CA, Ajbro KD, Koefoed K, Vestergaard ML, Veland IR, Henriques de Jesus MPR, Pedersen LB, Benmerah A, Andersen CY, Larsen LA et al (2013) TGF\u2010\u03b2 signaling is associated with endocytosis at the pocket region of the primary cilium. Cell Rep 3: 1806\u20131814","journal-title":"Cell Rep"},{"key":"BFEMBR201846589_CR64","doi-asserted-by":"crossref","first-page":"35542","DOI":"10.1038\/srep35542","volume":"6","author":"M\u2010N Labour","year":"2016","unstructured":"Labour M\u2010N, Riffault M, Christensen ST, Hoey DA (2016) TGF\u03b21 \u2010 induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3\u2010dependent manner. Sci Rep 6: 35542","journal-title":"Sci Rep"},{"key":"BFEMBR201846589_CR65","doi-asserted-by":"crossref","first-page":"eaam7464","DOI":"10.1126\/scisignal.aam7464","volume":"10","author":"S Gencer","year":"2017","unstructured":"Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH et al (2017) TGF\u2010\u03b2 receptor I\/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal 10: eaam7464","journal-title":"Sci Signal"},{"key":"BFEMBR201846589_CR66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ydbio.2008.02.026","volume":"317","author":"N Spassky","year":"2008","unstructured":"Spassky N, Han Y\u2010G, Aguilar A, Strehl L, Besse L, Laclef C, Ros MR, Garcia\u2010Verdugo JM, Alvarez\u2010Buylla A (2008) Primary cilia are required for cerebellar development and Shh\u2010dependent expansion of progenitor pool. Dev Biol 317: 246\u2013259","journal-title":"Dev Biol"},{"key":"BFEMBR201846589_CR67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0896-6273(00)80682-0","volume":"22","author":"RJ Wechsler\u2010Reya","year":"1999","unstructured":"Wechsler\u2010Reya RJ, Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103\u2013114","journal-title":"Neuron"},{"key":"BFEMBR201846589_CR68","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1073\/pnas.96.9.5043","volume":"96","author":"JR Marszalek","year":"1999","unstructured":"Marszalek JR, Ruiz\u2010Lozano P, Roberts E, Chien KR, Goldstein LS (1999) Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin\u2010II. Proc Natl Acad Sci USA 96: 5043\u20135048","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR69","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/dev.02732","volume":"134","author":"CJ Haycraft","year":"2007","unstructured":"Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK (2007) Intraflagellar transport is essential for endochondral bone formation. Development 134: 307\u2013316","journal-title":"Development"},{"key":"BFEMBR201846589_CR70","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/carcin\/bgt041","volume":"34","author":"MT Barakat","year":"2013","unstructured":"Barakat MT, Humke EW, Scott MP (2013) Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis 34: 1382\u20131392","journal-title":"Carcinogenesis"},{"key":"BFEMBR201846589_CR71","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2174\/1871527314666150429113851","volume":"14","author":"D Gate","year":"2015","unstructured":"Gate D, Danielpour M, Bannykh S, Town T (2015) Characterization of cancer stem cells and primary cilia in medulloblastoma. CNS Neurol Disord Drug Targets 14: 600\u2013611","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"BFEMBR201846589_CR72","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1038\/onc.2017.208","volume":"36","author":"SE Conduit","year":"2017","unstructured":"Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM (2017) A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene 36: 5969\u20135984","journal-title":"Oncogene"},{"key":"BFEMBR201846589_CR73","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1073\/pnas.1706977115","volume":"115","author":"SN Bay","year":"2018","unstructured":"Bay SN, Long AB, Caspary T (2018) Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation. Proc Natl Acad Sci USA 115: 1570\u20131575","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR74","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.celrep.2018.01.018","volume":"22","author":"IS Shimada","year":"2018","unstructured":"Shimada IS, Hwang S\u2010H, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z et al (2018) Basal suppression of the sonic hedgehog pathway by the G\u2010Protein\u2010Coupled receptor Gpr161 restricts medulloblastoma pathogenesis. Cell Rep 22: 1169\u20131184","journal-title":"Cell Rep"},{"key":"BFEMBR201846589_CR75","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11060-013-1340-y","volume":"117","author":"MR Sarkisian","year":"2014","unstructured":"Sarkisian MR, Siebzehnrubl D, Hoang\u2010Minh L, Deleyrolle L, Silver DJ, Siebzehnrubl FA, Guadiana SM, Srivinasan G, Semple\u2010Rowland S, Harrison JK et al (2014) Detection of primary cilia in human glioblastoma. J Neurooncol 117: 15\u201324","journal-title":"J Neurooncol"},{"key":"BFEMBR201846589_CR76","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/1471-2407-9-448","volume":"9","author":"JJ Moser","year":"2009","unstructured":"Moser JJ, Fritzler MJ, Rattner JB (2009) Primary ciliogenesis defects are associated with human astrocytoma\/glioblastoma cells. BMC Cancer 9: 448","journal-title":"BMC Cancer"},{"key":"BFEMBR201846589_CR77","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1472-6890-14-40","volume":"14","author":"JJ Moser","year":"2014","unstructured":"Moser JJ, Fritzler MJ, Rattner JB (2014) Ultrastructural characterization of primary cilia in pathologically characterized human glioblastoma multiforme (GBM) tumors. BMC Clin Pathol 14: 40","journal-title":"BMC Clin Pathol"},{"key":"BFEMBR201846589_CR78","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/embor.2013.80","volume":"14","author":"Y Yang","year":"2013","unstructured":"Yang Y, Roine N, M\u00e4kel\u00e4 TP (2013) CCRK depletion inhibits glioblastoma cell proliferation in a cilium\u2010dependent manner. EMBO Rep 14: 741\u2013747","journal-title":"EMBO Rep"},{"key":"BFEMBR201846589_CR79","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41388-017-0049-3","volume":"37","author":"YV Loskutov","year":"2018","unstructured":"Loskutov YV, Griffin CL, Marinak KM, Bobko A, Margaryan NV, Geldenhuys WJ, Sarkaria JN, Pugacheva EN (2018) LPA signaling is regulated through the primary cilium: a novel target in glioblastoma. Oncogene 37: 1457\u20131471","journal-title":"Oncogene"},{"key":"BFEMBR201846589_CR80","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ncb3327","volume":"18","author":"L Li","year":"2016","unstructured":"Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HGW, Calicchio ML, Zeng E, Salisbury JL, Wechsler\u2010Reya RJ et al (2016) Sonic Hedgehog promotes proliferation of Notch\u2010dependent monociliated choroid plexus tumour cells. Nat Cell Biol 18: 418\u2013430","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201846589_CR81","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fncel.2015.00039","volume":"9","author":"K Narita","year":"2015","unstructured":"Narita K, Takeda S (2015) Cilia in the choroid plexus: their roles in hydrocephalus and beyond. Front Cell Neurosci 9: 39","journal-title":"Front Cell Neurosci"},{"key":"BFEMBR201846589_CR82","first-page":"2291","volume":"142","author":"M Stasiulewicz","year":"2015","unstructured":"Stasiulewicz M, Gray SD, Mastromina I, Silva JC, Bj\u00f6rklund M, Seymour PA, Booth D, Thompson C, Green RJ, Hall EA et al (2015) A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development 142: 2291\u20132303","journal-title":"Development"},{"key":"BFEMBR201846589_CR83","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/34201","volume":"391","author":"J Xie","year":"1998","unstructured":"Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A et al (1998) Activating Smoothened mutations in sporadic basal\u2010cell carcinoma. Nature 391: 90\u201392","journal-title":"Nature"},{"key":"BFEMBR201846589_CR84","doi-asserted-by":"crossref","first-page":"e27410","DOI":"10.1371\/journal.pone.0027410","volume":"6","author":"J Kim","year":"2011","unstructured":"Kim J, Dabiri S, Seeley ES (2011) Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma. PLoS One 6: e27410","journal-title":"PLoS One"},{"key":"BFEMBR201846589_CR85","doi-asserted-by":"crossref","first-page":"150209","DOI":"10.1098\/rsob.150209","volume":"5","author":"PA Coelho","year":"2015","unstructured":"Coelho PA, Bury L, Shahbazi MN, Liakath\u2010Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC et al (2015) Over\u2010expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biol 5: 150209","journal-title":"Open Biol"},{"key":"BFEMBR201846589_CR86","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1007\/s11033-014-3546-2","volume":"41","author":"K Shinmura","year":"2014","unstructured":"Shinmura K, Kurabe N, Goto M, Yamada H, Natsume H, Konno H, Sugimura H (2014) PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer. Mol Biol Rep 41: 6635\u20136644","journal-title":"Mol Biol Rep"},{"key":"BFEMBR201846589_CR87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccell.2018.06.001","volume":"34","author":"D Zingg","year":"2018","unstructured":"Zingg D, Debbache J, Pe\u00f1a\u2010Hern\u00e1ndez R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Cal\u00e7ada RR, Tuncer E et al (2018) EZH2\u2010mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell 34: 69\u201384.e14","journal-title":"Cancer Cell"},{"key":"BFEMBR201846589_CR88","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1369\/jhc.2010.955856","volume":"58","author":"K Yuan","year":"2010","unstructured":"Yuan K, Frolova N, Xie Y, Wang D, Cook L, Kwon Y\u2010J, Steg AD, Serra R, Frost AR (2010) Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem 58: 857\u2013870","journal-title":"J Histochem Cytochem"},{"key":"BFEMBR201846589_CR89","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/gtc.12122","volume":"19","author":"K Nobutani","year":"2014","unstructured":"Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S et al (2014) Absence of primary cilia in cell cycle\u2010arrested human breast cancer cells. Genes Cells 19: 141\u2013152","journal-title":"Genes Cells"},{"key":"BFEMBR201846589_CR90","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2046-2530-3-7","volume":"3","author":"I Menzl","year":"2014","unstructured":"Menzl I, Lebeau L, Pandey R, Hassounah NB, Li FW, Nagle R, Weihs K, McDermott KM (2014) Loss of primary cilia occurs early in breast cancer development. Cilia 3: 7","journal-title":"Cilia"},{"key":"BFEMBR201846589_CR91","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1158\/1541-7786.MCR-17-0034","volume":"15","author":"NB Hassounah","year":"2017","unstructured":"Hassounah NB, Nunez M, Fordyce C, Roe D, Nagle R, Bunch T, McDermott KM (2017) Inhibition of ciliogenesis promotes hedgehog signaling, tumorigenesis, and metastasis in breast cancer. Mol Cancer Res 15: 1421\u20131430","journal-title":"Mol Cancer Res"},{"key":"BFEMBR201846589_CR92","first-page":"E10532","volume":"114","author":"VJ Guen","year":"2017","unstructured":"Guen VJ, Chavarria TE, Kr\u00f6ger C, Ye X, Weinberg RA, Lees JA (2017) EMT programs promote basal mammary stem cell and tumor\u2010initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Proc Natl Acad Sci USA 114: E10532\u2013E10539","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR93","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cub.2010.02.048","volume":"20","author":"KM McDermott","year":"2010","unstructured":"McDermott KM, Liu BY, Tlsty TD, Pazour GJ (2010) Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol 20: 731\u2013737","journal-title":"Curr Biol"},{"key":"BFEMBR201846589_CR94","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13058-017-0897-3","volume":"19","author":"S L\u00e9gar\u00e9","year":"2017","unstructured":"L\u00e9gar\u00e9 S, Chabot C, Basik M (2017) SPEN, a new player in primary cilia formation and cell migration in breast cancer. Breast Cancer Res 19: 104","journal-title":"Breast Cancer Res"},{"key":"BFEMBR201846589_CR95","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1158\/0008-5472.CAN-14-3475","volume":"75","author":"S L\u00e9gar\u00e9","year":"2015","unstructured":"L\u00e9gar\u00e9 S, Cavallone L, Mamo A, Chabot C, Sirois I, Magliocco A, Klimowicz A, Tonin PN, Buchanan M, Keilty D et al (2015) The estrogen receptor cofactor SPEN functions as a tumor suppressor and candidate biomarker of drug responsiveness in hormone\u2010dependent breast cancers. Cancer Res 75: 4351\u20134363","journal-title":"Cancer Res"},{"key":"BFEMBR201846589_CR96","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.18632\/oncotarget.7198","volume":"7","author":"NA Khan","year":"2016","unstructured":"Khan NA, Willemarck N, Talebi A, Marchand A, Binda MM, Dehairs J, Rueda\u2010Rincon N, Daniels VW, Bagadi M, Thimiri Govinda Raj DB et al (2016) Identification of drugs that restore primary cilium expression in cancer cells. Oncotarget 7: 9975\u20139992","journal-title":"Oncotarget"},{"key":"BFEMBR201846589_CR97","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1038\/onc.2009.220","volume":"28","author":"JM Bailey","year":"2009","unstructured":"Bailey JM, Mohr AM, Hollingsworth MA (2009) Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28: 3513\u20133525","journal-title":"Oncogene"},{"key":"BFEMBR201846589_CR98","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1158\/0008-5472.CAN-08-1290","volume":"69","author":"ES Seeley","year":"2009","unstructured":"Seeley ES, Carri\u00e8re C, Goetze T, Longnecker DS, Korc M (2009) Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res 69: 422\u2013430","journal-title":"Cancer Res"},{"key":"BFEMBR201846589_CR99","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1084\/jem.20170399","volume":"215","author":"Y\u2010Z Deng","year":"2017","unstructured":"Deng Y\u2010Z, Cai Z, Shi S, Jiang H, Shang Y\u2010R, Ma N, Wang J\u2010J, Guan D\u2010X, Chen T\u2010W, Rong Y\u2010F et al (2017) Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med 215: 177\u2013195","journal-title":"J Exp Med"},{"key":"BFEMBR201846589_CR100","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.humpath.2013.11.017","volume":"45","author":"K Emoto","year":"2014","unstructured":"Emoto K, Masugi Y, Yamazaki K, Effendi K, Tsujikawa H, Tanabe M, Kitagawa Y, Sakamoto M (2014) Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma. Hum Pathol 45: 817\u2013825","journal-title":"Hum Pathol"},{"key":"BFEMBR201846589_CR101","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1073\/pnas.0813203106","volume":"106","author":"H Tian","year":"2009","unstructured":"Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ (2009) Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 106: 4254\u20134259","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR102","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41568-018-0023-6","volume":"18","author":"H Liu","year":"2018","unstructured":"Liu H, Kiseleva AA, Golemis EA (2018) Ciliary signalling in cancer. Nat Rev Cancer 18: 511\u2013524","journal-title":"Nat Rev Cancer"},{"key":"BFEMBR201846589_CR103","doi-asserted-by":"crossref","first-page":"334","DOI":"10.15252\/embr.201541922","volume":"18","author":"T Kobayashi","year":"2017","unstructured":"Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht BD, Itoh H (2017) HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma. EMBO Rep 18: 334\u2013343","journal-title":"EMBO Rep"},{"key":"BFEMBR201846589_CR104","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ncb899","volume":"5","author":"A Hergovich","year":"2003","unstructured":"Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W (2003) Regulation of microtubule stability by the von Hippel\u2010Lindau tumour suppressor protein pVHL. Nat Cell Biol 5: 64\u201370","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201846589_CR105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/modpathol.2008.132","volume":"22","author":"P Schraml","year":"2009","unstructured":"Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W, Moch H (2009) Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia. Mod Pathol 22: 31\u201336","journal-title":"Mod Pathol"},{"key":"BFEMBR201846589_CR106","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2046-2530-2-2","volume":"2","author":"SG Basten","year":"2013","unstructured":"Basten SG, Willekers S, Vermaat JS, Slaats GG, Voest EE, van Diest PJ, Giles RH (2013) Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue. Cilia 2: 2","journal-title":"Cilia"},{"key":"BFEMBR201846589_CR107","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1681\/ASN.2013090984","volume":"26","author":"R Dere","year":"2015","unstructured":"Dere R, Perkins AL, Bawa\u2010Khalfe T, Jonasch D, Walker CL (2015) \u03b2\u2010catenin links von Hippel\u2010Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. J Am Soc Nephrol 26: 553\u2013564","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR201846589_CR108","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1074\/jbc.M114.589226","volume":"290","author":"X\u2010F Ding","year":"2015","unstructured":"Ding X\u2010F, Zhou J, Hu Q\u2010Y, Liu S\u2010C, Chen G (2015) The tumor suppressor pVHL down\u2010regulates never\u2010in\u2010mitosis A\u2010related kinase 8 via hypoxia\u2010inducible factors to maintain cilia in human renal cancer cells. J Biol Chem 290: 1389\u20131394","journal-title":"J Biol Chem"},{"key":"BFEMBR201846589_CR109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-pathol-012414-040306","volume":"10","author":"IJ Frew","year":"2015","unstructured":"Frew IJ, Moch H (2015) A clearer view of the molecular complexity of clear cell renal cell carcinoma. Annu Rev Pathol 10: 263\u2013289","journal-title":"Annu Rev Pathol"},{"key":"BFEMBR201846589_CR110","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm.4343","volume":"23","author":"S Harlander","year":"2017","unstructured":"Harlander S, Sch\u00f6nenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ (2017) Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice. Nat Med 23: 869\u2013877","journal-title":"Nat Med"},{"key":"BFEMBR201846589_CR111","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2046-2530-1-15","volume":"1","author":"DL Egeberg","year":"2012","unstructured":"Egeberg DL, Lethan M, Manguso R, Schneider L, Awan A, J\u00f8rgensen TS, Byskov AG, Pedersen LB, Christensen ST (2012) Primary cilia and aberrant cell signaling in epithelial ovarian cancer. Cilia 1: 15","journal-title":"Cilia"},{"key":"BFEMBR201846589_CR112","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature10212","volume":"474","author":"JP Medema","year":"2011","unstructured":"Medema JP, Vermeulen L (2011) Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474: 318\u2013326","journal-title":"Nature"},{"key":"BFEMBR201846589_CR113","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.15252\/embj.201488466","volume":"33","author":"C Rocha","year":"2014","unstructured":"Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P et al (2014) Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. EMBO J 33: 2247\u20132260","journal-title":"EMBO J"},{"key":"BFEMBR201846589_CR114","first-page":"1233","volume":"21","author":"J Dvorak","year":"2016","unstructured":"Dvorak J, Hadzi Nikolov D, Dusek L, Filipova A, Richter I, Buka D, Ryska A, Mokry J, Filip S, Melichar B et al (2016) Prognostic significance of the frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma. J BUON 21: 1233\u20131241","journal-title":"J BUON"},{"key":"BFEMBR201846589_CR115","first-page":"1477","volume":"22","author":"J Dvorak","year":"2017","unstructured":"Dvorak J, Hadzi Nikolov D, Dusek L, Filipova A, Richter I, Buka D, Ryska A, Mokry J, Filip S, Melichar B et al (2017) Association of the combined parameters including the frequency of primary cilia, CD8+ tumor infiltrating lymphocytes and PD\u20101 expression with the outcome in intestinal cancer. J BUON 22: 1477\u20131487","journal-title":"J BUON"},{"key":"BFEMBR201846589_CR116","doi-asserted-by":"crossref","first-page":"e68521","DOI":"10.1371\/journal.pone.0068521","volume":"8","author":"NB Hassounah","year":"2013","unstructured":"Hassounah NB, Nagle R, Saboda K, Roe DJ, Dalkin BL, McDermott KM (2013) Primary cilia are lost in preinvasive and invasive prostate cancer. PLoS One 8: e68521","journal-title":"PLoS One"},{"key":"BFEMBR201846589_CR117","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.1073\/pnas.1323265111","volume":"111","author":"W Fu","year":"2014","unstructured":"Fu W, Asp P, Canter B, Dynlacht BD (2014) Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc Natl Acad Sci USA 111: 9151\u20139156","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201846589_CR118","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.1038\/onc.2012.588","volume":"32","author":"L Ho","year":"2013","unstructured":"Ho L, Ali SA, Al\u2010Jazrawe M, Kandel R, Wunder JS, Alman BA (2013) Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. Oncogene 32: 5388\u20135396","journal-title":"Oncogene"},{"key":"BFEMBR201846589_CR119","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/B978-0-12-407757-7.00016-5","volume":"115","author":"MM Magiera","year":"2013","unstructured":"Magiera MM, Janke C (2013) Investigating tubulin posttranslational modifications with specific antibodies. Methods Cell Biol 115: 247\u2013267","journal-title":"Methods Cell Biol"},{"key":"BFEMBR201846589_CR120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/jclinpath-2016-204103","volume":"70","author":"B Yasar","year":"2017","unstructured":"Yasar B, Linton K, Slater C, Byers R (2017) Primary cilia are increased in number and demonstrate structural abnormalities in human cancer. J Clin Pathol 70: 571\u2013574","journal-title":"J Clin Pathol"},{"key":"BFEMBR201846589_CR121","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.201406055","volume":"206","author":"C Janke","year":"2014","unstructured":"Janke C (2014) The tubulin code: molecular components, readout mechanisms, and functions. J Cell Biol 206: 461\u2013472","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR122","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1083\/jcb.201612050","volume":"216","author":"S Gadadhar","year":"2017","unstructured":"Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bi\u00e8che I, Rusconi F, Janke C (2017) Tubulin glycylation controls primary cilia length. J Cell Biol 216: 2701\u20132713","journal-title":"J Cell Biol"},{"key":"BFEMBR201846589_CR123","doi-asserted-by":"crossref","first-page":"79117","DOI":"10.18632\/oncotarget.12997","volume":"7","author":"J Lee","year":"2016","unstructured":"Lee J, Yi S, Kang YE, Chang JY, Kim JT, Sul HJ, Kim JO, Kim JM, Kim J, Porcelli AM et al (2016) Defective ciliogenesis in thyroid h\u00fcrthle cell tumors is associated with increased autophagy. Oncotarget 7: 79117\u201379130","journal-title":"Oncotarget"},{"key":"BFEMBR201846589_CR124","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1016\/j.celrep.2018.05.016","volume":"23","author":"AD Jenks","year":"2018","unstructured":"Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M et al (2018) Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer. Cell Rep 23: 3042\u20133055","journal-title":"Cell Rep"},{"key":"BFEMBR201846589_CR125","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/mc.22690","volume":"56","author":"A Bakshi","year":"2017","unstructured":"Bakshi A, Chaudhary SC, Rana M, Elmets CA, Athar M (2017) Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol Carcinog 56: 2543\u20132557","journal-title":"Mol Carcinog"},{"key":"BFEMBR201846589_CR126","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/cam4.1171","volume":"6","author":"F Bautista","year":"2017","unstructured":"Bautista F, Fioravantti V, de Rojas T, Carceller F, Madero L, Lassaletta A, Moreno L (2017) Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update. Cancer Med 6: 2606\u20132624","journal-title":"Cancer Med"},{"key":"BFEMBR201846589_CR127","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/ijo.2015.3006","volume":"47","author":"AL Spann","year":"2015","unstructured":"Spann AL, Yuan K, Goliwas KF, Steg AD, Kaushik DD, Kwon Y\u2010J, Frost AR (2015) The presence of primary cilia in cancer cells does not predict responsiveness to modulation of smoothened activity. Int J Oncol 47: 269\u2013279","journal-title":"Int J Oncol"},{"key":"BFEMBR201846589_CR128","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1158\/2159-8290.CD-17-0281","volume":"7","author":"X Zhao","year":"2017","unstructured":"Zhao X, Pak E, Ornell KJ, Pazyra\u2010Murphy MF, MacKenzie EL, Chadwick EJ, Ponomaryov T, Kelleher JF, Segal RA (2017) A transposon screen identifies loss of primary cilia as a mechanism of resistance to SMO inhibitors. Cancer Discov 7: 1436\u20131449","journal-title":"Cancer Discov"},{"key":"BFEMBR201846589_CR129","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1111\/febs.13023","volume":"281","author":"S Colak","year":"2014","unstructured":"Colak S, Medema JP (2014) Cancer stem cells\u2013important players in tumor therapy resistance. FEBS J 281: 4779\u20134791","journal-title":"FEBS J"},{"key":"BFEMBR201846589_CR130","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nrm3227","volume":"12","author":"C Janke","year":"2011","unstructured":"Janke C, Bulinski JC (2011) Post\u2010translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol 12: 773\u2013786","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201846589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201846589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201846589\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201846589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201846589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:28:36Z","timestamp":1779110916000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201846589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":130,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,1]]}},"alternative-id":["BFEMBR201846589"],"URL":"https:\/\/doi.org\/10.15252\/embr.201846589","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]},"assertion":[{"value":"14 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR201846589"}}