{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:18:38Z","timestamp":1792721918100,"version":"4.5.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010629","name":"Fulbright Association","doi-asserted-by":"publisher","award":["FY\u20102017\u2010TR\u2010PD\u201001"],"award-info":[{"award-number":["FY\u20102017\u2010TR\u2010PD\u201001"]}],"id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["336643"],"award-info":[{"award-number":["336643"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["692511"],"award-info":[{"award-number":["692511"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1123"],"award-info":[{"award-number":["SFB 1123"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 267\u2010A02"],"award-info":[{"award-number":["TRR 267\u2010A02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Transregio 83"],"award-info":[{"award-number":["DFG Transregio 83"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Transregio 86"],"award-info":[{"award-number":["DFG Transregio 86"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2020,12,3]]},"DOI":"10.15252\/embr.202051462","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T03:11:01Z","timestamp":1604373061000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Inositol\u2010requiring enzyme\u20101 regulates phosphoinositide signaling lipids and macrophage growth"],"prefix":"10.1038","volume":"21","author":[{"given":"Syed Muhammad","family":"Hamid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mevlut","family":"Citir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem Murat","family":"Terzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-6968","authenticated-orcid":false,"given":"Ismail","family":"Cimen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli Ekin","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-6055","authenticated-orcid":false,"given":"Begum","family":"Kocaturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut Inci","family":"Onat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Arditi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-8714","authenticated-orcid":false,"given":"Christian","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Traynor\u2010Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5824-2171","authenticated-orcid":false,"given":"Carsten","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-1803","authenticated-orcid":false,"given":"Ebru","family":"Erbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"BFEMBR202051462_CR1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43036","volume":"7","author":"D Acosta\u2010Alvear","year":"2018","unstructured":"Acosta\u2010Alvear D, Karagoz GE, Frohlich F, Li H, Walther TC, Walter P (2018) The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife 7: e43036","journal-title":"Elife"},{"key":"BFEMBR202051462_CR2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tcb.2012.02.006","volume":"22","author":"C Appenzeller\u2010Herzog","year":"2012","unstructured":"Appenzeller\u2010Herzog C, Hall MN (2012) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 22: 274\u2013282","journal-title":"Trends Cell Biol"},{"key":"BFEMBR202051462_CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0065-2571(02)00043-2","volume":"43","author":"K Backers","year":"2003","unstructured":"Backers K, Blero D, Paternotte N, Zhang J, Erneux C (2003) The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5\u2010phosphatases. Adv Enzyme Regul 43: 15\u201328","journal-title":"Adv Enzyme Regul"},{"key":"BFEMBR202051462_CR4","first-page":"231","volume":"24","author":"T Balla","year":"2009","unstructured":"Balla T, Szentpetery Z, Kim YJ (2009) Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) 24: 231\u2013244","journal-title":"Physiology (Bethesda)"},{"key":"BFEMBR202051462_CR5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281\u2013297","journal-title":"Cell"},{"key":"BFEMBR202051462_CR6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.201010055","volume":"192","author":"S Behrman","year":"2011","unstructured":"Behrman S, Acosta\u2010Alvear D, Walter P (2011) A CHOP\u2010regulated microRNA controls rhodopsin expression. J Cell Biol 192: 919\u2013927","journal-title":"J Cell Biol"},{"key":"BFEMBR202051462_CR7","doi-asserted-by":"crossref","first-page":"BSR20190054","DOI":"10.1042\/BSR20190054","volume":"39","author":"K Ben\u2010Dror","year":"2019","unstructured":"Ben\u2010Dror K, Birk R (2019) Oleic acid ameliorates palmitic acid\u2010cellsinduced ER stress and inflammation markers in naive and cerulein\u2010treated exocrine pancreas. Biosci Rep 39: BSR20190054","journal-title":"Biosci Rep"},{"key":"BFEMBR202051462_CR8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ceb.2017.02.012","volume":"45","author":"I Ben\u2010Sahra","year":"2017","unstructured":"Ben\u2010Sahra I, Manning BD (2017) mTORC1 signaling and the metabolic control of cell growth. Curr Opin Cell Biol 45: 72\u201382","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBR202051462_CR9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","volume":"409","author":"E Bernstein","year":"2001","unstructured":"Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409: 363\u2013366","journal-title":"Nature"},{"key":"BFEMBR202051462_CR10","doi-asserted-by":"crossref","first-page":"D149","DOI":"10.1093\/nar\/gkm995","volume":"36","author":"D Betel","year":"2008","unstructured":"Betel D, Wilson M, Gabow A, Marks DS, Sander C (2008) The microRNA.org resource: targets and expression. Nucleic Acids Res 36: D149\u2013D153","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR202051462_CR11","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","volume":"11","author":"D Betel","year":"2010","unstructured":"Betel D, Koppal A, Agius P, Sander C, Leslie C (2010) Comprehensive modeling of microRNA targets predicts functional non\u2010conserved and non\u2010canonical sites. Genome Biol 11: R90","journal-title":"Genome Biol"},{"key":"BFEMBR202051462_CR12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.118.313854","volume":"124","author":"EA Blackwood","year":"2019","unstructured":"Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, M\u00fcller OJ et al (2019) ATF6 regulates cardiac hypertrophy by transcriptional induction of the mTORC1 activator, Rheb. Circ Res 124: 79\u201393","journal-title":"Circ Res"},{"key":"BFEMBR202051462_CR13","doi-asserted-by":"crossref","first-page":"17954","DOI":"10.1074\/jbc.M801395200","volume":"283","author":"R Brunsing","year":"2008","unstructured":"Brunsing R, Omori SA, Weber F, Bicknell A, Friend L, Rickert R, Niwa M (2008) B\u2010 and T\u2010cell development both involve activity of the unfolded protein response pathway. J Biol Chem 283: 17954\u201317961","journal-title":"J Biol Chem"},{"key":"BFEMBR202051462_CR14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41556-019-0329-y","volume":"21","author":"A Carreras\u2010Sureda","year":"2019","unstructured":"Carreras\u2010Sureda A, Jana F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos\u2010Fernandez E, Sassano ML et al (2019) Non\u2010canonical function of IRE1alpha determines mitochondria\u2010associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nat Cell Biol 21: 755\u2013767","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202051462_CR15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1083\/jcb.201603076","volume":"215","author":"A Chaix","year":"2016","unstructured":"Chaix A, Zarrinpar A, Panda S (2016) The circadian coordination of cell biology. J Cell Biol 215: 15\u201325","journal-title":"J Cell Biol"},{"key":"BFEMBR202051462_CR16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/genetics\/162.1.29","volume":"162","author":"HJ Chang","year":"2002","unstructured":"Chang HJ, Jones EW, Henry SA (2002) Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae. Genetics 162: 29\u201343","journal-title":"Genetics"},{"key":"BFEMBR202051462_CR17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature09092","volume":"465","author":"S Cheloufi","year":"2010","unstructured":"Cheloufi S, dos Santos CO, Chong MM, Hannon GJ (2010) A dicer\u2010independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465: 584\u2013589","journal-title":"Nature"},{"key":"BFEMBR202051462_CR18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","volume":"564","author":"J Chen","year":"2018","unstructured":"Chen J, Chen ZJ (2018) PtdIns4P on dispersed trans\u2010Golgi network mediates NLRP3 inflammasome activation. Nature 564: 71\u201376","journal-title":"Nature"},{"key":"BFEMBR202051462_CR19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nature03868","volume":"436","author":"TP Chendrimada","year":"2005","unstructured":"Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436: 740\u2013744","journal-title":"Nature"},{"key":"BFEMBR202051462_CR20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ceca.2017.02.009","volume":"63","author":"WY Chung","year":"2017","unstructured":"Chung WY, Jha A, Ahuja M, Muallem S (2017) Ca(2+) influx at the ER\/PM junctions. Cell Calcium 63: 29\u201332","journal-title":"Cell Calcium"},{"key":"BFEMBR202051462_CR21","doi-asserted-by":"crossref","first-page":"358ra126","DOI":"10.1126\/scitranslmed.aaf9087","volume":"8","author":"I Cimen","year":"2016","unstructured":"Cimen I, Kocaturk B, Koyuncu S, Tufanli O, Onat UI, Yildirim AD, Apaydin O, Demirsoy S, Aykut ZG, Nguyen UT et al (2016) Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci Transl Med 8: 358ra126","journal-title":"Sci Transl Med"},{"key":"BFEMBR202051462_CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cmet.2009.11.002","volume":"11","author":"G Cretenet","year":"2010","unstructured":"Cretenet G, le Clech M, Gachon F (2010) Circadian clock\u2010coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver. Cell Metab 11: 47\u201357","journal-title":"Cell Metab"},{"key":"BFEMBR202051462_CR23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1677\/JOE-08-0041","volume":"197","author":"E Diakogiannaki","year":"2008","unstructured":"Diakogiannaki E, Welters HJ, Morgan NG (2008) Differential regulation of the endoplasmic reticulum stress response in pancreatic beta\u2010cells exposed to long\u2010chain saturated and monounsaturated fatty acids. J Endocrinol 197: 553\u2013563","journal-title":"J Endocrinol"},{"key":"BFEMBR202051462_CR24","doi-asserted-by":"crossref","first-page":"30749","DOI":"10.1074\/jbc.R000015200","volume":"275","author":"E Duplus","year":"2000","unstructured":"Duplus E, Glorian M, Forest C (2000) Fatty acid regulation of gene transcription. J Biol Chem 275: 30749\u201330752","journal-title":"J Biol Chem"},{"key":"BFEMBR202051462_CR25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1242\/jcs.179663","volume":"129","author":"W Elong Edimo","year":"2016","unstructured":"Elong Edimo W, Ghosh S, Derua R, Janssens V, Waelkens E, Vanderwinden JM, Robe P, Erneux C (2016) SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells. J Cell Sci 129: 1101\u20131114","journal-title":"J Cell Sci"},{"key":"BFEMBR202051462_CR26","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm.2067","volume":"15","author":"E Erbay","year":"2009","unstructured":"Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF et al (2009) Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 15: 1383\u20131391","journal-title":"Nat Med"},{"key":"BFEMBR202051462_CR27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","volume":"170","author":"DA Fruman","year":"2017","unstructured":"Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT (2017) The PI3K pathway in human disease. Cell 170: 605\u2013635","journal-title":"Cell"},{"key":"BFEMBR202051462_CR28","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/ATVBAHA.111.237693","volume":"32","author":"GS Getz","year":"2012","unstructured":"Getz GS, Reardon CA (2012) Animal models of atherosclerosis. Arterioscler Thromb Vasc Biol 32: 1104\u20131115","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFEMBR202051462_CR29","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20390","volume":"5","author":"JA Gomez","year":"2016","unstructured":"Gomez JA, Rutkowski DT (2016) Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression. Elife 5: e20390","journal-title":"Elife"},{"key":"BFEMBR202051462_CR30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molcel.2017.06.012","volume":"67","author":"K Halbleib","year":"2017","unstructured":"Halbleib K, Pesek K, Covino R, Hofbauer HF, Wunnicke D, Hanelt I, Hummer G, Ernst R (2017) Activation of the unfolded protein response by lipid bilayer stress. Mol Cell 67: 673\u2013684 e8","journal-title":"Mol Cell"},{"key":"BFEMBR202051462_CR31","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","volume":"273","author":"K Hara","year":"1998","unstructured":"Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J (1998) Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF\u20104E BP1 through a common effector mechanism. J Biol Chem 273: 14484\u201314494","journal-title":"J Biol Chem"},{"key":"BFEMBR202051462_CR32","doi-asserted-by":"crossref","first-page":"16420","DOI":"10.1073\/pnas.1906999116","volume":"116","author":"JM Harnoss","year":"2019","unstructured":"Harnoss JM, le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D et al (2019) Disruption of IRE1alpha through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci USA 116: 16420\u201316429","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR33","doi-asserted-by":"crossref","first-page":"34525","DOI":"10.1074\/jbc.M704300200","volume":"282","author":"A Hayashi","year":"2007","unstructured":"Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T (2007) The role of brain\u2010derived neurotrophic factor (BDNF)\u2010induced XBP1 splicing during brain development. J Biol Chem 282: 34525\u201334534","journal-title":"J Biol Chem"},{"key":"BFEMBR202051462_CR34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012732","volume":"5","author":"KA Henry","year":"2010","unstructured":"Henry KA, Blank HM, Hoose SA, Polymenis M (2010) The unfolded protein response is not necessary for the G1\/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae. PLoS One 5: e12732","journal-title":"PLoS One"},{"key":"BFEMBR202051462_CR35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chemphyslip.2013.12.013","volume":"180","author":"SA Henry","year":"2014","unstructured":"Henry SA, Gaspar ML, Jesch SA (2014) The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast. Chem Phys Lipids 180: 23\u201343","journal-title":"Chem Phys Lipids"},{"key":"BFEMBR202051462_CR36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","volume":"8","author":"GS Hotamisligil","year":"2008","unstructured":"Hotamisligil GS, Erbay E (2008) Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8: 923\u2013934","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR202051462_CR37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900\u2013917","journal-title":"Cell"},{"key":"BFEMBR202051462_CR38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BST0370217","volume":"37","author":"J Huang","year":"2009","unstructured":"Huang J, Manning BD (2009) A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37: 217\u2013222","journal-title":"Biochem Soc Trans"},{"key":"BFEMBR202051462_CR39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1194\/jlr.M007104","volume":"52","author":"J Ishiyama","year":"2011","unstructured":"Ishiyama J, Taguchi R, Akasaka Y, Shibata S, Ito M, Nagasawa M, Murakami K (2011) Unsaturated FAs prevent palmitate\u2010induced LOX\u20101 induction via inhibition of ER stress in macrophages. J Lipid Res 52: 299\u2013307","journal-title":"J Lipid Res"},{"key":"BFEMBR202051462_CR40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nm970","volume":"10","author":"T Iwawaki","year":"2004","unstructured":"Iwawaki T, Akai R, Kohno K, Miura M (2004) A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med 10: 98\u2013102","journal-title":"Nat Med"},{"key":"BFEMBR202051462_CR41","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0903775106","volume":"106","author":"T Iwawaki","year":"2009","unstructured":"Iwawaki T, Akai R, Yamanaka S, Kohno K (2009) Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci USA 106: 16657\u201316662","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR42","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1210\/en.2007-0820","volume":"149","author":"S Kagawa","year":"2008","unstructured":"Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T (2008) Impact of transgenic overexpression of SH2\u2010containing inositol 5'\u2010phosphatase 2 on glucose metabolism and insulin signaling in mice. Endocrinology 149: 642\u2013650","journal-title":"Endocrinology"},{"key":"BFEMBR202051462_CR43","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","volume":"116","author":"H Kanda","year":"2006","unstructured":"Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K et al (2006) MCP\u20101 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116: 1494\u20131505","journal-title":"J Clin Invest"},{"key":"BFEMBR202051462_CR44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/srep00799","volume":"2","author":"N Kawasaki","year":"2012","unstructured":"Kawasaki N, Asada R, Saito A, Kanemoto S, Imaizumi K (2012) Obesity\u2010induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Sci Rep 2: 799","journal-title":"Sci Rep"},{"key":"BFEMBR202051462_CR45","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.celrep.2019.10.109","volume":"29","author":"TJ Kelly","year":"2019","unstructured":"Kelly TJ, Brummer A, Hooshdaran N, Tariveranmoshabad M, Zamudio JR (2019) Temporal control of the TGF\u2010beta signaling network by mouse ESC MicroRNA targets of different affinities. Cell Rep 29: 2702\u20132717 e7","journal-title":"Cell Rep"},{"key":"BFEMBR202051462_CR46","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.devcel.2011.09.005","volume":"21","author":"YJ Kim","year":"2011","unstructured":"Kim YJ, Guzman\u2010Hernandez ML, Balla T (2011) A highly dynamic ER\u2010derived phosphatidylinositol\u2010synthesizing organelle supplies phosphoinositides to cellular membranes. Dev Cell 21: 813\u2013824","journal-title":"Dev Cell"},{"key":"BFEMBR202051462_CR47","first-page":"E1881","volume":"113","author":"YK Kim","year":"2016","unstructured":"Kim YK, Kim B, Kim VN (2016) Re\u2010evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis. Proc Natl Acad Sci USA 113: E1881\u2013E1889","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR48","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.bbalip.2012.01.001","volume":"1821","author":"H Knaevelsrud","year":"2012","unstructured":"Knaevelsrud H, Simonsen A (2012) Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease. Biochim Biophys Acta 1821: 1133\u20131145","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBR202051462_CR49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1741-7007-9-47","volume":"9","author":"AV Korennykh","year":"2011","unstructured":"Korennykh AV, Korostelev AA, Egea PF, Finer\u2010Moore J, Stroud RM, Zhang C, Shokat KM, Walter P (2011) Structural and functional basis for RNA cleavage by Ire1. BMC Biol 9: 47","journal-title":"BMC Biol"},{"key":"BFEMBR202051462_CR50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(93)90144-F","volume":"73","author":"J Kunz","year":"1993","unstructured":"Kunz J, Henriquez R, Schneider U, Deuter\u2010Reinhard M, Movva NR, Hall MN (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73: 585\u2013596","journal-title":"Cell"},{"key":"BFEMBR202051462_CR51","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1128\/MCB.23.21.7448-7459.2003","volume":"23","author":"AH Lee","year":"2003","unstructured":"Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP\u20101 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448\u20137459","journal-title":"Mol Cell Biol"},{"key":"BFEMBR202051462_CR52","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI18730","volume":"114","author":"AC Li","year":"2004","unstructured":"Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL et al (2004) Differential inhibition of macrophage foam\u2010cell formation and atherosclerosis in mice by PPARalpha, beta\/delta, and gamma. J Clin Invest 114: 1564\u20131576","journal-title":"J Clin Invest"},{"key":"BFEMBR202051462_CR53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jmcb\/mjv066","volume":"8","author":"D Liu","year":"2016","unstructured":"Liu D, Liu X, Zhou T, Yao W, Zhao J, Zheng Z, Jiang W, Wang F, Aikhionbare FO, Hill DL et al (2016) IRE1\u2010RACK1 axis orchestrates ER stress preconditioning\u2010elicited cytoprotection from ischemia\/reperfusion injury in liver. J Mol Cell Biol 8: 144\u2013156","journal-title":"J Mol Cell Biol"},{"key":"BFEMBR202051462_CR54","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","volume":"129","author":"BD Manning","year":"2007","unstructured":"Manning BD, Cantley LC (2007) AKT\/PKB signaling: navigating downstream. Cell 129: 1261\u20131274","journal-title":"Cell"},{"key":"BFEMBR202051462_CR55","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","volume":"169","author":"BD Manning","year":"2017","unstructured":"Manning BD, Toker A (2017) AKT\/PKB signaling: navigating the network. Cell 169: 381\u2013405","journal-title":"Cell"},{"key":"BFEMBR202051462_CR56","doi-asserted-by":"crossref","first-page":"C1117","DOI":"10.1152\/ajpcell.00061.2013","volume":"304","author":"M Maurel","year":"2013","unstructured":"Maurel M, Chevet E (2013) Endoplasmic reticulum stress signaling: the microRNA connection. Am J Physiol Cell Physiol 304: C1117\u2013C1126","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFEMBR202051462_CR57","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2010.82","volume":"20","author":"M Mehrpour","year":"2010","unstructured":"Mehrpour M, Esclatine A, Beau I, Codogno P (2010) Overview of macroautophagy regulation in mammalian cells. Cell Res 20: 748\u2013762","journal-title":"Cell Res"},{"key":"BFEMBR202051462_CR58","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","volume":"13","author":"KJ Moore","year":"2013","unstructured":"Moore KJ, Sheedy FJ, Fisher EA (2013) Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 13: 709\u2013721","journal-title":"Nat Rev Immunol"},{"key":"BFEMBR202051462_CR59","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1091\/mbc.E15-02-0074","volume":"26","author":"K Moore","year":"2015","unstructured":"Moore K, Hollien J (2015) Ire1\u2010mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Mol Biol Cell 26: 2873\u20132884","journal-title":"Mol Biol Cell"},{"key":"BFEMBR202051462_CR60","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2174\/1570159X16666180416094646","volume":"16","author":"H Ni","year":"2018","unstructured":"Ni H, Rui Q, Li D, Gao R, Chen G (2018) The role of IRE1 signaling in the central nervous system diseases. Curr Neuropharmacol 16: 1340\u20131347","journal-title":"Curr Neuropharmacol"},{"key":"BFEMBR202051462_CR61","doi-asserted-by":"crossref","first-page":"11629","DOI":"10.1074\/jbc.M111.338673","volume":"287","author":"J Oh","year":"2012","unstructured":"Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, Cella M, Bernal\u2010Mizrachi C (2012) Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem 287: 11629\u201311641","journal-title":"J Biol Chem"},{"key":"BFEMBR202051462_CR62","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2018.12.055","volume":"73","author":"UI Onat","year":"2019","unstructured":"Onat UI, Yildirim AD, Tufanli O, Cimen I, Kocaturk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J et al (2019a) Intercepting the lipid\u2010induced integrated stress response reduces atherosclerosis. J Am Coll Cardiol 73: 1149\u20131169","journal-title":"J Am Coll Cardiol"},{"key":"BFEMBR202051462_CR63","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.metabol.2016.05.002","volume":"65","author":"MJ Pagliassotti","year":"2016","unstructured":"Pagliassotti MJ, Kim PY, Estrada AL, Stewart CM, Gentile CL (2016) Endoplasmic reticulum stress in obesity and obesity\u2010related disorders: an expanded view. Metabolism 65: 1238\u20131246","journal-title":"Metabolism"},{"key":"BFEMBR202051462_CR64","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkt393","volume":"41","author":"MD Paraskevopoulou","year":"2013","unstructured":"Paraskevopoulou MD, Georgakilas G, Kostoulas N, Vlachos IS, Vergoulis T, Reczko M, Filippidis C, Dalamagas T, Hatzigeorgiou AG (2013) DIANA\u2010microT web server v5.0: service integration into miRNA functional analysis workflows. Nucleic Acids Res 41: W169\u2013W173","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR202051462_CR65","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3945\/jn.109.119883","volume":"140","author":"KT Pfaffenbach","year":"2010","unstructured":"Pfaffenbach KT, Nivala AM, Reese L, Ellis F, Wang D, Wei Y, Pagliassotti MJ (2010) Rapamycin inhibits postprandial\u2010mediated X\u2010box\u2010binding protein\u20101 splicing in rat liver. J Nutr 140: 879\u2013884","journal-title":"J Nutr"},{"key":"BFEMBR202051462_CR66","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1567-1364.2010.00674.x","volume":"10","author":"L Pineau","year":"2010","unstructured":"Pineau L, Ferreira T (2010) Lipid\u2010induced ER stress in yeast and beta cells: parallel trails to a common fate. FEMS Yeast Res 10: 1035\u20131045","journal-title":"FEMS Yeast Res"},{"key":"BFEMBR202051462_CR67","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/ncb3440","volume":"18","author":"LE Rameh","year":"2016","unstructured":"Rameh LE, Mackey AM (2016) IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nat Cell Biol 18: 1263\u20131265","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202051462_CR68","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/bioinformatics\/bts043","volume":"28","author":"M Reczko","year":"2012","unstructured":"Reczko M, Maragkakis M, Alexiou P, Grosse I, Hatzigeorgiou AG (2012) Functional microRNA targets in protein coding sequences. Bioinformatics 28: 771\u2013776","journal-title":"Bioinformatics"},{"key":"BFEMBR202051462_CR69","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.4049\/jimmunol.1700845","volume":"199","author":"M Riera\u2010Borrull","year":"2017","unstructured":"Riera\u2010Borrull M, Cuevas VD, Alonso B, Vega MA, Joven J, Izquierdo E, Corbi AL (2017) Palmitate conditions macrophages for enhanced responses toward inflammatory stimuli via JNK activation. J Immunol 199: 3858\u20133869","journal-title":"J Immunol"},{"key":"BFEMBR202051462_CR70","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR202051462_CR71","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.201003138","volume":"189","author":"DT Rutkowski","year":"2010","unstructured":"Rutkowski DT, Hegde RS (2010) Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol 189: 783\u2013794","journal-title":"J Cell Biol"},{"key":"BFEMBR202051462_CR72","doi-asserted-by":"crossref","first-page":"16497","DOI":"10.1038\/s41598-017-16662-1","volume":"7","author":"M Sanchez\u2010Alvarez","year":"2017","unstructured":"Sanchez\u2010Alvarez M, del Pozo MA, Bakal C (2017) AKT\u2010mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER\u2010mitochondria contacts. Sci Rep 7: 16497","journal-title":"Sci Rep"},{"key":"BFEMBR202051462_CR73","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1073\/pnas.0800939105","volume":"105","author":"DM Schewe","year":"2008","unstructured":"Schewe DM, Aguirre\u2010Ghiso JA (2008) ATF6alpha\u2010Rheb\u2010mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci USA 105: 10519\u201310524","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR74","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.200907074","volume":"187","author":"S Schuck","year":"2009","unstructured":"Schuck S, Prinz WA, Thorn KS, Voss C, Walter P (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol 187: 525\u2013536","journal-title":"J Cell Biol"},{"key":"BFEMBR202051462_CR75","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","volume":"15","author":"M Shimobayashi","year":"2014","unstructured":"Shimobayashi M, Hall MN (2014) Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol 15: 155\u2013162","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR202051462_CR76","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","volume":"13","author":"I Tabas","year":"2011","unstructured":"Tabas I, Ron D (2011) Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13: 184\u2013190","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202051462_CR77","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/hep.24349","volume":"54","author":"PC Thakur","year":"2011","unstructured":"Thakur PC, Stuckenholz C, Rivera MR, Davison JM, Yao JK, Amsterdam A, Sadler KC, Bahary N (2011) Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt\u2010deficient zebrafish. Hepatology 54: 452\u2013462","journal-title":"Hepatology"},{"key":"BFEMBR202051462_CR78","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbalip.2017.02.002","volume":"1862","author":"A Traynor\u2010Kaplan","year":"2017","unstructured":"Traynor\u2010Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B (2017) Fatty\u2010acyl chain profiles of cellular phosphoinositides. Biochim Biophys Acta Mol Cell Biol Lipids 1862: 513\u2013522","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"BFEMBR202051462_CR79","doi-asserted-by":"crossref","first-page":"E1395","DOI":"10.1073\/pnas.1621188114","volume":"114","author":"O Tufanli","year":"2017","unstructured":"Tufanli O, Telkoparan Akillilar P, Acosta\u2010Alvear D, Kocaturk B, Onat UI, Hamid SM, Cimen I, Walter P, Weber C, Erbay E (2017) Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci USA 114: E1395\u2013E1404","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR80","doi-asserted-by":"crossref","first-page":"36758","DOI":"10.1038\/srep36758","volume":"6","author":"K Ueno","year":"2016","unstructured":"Ueno K, Samura M, Nakamura T, Tanaka Y, Takeuchi Y, Kawamura D, Takahashi M, Hosoyama T, Morikage N, Hamano K (2016) Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA\u2010762 and miR\u20103072\u20105p. Sci Rep 6: 36758","journal-title":"Sci Rep"},{"key":"BFEMBR202051462_CR81","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1226191","volume":"338","author":"JP Upton","year":"2012","unstructured":"Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A et al (2012) IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase\u20102. Science 338: 818\u2013822","journal-title":"Science"},{"key":"BFEMBR202051462_CR82","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1073\/pnas.1217611110","volume":"110","author":"R Volmer","year":"2013","unstructured":"Volmer R, van der Ploeg K, Ron D (2013) Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci USA 110: 4628\u20134633","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR83","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ceb.2014.12.002","volume":"33","author":"R Volmer","year":"2015","unstructured":"Volmer R, Ron D (2015) Lipid\u2010dependent regulation of the unfolded protein response. Curr Opin Cell Biol 33: 67\u201373","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBR202051462_CR84","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081\u20131086","journal-title":"Science"},{"key":"BFEMBR202051462_CR85","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-nutr-071816-064614","volume":"37","author":"DD Wang","year":"2017","unstructured":"Wang DD, Hu FB (2017) Dietary fat and risk of cardiovascular disease: recent controversies and advances. Annu Rev Nutr 37: 423\u2013446","journal-title":"Annu Rev Nutr"},{"key":"BFEMBR202051462_CR86","volume":"11","author":"JM Wang","year":"2018","unstructured":"Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH et al (2018) IRE1alpha prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Sci Signal 11: eaao4617","journal-title":"Sci Signal"},{"key":"BFEMBR202051462_CR87","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.1152\/ajpendo.00644.2005","volume":"291","author":"Y Wei","year":"2006","unstructured":"Wei Y, Wang D, Topczewski F, Pagliassotti MJ (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291: E275\u2013E281","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFEMBR202051462_CR88","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/CIRCULATIONAHA.117.031589","volume":"138","author":"Y Wei","year":"2018","unstructured":"Wei Y, Corbalan\u2010Campos J, Gurung R, Natarelli L, Zhu M, Exner N, Erhard F, Greulich F, Geissler C, Uhlenhaut NH et al (2018) Dicer in macrophages prevents atherosclerosis by promoting mitochondrial oxidative metabolism. Circulation 138: 2007\u20132020","journal-title":"Circulation"},{"key":"BFEMBR202051462_CR89","doi-asserted-by":"crossref","first-page":"116569","DOI":"10.1016\/j.lfs.2019.116569","volume":"231","author":"T Wu","year":"2019","unstructured":"Wu T, Jiang N, Ji Z, Shi G (2019) The IRE1 signaling pathway is involved in the protective effect of low\u2010dose LPS on myocardial ischemia\u2010reperfusion injury. Life Sci 231: 116569","journal-title":"Life Sci"},{"key":"BFEMBR202051462_CR90","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"S Wullschleger","year":"2006","unstructured":"Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124: 471\u2013484","journal-title":"Cell"},{"key":"BFEMBR202051462_CR91","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.molcel.2011.07.024","volume":"43","author":"JS Yang","year":"2011","unstructured":"Yang JS, Lai EC (2011) Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell 43: 892\u2013903","journal-title":"Mol Cell"},{"key":"BFEMBR202051462_CR92","doi-asserted-by":"crossref","first-page":"19300","DOI":"10.1073\/pnas.0803992105","volume":"105","author":"J Yu","year":"2008","unstructured":"Yu J, Ryan DG, Getsios S, Oliveira\u2010Fernandes M, Fatima A, Lavker RM (2008) MicroRNA\u2010184 antagonizes microRNA\u2010205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci USA 105: 19300\u201319305","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR93","first-page":"Unit 14 1","volume":"Chapter 14","author":"X Zhang","year":"2008","unstructured":"Zhang X, Goncalves R, Mosser DM (2008) The isolation and characterization of murine macrophages. Curr Protoc Immunol Chapter 14: Unit 14 1","journal-title":"Curr Protoc Immunol"},{"key":"BFEMBR202051462_CR94","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/10495398.2017.1322974","volume":"29","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Xiang L, Liu Y, Niu M, Yuan J, Chen H (2018) Atherosclerosis induced by a high\u2010cholesterol and high\u2010fat diet in the inbred strain of the wuzhishan miniature pig. Anim Biotechnol 29: 110\u2013118","journal-title":"Anim Biotechnol"},{"key":"BFEMBR202051462_CR95","doi-asserted-by":"crossref","first-page":"14343","DOI":"10.1073\/pnas.0606480103","volume":"103","author":"J Zhou","year":"2006","unstructured":"Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ (2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci USA 103: 14343\u201314348","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202051462_CR96","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b4828aa9-5156-499b-9f30-a8f9c9dd4f8e","volume":"8","author":"L Zhou","year":"2013","unstructured":"Zhou L, Zang G, Zhang G, Wang H, Zhang X, Johnston N, Min W, Luke P, Jevnikar A, Haig A et al (2013) MicroRNA and mRNA signatures in ischemia reperfusion injury in heart transplantation. PLoS One 8: e79805","journal-title":"PLoS One"},{"key":"BFEMBR202051462_CR97","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21\u201335","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202051462.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/embr.202051462","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202051462\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202051462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202051462.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:46:10Z","timestamp":1779111970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202051462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":97,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,3]]}},"alternative-id":["BFEMBR202051462"],"URL":"https:\/\/doi.org\/10.15252\/embr.202051462","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]},"assertion":[{"value":"4 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202051462"}}