{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:14:58Z","timestamp":1790964898673,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"crossref","award":["D110\u2010G9603"],"award-info":[{"award-number":["D110\u2010G9603"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2018R1D1R3B05048283"],"award-info":[{"award-number":["2018R1D1R3B05048283"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2018R1D1A1B07048220"],"award-info":[{"award-number":["2018R1D1A1B07048220"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2023,9,6]]},"DOI":"10.15252\/embr.202255376","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T05:10:15Z","timestamp":1690521015000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intracellular growth of Brucella is mediated by Dps\u2010dependent activation of ferritinophagy"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-8193","authenticated-orcid":false,"given":"Huynh Tan","family":"Hop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-7276","authenticated-orcid":false,"given":"Tran Xuan Ngoc","family":"Huy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-6416","authenticated-orcid":false,"given":"Hu Jang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5795-2019","authenticated-orcid":false,"given":"Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"BFEMBR202255376_CR1","doi-asserted-by":"crossref","first-page":"18499","DOI":"10.1073\/pnas.0607055103","volume":"103","author":"RJ Abergel","year":"2006","unstructured":"Abergel RJ, Wilson MK, Arceneaux JE, Hoette TM, Strong RK, Byers BR, Raymond KN (2006) Anthrax pathogen evades the mammalian immune system through stealth siderophore production. Proc Natl Acad Sci USA 103: 18499\u201318503","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255376_CR2","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1101\/gad.6.12b.2646","volume":"6","author":"M Almiron","year":"1992","unstructured":"Almiron M, Link AJ, Furlong D, Kolter R (1992) A novel DNA\u2010binding protein with regulatory and protective roles in starved Escherichia coli. Genes Dev 6: 2646\u20132654","journal-title":"Genes Dev"},{"key":"BFEMBR202255376_CR3","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1084\/jem.20181776","volume":"216","author":"EP Amaral","year":"2019","unstructured":"Amaral EP, Costa DL, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, Mayer\u2010Barber KD, Andrade BB, Sher A (2019) A major role for ferroptosis in Mycobacterium tuberculosis\u2010induced cell death and tissue necrosis. J Exp Med 216: 556\u2013570","journal-title":"J Exp Med"},{"key":"BFEMBR202255376_CR4","volume":"2012","author":"ED Avila\u2010Calderon","year":"2012","unstructured":"Avila\u2010Calderon ED, Lopez\u2010Merino A, Jain N, Peralta H, Lopez\u2010Villegas EO, Sriranganathan N, Boyle SM, Witonsky S, Contreras\u2010Rodriguez A (2012) Characterization of outer membrane vesicles from Brucella melitensis and protection induced in mice. Clin Dev Immunol 2012: 352493","journal-title":"Clin Dev Immunol"},{"key":"BFEMBR202255376_CR5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1080\/15548627.2016.1160176","volume":"12","author":"KA Bauckman","year":"2016","unstructured":"Bauckman KA, Mysorekar IU (2016) Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells. Autophagy 12: 850\u2013863","journal-title":"Autophagy"},{"key":"BFEMBR202255376_CR6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","volume":"13","author":"JE Cassat","year":"2013","unstructured":"Cassat JE, Skaar EP (2013) Iron in infection and immunity. Cell Host Microbe 13: 509\u2013519","journal-title":"Cell Host Microbe"},{"key":"BFEMBR202255376_CR7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","volume":"198","author":"J Celli","year":"2003","unstructured":"Celli J, de Chastellier C, Franchini DM, Pizarro\u2010Cerda J, Moreno E, Gorvel JP (2003) Brucella evades macrophage killing via VirB\u2010dependent sustained interactions with the endoplasmic reticulum. J Exp Med 198: 545\u2013556","journal-title":"J Exp Med"},{"key":"BFEMBR202255376_CR8","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1073\/pnas.97.3.1252","volume":"97","author":"JJ De Voss","year":"2000","unstructured":"De Voss JJ, Rutter K, Schroeder BG, Su H, Zhu Y, Barry CE 3rd (2000) The salicylate\u2010derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc Natl Acad Sci USA 97: 1252\u20131257","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255376_CR9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.124.5.677","volume":"124","author":"M Desjardins","year":"1994","unstructured":"Desjardins M, Huber LA, Parton RG, Griffiths G (1994) Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. J Cell Biol 124: 677\u2013688","journal-title":"J Cell Biol"},{"key":"BFEMBR202255376_CR10","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2010.04.040","volume":"141","author":"LR Devireddy","year":"2010","unstructured":"Devireddy LR, Hart DO, Goetz DH, Green MR (2010) A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 141: 1006\u20131017","journal-title":"Cell"},{"key":"BFEMBR202255376_CR11","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS et\u00a0al (2012) Ferroptosis: an iron\u2010dependent form of nonapoptotic cell death. Cell 149: 1060\u20131072","journal-title":"Cell"},{"key":"BFEMBR202255376_CR12","volume":"94","author":"C Fillebeen","year":"2014","unstructured":"Fillebeen C, Wilkinson N, Pantopoulos K (2014) Electrophoretic mobility shift assay (EMSA) for the study of RNA\u2010protein interactions: the IRE\/IRP example. J Vis Exp 94: 52230","journal-title":"J Vis Exp"},{"key":"BFEMBR202255376_CR13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","volume":"432","author":"TH Flo","year":"2004","unstructured":"Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432: 917\u2013921","journal-title":"Nature"},{"key":"BFEMBR202255376_CR14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020087","volume":"2","author":"DB Friedman","year":"2006","unstructured":"Friedman DB, Stauff DL, Pishchany G, Whitwell CW, Torres VJ, Skaar EP (2006) Staphylococcus aureus redirects central metabolism to increase iron availability. PLoS Pathog 2: e87","journal-title":"PLoS Pathog"},{"key":"BFEMBR202255376_CR15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1128\/IAI.72.2.1155-1158.2004","volume":"72","author":"TA Halsey","year":"2004","unstructured":"Halsey TA, Vazquez\u2010Torres A, Gravdahl DJ, Fang FC, Libby SJ (2004) The ferritin\u2010like Dps protein is required for Salmonella enterica serovar Typhimurium oxidative stress resistance and virulence. Infect Immun 72: 1155\u20131158","journal-title":"Infect Immun"},{"key":"BFEMBR202255376_CR16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcdb.2020.12.005","volume":"115","author":"D Haschka","year":"2021","unstructured":"Haschka D, Hoffmann A, Weiss G (2021) Iron in immune cell function and host defense. Semin Cell Dev Biol 115: 27\u201336","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMBR202255376_CR17","volume":"7","author":"HT Hop","year":"2017","unstructured":"Hop HT, Reyes AWB, Huy TXN, Arayan LT, Min W, Lee HJ, Rhee MH, Chang HH, Kim S (2017) Activation of NF\u2010kB\u2010mediated TNF\u2010induced antimicrobial immunity is required for the efficient Brucella abortus clearance in RAW 264.7 cells. Front Cell Infect Microbiol 7: 437","journal-title":"Front Cell Infect Microbiol"},{"key":"BFEMBR202255376_CR18","volume":"20","author":"HT Hop","year":"2018","unstructured":"Hop HT, Arayan LT, Huy TXN, Reyes AWB, Baek EJ, Min W, Lee HJ, Rhee\u00a0MH, Watanabe K, Chang HH et\u00a0al (2018a) Lipocalin 2 (Lcn2) interferes with iron uptake by Brucella abortus and dampens immunoregulation during infection of RAW 264.7 macrophages. Cell Microbiol 20: e12813","journal-title":"Cell Microbiol"},{"key":"BFEMBR202255376_CR19","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/j.vaccine.2018.04.019","volume":"36","author":"HT Hop","year":"2018","unstructured":"Hop HT, Arayan LT, Huy TXN, Reyes AWB, Min W, Lee HJ, Park SJ, Chang HH, Kim S (2018b) Immunization of BALB\/c mice with a combination of four recombinant Brucella abortus proteins, AspC, Dps, InpB and Ndk, confers a marked protection against a virulent strain of Brucella abortus. Vaccine 36: 3027\u20133033","journal-title":"Vaccine"},{"key":"BFEMBR202255376_CR20","volume":"87","author":"HT Hop","year":"2019","unstructured":"Hop HT, Huy TXN, Reyes AWB, Arayan LT, Vu SH, Min W, Lee HJ, Kang CK, Kim DH, Tark DS et\u00a0al (2019) Interleukin 6 promotes Brucella abortus clearance by controlling bactericidal activity of macrophages and CD8(+) T cell differentiation. Infect Immun 87: e00431\u201019","journal-title":"Infect Immun"},{"key":"BFEMBR202255376_CR21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/elps.201100460","volume":"33","author":"MC Huang","year":"2012","unstructured":"Huang MC, Cheong WC, Lim LS, Li MH (2012) A simple, high sensitivity mutation screening using Ampligase mediated T7 endonuclease I and Surveyor nuclease with microfluidic capillary electrophoresis. Electrophoresis 33: 788\u2013796","journal-title":"Electrophoresis"},{"key":"BFEMBR202255376_CR22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/71236","volume":"7","author":"A Ilari","year":"2000","unstructured":"Ilari A, Stefanini S, Chiancone E, Tsernoglou D (2000) The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron\u2010binding site. Nat Struct Biol 7: 38\u201343","journal-title":"Nat Struct Biol"},{"key":"BFEMBR202255376_CR23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1128\/JB.185.3.1010-1017.2003","volume":"185","author":"T Ishikawa","year":"2003","unstructured":"Ishikawa T, Mizunoe Y, Kawabata S, Takade A, Harada M, Wai SN, Yoshida\u00a0S (2003) The iron\u2010binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni. J Bacteriol 185: 1010\u20131017","journal-title":"J Bacteriol"},{"key":"BFEMBR202255376_CR24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ymeth.2017.03.021","volume":"121\u2010122","author":"AM Jacobi","year":"2017","unstructured":"Jacobi AM, Rettig GR, Turk R, Collingwood MA, Zeiner SA, Quadros RM, Harms DW, Bonthuis PJ, Gregg C, Ohtsuka M et\u00a0al (2017) Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes. Methods 121\u2010122: 16\u201328","journal-title":"Methods"},{"key":"BFEMBR202255376_CR25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/cimm.1993.1121","volume":"148","author":"X Jiang","year":"1993","unstructured":"Jiang X, Baldwin CL (1993) Iron augments macrophage\u2010mediated killing of Brucella abortus alone and in conjunction with interferon\u2010gamma. Cell Immunol 148: 397\u2013407","journal-title":"Cell Immunol"},{"key":"BFEMBR202255376_CR26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","volume":"151","author":"X Jiang","year":"1993","unstructured":"Jiang X, Leonard B, Benson R, Baldwin CL (1993) Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide. Cell Immunol 151: 309\u2013319","journal-title":"Cell Immunol"},{"key":"BFEMBR202255376_CR27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cimid.2014.06.001","volume":"37","author":"JJ Lee","year":"2014","unstructured":"Lee JJ, Lim JJ, Kim DG, Simborio HL, Kim DH, Reyes AW, Min W, Lee HJ, Kim DH, Chang HH et\u00a0al (2014) Characterization of culture supernatant\u00a0proteins from Brucella abortus and its protection effects against murine brucellosis. Comp Immunol Microbiol Infect Dis 37: 221\u2013228","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"BFEMBR202255376_CR28","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","volume":"278","author":"N Li","year":"2003","unstructured":"Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, Robinson JP (2003) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 278: 8516\u20138525","journal-title":"J Biol Chem"},{"key":"BFEMBR202255376_CR29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nchembio717","volume":"1","author":"M Luo","year":"2005","unstructured":"Luo M, Fadeev EA, Groves JT (2005) Mycobactin\u2010mediated iron acquisition within macrophages. Nat Chem Biol 1: 149\u2013153","journal-title":"Nat Chem Biol"},{"key":"BFEMBR202255376_CR30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (2014) Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509: 105\u2013109","journal-title":"Nature"},{"key":"BFEMBR202255376_CR31","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1081147","volume":"299","author":"SK Mazmanian","year":"2003","unstructured":"Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O (2003) Passage of heme\u2010iron across the envelope of Staphylococcus aureus. Science 299: 906\u2013909","journal-title":"Science"},{"key":"BFEMBR202255376_CR32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nprot.2017.153","volume":"13","author":"H Miura","year":"2018","unstructured":"Miura H, Quadros RM, Gurumurthy CB, Ohtsuka M (2018) Easi\u2010CRISPR for creating knock\u2010in and conditional knockout mouse models using long ssDNA donors. Nat Protoc 13: 195\u2013215","journal-title":"Nat Protoc"},{"key":"BFEMBR202255376_CR33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1097-2765(00)80282-8","volume":"2","author":"M Muckenthaler","year":"1998","unstructured":"Muckenthaler M, Gray NK, Hentze MW (1998) IRP\u20101 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap\u2010binding complex eIF4F. Mol Cell 2: 383\u2013388","journal-title":"Mol Cell"},{"key":"BFEMBR202255376_CR34","first-page":"23","volume":"4","author":"J Pei","year":"2014","unstructured":"Pei J, Kahl\u2010McDonagh M, Ficht TA (2014) Brucella dissociation is essential for macrophage egress and bacterial dissemination. Front Cell Infect Microbiol 4: 23","journal-title":"Front Cell Infect Microbiol"},{"key":"BFEMBR202255376_CR35","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood-2005-06-2259","volume":"107","author":"C Peyssonnaux","year":"2006","unstructured":"Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V (2006) TLR4\u2010dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107: 3727\u20133732","journal-title":"Blood"},{"key":"BFEMBR202255376_CR36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chom.2010.11.002","volume":"8","author":"G Pishchany","year":"2010","unstructured":"Pishchany G, McCoy AL, Torres VJ, Krause JC, Crowe JE Jr, Fabry ME, Skaar EP (2010) Specificity for human hemoglobin enhances Staphylococcus aureus infection. Cell Host Microbe 8: 544\u2013550","journal-title":"Cell Host Microbe"},{"key":"BFEMBR202255376_CR37","doi-asserted-by":"crossref","first-page":"C154","DOI":"10.1152\/ajpcell.00325.2011","volume":"302","author":"T Pisitkun","year":"2012","unstructured":"Pisitkun T, Hoffert JD, Saeed F, Knepper MA (2012) NHLBI\u2010AbDesigner: an online tool for design of peptide\u2010directed antibodies. Am J Physiol Cell Physiol 302: C154\u2013C164","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFEMBR202255376_CR38","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1365-2958.2005.04756.x","volume":"57","author":"AT Pulliainen","year":"2005","unstructured":"Pulliainen AT, Kauko A, Haataja S, Papageorgiou AC, Finne J (2005) Dps\/Dpr ferritin\u2010like protein: insights into the mechanism of iron incorporation and evidence for a central role in cellular iron homeostasis in Streptococcus suis. Mol Microbiol 57: 1086\u20131100","journal-title":"Mol Microbiol"},{"key":"BFEMBR202255376_CR39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1017\/S1466252312000047","volume":"13","author":"RM Roop 2nd","year":"2012","unstructured":"Roop RM 2nd (2012) Metal acquisition and virulence in Brucella. Anim Health Res Rev 13: 10\u201320","journal-title":"Anim Health Res Rev"},{"key":"BFEMBR202255376_CR40","doi-asserted-by":"crossref","first-page":"10637","DOI":"10.1038\/s41598-017-11283-0","volume":"7","author":"MS Roset","year":"2017","unstructured":"Roset MS, Alefantis TG, DelVecchio VG, Briones G (2017) Iron\u2010dependent reconfiguration of the proteome underlies the intracellular lifestyle of Brucella abortus. Sci Rep 7: 10637","journal-title":"Sci Rep"},{"key":"BFEMBR202255376_CR41","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040114","volume":"11","author":"N Santana\u2010Codina","year":"2018","unstructured":"Santana\u2010Codina N, Mancias JD (2018) The role of NCOA4\u2010mediated ferritinophagy in health and disease. Pharmaceuticals (Basel) 11: 114","journal-title":"Pharmaceuticals (Basel)"},{"key":"BFEMBR202255376_CR42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008017","volume":"4","author":"R Saraswathi","year":"2009","unstructured":"Saraswathi R, Pait Chowdhury R, Williams SM, Ghatak P, Chatterji D (2009) The mycobacterial MsDps2 protein is a nucleoid\u2010forming DNA binding protein regulated by sigma factors sigma and sigma. PloS One 4: e8017","journal-title":"PloS One"},{"key":"BFEMBR202255376_CR43","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41598-018-19441-8","volume":"8","author":"MF Sentmanat","year":"2018","unstructured":"Sentmanat MF, Peters ST, Florian CP, Connelly JP, Pruett\u2010Miller SM (2018) A survey of validation strategies for CRISPR\u2010Cas9 editing. Sci Rep 8: 888","journal-title":"Sci Rep"},{"key":"BFEMBR202255376_CR44","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2016.02.016","volume":"44","author":"MP Soares","year":"2016","unstructured":"Soares MP, Hamza I (2016) Macrophages and iron metabolism. Immunity 44: 492\u2013504","journal-title":"Immunity"},{"key":"BFEMBR202255376_CR45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1600-0854.2008.00718.x","volume":"9","author":"T Starr","year":"2008","unstructured":"Starr T, Ng TW, Wehrly TD, Knodler LA, Celli J (2008) Brucella intracellular replication requires trafficking through the late endosomal\/lysosomal compartment. Traffic 9: 678\u2013694","journal-title":"Traffic"},{"key":"BFEMBR202255376_CR46","first-page":"G1031","volume":"274","author":"A Staubli","year":"1998","unstructured":"Staubli A, Boelsterli UA (1998) The labile iron pool in hepatocytes: prooxidant\u2010induced increase in free iron precedes oxidative cell injury. Am J Physiol 274: G1031\u2013G1037","journal-title":"Am J Physiol"},{"key":"BFEMBR202255376_CR47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chom.2007.03.001","volume":"1","author":"VJ Torres","year":"2007","unstructured":"Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP (2007) A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Cell Host Microbe 1: 109\u2013119","journal-title":"Cell Host Microbe"},{"key":"BFEMBR202255376_CR48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1084\/jem.20021980","volume":"198","author":"M Watarai","year":"2003","unstructured":"Watarai M, Kim S, Erdenebaatar J, Makino S, Horiuchi M, Shirahata T, Sakaguchi S, Katamine S (2003) Cellular prion protein promotes Brucella infection into macrophages. J Exp Med 198: 5\u201317","journal-title":"J Exp Med"},{"key":"BFEMBR202255376_CR49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/imr.12266","volume":"264","author":"G Weiss","year":"2015","unstructured":"Weiss G, Schaible UE (2015) Macrophage defense mechanisms against intracellular bacteria. Immunol Rev 264: 182\u2013203","journal-title":"Immunol Rev"},{"key":"BFEMBR202255376_CR50","volume":"12","author":"X Xia","year":"2017","unstructured":"Xia X, Larios\u2010Valencia J, Liu Z, Xiang F, Kan B, Wang H, Zhu J (2017) OxyR\u2010activated expression of Dps is important for Vibrio cholerae oxidative stress resistance and pathogenesis. PloS One 12: e0171201","journal-title":"PloS One"},{"key":"BFEMBR202255376_CR51","volume":"118","author":"Q Yan","year":"2021","unstructured":"Yan Q, Zhang W, Lin M, Teymournejad O, Budachetri K, Lakritz J, Rikihisa Y (2021) Iron robbery by intracellular pathogen via bacterial effector\u2010induced ferritinophagy. Proc Natl Acad Sci USA 118: e2026598118","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255376_CR52","volume":"2017","author":"J Zhang","year":"2017","unstructured":"Zhang J, Wang Q, Xu C, Lu Y, Hu H, Qin B, Wang Y, He D, Li C, Yu X et\u00a0al (2017) MitoTEMPO prevents oxalate induced injury in NRK\u201052E cells via inhibiting mitochondrial dysfunction and modulating oxidative stress. Oxid Med Cell Longev 2017: 7528090","journal-title":"Oxid Med Cell Longev"},{"key":"BFEMBR202255376_CR53","doi-asserted-by":"crossref","first-page":"27689","DOI":"10.1074\/jbc.M202094200","volume":"277","author":"G Zhao","year":"2002","unstructured":"Zhao G, Ceci P, Ilari A, Giangiacomo L, Laue TM, Chiancone E, Chasteen ND (2002) Iron and hydrogen peroxide detoxification properties of DNA\u2010binding protein from starved cells. A ferritin\u2010like DNA\u2010binding protein of Escherichia coli. J Biol Chem 277: 27689\u201327696","journal-title":"J Biol Chem"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202255376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202255376\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202255376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202255376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:07:15Z","timestamp":1779113235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202255376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,6]]}},"alternative-id":["BFEMBR202255376"],"URL":"https:\/\/doi.org\/10.15252\/embr.202255376","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,28]]},"assertion":[{"value":"9 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure and competing interests statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202255376"}}