{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:20:45Z","timestamp":1793254845824,"version":"4.5.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005028","name":"Benozyio Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["757743"],"award-info":[{"award-number":["757743"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["619\/16"],"award-info":[{"award-number":["619\/16"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["119034"],"award-info":[{"award-number":["119034"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2020,1,7]]},"DOI":"10.15252\/embr.201947882","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T08:34:36Z","timestamp":1576053276000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Schistosomal extracellular vesicle\u2010enclosed miRNAs modulate host T helper cell differentiation"],"prefix":"10.1038","volume":"21","author":[{"given":"Tal","family":"Meningher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0883-8425","authenticated-orcid":false,"given":"Yiftah","family":"Barsheshet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Ofir\u2010Birin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Brant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elya","family":"Dekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechezkel","family":"Sidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-9084","authenticated-orcid":false,"given":"Eli","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-0193","authenticated-orcid":false,"given":"Neta","family":"Regev\u2010Rudzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-9564","authenticated-orcid":false,"given":"Orly","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-1840","authenticated-orcid":false,"given":"Dror","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"BFEMBR201947882_CR1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2310\/7060.2003.35759","volume":"10","author":"MP Grobusch","year":"2003","unstructured":"Grobusch MP, Muhlberger N, Jelinek T, Bisoffi Z, Corachan M, Harms G, Matteelli A, Fry G, Hatz C, Gjorup I et\u00a0al (2003) Imported schistosomiasis in Europe: sentinel surveillance data from TropNetEurop. J Travel Med 10: 164\u2013169","journal-title":"J Travel Med"},{"key":"BFEMBR201947882_CR2","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3201\/eid1211.060340","volume":"12","author":"E Meltzer","year":"2006","unstructured":"Meltzer E, Artom G, Marva E, Assous MV, Rahav G, Schwartzt E (2006) Schistosomiasis among travelers: new aspects of an old disease. Emerg Infect Dis 12: 1696\u20131700","journal-title":"Emerg Infect Dis"},{"key":"BFEMBR201947882_CR3","first-page":"386","volume":"26","author":"L Hornstein","year":"1990","unstructured":"Hornstein L, Lederer G, Schechter J, Greenberg Z, Boem R, Bilguray B, Giladi L, Hamburger J (1990) Persistent Schistosoma mansoni infection in Yemeni immigrants to Israel. Isr J Med Sci 26: 386\u2013389","journal-title":"Isr J Med Sci"},{"key":"BFEMBR201947882_CR4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4269\/ajtmh.1974.23.902","volume":"23","author":"KS Warren","year":"1974","unstructured":"Warren KS, Mahmoud AA, Cummings P, Murphy DJ, Houser HB (1974) Schistosomiasis mansoni in Yemeni in California: duration of infection, presence of disease, therapeutic management. Am J Trop Med Hyg 23: 902\u2013909","journal-title":"Am J Trop Med Hyg"},{"key":"BFEMBR201947882_CR5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nri1601","volume":"5","author":"DW Dunne","year":"2005","unstructured":"Dunne DW, Cooke A (2005) A worm's eye view of the immune system: consequences for evolution of human autoimmune disease. Nat Rev Immunol 5: 420\u2013426","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201947882_CR6","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1408::AID-IMMU1408>3.0.CO;2-H","volume":"28","author":"PG Fallon","year":"1998","unstructured":"Fallon PG, Smith P, Dunne DW (1998) Type 1 and type 2 cytokine\u2010producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection. Eur J Immunol 28: 1408\u20131416","journal-title":"Eur J Immunol"},{"key":"BFEMBR201947882_CR7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0105-2896.2004.00187.x","volume":"201","author":"EJ Pearce","year":"2004","unstructured":"Pearce EJ, C MK, Sun J, Taylor J, McKee AS, Cervi L (2004) Th2 response polarization during infection with the helminth parasite Schistosoma mansoni. Immunol Rev 201: 117\u2013126","journal-title":"Immunol Rev"},{"key":"BFEMBR201947882_CR8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00281-012-0354-4","volume":"34","author":"K Fairfax","year":"2012","unstructured":"Fairfax K, Nascimento M, Huang SC, Everts B, Pearce EJ (2012) Th2 responses in schistosomiasis. Semin Immunopathol 34: 863\u2013871","journal-title":"Semin Immunopathol"},{"key":"BFEMBR201947882_CR9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.coi.2012.06.003","volume":"24","author":"RM Maizels","year":"2012","unstructured":"Maizels RM, Hewitson JP, Smith KA (2012) Susceptibility and immunity to helminth parasites. Curr Opin Immunol 24: 459\u2013466","journal-title":"Curr Opin Immunol"},{"key":"BFEMBR201947882_CR10","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","volume":"112","author":"J Zhu","year":"2008","unstructured":"Zhu J, Paul WE (2008) CD4 T cells: fates, functions, and faults. Blood 112: 1557\u20131569","journal-title":"Blood"},{"key":"BFEMBR201947882_CR11","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1258\/0007142001903634","volume":"56","author":"A Rao","year":"2000","unstructured":"Rao A, Avni O (2000) Molecular aspects of T\u2010cell differentiation. Br Med Bull 56: 969\u2013984","journal-title":"Br Med Bull"},{"key":"BFEMBR201947882_CR12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0952-7915(00)00158-8","volume":"12","author":"O Avni","year":"2000","unstructured":"Avni O, Rao A (2000) T cell differentiation: a mechanistic view. Curr Opin Immunol 12: 654\u2013659","journal-title":"Curr Opin Immunol"},{"key":"BFEMBR201947882_CR13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","volume":"30","author":"L Zhou","year":"2009","unstructured":"Zhou L, Chong MM, Littman DR (2009) Plasticity of CD4+ T cell lineage differentiation. Immunity 30: 646\u2013655","journal-title":"Immunity"},{"key":"BFEMBR201947882_CR14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3109\/08830185.2012.762361","volume":"32","author":"Y Yao","year":"2013","unstructured":"Yao Y, Simard AR, Shi FD, Hao J (2013) IL\u201010\u2010producing lymphocytes in inflammatory disease. Int Rev Immunol 32: 324\u2013336","journal-title":"Int Rev Immunol"},{"key":"BFEMBR201947882_CR15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri2992","volume":"11","author":"JE Allen","year":"2011","unstructured":"Allen JE, Maizels RM (2011) Diversity and dialogue in immunity to helminths. Nat Rev Immunol 11: 375\u2013388","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201947882_CR16","first-page":"821578","volume":"2011","author":"E Danilowicz\u2010Luebert","year":"2011","unstructured":"Danilowicz\u2010Luebert E, O'Regan NL, Steinfelder S, Hartmann S (2011) Modulation of specific and allergy\u2010related immune responses by helminths. J Biomed Biotechnol 2011: 821578","journal-title":"J Biomed Biotechnol"},{"key":"BFEMBR201947882_CR17","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3389\/fimmu.2018.00664","volume":"9","author":"CC Motran","year":"2018","unstructured":"Motran CC, Silvane L, Chiapello LS, Theumer MG, Ambrosio LF, Volpini X, Celias DP, Cervi L (2018) Helminth infections: recognition and modulation of the immune response by innate immune cells. Front Immunol 9: 664","journal-title":"Front Immunol"},{"key":"BFEMBR201947882_CR18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.159.2.777","volume":"159","author":"LR Brunet","year":"1997","unstructured":"Brunet LR, Finkelman FD, Cheever AW, Kopf MA, Pearce EJ (1997) IL\u20104 protects against TNF\u2010alpha\u2010mediated cachexia and death during acute schistosomiasis. J Immunol 159: 777\u2013785","journal-title":"J Immunol"},{"key":"BFEMBR201947882_CR19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1086\/324668","volume":"185","author":"AR de Jesus","year":"2002","unstructured":"de Jesus AR, Silva A, Santana LB, Magalhaes A, de Jesus AA, de Almeida RP, Rego MA, Burattini MN, Pearce EJ, Carvalho EM (2002) Clinical and immunologic evaluation of 31 patients with acute Schistosomiasis mansoni. J Infect Dis 185: 98\u2013105","journal-title":"J Infect Dis"},{"key":"BFEMBR201947882_CR20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","volume":"2","author":"EJ Pearce","year":"2002","unstructured":"Pearce EJ, MacDonald AS (2002) The immunobiology of schistosomiasis. Nat Rev Immunol 2: 499\u2013511","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201947882_CR21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/pim.12194","volume":"37","author":"TB Nutman","year":"2015","unstructured":"Nutman TB (2015) Looking beyond the induction of Th2 responses to explain immunomodulation by helminths. Parasite Immunol 37: 304\u2013313","journal-title":"Parasite Immunol"},{"key":"BFEMBR201947882_CR22","doi-asserted-by":"crossref","first-page":"48122","DOI":"10.1074\/jbc.M206941200","volume":"277","author":"D van der Kleij","year":"2002","unstructured":"van der Kleij D, Latz E, Brouwers JF, Kruize YC, Schmitz M, Kurt\u2010Jones EA, Espevik T, de Jong EC, Kapsenberg ML, Golenbock DT et\u00a0al (2002) A novel host\u2010parasite lipid cross\u2010talk. Schistosomal lyso\u2010phosphatidylserine activates toll\u2010like receptor 2 and affects immune polarization. J Biol Chem 277: 48122\u201348129","journal-title":"J Biol Chem"},{"key":"BFEMBR201947882_CR23","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1002\/eji.200939335","volume":"39","author":"X Wang","year":"2009","unstructured":"Wang X, Zhou S, Chi Y, Wen X, Hoellwarth J, He L, Liu F, Wu C, Dhesi S, Zhao J et\u00a0al (2009) CD4+ CD25+ Treg induction by an HSP60\u2010derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent. Eur J Immunol 39: 3052\u20133065","journal-title":"Eur J Immunol"},{"key":"BFEMBR201947882_CR24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200: 373\u2013383","journal-title":"J Cell Biol"},{"key":"BFEMBR201947882_CR25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","volume":"9","author":"C Thery","year":"2009","unstructured":"Thery C, Ostrowski M, Segura E (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9: 581\u2013593","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201947882_CR26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","volume":"30","author":"M Colombo","year":"2014","unstructured":"Colombo M, Raposo G, Thery C (2014) Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30: 255\u2013289","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBR201947882_CR27","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2013.04.029","volume":"153","author":"N Regev\u2010Rudzki","year":"2013","unstructured":"Regev\u2010Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF et\u00a0al (2013) Cell\u2010cell communication between malaria\u2010infected red blood cells via exosome\u2010like vesicles. Cell 153: 1120\u20131133","journal-title":"Cell"},{"key":"BFEMBR201947882_CR28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2180-10-20","volume":"10","author":"A Geiger","year":"2010","unstructured":"Geiger A, Hirtz C, Becue T, Bellard E, Centeno D, Gargani D, Rossignol M, Cuny G, Peltier JB (2010) Exocytosis and protein secretion in Trypanosoma. BMC Microbiol 10: 20","journal-title":"BMC Microbiol"},{"key":"BFEMBR201947882_CR29","doi-asserted-by":"crossref","first-page":"25040","DOI":"10.3402\/jev.v3.25040","volume":"3","author":"A Marcilla","year":"2014","unstructured":"Marcilla A, Martin\u2010Jaular L, Trelis M, de Menezes\u2010Neto A, Osuna A, Bernal D, Fernandez\u2010Becerra C, Almeida IC, Del Portillo HA (2014) Extracellular vesicles in parasitic diseases. J Extracell Vesicles 3: 25040","journal-title":"J Extracell Vesicles"},{"key":"BFEMBR201947882_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2015.09.002","volume":"46","author":"J Sotillo","year":"2016","unstructured":"Sotillo J, Pearson M, Potriquet J, Becker L, Pickering D, Mulvenna J, Loukas A (2016) Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates. Int J Parasitol 46: 1\u20135","journal-title":"Int J Parasitol"},{"key":"BFEMBR201947882_CR31","doi-asserted-by":"crossref","first-page":"25885","DOI":"10.1038\/srep25885","volume":"6","author":"L Zhu","year":"2016","unstructured":"Zhu L, Liu J, Dao J, Lu K, Li H, Gu H, Liu J, Feng X, Cheng G (2016) Molecular characterization of Schistosoma japonicum exosome\u2010like vesicles reveals their regulatory roles in parasite\u2010host interactions. Sci Rep 6: 25885","journal-title":"Sci Rep"},{"key":"BFEMBR201947882_CR32","doi-asserted-by":"crossref","first-page":"28665","DOI":"10.3402\/jev.v4.28665","volume":"4","author":"FC Nowacki","year":"2015","unstructured":"Nowacki FC, Swain MT, Klychnikov OI, Niazi U, Ivens A, Quintana JF, Hensbergen PJ, Hokke CH, Buck AH, Hoffmann KF (2015) Protein and small non\u2010coding RNA\u2010enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni. J Extracell Vesicles 4: 28665","journal-title":"J Extracell Vesicles"},{"key":"BFEMBR201947882_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"W da Huang","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1\u201313","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR201947882_CR34","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W da Huang","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44\u201357","journal-title":"Nat Protoc"},{"key":"BFEMBR201947882_CR35","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00436-015-4492-1","volume":"114","author":"Y Yu","year":"2015","unstructured":"Yu Y, Deng W, Lei J (2015) Interleukin\u201033 promotes Th2 immune responses in infected mice with Schistosoma japonicum. Parasitol Res 114: 2911\u20132918","journal-title":"Parasitol Res"},{"key":"BFEMBR201947882_CR36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2332\/allergolint.13-OA-0672","volume":"63","author":"N Murakami\u2010Satsutani","year":"2014","unstructured":"Murakami\u2010Satsutani N, Ito T, Nakanishi T, Inagaki N, Tanaka A, Vien PT, Kibata K, Inaba M, Nomura S (2014) IL\u201033 promotes the induction and maintenance of Th2 immune responses by enhancing the function of OX40 ligand. Allergol Int 63: 443\u2013455","journal-title":"Allergol Int"},{"key":"BFEMBR201947882_CR37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.191.2.375","volume":"191","author":"H Akiba","year":"2000","unstructured":"Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura K (2000) Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 191: 375\u2013380","journal-title":"J Exp Med"},{"key":"BFEMBR201947882_CR38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/11.1.81","volume":"11","author":"T Imai","year":"1999","unstructured":"Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, Yoshie O (1999) Selective recruitment of CCR4\u2010bearing Th2 cells toward antigen\u2010presenting cells by the CC chemokines thymus and activation\u2010regulated chemokine and macrophage\u2010derived chemokine. Int Immunol 11: 81\u201388","journal-title":"Int Immunol"},{"key":"BFEMBR201947882_CR39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20050308","volume":"202","author":"S Chakravarti","year":"2005","unstructured":"Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK (2005) Tim\u20102 regulates T helper type 2 responses and autoimmunity. J Exp Med 202: 437\u2013444","journal-title":"J Exp Med"},{"key":"BFEMBR201947882_CR40","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","volume":"415","author":"L Monney","year":"2002","unstructured":"Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA et\u00a0al (2002) Th1\u2010specific cell surface protein Tim\u20103 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536\u2013541","journal-title":"Nature"},{"key":"BFEMBR201947882_CR41","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1517\/14712598.2013.845661","volume":"13","author":"LV Riella","year":"2013","unstructured":"Riella LV, Sayegh MH (2013) T\u2010cell co\u2010stimulatory blockade in transplantation: two steps forward one step back!. Expert Opin Biol Ther 13: 1557\u20131568","journal-title":"Expert Opin Biol Ther"},{"key":"BFEMBR201947882_CR42","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.164.8.2011072","volume":"164","author":"M Okano","year":"2001","unstructured":"Okano M, Azuma M, Yoshino T, Hattori H, Nakada M, Satoskar AR, Harn DA Jr, Nakayama E, Akagi T, Nishizaki K (2001) Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. Am J Respir Crit Care Med 164: 1501\u20131507","journal-title":"Am J Respir Crit Care Med"},{"key":"BFEMBR201947882_CR43","first-page":"1701059","volume":"2016","author":"P Huang","year":"2016","unstructured":"Huang P, Zhou Y, Liu Z, Zhang P (2016) Interaction between ANXA1 and GATA\u20103 in immunosuppression of CD4(+) T Cells. Mediators Inflamm 2016: 1701059","journal-title":"Mediators Inflamm"},{"key":"BFEMBR201947882_CR44","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1182\/blood-2009-07-231449","volume":"115","author":"C Barres","year":"2010","unstructured":"Barres C, Blanc L, Bette\u2010Bobillo P, Andre S, Mamoun R, Gabius HJ, Vidal M (2010) Galectin\u20105 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood 115: 696\u2013705","journal-title":"Blood"},{"key":"BFEMBR201947882_CR45","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","volume":"10","author":"E Macia","year":"2006","unstructured":"Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T (2006) Dynasore, a cell\u2010permeable inhibitor of dynamin. Dev Cell 10: 839\u2013850","journal-title":"Dev Cell"},{"key":"BFEMBR201947882_CR46","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1515\/hsz-2013-0141","volume":"394","author":"F Momen\u2010Heravi","year":"2013","unstructured":"Momen\u2010Heravi F, Balaj L, Alian S, Mantel PY, Halleck AE, Trachtenberg AJ, Soria CE, Oquin S, Bonebreak CM, Saracoglu E et\u00a0al (2013) Current methods for the isolation of extracellular vesicles. Biol Chem 394: 1253\u20131262","journal-title":"Biol Chem"},{"key":"BFEMBR201947882_CR47","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/j.1538-7836.2010.04074.x","volume":"8","author":"E van der Pol","year":"2010","unstructured":"van der Pol E, Hoekstra AG, Sturk A, Otto C, van Leeuwen TG, Nieuwland R (2010) Optical and non\u2010optical methods for detection and characterization of microparticles and exosomes. J Thromb Haemost 8: 2596\u20132607","journal-title":"J Thromb Haemost"},{"key":"BFEMBR201947882_CR48","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1371\/journal.pntd.0001455","volume":"6","author":"AV Protasio","year":"2012","unstructured":"Protasio AV, Tsai IJ, Babbage A, Nichol S, Hunt M, Aslett MA, De Silva N, Velarde GS, Anderson TJ, Clark RC et\u00a0al (2012) A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis 6: e1455","journal-title":"PLoS Negl Trop Dis"},{"key":"BFEMBR201947882_CR49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT et\u00a0al (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25\u201329","journal-title":"Nat Genet"},{"key":"BFEMBR201947882_CR50","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/pmic.201400515","volume":"15","author":"M Pathan","year":"2015","unstructured":"Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A et\u00a0al (2015) FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics 15: 2597\u20132601","journal-title":"Proteomics"},{"key":"BFEMBR201947882_CR51","doi-asserted-by":"crossref","first-page":"D516","DOI":"10.1093\/nar\/gky1029","volume":"47","author":"M Pathan","year":"2019","unstructured":"Pathan M, Fonseka P, Chitti SV, Kang T, Sanwlani R, Van Deun J, Hendrix A, Mathivanan S (2019) Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles. Nucleic Acids Res 47: D516\u2013D519","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR201947882_CR52","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","volume":"7","author":"C Thery","year":"2018","unstructured":"Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin\u2010Smith GK et\u00a0al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 7: 1535750","journal-title":"J Extracell Vesicles"},{"key":"BFEMBR201947882_CR53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","volume":"23","author":"N Bushati","year":"2007","unstructured":"Bushati N, Cohen SM (2007) microRNA functions. Annu Rev Cell Dev Biol 23: 175\u2013205","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBR201947882_CR54","first-page":"1","volume":"96","author":"SC Li","year":"2010","unstructured":"Li SC, Chan WC, Hu LY, Lai CH, Hsu CN, Lin WC (2010) Identification of homologous microRNAs in 56 animal genomes. Genomics 96: 1\u20139","journal-title":"Genomics"},{"key":"BFEMBR201947882_CR55","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1194\/jlr.R034991","volume":"54","author":"KJ Rayner","year":"2013","unstructured":"Rayner KJ, Hennessy EJ (2013) Extracellular communication via microRNA: lipid particles have a new message. J Lipid Res 54: 1174\u20131181","journal-title":"J Lipid Res"},{"key":"BFEMBR201947882_CR56","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/jcp.24344","volume":"228","author":"L Xu","year":"2013","unstructured":"Xu L, Yang BF, Ai J (2013) MicroRNA transport: a new way in cell communication. J Cell Physiol 228: 1713\u20131719","journal-title":"J Cell Physiol"},{"key":"BFEMBR201947882_CR57","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/1471-2164-10-464","volume":"10","author":"CS Copeland","year":"2009","unstructured":"Copeland CS, Marz M, Rose D, Hertel J, Brindley PJ, Santana CB, Kehr S, Attolini CS, Stadler PF (2009) Homology\u2010based annotation of non\u2010coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum. BMC Genom 10: 464","journal-title":"BMC Genom"},{"key":"BFEMBR201947882_CR58","doi-asserted-by":"crossref","first-page":"e8206","DOI":"10.1371\/journal.pone.0008206","volume":"4","author":"J Huang","year":"2009","unstructured":"Huang J, Hao P, Chen H, Hu W, Yan Q, Liu F, Han ZG (2009) Genome\u2010wide identification of Schistosoma japonicum microRNAs using a deep\u2010sequencing approach. PLoS One 4: e8206","journal-title":"PLoS One"},{"key":"BFEMBR201947882_CR59","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00436-010-1927-6","volume":"107","author":"Q Liu","year":"2010","unstructured":"Liu Q, Tuo W, Gao H, Zhu XQ (2010) MicroRNAs of parasites: current status and future perspectives. Parasitol Res 107: 501\u2013507","journal-title":"Parasitol Res"},{"key":"BFEMBR201947882_CR60","doi-asserted-by":"crossref","first-page":"e596","DOI":"10.1371\/journal.pntd.0000596","volume":"4","author":"Z Wang","year":"2010","unstructured":"Wang Z, Xue X, Sun J, Luo R, Xu X, Jiang Y, Zhang Q, Pan W (2010) An \u201cin\u2010depth\u201d description of the small non\u2010coding RNA population of Schistosoma japonicum Schistosomulum. PLoS Negl Trop Dis 4: e596","journal-title":"PLoS Negl Trop Dis"},{"key":"BFEMBR201947882_CR61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygeno.2011.05.007","volume":"98","author":"M de Souza Gomes","year":"2011","unstructured":"de Souza Gomes M, Muniyappa MK, Carvalho SG, Guerra\u2010Sa R, Spillane C (2011) Genome\u2010wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics 98: 96\u2013111","journal-title":"Genomics"},{"key":"BFEMBR201947882_CR62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2164-12-47","volume":"12","author":"MC Simoes","year":"2011","unstructured":"Simoes MC, Lee J, Djikeng A, Cerqueira GC, Zerlotini A, da Silva\u2010Pereira RA, Dalby AR, LoVerde P, El\u2010Sayed NM, Oliveira G (2011) Identification of Schistosoma mansoni microRNAs. BMC Genom 12: 47","journal-title":"BMC Genom"},{"key":"BFEMBR201947882_CR63","first-page":"378","volume":"215","author":"T Meningher","year":"2017","unstructured":"Meningher T, Lerman G, Regev\u2010Rudzki N, Gold D, Ben\u2010Dov IZ, Sidi Y, Avni D, Schwartz E (2017) Schistosomal MicroRNAs isolated from extracellular vesicles in sera of infected patients: a new tool for diagnosis and follow\u2010up of human schistosomiasis. J Infect Dis 215: 378\u2013386","journal-title":"J Infect Dis"},{"key":"BFEMBR201947882_CR64","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1038\/s41598-018-21587-4","volume":"8","author":"V Samoil","year":"2018","unstructured":"Samoil V, Dagenais M, Ganapathy V, Aldridge J, Glebov A, Jardim A, Ribeiro P (2018) Vesicle\u2010based secretion in schistosomes: analysis of protein and microRNA (miRNA) content of exosome\u2010like vesicles derived from Schistosoma mansoni. Sci Rep 8: 3286","journal-title":"Sci Rep"},{"key":"BFEMBR201947882_CR65","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1017\/S0031182013000917","volume":"140","author":"G Cheng","year":"2013","unstructured":"Cheng G, Luo R, Hu C, Cao J, Jin Y (2013) Deep sequencing\u2010based identification of pathogen\u2010specific microRNAs in the plasma of rabbits infected with Schistosoma japonicum. Parasitology 140: 1751\u20131761","journal-title":"Parasitology"},{"key":"BFEMBR201947882_CR66","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1261\/rna.768207","volume":"13","author":"CB Nielsen","year":"2007","unstructured":"Nielsen CB, Shomron N, Sandberg R, Hornstein E, Kitzman J, Burge CB (2007) Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA 13: 1894\u20131910","journal-title":"RNA"},{"key":"BFEMBR201947882_CR67","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.4049\/jimmunol.174.11.7154","volume":"174","author":"D Artis","year":"2005","unstructured":"Artis D, Kane CM, Fiore J, Zaph C, Shapira S, Joyce K, Macdonald A, Hunter C, Scott P, Pearce EJ (2005) Dendritic cell\u2010intrinsic expression of NF\u2010kappa B1 is required to promote optimal Th2 cell differentiation. J Immunol 174: 7154\u20137159","journal-title":"J Immunol"},{"key":"BFEMBR201947882_CR68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/83158","volume":"2","author":"J Das","year":"2001","unstructured":"Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A (2001) A critical role for NF\u2010kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2: 45\u201350","journal-title":"Nat Immunol"},{"key":"BFEMBR201947882_CR69","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1074\/jbc.M807302200","volume":"284","author":"EJ Scheinman","year":"2009","unstructured":"Scheinman EJ, Avni O (2009) Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin\u20104 receptor and T cell receptor. J Biol Chem 284: 3037\u20133048","journal-title":"J Biol Chem"},{"key":"BFEMBR201947882_CR70","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/eji.200324687","volume":"34","author":"M Li\u2010Weber","year":"2004","unstructured":"Li\u2010Weber M, Giaisi M, Baumann S, Palfi K, Krammer PH (2004) NF\u2010kappa B synergizes with NF\u2010AT and NF\u2010IL6 in activation of the IL\u20104 gene in T cells. Eur J Immunol 34: 1111\u20131118","journal-title":"Eur J Immunol"},{"key":"BFEMBR201947882_CR71","doi-asserted-by":"crossref","first-page":"36916","DOI":"10.1074\/jbc.M301598200","volume":"278","author":"H Sakurai","year":"2003","unstructured":"Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I (2003) Tumor necrosis factor\u2010alpha\u2010induced IKK phosphorylation of NF\u2010kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem 278: 36916\u201336923","journal-title":"J Biol Chem"},{"key":"BFEMBR201947882_CR72","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00535-013-0931-x","volume":"49","author":"YS Roh","year":"2014","unstructured":"Roh YS, Song J, Seki E (2014) TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol 49: 185\u2013194","journal-title":"J Gastroenterol"},{"key":"BFEMBR201947882_CR73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12943-015-0338-9","volume":"14","author":"L Zehavi","year":"2015","unstructured":"Zehavi L, Schayek H, Jacob\u2010Hirsch J, Sidi Y, Leibowitz\u2010Amit R, Avni D (2015) MiR\u2010377 targets E2F3 and alters the NF\u2010kB signaling pathway through MAP3K7 in malignant melanoma. Mol Cancer 14: 68","journal-title":"Mol Cancer"},{"key":"BFEMBR201947882_CR74","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/326711a0","volume":"326","author":"G Nabel","year":"1987","unstructured":"Nabel G, Baltimore D (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711\u2013713","journal-title":"Nature"},{"key":"BFEMBR201947882_CR75","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1084\/jem.20091903","volume":"206","author":"RM Maizels","year":"2009","unstructured":"Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA (2009) Regulation of pathogenesis and immunity in helminth infections. J Exp Med 206: 2059\u20132066","journal-title":"J Exp Med"},{"key":"BFEMBR201947882_CR76","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pt.2011.01.001","volume":"27","author":"DR Neill","year":"2011","unstructured":"Neill DR, McKenzie AN (2011) Nuocytes and beyond: new insights into helminth expulsion. Trends Parasitol 27: 214\u2013221","journal-title":"Trends Parasitol"},{"key":"BFEMBR201947882_CR77","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","volume":"18","author":"M Karin","year":"2000","unstructured":"Karin M, Ben\u2010Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF\u2010[kappa]B activity. Annu Rev Immunol 18: 621\u2013663","journal-title":"Annu Rev Immunol"},{"key":"BFEMBR201947882_CR78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2147\/ITT.S61528","volume":"4","author":"LT Stiemsma","year":"2015","unstructured":"Stiemsma LT, Reynolds LA, Turvey SE, Finlay BB (2015) The hygiene hypothesis: current perspectives and future therapies. Immunotargets Ther 4: 143\u2013157","journal-title":"Immunotargets Ther"},{"key":"BFEMBR201947882_CR79","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actatropica.2018.08.032","volume":"188","author":"GM Alexandre\u2010Silva","year":"2018","unstructured":"Alexandre\u2010Silva GM, Brito\u2010Souza PA, Oliveira ACS, Cerni FA, Zottich U, Pucca MB (2018) The hygiene hypothesis at a glance: early exposures, immune mechanism and novel therapies. Acta Trop 188: 16\u201326","journal-title":"Acta Trop"},{"key":"BFEMBR201947882_CR80","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri.2017.111","volume":"18","author":"JF Bach","year":"2018","unstructured":"Bach JF (2018) The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. Nat Rev Immunol 18: 105\u2013120","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201947882_CR81","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12916-015-0306-7","volume":"13","author":"M Versini","year":"2015","unstructured":"Versini M, Jeandel PY, Bashi T, Bizzaro G, Blank M, Shoenfeld Y (2015) Unraveling the hygiene hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications. BMC Med 13: 81","journal-title":"BMC Med"},{"key":"BFEMBR201947882_CR82","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1067\/mai.2003.1381","volume":"111","author":"M Medeiros Jr","year":"2003","unstructured":"Medeiros M Jr, Figueiredo JP, Almeida MC, Matos MA, Araujo MI, Cruz AA, Atta AM, Rego MA, de Jesus AR, Taketomi EA et\u00a0al (2003) Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol 111: 947\u2013951","journal-title":"J Allergy Clin Immunol"},{"key":"BFEMBR201947882_CR83","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1590\/0037-8682-0249-2014","volume":"47","author":"SM Oliveira","year":"2014","unstructured":"Oliveira SM, Bezerra FS, Carneiro TR, Pinheiro MC, Queiroz JA (2014) Association between allergic responses and Schistosoma mansoni infection in residents in a low\u2010endemic setting in Brazil. Rev Soc Bras Med Trop 47: 770\u2013774","journal-title":"Rev Soc Bras Med Trop"},{"key":"BFEMBR201947882_CR84","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijpddr.2017.05.002","volume":"7","author":"D Gold","year":"2017","unstructured":"Gold D, Alian M, Domb A, Karawani Y, Jbarien M, Chollet J, Haynes RK, Wong HN, Buchholz V, Greiner A et\u00a0al (2017) Elimination of Schistosoma mansoni in infected mice by slow release of artemisone. Int J Parasitol Drugs Drug Resist 7: 241\u2013247","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"BFEMBR201947882_CR85","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/ni808","volume":"3","author":"O Avni","year":"2002","unstructured":"Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A (2002) T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 3: 643\u2013651","journal-title":"Nat Immunol"},{"key":"BFEMBR201947882_CR86","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1750-2187-6-5","volume":"6","author":"E Jacob","year":"2011","unstructured":"Jacob E, Hod\u2010Dvorai R, Ben\u2010Mordechai OL, Boyko Y, Avni O (2011) Dual function of polycomb group proteins in differentiated murine T helper (CD4+) cells. J Mol Signal 6: 5","journal-title":"J Mol Signal"},{"key":"BFEMBR201947882_CR87","first-page":"Unit 3 22","volume":"Chapter 3","author":"C Thery","year":"2006","unstructured":"Thery C, Amigorena S, Raposo G, Clayton A (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol\/editorial board, Juan S Bonifacino [et\u00a0al] Chapter 3: Unit 3 22","journal-title":"Curr Protoc Cell Biol"},{"key":"BFEMBR201947882_CR88","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/s41467-017-02083-1","volume":"8","author":"X Sisquella","year":"2017","unstructured":"Sisquella X, Ofir\u2010Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ et\u00a0al (2017) Malaria parasite DNA\u2010harbouring vesicles activate cytosolic immune sensors. Nat Commun 8: 1985","journal-title":"Nat Commun"},{"key":"BFEMBR201947882_CR89","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ymeth.2012.01.002","volume":"56","author":"BJ Tauro","year":"2012","unstructured":"Tauro BJ, Greening DW, Mathias RA, Ji H, Mathivanan S, Scott AM, Simpson RJ (2012) Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863\u2010derived exosomes. Methods 56: 293\u2013304","journal-title":"Methods"},{"key":"BFEMBR201947882_CR90","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1096\/fj.11-202077","volume":"26","author":"BM Coleman","year":"2012","unstructured":"Coleman BM, Hanssen E, Lawson VA, Hill AF (2012) Prion\u2010infected cells regulate the release of exosomes with distinct ultrastructural features. FASEB J 26: 4160\u20134173","journal-title":"FASEB J"},{"key":"BFEMBR201947882_CR91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","volume":"74","author":"I Raphael","year":"2015","unstructured":"Raphael I, Nalawade S, Eagar TN, Forsthuber TG (2015) T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 74: 5\u201317","journal-title":"Cytokine"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201947882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201947882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201947882\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201947882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201947882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:33:55Z","timestamp":1779111235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201947882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,7]]}},"alternative-id":["BFEMBR201947882"],"URL":"https:\/\/doi.org\/10.15252\/embr.201947882","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737071593.793569306","asserted-by":"object"}]},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"assertion":[{"value":"7 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR201947882"}}