{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:30:44Z","timestamp":1779114644921,"version":"3.51.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000070","name":"HHS | NIH | National Institute of\n                  Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["1T32EB016652"],"award-info":[{"award-number":["1T32EB016652"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015502","name":"Dialysis Clinics","doi-asserted-by":"publisher","award":["2019-06"],"award-info":[{"award-number":["2019-06"]}],"id":[{"id":"10.13039\/100015502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R37DK039773"],"award-info":[{"award-number":["R37DK039773"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK072381"],"award-info":[{"award-number":["R01DK072381"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["UH3TR002155"],"award-info":[{"award-number":["UH3TR002155"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH training","award":["T32HL007609"],"award-info":[{"award-number":["T32HL007609"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2021,6,4]]},"DOI":"10.15252\/embr.202051169","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T03:15:56Z","timestamp":1621912556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Orphan nuclear receptor COUP-TFII enhances myofibroblast\n              glycolysis leading to kidney fibrosis"],"prefix":"10.1038","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-8202","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Galichon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C","family":"Figueroa-Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Tamayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake J-K","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4187-5829","authenticated-orcid":false,"given":"Marian","family":"Kalocsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gonzalez-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S","family":"Chancay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle W","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan N","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaharu","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-9231","authenticated-orcid":false,"given":"M Todd","family":"Valerius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Wilflingseder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario R","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elazer R","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-386X","authenticated-orcid":false,"given":"Joseph V","family":"Bonventre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"BFEMBR202051169_CR1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","volume":"11","author":"RJ Akhurst","year":"2012","unstructured":"Akhurst RJ, Hata A (2012) Targeting the TGF\u03b2 signalling pathway in\n                  disease. Nat Rev Drug Discov 11: 790\u2013811","journal-title":"Nat Rev Drug Discov"},{"key":"BFEMBR202051169_CR2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.steroids.2018.11.013","volume":"141","author":"UM Ashraf","year":"2019","unstructured":"Ashraf UM, Sanchez ER, Kumarasamy S (2019) COUP-TFII revisited: Its\n                  role in metabolic gene regulation. Steroids 141: 63\u201369","journal-title":"Steroids"},{"key":"BFEMBR202051169_CR3","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6075403","volume":"2018","author":"A Avagliano","year":"2018","unstructured":"Avagliano A, Granato G, Ruocco MR, Romano V, Belviso I, Carfora A,\n                  Montagnani S, Arcucci A (2018) Metabolic reprogramming of cancer associated\n                  fibroblasts: the slavery of stromal fibroblasts. Biomed Res Int 2018:\n                  6075403","journal-title":"Biomed Res Int"},{"key":"BFEMBR202051169_CR4","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/bjc.2014.373","volume":"111","author":"Y Bao","year":"2014","unstructured":"Bao Y, Gu D, Feng W, Sun X, Wang X, Zhang X, Shi Q, Cui G, Yu H,\n                  Tang C et al (2014) COUP-TFII regulates\n                  metastasis of colorectal adenocarcinoma cells by modulating Snail1. Br J Cancer\n                  111: 933\u2013943","journal-title":"Br J Cancer"},{"key":"BFEMBR202051169_CR5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/acs.jproteome.5b00767","volume":"15","author":"T Basak","year":"2016","unstructured":"Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore\n                  RM (2016) Comprehensive characterization of glycosylation and hydroxylation of\n                  basement membrane collagen IV by high-resolution mass spectrometry. J Proteome Res\n                  15: 245\u2013258","journal-title":"J Proteome Res"},{"key":"BFEMBR202051169_CR6","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","volume":"121","author":"JV Bonventre","year":"2011","unstructured":"Bonventre JV, Yang L (2011) Cellular pathophysiology of ischemic\n                  acute kidney injury. J Clin Invest 121: 4210\u20134221","journal-title":"J Clin Invest"},{"key":"BFEMBR202051169_CR7","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.celrep.2019.04.012","volume":"27","author":"PT Brinkkoetter","year":"2019","unstructured":"Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, \u00d6zel C, Koehler\n                  S, Hagmann HH, Ising C, Kuczkowski A et al\n                  (2019) Anaerobic glycolysis maintains the glomerular filtration barrier\n                  independent of mitochondrial metabolism and dynamics. Cell Rep 27:\n                  1551\u20131566.e1555","journal-title":"Cell Rep"},{"key":"BFEMBR202051169_CR8","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jhep.2016.11.003","volume":"66","author":"E Ceni","year":"2017","unstructured":"Ceni E, Mello T, Polvani S, Vasseur-Cognet M, Tarocchi M, Tempesti\n                  S, Cavalieri D, Beltrame L, Marroncini G, Pinzani M et\n                    al (2017) The orphan nuclear receptor COUP-TFII coordinates\n                  hypoxia-independent proangiogenic responses in hepatic stellate cells. J Hepatol\n                  66: 754\u2013764","journal-title":"J Hepatol"},{"key":"BFEMBR202051169_CR9","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1210\/me.2011-1305","volume":"26","author":"X Chen","year":"2012","unstructured":"Chen X, Qin J, Cheng CM, Tsai MJ, Tsai SY (2012) COUP-TFII is a\n                  major regulator of cell cycle and Notch signaling pathways. Mol Endocrinol 26:\n                  1268\u20131277","journal-title":"Mol Endocrinol"},{"key":"BFEMBR202051169_CR10","doi-asserted-by":"crossref","first-page":"F561","DOI":"10.1152\/ajprenal.00036.2017","volume":"313","author":"H Ding","year":"2017","unstructured":"Ding H, Jiang L, Xu J, Bai F, Zhou Y, Yuan Q, Luo J, Zen K, Yang J\n                  (2017) Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast\n                  activation and renal fibrosis. Am J Physiol Renal Physiol 313:\n                  F561\u2013F575","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFEMBR202051169_CR11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","volume":"8","author":"JS Duffield","year":"2013","unstructured":"Duffield JS, Lupher M, Thannickal VJ, Wynn TA (2013) Host responses\n                  in tissue repair and fibrosis. Annu Rev Pathol 8: 241\u2013276","journal-title":"Annu Rev Pathol"},{"key":"BFEMBR202051169_CR12","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1172\/JCI72267","volume":"124","author":"JS Duffield","year":"2014","unstructured":"Duffield JS (2014) Cellular and molecular mechanisms in kidney\n                  fibrosis. J Clin Invest 124: 2299\u20132306","journal-title":"J Clin Invest"},{"key":"BFEMBR202051169_CR13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2019.04.013","volume":"30","author":"PA Dumesic","year":"2019","unstructured":"Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N,\n                  Jedrychowski M, Paschini M, Kazak L, Wilensky SE et\n                    al (2019) An evolutionarily conserved uORF regulates pgc1\u03b1 and\n                  oxidative metabolism in mice, flies, and Bluefin tuna. Cell Metab 30:\n                  190\u2013200.e196","journal-title":"Cell Metab"},{"key":"BFEMBR202051169_CR14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","volume":"4","author":"JE Elias","year":"2007","unstructured":"Elias JE, Gygi SP (2007) Target-decoy search strategy for increased\n                  confidence in large-scale protein identifications by mass spectrometry. Nat\n                  Methods 4: 207\u2013214","journal-title":"Nat Methods"},{"key":"BFEMBR202051169_CR15","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"JK Eng","year":"1994","unstructured":"Eng JK, McCormack AL, Yates JR (1994) An approach to correlate\n                  tandem mass spectral data of peptides with amino acid sequences in a protein\n                  database. J Am Soc Mass Spectrom 5: 976\u2013989","journal-title":"J Am Soc Mass Spectrom"},{"key":"BFEMBR202051169_CR16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","volume":"11","author":"LL Falke","year":"2015","unstructured":"Falke LL, Gholizadeh S, Goldschmeding R, Kok RJ, Nguyen TQ (2015)\n                  Diverse origins of the myofibroblast-implications for kidney fibrosis. Nat Rev\n                  Nephrol 11: 233\u2013244","journal-title":"Nat Rev Nephrol"},{"key":"BFEMBR202051169_CR17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s12094-019-02190-z","volume":"22","author":"X Fang","year":"2020","unstructured":"Fang X, Liu CX, Zeng XR, Huang XM, Chen WL, Wang Y, Ai F (2020)\n                  Orphan nuclear receptor COUP-TFII is an oncogenic gene in renal cell carcinoma.\n                  Clin Transl Oncol 22: 772\u2013781","journal-title":"Clin Transl Oncol"},{"key":"BFEMBR202051169_CR18","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1681\/ASN.2017020130","volume":"28","author":"SH Han","year":"2017","unstructured":"Han SH, Wu MY, Nam BY, Park JT, Yoo TH, Kang SW, Park J, Chinga F,\n                  Li SY, Susztak K (2017) PGC-1alpha protects from notch-induced kidney fibrosis\n                  development. J Am Soc Nephrol 28: 3312\u20133322","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR202051169_CR19","doi-asserted-by":"crossref","first-page":"14026","DOI":"10.1111\/jcmm.16013","volume":"24","author":"J Henderson","year":"2020","unstructured":"Henderson J, Duffy L, Stratton R, Ford D, O'Reilly S (2020)\n                  Metabolic reprogramming of glycolysis and glutamine metabolism are key events in\n                  myofibroblast transition in systemic sclerosis pathogenesis. J Cell Mol Med 24:\n                  14026\u201314038","journal-title":"J Cell Mol Med"},{"key":"BFEMBR202051169_CR20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fcell.2018.00150","volume":"6","author":"W Hou","year":"2018","unstructured":"Hou W, Syn WK (2018) Role of metabolism in hepatic stellate cell\n                  activation and fibrogenesis. Front Cell Dev Biol 6: 150","journal-title":"Front Cell Dev Biol"},{"key":"BFEMBR202051169_CR21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","volume":"2","author":"BD Humphreys","year":"2008","unstructured":"Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S,\n                  Duffield JS, McMahon AP, Bonventre JV (2008) Intrinsic epithelial cells repair the\n                  kidney after injury. Cell Stem Cell 2: 284\u2013291","journal-title":"Cell Stem Cell"},{"key":"BFEMBR202051169_CR22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","volume":"176","author":"BD Humphreys","year":"2010","unstructured":"Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre\n                  JV, Valerius MT, McMahon AP, Duffield JS (2010) Fate tracing reveals the pericyte\n                  and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176:\n                  85\u201397","journal-title":"Am J Pathol"},{"key":"BFEMBR202051169_CR23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","volume":"80","author":"BD Humphreys","year":"2018","unstructured":"Humphreys BD (2018) Mechanisms of renal fibrosis. Annu Rev Physiol\n                  80: 309\u2013326","journal-title":"Annu Rev Physiol"},{"key":"BFEMBR202051169_CR24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0022-4804(76)90108-6","volume":"20","author":"MJ Im","year":"1976","unstructured":"Im MJ, Freshwater MF, Hoopes JE (1976) Enzyme activities in\n                  granulation tissue: energy for collagen synthesis. J Surg Res 20:\n                  121\u2013125","journal-title":"J Surg Res"},{"key":"BFEMBR202051169_CR25","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran\n                  R, Wang AY, Yang CW (2013) Chronic kidney disease: global dimension and\n                  perspectives. Lancet 382: 260\u2013272","journal-title":"Lancet"},{"key":"BFEMBR202051169_CR26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1096\/fj.04-1604fje","volume":"19","author":"S Kale","year":"2005","unstructured":"Kale S, Hanai J, Chan B, Karihaloo A, Grotendorst G, Cantley L,\n                  Sukhatme VP (2005) Microarray analysis of in\n                    vitro pericyte differentiation reveals an angiogenic program of gene\n                  expression. FASEB J 19: 270\u2013271","journal-title":"FASEB J"},{"key":"BFEMBR202051169_CR27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","volume":"21","author":"HM Kang","year":"2015","unstructured":"Kang HM, Ahn SH, Choi P, Ko Y-A, Han SH, Chinga F, Park ASD, Tao J,\n                  Sharma K, Pullman J et al (2015) Defective\n                  fatty acid oxidation in renal tubular epithelial cells has a key role in kidney\n                  fibrosis development. Nat Med 21: 37\u201346","journal-title":"Nat Med"},{"key":"BFEMBR202051169_CR28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/path.4104","volume":"229","author":"F Klingberg","year":"2013","unstructured":"Klingberg F, Hinz B, White ES (2013) The myofibroblast matrix:\n                  implications for tissue repair and fibrosis. J Pathol 229:\n                  298\u2013309","journal-title":"J Pathol"},{"key":"BFEMBR202051169_CR29","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.stemcr.2014.08.008","volume":"3","author":"A Kobayashi","year":"2014","unstructured":"Kobayashi A, Mugford JW, Krautzberger AM, Naiman N, Liao J, McMahon\n                  AP (2014) Identification of a multipotent self-renewing stromal progenitor\n                  population during mammalian kidney organogenesis. Stem Cell Rep 3:\n                  650\u2013662","journal-title":"Stem Cell Rep"},{"key":"BFEMBR202051169_CR30","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1164\/rccm.201201-0084OC","volume":"186","author":"RM Kottmann","year":"2012","unstructured":"Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T,\n                  Salibi R, Honnons S, Jones C, Isern NG, Hu JZ et\n                    al (2012) Lactic acid is elevated in idiopathic pulmonary fibrosis\n                  and induces myofibroblast differentiation via pH-dependent activation of\n                  transforming growth factor-beta. Am J Respir Crit Care Med 186:\n                  740\u2013751","journal-title":"Am J Respir Crit Care Med"},{"key":"BFEMBR202051169_CR31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2014.11.004","volume":"16","author":"R Kramann","year":"2015","unstructured":"Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie\n                  PA, Henderson JM, Ebert BL, Humphreys BD (2015) Perivascular Gli1+ progenitors are\n                  key contributors to injury-induced organ fibrosis. Cell Stem Cell 16:\n                  51\u201366","journal-title":"Cell Stem Cell"},{"key":"BFEMBR202051169_CR32","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1681\/ASN.2015020177","volume":"27","author":"R Lan","year":"2016","unstructured":"Lan R, Geng H, Singha PK, Saikumar P, Bottinger EP, Weinberg JM,\n                  Venkatachalam MA (2016) Mitochondrial pathology and glycolytic shift during\n                  proximal tubule atrophy after ischemic AKI. J Am Soc Nephrol 27:\n                  3356\u20133367","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR202051169_CR33","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1681\/ASN.2017121283","volume":"29","author":"DR Lemos","year":"2018","unstructured":"Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N,\n                  Miyoshi T, Susa K, Johnson BG, Soliman K et al\n                  (2018) Interleukin-1beta activates a MYC-dependent metabolic switch in kidney\n                  stromal cells necessary for progressive tubulointerstitial fibrosis. J Am Soc\n                  Nephrol 29: 1690\u20131705","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR202051169_CR34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","volume":"24","author":"MO Li","year":"2006","unstructured":"Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006)\n                  Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol\n                  24: 99\u2013146","journal-title":"Annu Rev Immunol"},{"key":"BFEMBR202051169_CR35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cmet.2008.12.002","volume":"9","author":"L Li","year":"2009","unstructured":"Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L,\n                  Tsai SY, Tsai MJ (2009) The nuclear orphan receptor COUP-TFII plays an essential\n                  role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab 9:\n                  77\u201387","journal-title":"Cell Metab"},{"key":"BFEMBR202051169_CR36","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2353\/ajpath.2008.080433","volume":"173","author":"SL Lin","year":"2008","unstructured":"Lin SL, Kisseleva T, Brenner DA, Duffield JS (2008) Pericytes and\n                  perivascular fibroblasts are the primary source of collagen-producing cells in\n                  obstructive fibrosis of the kidney. Am J Pathol 173: 1617\u20131627","journal-title":"Am J Pathol"},{"key":"BFEMBR202051169_CR37","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1681\/ASN.2016111246","volume":"28","author":"J Liu","year":"2017","unstructured":"Liu J, Edgington-Giordano F, Dugas C, Abrams A, Katakam P, Satou R,\n                  Saifudeen Z (2017) Regulation of nephron progenitor cell self-renewal by\n                  intermediary metabolism. J Am Soc Nephrol 28: 3323\u20133335","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR202051169_CR38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","volume":"13","author":"L Madisen","year":"2010","unstructured":"Madisen L, Zwingman TA, Sunkin SM, Oh SW, Zariwala HA, Gu H, Ng LL,\n                  Palmiter RD, Hawrylycz MJ, Jones AR et al\n                  (2010) A robust and high-throughput Cre reporting and characterization system for\n                  the whole mouse brain. Nat Neurosci 13: 133\u2013140","journal-title":"Nat Neurosci"},{"key":"BFEMBR202051169_CR39","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","volume":"86","author":"GC McAlister","year":"2014","unstructured":"McAlister GC, Nusinow DP, Jedrychowski MP, Wuhr M, Huttlin EL,\n                  Erickson BK, Rad R, Haas W, Gygi SP (2014) MultiNotch MS3 enables accurate,\n                  sensitive, and multiplexed detection of differential expression across cancer cell\n                  line proteomes. Anal Chem 86: 7150\u20137158","journal-title":"Anal Chem"},{"key":"BFEMBR202051169_CR40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ki.2011.327","volume":"81","author":"XM Meng","year":"2012","unstructured":"Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY (2012)\n                  Disruption of Smad4 impairs TGF-beta\/Smad3 and Smad7 transcriptional regulation\n                  during renal inflammation and fibrosis in vivo\n                  and in vitro. Kidney Int 81:\n                  266\u2013279","journal-title":"Kidney Int"},{"key":"BFEMBR202051169_CR41","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nbt.3392","volume":"33","author":"R Morizane","year":"2015","unstructured":"Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV\n                  (2015) Nephron organoids derived from human pluripotent stem cells model kidney\n                  development and injury. Nat Biotechnol 33: 1193\u20131200","journal-title":"Nat Biotechnol"},{"key":"BFEMBR202051169_CR42","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nprot.2008.38","volume":"3","author":"A Mukhopadhyay","year":"2008","unstructured":"Mukhopadhyay A, Deplancke B, Walhout AJ, Tissenbaum HA (2008)\n                  Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative\n                  real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protoc 3:\n                  698\u2013709","journal-title":"Nat Protoc"},{"key":"BFEMBR202051169_CR43","volume":"10","author":"S Nakagawa","year":"2015","unstructured":"Nakagawa S, Nishihara K, Miyata H, Shinke H, Tomita E, Kajiwara M,\n                  Matsubara T, Iehara N, Igarashi Y, Yamada H et\n                    al (2015) Molecular markers of tubulointerstitial fibrosis and\n                  tubular cell damage in patients with chronic kidney disease. PLoS One 10:\n                  e0136994","journal-title":"PLoS One"},{"key":"BFEMBR202051169_CR44","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00726-018-2611-x","volume":"50","author":"P de Paz-Lugo","year":"2018","unstructured":"de Paz-Lugo P, Lupianez JA, Melendez-Hevia E (2018) High glycine\n                  concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an\n                  important cause of osteoarthritis. Amino Acids 50: 1357\u20131365","journal-title":"Amino Acids"},{"key":"BFEMBR202051169_CR45","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/ncomms3427","volume":"4","author":"CV Pecot","year":"2013","unstructured":"Pecot CV, Rupaimoole R, Yang Da, Akbani R, Ivan C, Lu C, Wu S, Han\n                  H-D, Shah MY, Rodriguez-Aguayo C et al (2013)\n                  Tumour angiogenesis regulation by the miR-200 family. Nat Commun 4:\n                  2427","journal-title":"Nat Commun"},{"key":"BFEMBR202051169_CR46","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1101\/gad.13.8.1037","volume":"13","author":"FA Pereira","year":"1999","unstructured":"Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (1999) The orphan\n                  nuclear receptor COUP-TFII is required for angiogenesis and heart development.\n                  Genes Dev 13: 1037\u20131049","journal-title":"Genes Dev"},{"key":"BFEMBR202051169_CR47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00418-008-0433-8","volume":"130","author":"N Picard","year":"2008","unstructured":"Picard N, Baum O, Vogetseder A, Kaissling B, Le Hir M (2008) Origin\n                  of renal myofibroblasts in the model of unilateral ureter obstruction in the rat.\n                  Histochem Cell Biol 130: 141\u2013155","journal-title":"Histochem Cell Biol"},{"key":"BFEMBR202051169_CR48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1289\/ehp.8980221","volume":"80","author":"DF Pinney","year":"1989","unstructured":"Pinney DF, Emerson Jr CP (1989) 10T1\/2 cells: an in vitro model for molecular genetic analysis of\n                  mesodermal determination and differentiation. Environ Health Perspect 80:\n                  221\u2013227","journal-title":"Environ Health Perspect"},{"key":"BFEMBR202051169_CR49","doi-asserted-by":"crossref","first-page":"E868","DOI":"10.1152\/ajpendo.00433.2014","volume":"308","author":"J Planchais","year":"2015","unstructured":"Planchais J, Boutant M, Fauveau V, Qing LD, Sabra-Makke L, Bossard\n                  P, Vasseur-Cognet M, Pegorier JP (2015) The role of chicken ovalbumin upstream\n                  promoter transcription factor II in the regulation of hepatic fatty acid oxidation\n                  and gluconeogenesis in newborn mice. Am J Physiol Endocrinol Metab 308:\n                  E868\u2013E878","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFEMBR202051169_CR50","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/ijc.28502","volume":"134","author":"S Polvani","year":"2014","unstructured":"Polvani S, Tarocchi M, Tempesti S, Mello T, Ceni E, Buccoliero F,\n                  D'Amico M, Boddi V, Farsi M, Nesi S et al\n                  (2014) COUP-TFII in pancreatic adenocarcinoma: clinical implication for patient\n                  survival and tumor progression. Int J Cancer 134: 1648\u20131658","journal-title":"Int J Cancer"},{"key":"BFEMBR202051169_CR51","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt369","volume":"106","author":"DR Principe","year":"2014","unstructured":"Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L,\n                  Pasche B, Lee C, Grippo PJ (2014) TGF-beta: duality of function between tumor\n                  prevention and carcinogenesis. J Natl Cancer Inst 106: djt369","journal-title":"J Natl Cancer Inst"},{"key":"BFEMBR202051169_CR52","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.2337\/db05-0603","volume":"55","author":"G Proctor","year":"2006","unstructured":"Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M (2006)\n                  Regulation of renal fatty acid and cholesterol metabolism, inflammation, and\n                  fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 55:\n                  2502\u20132509","journal-title":"Diabetes"},{"key":"BFEMBR202051169_CR53","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature11674","volume":"493","author":"J Qin","year":"2013","unstructured":"Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala\n                  G, Lin X, Feng XH et al (2013) COUP-TFII\n                  inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature\n                  493: 236\u2013240","journal-title":"Nature"},{"key":"BFEMBR202051169_CR54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrneph.2017.173","volume":"14","author":"TJ Rabelink","year":"2018","unstructured":"Rabelink TJ, Carmeliet P (2018) Renal metabolism in 2017:\n                  Glycolytic adaptation and progression of kidney disease. Nat Rev Nephrol 14:\n                  75\u201376","journal-title":"Nat Rev Nephrol"},{"key":"BFEMBR202051169_CR55","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","volume":"8","author":"FA Ran","year":"2013","unstructured":"Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013)\n                  Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8:\n                  2281\u20132308","journal-title":"Nat Protoc"},{"key":"BFEMBR202051169_CR56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1165\/rcmb.2014-0445OC","volume":"54","author":"S Rangarajan","year":"2016","unstructured":"Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders YY, Ding\n                  Q, Antony VB, Zhang J, Zmijewski J, Thannickal VJ (2016) Novel mechanisms for the\n                  antifibrotic action of nintedanib. Am J Respir Cell Mol Biol 54:\n                  51\u201359","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFEMBR202051169_CR57","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","volume":"372","author":"DC Rockey","year":"2015","unstructured":"Rockey DC, Bell PD, Hill JA (2015) Fibrosis\u2013a common pathway to\n                  organ injury and failure. N Engl J Med 372: 1138\u20131149","journal-title":"N Engl J Med"},{"key":"BFEMBR202051169_CR58","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.88","volume":"3","author":"P Romagnani","year":"2017","unstructured":"Romagnani P, Remuzzi G, Glassock R, Levin A, Jager KJ, Tonelli M,\n                  Massy Z, Wanner C, Anders HJ (2017) Chronic kidney disease. Nat Rev Dis Primers 3:\n                  17088","journal-title":"Nat Rev Dis Primers"},{"key":"BFEMBR202051169_CR59","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2012.10.050","volume":"151","author":"J Ruas","year":"2012","unstructured":"Ruas J, White J, Rao R, Kleiner S, Brannan K, Harrison B, Greene N,\n                  Wu J, Estall J, Irving B et al (2012) A PGC-1\u03b1\n                  isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell\n                  151: 1319\u20131331","journal-title":"Cell"},{"key":"BFEMBR202051169_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endocr\/bqz046","volume":"161","author":"IR Schlaepfer","year":"2020","unstructured":"Schlaepfer IR, Joshi M (2020) CPT1A-mediated fat oxidation,\n                  mechanisms, and therapeutic potential. Endocrinology 161: 1\u201314","journal-title":"Endocrinology"},{"key":"BFEMBR202051169_CR61","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha Vk, Mukherjee S, Ebert Bl, Gillette\n                  Ma, Paulovich A, Pomeroy Sl, Golub Tr, Lander Es et\n                    al (2005) Gene set enrichment analysis: a knowledge-based approach\n                  for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:\n                  15545\u201315550","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051169_CR62","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1242\/dev.01808","volume":"132","author":"N Takamoto","year":"2005","unstructured":"Takamoto N, You LR, Moses K, Chiang C, Zimmer WE, Schwartz RJ,\n                  DeMayo FJ, Tsai MJ, Tsai SY (2005) COUP-TFII is essential for radial and\n                  anteroposterior patterning of the stomach. Development 132:\n                  2179\u20132189","journal-title":"Development"},{"key":"BFEMBR202051169_CR63","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","volume":"8","author":"L Ting","year":"2011","unstructured":"Ting L, Rad R, Gygi SP, Haas W (2011) MS3 eliminates ratio\n                  distortion in isobaric multiplexed quantitative proteomics. Nat Methods 8:\n                  937\u2013940","journal-title":"Nat Methods"},{"key":"BFEMBR202051169_CR64","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002)\n                  Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev\n                  Mol Cell Biol 3: 349\u2013363","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR202051169_CR65","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","volume":"531","author":"MT Tran","year":"2016","unstructured":"Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W,\n                  Clish CB, Stillman IE, Karumanchi SA, Rhee EP et\n                    al (2016) PGC1alpha drives NAD biosynthesis linking oxidative\n                  metabolism to renal protection. Nature 531: 528\u2013532","journal-title":"Nature"},{"key":"BFEMBR202051169_CR66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","volume":"138","author":"D Wessel","year":"1984","unstructured":"Wessel D, Flugge UI (1984) A method for the quantitative recovery\n                  of protein in dilute solution in the presence of detergents and lipids. Anal\n                  Biochem 138: 141\u2013143","journal-title":"Anal Biochem"},{"key":"BFEMBR202051169_CR67","doi-asserted-by":"crossref","first-page":"19619","DOI":"10.1073\/pnas.1908706116","volume":"116","author":"PC Wilson","year":"2019","unstructured":"Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling\n                  PA, Waikar SS, Humphreys BD (2019) The single-cell transcriptomic landscape of\n                  early human diabetic nephropathy. Proc Natl Acad Sci USA 116:\n                  19619\u201319625","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051169_CR68","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1038\/ncomms9245","volume":"6","author":"S-P Wu","year":"2015","unstructured":"Wu S-P, Kao C-Y, Wang L, Creighton CJ, Yang J, Donti TR, Harmancey\n                  R, Vasquez HG, Graham BH, Bellen HJ et al\n                  (2015) Increased COUP-TFII expression in adult hearts induces mitochondrial\n                  dysfunction resulting in heart failure. Nat Commun 6: 8245","journal-title":"Nat Commun"},{"key":"BFEMBR202051169_CR69","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.2018090912","volume":"30","author":"H Wu","year":"2019","unstructured":"Wu H, Kirita Y, Donnelly EL, Humphreys BD (2019) Advantages of\n                  single-nucleus over single-cell RNA sequencing of adult kidney: rare cell types\n                  and novel cell states revealed in fibrosis. J Am Soc Nephrol 30:\n                  23\u201332","journal-title":"J Am Soc Nephrol"},{"key":"BFEMBR202051169_CR70","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2012","unstructured":"Wynn TA, Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic\n                  translation for fibrotic disease. Nat Med 18: 1028\u20131040","journal-title":"Nat Med"},{"key":"BFEMBR202051169_CR71","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1164\/rccm.201504-0780OC","volume":"192","author":"N Xie","year":"2015","unstructured":"Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu RM, Bernard K,\n                  Thannickal VJ, Liu G (2015) Glycolytic reprogramming in myofibroblast\n                  differentiation and lung fibrosis. Am J Respir Crit Care Med 192:\n                  1462\u20131474","journal-title":"Am J Respir Crit Care Med"},{"key":"BFEMBR202051169_CR72","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1172\/JCI87414","volume":"126","author":"X Xie","year":"2016","unstructured":"Xie X, Tsai SY, Tsai MJ (2016) COUP-TFII regulates satellite cell\n                  function and muscular dystrophy. J Clin Invest 126: 3929\u20133941","journal-title":"J Clin Invest"},{"key":"BFEMBR202051169_CR73","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","volume":"16","author":"L Yang","year":"2010","unstructured":"Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV (2010)\n                  Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury. Nat\n                  Med 16: 535\u2013543. 531p following 143","journal-title":"Nat Med"},{"key":"BFEMBR202051169_CR74","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fmed.2018.00010","volume":"5","author":"DC Zank","year":"2018","unstructured":"Zank DC, Bueno M, Mora AL, Rojas M (2018) Idiopathic pulmonary\n                  fibrosis: aging, mitochondrial dysfunction, and cellular bioenergetics. Front Med\n                  (Lausanne) 5: 10","journal-title":"Front Med (Lausanne)"},{"key":"BFEMBR202051169_CR75","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-7075-11-10","volume":"11","author":"S Zhang","year":"2014","unstructured":"Zhang S, Hulver MW, McMillan RP, Cline MA, Gilbert ER (2014) The\n                  pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility. Nutr\n                  Metab 11: 10","journal-title":"Nutr Metab"},{"key":"BFEMBR202051169_CR76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s42255-018-0008-5","volume":"1","author":"X Zhao","year":"2019","unstructured":"Zhao X, Psarianos P, Ghoraie LS, Yip K, Goldstein D, Gilbert R,\n                  Witterick I, Pang H, Hussain A, Lee JH et al\n                  (2019) Metabolic regulation of dermal fibroblasts contributes to skin\n                  extracellular matrix homeostasis and fibrosis. Nat Metab 1:\n                  147\u2013157","journal-title":"Nat Metab"},{"key":"BFEMBR202051169_CR77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41573-019-0040-5","volume":"19","author":"X Zhao","year":"2020","unstructured":"Zhao X, Kwan JYY, Yip K, Liu PP, Liu FF (2020) Targeting metabolic\n                  dysregulation for fibrosis therapy. Nat Rev Drug Discov 19:\n                  57\u201375","journal-title":"Nat Rev Drug Discov"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202051169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.202051169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202051169\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202051169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202051169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:45:42Z","timestamp":1779111942000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202051169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,4]]}},"alternative-id":["BFEMBR202051169"],"URL":"https:\/\/doi.org\/10.15252\/embr.202051169","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"24 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Bonventre is cofounder and holds equity in Goldfinch Bio. He is\n                co-inventor on KIM-1 and kidney organoid patents assigned to Mass General Brigham.\n                Dr. Bonventre's interests were reviewed and are managed by BWH and Partners\n                HealthCare in accordance with their conflict of interest policies. The other authors\n                declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202051169"}}