{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:34:58Z","timestamp":1793252098364,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010LABX\u20100024"],"award-info":[{"award-number":["ANR\u201011\u2010LABX\u20100024"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["819314"],"award-info":[{"award-number":["819314"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2021,3,3]]},"DOI":"10.15252\/embr.201949617","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T20:58:21Z","timestamp":1613595501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The UPR sensor IRE1\u03b1 promotes dendritic cell responses to control Toxoplasma gondii infection"],"prefix":"10.1038","volume":"22","author":[{"given":"Ana\u00efs F","family":"Poncet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Bosteels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-1091","authenticated-orcid":false,"given":"Eik","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylia","family":"Chehade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-2045","authenticated-orcid":false,"given":"Sofie","family":"Rennen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Huot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Peucelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mar\u00e9chal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-8976","authenticated-orcid":false,"given":"Jamal","family":"Khalife","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-2161","authenticated-orcid":false,"given":"Nicolas","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1636","authenticated-orcid":false,"given":"Sophie","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-955X","authenticated-orcid":false,"given":"Sabrina","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"BFEMBR201949617_CR1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chom.2012.12.003","volume":"13","author":"WA Andrade","year":"2013","unstructured":"Andrade WA, Souza MC, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT(2013) Combined action of nucleic acid-sensing Toll-like receptors and TLR11\/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe 13: 42\u201353","journal-title":"Cell Host Microbe"},{"key":"BFEMBR201949617_CR2","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00915-20","volume":"11","author":"L Augusto","year":"2020","unstructured":"Augusto L, Martynowicz J, Amin PH, Alakhras NS, Kaplan MH, Wek RC, Sullivan WJ (2020) Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells. mBio 11: e00915-20.","journal-title":"mBio"},{"key":"BFEMBR201949617_CR3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12173","volume":"37","author":"N Blanchard","year":"2015","unstructured":"Blanchard N, Dunay IR, Schl\u00fcter D (2015) Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system. Parasite Immunol 37: 150\u2013158","journal-title":"Parasite Immunol"},{"key":"BFEMBR201949617_CR4","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/MCB.00013-15","volume":"35","author":"MD Bright","year":"2015","unstructured":"Bright MD, Itzhak DN, Wardell CP, Morgan GJ, Davies FE (2015) Cleavage of BLOC1S1 mRNA by IRE1 is sequence specific, temporally separate from XBP1 splicing, and dispensable for cell viability under acute endoplasmic reticulum stress. Mol Cell Biol 35: 2186\u20132202","journal-title":"Mol Cell Biol"},{"key":"BFEMBR201949617_CR5","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.cell.2011.11.021","volume":"147","author":"I Cebrian","year":"2011","unstructured":"Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A (2011) Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells. Cell 147: 1355\u20131368","journal-title":"Cell"},{"key":"BFEMBR201949617_CR6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrmicro3393","volume":"13","author":"J Celli","year":"2015","unstructured":"Celli J, Tsolis RM (2015) Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? Nat Rev Microbiol 13: 71\u201382","journal-title":"Nat Rev Microbiol"},{"key":"BFEMBR201949617_CR7","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1073\/pnas.1104491109","volume":"109","author":"G Clavarino","year":"2012","unstructured":"Clavarino G, Cl\u00e1udio N, Dalet A, Terawaki S, Couderc T, Chasson L, Ceppi M, Schmidt EK, Wenger T, Lecuit M et al (2012) Protein phosphatase 1 subunit Ppp1r15a\/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Proc Natl Acad Sci USA 109: 3006\u20133011","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201949617_CR8","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cell.2015.05.025","volume":"161","author":"JR Cubillos-Ruiz","year":"2015","unstructured":"Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K et al (2015) ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161: 1527\u20131538","journal-title":"Cell"},{"key":"BFEMBR201949617_CR9","doi-asserted-by":"crossref","first-page":"761","DOI":"10.15252\/embj.201695000","volume":"36","author":"A Dalet","year":"2017","unstructured":"Dalet A, Arg\u00fcello RJ, Combes A, Spinelli L, Jaeger S, Fallet M, Vu Manh T-P, Mendes A, Perego J, Reverendo M et al (2017) Protein synthesis inhibition and GADD34 control IFN-\u03b2 heterogeneous expression in response to dsRNA. EMBO J 36: 761\u2013782","journal-title":"EMBO J"},{"key":"BFEMBR201949617_CR10","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/embj.201488027","volume":"33","author":"M Dalod","year":"2014","unstructured":"Dalod M, Chelbi R, Malissen B, Lawrence T (2014) Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J 33: 1104\u20131116","journal-title":"EMBO J"},{"key":"BFEMBR201949617_CR11","volume":"8","author":"MS Deffieu","year":"2019","unstructured":"Deffieu MS, Alayi TD, Slomianny C, Tomavo S (2019) The Toxoplasma gondii dense granule protein TgGRA3 interacts with host Golgi and dysregulates anterograde transport. Biol Open 8: bio039818","journal-title":"Biol Open"},{"key":"BFEMBR201949617_CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.12703\/P6-97","volume":"6","author":"J Deguine","year":"2014","unstructured":"Deguine J, Barton GM (2014) MyD88: a central player in innate immune signaling. F1000prime Rep 6: 97","journal-title":"F1000prime Rep"},{"key":"BFEMBR201949617_CR13","doi-asserted-by":"crossref","first-page":"108008","DOI":"10.1016\/j.celrep.2020.108008","volume":"32","author":"D Fisch","year":"2020","unstructured":"Fisch D, Clough B, Domart M-C, Encheva V, Bando H, Snijders AP, Collinson LM, Yamamoto M, Shenoy AR, Frickel E-M (2020) Human GBP1 differentially targets salmonella and toxoplasma to license recognition of microbial ligands and caspase-mediated death. Cell Rep 32: 108008","journal-title":"Cell Rep"},{"key":"BFEMBR201949617_CR14","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02231-15","volume":"7","author":"M Franco","year":"2016","unstructured":"Franco M, Panas MW, Marino ND, Lee M-CW, Buchholz KR, Kelly FD, Bednarski JJ, Sleckman BP, Pourmand N, Boothroyd JC (2016) A novel secreted protein, MYR1, is central to Toxoplasma\u2019s manipulation of host cells. mBio 7: e02231\u2013e2215","journal-title":"mBio"},{"key":"BFEMBR201949617_CR15","doi-asserted-by":"crossref","first-page":"FSO198","DOI":"10.4155\/fsoa-2017-0020","volume":"3","author":"L Galluzzi","year":"2017","unstructured":"Galluzzi L, Diotallevi A, Magnani M (2017) Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites. Future Sci OA 3: FSO198","journal-title":"Future Sci OA"},{"key":"BFEMBR201949617_CR16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.20082108","volume":"206","author":"RS Goldszmid","year":"2009","unstructured":"Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A (2009) Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med 206: 399\u2013410","journal-title":"J Exp Med"},{"key":"BFEMBR201949617_CR17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2016.62","volume":"16","author":"J Grootjans","year":"2016","unstructured":"Grootjans J, Kaser A, Kaufman RJ, Blumberg RS (2016) The unfolded protein response in immunity and inflammation. Nat Rev Immunol 16: 469\u2013484","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR201949617_CR18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/IAI.73.2.703-711.2005","volume":"73","author":"M-J Gubbels","year":"2005","unstructured":"Gubbels M-J, Striepen B, Shastri N, Turkoz M, Robey EA (2005) Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infect Immun 73: 703\u2013711","journal-title":"Infect Immun"},{"key":"BFEMBR201949617_CR19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/CMR.00005-17","volume":"30","author":"M-A Hakimi","year":"2017","unstructured":"Hakimi M-A, Olias P, Sibley LD (2017) Toxoplasma Effectors Targeting Host Signaling and Transcription. Clin Microbiol Rev 30: 615\u2013645","journal-title":"Clin Microbiol Rev"},{"key":"BFEMBR201949617_CR20","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1172\/JCI60659","volume":"122","author":"J Helft","year":"2012","unstructured":"Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M et al (2012) Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest 122: 4037\u20134047","journal-title":"J Clin Invest"},{"key":"BFEMBR201949617_CR21","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","volume":"9","author":"Heng TSP, Painter MW & Immunological Genome Project Consortium","year":"2008","unstructured":"Heng TSP, Painter MW & Immunological Genome Project Consortium (2008) The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol 9: 1091\u20131094","journal-title":"Nat Immunol"},{"key":"BFEMBR201949617_CR22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200903014","volume":"186","author":"J Hollien","year":"2009","unstructured":"Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS (2009) Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol 186: 323\u2013331","journal-title":"J Cell Biol"},{"key":"BFEMBR201949617_CR123","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1126\/science.2326647","volume":"248","author":"N Hosken","year":"1990","unstructured":"Hosken N, Bevan M (1990) Defective presentation of endogenous antigen by a cell line expressing class I molecules. Science 248: 367\u2013370","journal-title":"Science"},{"key":"BFEMBR201949617_CR23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1073\/pnas.1011549108","volume":"108","author":"B Hou","year":"2011","unstructured":"Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F (2011) Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci USA 108: 278\u2013283","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201949617_CR24","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/nm1004-1014","volume":"10","author":"T Iwawaki","year":"2004","unstructured":"Iwawaki T, Kohno K, Miura M (2004) Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo. Nat Med 10: 1014","journal-title":"Nat Med"},{"key":"BFEMBR201949617_CR25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000505","volume":"5","author":"B John","year":"2009","unstructured":"John B, Harris TH, Tait ED, Wilson EH, Gregg B, Ng LG, Mrass P, Roos DS, Dzierszinski F, Weninger W et al (2009) Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii. PLoS Pathog 5: e1000505","journal-title":"PLoS Pathog"},{"key":"BFEMBR201949617_CR126","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1073\/pnas.89.13.6020","volume":"89","author":"J Karttunen","year":"1992","unstructured":"Karttunen J, Sanderson S, Shastri N (1992) Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T cell antigens. Proc Natl Acad Sci USA 89: 6020\u20136024","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR201949617_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3347\/kjp.2008.46.4.209","volume":"46","author":"JY Kim","year":"2008","unstructured":"Kim JY, Ahn H-J, Ryu KJ, Nam H-W (2008) Interaction between parasitophorous vacuolar membrane-associated GRA3 and calcium modulating ligand of host cell endoplasmic reticulum in the parasitism of Toxoplasma gondii. Korean J Parasitol 46: 209\u2013216","journal-title":"Korean J Parasitol"},{"key":"BFEMBR201949617_CR27","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1016\/j.celrep.2018.05.068","volume":"23","author":"ME Kirkling","year":"2018","unstructured":"Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A et al (2018) Notch signaling facilitates in vitro generation of cross-presenting classical dendritic cells. Cell Rep 23: 3658\u20133672.e6","journal-title":"Cell Rep"},{"key":"BFEMBR201949617_CR28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","volume":"38","author":"AA Koblansky","year":"2013","unstructured":"Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S (2013) Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity 38: 119\u2013130","journal-title":"Immunity"},{"key":"BFEMBR201949617_CR29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008327","volume":"16","author":"AK Kongsomboonvech","year":"2020","unstructured":"Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ et al (2020) Na\u00efve CD8 T cell IFN\u03b3 responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. PLoS Pathog 16: e1008327","journal-title":"PLoS Pathog"},{"key":"BFEMBR201949617_CR30","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1126\/science.1158042","volume":"320","author":"A-H Lee","year":"2008","unstructured":"Lee A-H, Scapa EF, Cohen DE, Glimcher LH (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492\u20131496","journal-title":"Science"},{"key":"BFEMBR201949617_CR31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.celrep.2015.09.005","volume":"13","author":"Y Lee","year":"2015","unstructured":"Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M (2015) p62 Plays a Specific Role in Interferon-\u03b3-Induced Presentation of a Toxoplasma Vacuolar Antigen. Cell Rep 13: 223\u2013233","journal-title":"Cell Rep"},{"key":"BFEMBR201949617_CR32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fimmu.2017.00639","volume":"8","author":"S M\u00e1rquez","year":"2017","unstructured":"M\u00e1rquez S, Fern\u00e1ndez JJ, Ter\u00e1n-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos-Ruiz JR, Fern\u00e1ndez N et al (2017) Endoplasmic reticulum stress sensor IRE1\u03b1 enhances IL-23 expression by human dendritic cells. Front Immunol 8: 639","journal-title":"Front Immunol"},{"key":"BFEMBR201949617_CR33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","volume":"11","author":"F Martinon","year":"2010","unstructured":"Martinon F, Chen X, Lee A-H, Glimcher LH (2010) Toll-like receptor activation of XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411\u2013418","journal-title":"Nat Immunol"},{"key":"BFEMBR201949617_CR34","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.3389\/fimmu.2018.03050","volume":"9","author":"B Medel","year":"2018","unstructured":"Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F (2018) IRE1\u03b1 activation in bone marrow-derived dendritic cells modulates innate recognition of melanoma cells and favors CD8+ T cell priming. Front Immunol 9: 3050","journal-title":"Front Immunol"},{"key":"BFEMBR201949617_CR35","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2019.03.018","volume":"177","author":"DA Mogilenko","year":"2019","unstructured":"Mogilenko DA, Haas JT, L\u2019homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L et al (2019) Metabolic and innate immune cues merge into a specific inflammatory response via the UPR. Cell 177: 1201\u20131216.e19","journal-title":"Cell"},{"key":"BFEMBR201949617_CR36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02401-17","volume":"9","author":"A Naor","year":"2018","unstructured":"Naor A, Panas MW, Marino N, Coffey MJ, Tonkin CJ, Boothroyd JC (2018) MYR1-dependent effectors are the major drivers of a host cell\u2019s early response to toxoplasma, including counteracting MYR1-independent effects. mBio 9: e02401-17","journal-title":"mBio"},{"key":"BFEMBR201949617_CR37","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.153.5.1011","volume":"153","author":"I Novoa","year":"2001","unstructured":"Novoa I, Zeng H, Harding HP, Ron D (2001) Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 153: 1011\u20131022","journal-title":"J Cell Biol"},{"key":"BFEMBR201949617_CR38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.coi.2018.04.020","volume":"52","author":"F Osorio","year":"2018","unstructured":"Osorio F, Lambrecht BN, Janssens S (2018) Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways. Curr Opin Immunol 52: 100\u2013107","journal-title":"Curr Opin Immunol"},{"key":"BFEMBR201949617_CR39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/ni.2808","volume":"15","author":"F Osorio","year":"2014","unstructured":"Osorio F, Tavernier SJ, Hoffmann E, Saeys Y, Martens L, Vetters J, Delrue I, De Rycke R, Parthoens E, Pouliot P et al (2014) The unfolded-protein-response sensor IRE-1\u03b1 regulates the function of CD8\u03b1+ dendritic cells. Nat Immunol 15: 248\u2013257","journal-title":"Nat Immunol"},{"key":"BFEMBR201949617_CR40","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00674-19","volume":"10","author":"MW Panas","year":"2019","unstructured":"Panas MW, Naor A, Cygan AM, Boothroyd JC (2019) Toxoplasma controls host cyclin e expression through the use of a novel MYR1-dependent effector protein, HCE1. mBio 10: e00674-19","journal-title":"mBio"},{"key":"BFEMBR201949617_CR41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001845","volume":"12","author":"L Pernas","year":"2014","unstructured":"Pernas L, Adomako-Ankomah Y, Shastri AJ, Ewald SE, Treeck M, Boyle JP, Boothroyd JC (2014) Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response. PLoS Biol 12: e1001845","journal-title":"PLoS Biol"},{"key":"BFEMBR201949617_CR42","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cmet.2018.02.018","volume":"27","author":"L Pernas","year":"2018","unstructured":"Pernas L, Bean C, Boothroyd JC, Scorrano L (2018) Mitochondria restrict growth of the intracellular parasite toxoplasma gondii by limiting its uptake of fatty acids. Cell Metab 27: 886\u2013897","journal-title":"Cell Metab"},{"key":"BFEMBR201949617_CR43","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.pt.2019.08.001","volume":"35","author":"AF Poncet","year":"2019","unstructured":"Poncet AF, Blanchard N, Marion S (2019) Toxoplasma and dendritic cells: an intimate relationship that deserves further scrutiny. Trends Parasitol 35: 870\u2013886","journal-title":"Trends Parasitol"},{"key":"BFEMBR201949617_CR44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1743-422X-10-36","volume":"10","author":"APS Rathore","year":"2013","unstructured":"Rathore APS, Ng M-L, Vasudevan SG (2013) Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2\u03b1 phosphorylation. Virol J 10: 36","journal-title":"Virol J"},{"key":"BFEMBR201949617_CR145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2334-3-7","volume":"3","author":"U Reischl","year":"2003","unstructured":"Reischl U, Bretagne S, Kr\u0308ger D, Ernault P, Costa J-M (2003) Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes. BMC Infect Dis 3: 7","journal-title":"BMC Infect Dis"},{"key":"BFEMBR201949617_CR45","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/febs.14391","volume":"286","author":"M Reverendo","year":"2019","unstructured":"Reverendo M, Mendes A, Arg\u00fcello RJ, Gatti E, Pierre P (2019) At the crossway of ER-stress and proinflammatory responses. FEBS J 286: 297\u2013310","journal-title":"FEBS J"},{"key":"BFEMBR201949617_CR46","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1083\/jcb.201701108","volume":"216","author":"JD Romano","year":"2017","unstructured":"Romano JD, Nolan SJ, Porter C, Ehrenman K, Hartman EJ, Hsia R-C, Coppens I (2017) The parasite Toxoplasma sequesters diverse Rab host vesicles within an intravacuolar network. J Cell Biol 216: 4235\u20134254","journal-title":"J Cell Biol"},{"key":"BFEMBR201949617_CR47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007871","volume":"15","author":"A Sardinha-Silva","year":"2019","unstructured":"Sardinha-Silva A, Mendon\u00e7a-Natividade FC, Pinzan CF, Lopes CD, Costa DL, Jacot D, Fernandes FF, Zorzetto-Fernandes ALV, Gay NJ, Sher A et al (2019) The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming. PLoS Pathog 15: e1007871","journal-title":"PLoS Pathog"},{"key":"BFEMBR201949617_CR148","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.4049\/jimmunol.0804307","volume":"182","author":"M Schaeffer","year":"2009","unstructured":"Schaeffer M, Han S-J, Chtanova T, van Dooren GG, Herzmark P, Chen Y, Roysam B, Striepen B, Robey EA (2009) Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol 182: 6379\u20136393","journal-title":"J Immunol"},{"key":"BFEMBR201949617_CR48","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.celrep.2013.03.024","volume":"3","author":"MD Shoulders","year":"2013","unstructured":"Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL (2013) Stress-independent activation of XBP1s and\/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep 3: 1279\u20131292","journal-title":"Cell Rep"},{"issue":"Pt 17","key":"BFEMBR201949617_CR49","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1242\/jcs.110.17.2117","volume":"110","author":"AP Sinai","year":"1997","unstructured":"Sinai AP, Webster P, Joiner KA (1997) Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction. J Cell Sci 110(Pt 17): 2117\u20132128","journal-title":"J Cell Sci"},{"key":"BFEMBR201949617_CR50","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/ni1129","volume":"5","author":"CM Smith","year":"2004","unstructured":"Smith CM, Wilson NS, Waithman J, Villadangos JA, Carbone FR, Heath WR, Belz GT (2004) Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity. Nat Immunol 5: 1143\u20131148","journal-title":"Nat Immunol"},{"key":"BFEMBR201949617_CR51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fimmu.2018.00422","volume":"9","author":"JA Smith","year":"2018","unstructured":"Smith JA (2018) Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity. Front Immunol 9: 422","journal-title":"Front Immunol"},{"key":"BFEMBR201949617_CR52","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1074\/jbc.M609490200","volume":"282","author":"R Sriburi","year":"2007","unstructured":"Sriburi R, Bommiasamy H, Buldak GL, Robbins GR, Frank M, Jackowski S, Brewer JW (2007) Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. J Biol Chem 282: 7024\u20137034","journal-title":"J Biol Chem"},{"key":"BFEMBR201949617_CR53","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ncb3518","volume":"19","author":"SJ Tavernier","year":"2017","unstructured":"Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L et al (2017) Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival. Nat Cell Biol 19: 698\u2013710","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201949617_CR54","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41556-018-0141-0","volume":"20","author":"H Urra","year":"2018","unstructured":"Urra H, Henriquez DR, C\u00e1novas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S et al (2018) IRE1\u03b1 governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol 20: 942\u2013953","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201949617_CR55","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081\u20131086","journal-title":"Science"},{"key":"BFEMBR201949617_CR56","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ncb1996","volume":"11","author":"CW Woo","year":"2009","unstructured":"Woo CW, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald KA, Ron D, Tabas I (2009) Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol 11: 1473\u20131480","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201949617_CR57","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ncb2408","volume":"14","author":"CW Woo","year":"2012","unstructured":"Woo CW, Kutzler L, Kimball SR, Tabas I (2012) Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B. Nat Cell Biol 14: 192\u2013200","journal-title":"Nat Cell Biol"},{"key":"BFEMBR201949617_CR58","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.20101660","volume":"208","author":"M Yamamoto","year":"2011","unstructured":"Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H et al (2011) ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J Exp Med 208: 1533\u20131546","journal-title":"J Exp Med"},{"key":"BFEMBR201949617_CR59","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.1109893","volume":"308","author":"F Yarovinsky","year":"2005","unstructured":"Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S et al (2005) TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308: 1626\u20131629","journal-title":"Science"},{"key":"BFEMBR201949617_CR60","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","volume":"107","author":"H Yoshida","year":"2001","unstructured":"Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881\u2013891","journal-title":"Cell"},{"key":"BFEMBR201949617_CR61","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.4049\/jimmunol.1500089","volume":"194","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Chen G, Liu Z, Tian S, Zhang J, Carey CD, Murphy KM, Storkus WJ (2015) Falo LD & You Z (2015) Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity. J Immunol 194: 5937\u20135947","journal-title":"J Immunol"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201949617.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.201949617","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.201949617\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.201949617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.201949617.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:45:25Z","timestamp":1779111925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.201949617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,3]]}},"alternative-id":["BFEMBR201949617"],"URL":"https:\/\/doi.org\/10.15252\/embr.201949617","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"assertion":[{"value":"7 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR201949617"}}