{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:13:46Z","timestamp":1791220426294,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010790","name":"ERASMUS+","doi-asserted-by":"publisher","award":["17\/COEN\/3474"],"award-info":[{"award-number":["17\/COEN\/3474"]}],"id":[{"id":"10.13039\/501100010790","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases","award":["BM2013003"],"award-info":[{"award-number":["BM2013003"]}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["82022022"],"award-info":[{"award-number":["82022022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["82071274"],"award-info":[{"award-number":["82071274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["31771117"],"award-info":[{"award-number":["31771117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation Ireland","award":["17\/JPND\/3455"],"award-info":[{"award-number":["17\/JPND\/3455"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of the Jiangsu Higher Education Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2023,9,6]]},"DOI":"10.15252\/embr.202255859","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T03:12:16Z","timestamp":1690513936000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["UBQLN2 and HSP70 participate in Parkin\u2010mediated mitophagy by facilitating outer mitochondrial membrane rupture"],"prefix":"10.1038","volume":"24","author":[{"given":"Qilian","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-3267","authenticated-orcid":false,"given":"Guoqiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-8524","authenticated-orcid":false,"given":"Kin Yip","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-8057","authenticated-orcid":false,"given":"Heiko","family":"Dussmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-7794","authenticated-orcid":false,"given":"Jochen HM","family":"Prehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-2260","authenticated-orcid":false,"given":"Hongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-0509","authenticated-orcid":false,"given":"Zheng","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"BFEMBR202255859_CR1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3233\/JAD-170173","volume":"59","author":"OO Adegoke","year":"2017","unstructured":"Adegoke OO, Qiao F, Liu Y, Longley K, Feng S, Wang H (2017) Overexpression of ubiquilin\u20101 alleviates Alzheimer's disease\u2010caused cognitive and motor deficits and reduces amyloid\u2010beta accumulation in mice. J Alzheimers Dis 59: 575\u2013590","journal-title":"J Alzheimers Dis"},{"key":"BFEMBR202255859_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41556-017-0007-x","volume":"20","author":"H An","year":"2018","unstructured":"An H, Harper JW (2018) Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy. Nat Cell Biol 20: 135\u2013143","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202255859_CR3","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/hmg\/ddr048","volume":"20","author":"NC Chan","year":"2011","unstructured":"Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, Hess S, Chan DC (2011) Broad activation of the ubiquitin\u2010proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 20: 1726\u20131737","journal-title":"Hum Mol Genet"},{"key":"BFEMBR202255859_CR4","doi-asserted-by":"crossref","first-page":"38214","DOI":"10.1074\/jbc.M110.101469","volume":"285","author":"D Chen","year":"2010","unstructured":"Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G (2010) Parkin mono\u2010ubiquitinates Bcl\u20102 and regulates autophagy. J Biol Chem 285: 38214\u201338223","journal-title":"J Biol Chem"},{"key":"BFEMBR202255859_CR5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/aps.2017.163","volume":"39","author":"D Chen","year":"2018","unstructured":"Chen D, Li YP, Yu YX, Zhou T, Liu C, Fei EK, Gao F, Mu CC, Ren HG, Wang GH (2018) Dendritic cell nuclear protein\u20101 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N\u2010acetyltransferase in C6 cells. Acta Pharmacol Sin 39: 597\u2013606","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature10353","volume":"477","author":"HX Deng","year":"2011","unstructured":"Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H et\u00a0al (2011) Mutations in UBQLN2 cause dominant X\u2010linked juvenile and adult\u2010onset ALS and ALS\/dementia. Nature 477: 211\u2013215","journal-title":"Nature"},{"key":"BFEMBR202255859_CR7","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1080\/15548627.2020.1734330","volume":"16","author":"CS Evans","year":"2020","unstructured":"Evans CS, Holzbaur ELF (2020) Lysosomal degradation of depolarized mitochondria is rate\u2010limiting in OPTN\u2010dependent neuronal mitophagy. Autophagy 16: 962\u2013964","journal-title":"Autophagy"},{"key":"BFEMBR202255859_CR8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ana.24164","volume":"75","author":"AC Fahed","year":"2014","unstructured":"Fahed AC, McDonough B, Gouvion CM, Newell KL, Dure LS, Bebin M, Bick AG, Seidman JG, Harter DH, Seidman CE (2014) UBQLN2 mutation causing heterogeneous X\u2010linked dominant neurodegeneration. Ann Neurol 75: 793\u2013798","journal-title":"Ann Neurol"},{"key":"BFEMBR202255859_CR9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/aps.2017.25","volume":"38","author":"LM Fang","year":"2017","unstructured":"Fang LM, Li B, Guan JJ, Xu HD, Shen GH, Gao QG, Qin ZH (2017) Transcription factor EB is involved in autophagy\u2010mediated chemoresistance to doxorubicin in human cancer cells. Acta Pharmacol Sin 38: 1305\u20131316","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan\u2010Olive MM, Caponio D, Dan X et\u00a0al (2019) Mitophagy inhibits amyloid\u2010beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci 22: 401\u2013412","journal-title":"Nat Neurosci"},{"key":"BFEMBR202255859_CR11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","volume":"110","author":"A Fleming","year":"2022","unstructured":"Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, Puri C, Scrivo A, Skidmore J, Son SM et\u00a0al (2022) The different autophagy degradation pathways and neurodegeneration. Neuron 110: 935\u2013966","journal-title":"Neuron"},{"key":"BFEMBR202255859_CR12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-018-0224-x","volume":"559","author":"C Gladkova","year":"2018","unstructured":"Gladkova C, Maslen SL, Skehel JM, Komander D (2018) Mechanism of parkin activation by PINK1. Nature 559: 410\u2013414","journal-title":"Nature"},{"key":"BFEMBR202255859_CR13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41401-018-0064-0","volume":"40","author":"DK Guo","year":"2019","unstructured":"Guo DK, Zhu Y, Sun HY, Xu XY, Zhang S, Hao ZB, Wang GH, Mu CC, Ren HG (2019) Pharmacological activation of REV\u2010ERBalpha represses LPS\u2010induced microglial activation through the NF\u2010kappaB pathway. Acta Pharmacol Sin 40: 26\u201334","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025053118","volume":"118","author":"O Harding","year":"2021","unstructured":"Harding O, Evans CS, Ye J, Cheung J, Maniatis T, Holzbaur ELF (2021) ALS\u2010 and FTD\u2010associated missense mutations in TBK1 differentially disrupt mitophagy. Proc Natl Acad Sci USA 118: e2025053118","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255859_CR15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","volume":"19","author":"JW Harper","year":"2018","unstructured":"Harper JW, Ordureau A, Heo JM (2018) Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol 19: 93\u2013108","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMBR202255859_CR16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","volume":"60","author":"JM Heo","year":"2015","unstructured":"Heo JM, Ordureau A, Paulo JA, Rinehart J, Harper JW (2015) The PINK1\u2010PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy. Mol Cell 60: 7\u201320","journal-title":"Mol Cell"},{"key":"BFEMBR202255859_CR17","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948317","volume":"21","author":"L Herhaus","year":"2020","unstructured":"Herhaus L, Bhaskara RM, Lystad AH, Gestal\u2010Mato U, Covarrubias\u2010Pinto A, Bonn F, Simonsen A, Hummer G, Dikic I (2020) TBK1\u2010mediated phosphorylation of LC3C and GABARAP\u2010L2 controls autophagosome shedding by ATG4 protease. EMBO Rep 21: e48317","journal-title":"EMBO Rep"},{"key":"BFEMBR202255859_CR18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2016.07.001","volume":"166","author":"R Hjerpe","year":"2016","unstructured":"Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M et\u00a0al (2016) UBQLN2 mediates autophagy\u2010independent protein aggregate clearance by the proteasome. Cell 166: 935\u2013949","journal-title":"Cell"},{"key":"BFEMBR202255859_CR19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molcel.2016.05.020","volume":"63","author":"E Itakura","year":"2016","unstructured":"Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS (2016) Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation. Mol Cell 63: 21\u201333","journal-title":"Mol Cell"},{"key":"BFEMBR202255859_CR20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1083\/jcb.201402104","volume":"205","author":"LA Kane","year":"2014","unstructured":"Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ (2014) PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol 205: 143\u2013153","journal-title":"J Cell Biol"},{"key":"BFEMBR202255859_CR21","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.chembiol.2011.05.013","volume":"18","author":"H Katayama","year":"2011","unstructured":"Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A (2011) A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol 18: 1042\u20131052","journal-title":"Chem Biol"},{"key":"BFEMBR202255859_CR22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0014-5793(00)01135-2","volume":"467","author":"FJ Kaye","year":"2000","unstructured":"Kaye FJ, Modi S, Ivanovska I, Koonin EV, Thress K, Kubo A, Kornbluth S, Rose MD (2000) A family of ubiquitin\u2010like proteins binds the ATPase domain of Hsp70\u2010like Stch. FEBS Lett 467: 348\u2013355","journal-title":"FEBS Lett"},{"key":"BFEMBR202255859_CR23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BJ20140334","volume":"460","author":"A Kazlauskaite","year":"2014","unstructured":"Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM (2014) Parkin is activated by PINK1\u2010dependent phosphorylation of ubiquitin at Ser65. Biochem J 460: 127\u2013139","journal-title":"Biochem J"},{"key":"BFEMBR202255859_CR24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","volume":"40","author":"JS Kerr","year":"2017","unstructured":"Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF (2017) Mitophagy and Alzheimer's disease: cellular and molecular mechanisms. Trends Neurosci 40: 151\u2013166","journal-title":"Trends Neurosci"},{"key":"BFEMBR202255859_CR25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuron.2013.02.029","volume":"78","author":"NC Kim","year":"2013","unstructured":"Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP et\u00a0al (2013) VCP is essential for mitochondrial quality control by PINK1\/Parkin and this function is impaired by VCP mutations. Neuron 78: 65\u201380","journal-title":"Neuron"},{"key":"BFEMBR202255859_CR26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature13392","volume":"510","author":"F Koyano","year":"2014","unstructured":"Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T et\u00a0al (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510: 162\u2013166","journal-title":"Nature"},{"key":"BFEMBR202255859_CR27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","volume":"30","author":"S Lautrup","year":"2019","unstructured":"Lautrup S, Sinclair DA, Mattson MP, Fang EF (2019) NAD+ in brain aging and neurodegenerative disorders. Cell Metab 30: 630\u2013655","journal-title":"Cell Metab"},{"key":"BFEMBR202255859_CR28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","volume":"22","author":"M Lazarou","year":"2012","unstructured":"Lazarou M, Jin SM, Kane LA, Youle RJ (2012) Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 22: 320\u2013333","journal-title":"Dev Cell"},{"key":"BFEMBR202255859_CR29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","volume":"524","author":"M Lazarou","year":"2015","unstructured":"Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ (2015) The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524: 309\u2013314","journal-title":"Nature"},{"key":"BFEMBR202255859_CR30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.15252\/embr.201439820","volume":"16","author":"JR Liang","year":"2015","unstructured":"Liang JR, Martinez A, Lane JD, Mayor U, Clague MJ, Urbe S (2015) USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO Rep 16: 618\u2013627","journal-title":"EMBO Rep"},{"key":"BFEMBR202255859_CR31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"SC Ling","year":"2013","unstructured":"Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79: 416\u2013438","journal-title":"Neuron"},{"key":"BFEMBR202255859_CR32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","volume":"26","author":"G Lou","year":"2020","unstructured":"Lou G, Palikaras K, Lautrup S, Scheibye\u2010Knudsen M, Tavernarakis N, Fang EF (2020) Mitophagy and neuroprotection. Trends Mol Med 26: 8\u201320","journal-title":"Trends Mol Med"},{"key":"BFEMBR202255859_CR33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2008.10.010","volume":"60","author":"MP Mattson","year":"2008","unstructured":"Mattson MP, Gleichmann M, Cheng A (2008) Mitochondria in neuroplasticity and neurological disorders. Neuron 60: 748\u2013766","journal-title":"Neuron"},{"key":"BFEMBR202255859_CR34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.molcel.2017.08.020","volume":"68","author":"MA Michel","year":"2017","unstructured":"Michel MA, Swatek KN, Hospenthal MK, Komander D (2017) Ubiquitin linkage\u2010specific affimers reveal insights into K6\u2010linked ubiquitin signaling. Mol Cell 68: 233\u2013246","journal-title":"Mol Cell"},{"key":"BFEMBR202255859_CR35","first-page":"E3349","volume":"113","author":"AS Moore","year":"2016","unstructured":"Moore AS, Holzbaur EL (2016) Dynamic recruitment and activation of ALS\u2010associated TBK1 with its target optineurin are required for efficient mitophagy. Proc Natl Acad Sci USA 113: E3349\u2013E3358","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255859_CR36","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795\u2013803","journal-title":"J Cell Biol"},{"key":"BFEMBR202255859_CR37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","volume":"6","author":"D Narendra","year":"2010","unstructured":"Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ (2010) p62\/SQSTM1 is required for Parkin\u2010induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6: 1090\u20131106","journal-title":"Autophagy"},{"key":"BFEMBR202255859_CR38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","volume":"56","author":"A Ordureau","year":"2014","unstructured":"Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA et\u00a0al (2014) Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell 56: 360\u2013375","journal-title":"Mol Cell"},{"key":"BFEMBR202255859_CR39","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.molcel.2019.11.013","volume":"77","author":"A Ordureau","year":"2020","unstructured":"Ordureau A, Paulo JA, Zhang J, An H, Swatek KN, Cannon JR, Wan Q, Komander D, Harper JW (2020) Global landscape and dynamics of Parkin and USP30\u2010dependent ubiquitylomes in ineurons during mitophagic signaling. Mol Cell 77: 1124\u20131142","journal-title":"Mol Cell"},{"key":"BFEMBR202255859_CR40","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/hmg\/ddu575","volume":"24","author":"M Osaka","year":"2015","unstructured":"Osaka M, Ito D, Yagi T, Nihei Y, Suzuki N (2015) Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. Hum Mol Genet 24: 1617\u20131629","journal-title":"Hum Mol Genet"},{"key":"BFEMBR202255859_CR41","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","volume":"28","author":"S Pickles","year":"2018","unstructured":"Pickles S, Vigie P, Youle RJ (2018) Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr Biol 28: R170\u2013R185","journal-title":"Curr Biol"},{"key":"BFEMBR202255859_CR42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"AM Pickrell","year":"2015","unstructured":"Pickrell AM, Youle RJ (2015) The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron 85: 257\u2013273","journal-title":"Neuron"},{"key":"BFEMBR202255859_CR43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11636-5","volume":"10","author":"R Puri","year":"2019","unstructured":"Puri R, Cheng X\u2010T, Lin M\u2010Y, Huang N, Sheng Z\u2010H (2019) Mul1 restrains Parkin\u2010mediated mitophagy in mature neurons by maintaining ER\u2010mitochondrial contacts. Nat Commun 10: 3645","journal-title":"Nat Commun"},{"key":"BFEMBR202255859_CR44","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41418-018-0219-z","volume":"26","author":"A Rakovic","year":"2019","unstructured":"Rakovic A, Ziegler J, Martensson CU, Prasuhn J, Shurkewitsch K, Konig P, Paulson HL, Klein C (2019) PINK1\u2010dependent mitophagy is driven by the UPS and can occur independently of LC3 conversion. Cell Death Differ 26: 1428\u20131441","journal-title":"Cell Death Differ"},{"key":"BFEMBR202255859_CR45","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/aps.2016.42","volume":"37","author":"ZX Ren","year":"2016","unstructured":"Ren ZX, Zhao YF, Cao T, Zhen XC (2016) Dihydromyricetin protects neurons in an MPTP\u2010induced model of Parkinson's disease by suppressing glycogen synthase kinase\u20103 beta activity. Acta Pharmacol Sin 37: 1315\u20131324","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40478-019-0758-7","volume":"7","author":"L Renaud","year":"2019","unstructured":"Renaud L, Picher\u2010Martel V, Codron P, Julien JP (2019) Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia. Acta Neuropathol Commun 7: 103","journal-title":"Acta Neuropathol Commun"},{"key":"BFEMBR202255859_CR47","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1523926113","volume":"113","author":"B Richter","year":"2016","unstructured":"Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA et\u00a0al (2016) Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci USA 113: 4039\u20134044","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255859_CR48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41594-018-0088-7","volume":"25","author":"V Sauve","year":"2018","unstructured":"Sauve V, Sung G, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe JF, Lukacs GL, Gehring K (2018) Mechanism of parkin activation by phosphorylation. Nat Struct Mol Biol 25: 623\u2013630","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMBR202255859_CR49","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41556-019-0281-x","volume":"21","author":"M Senturk","year":"2019","unstructured":"Senturk M, Lin G, Zuo ZY, Mao DX, Watson E, Mikos AG, Bellen HJ (2019) Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol 21: 384\u2013396","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202255859_CR50","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/nprot.2017.060","volume":"12","author":"N Sun","year":"2017","unstructured":"Sun N, Malide D, Liu J, Rovira II, Combs CA, Finkel T (2017) A fluorescence\u2010based imaging method to measure in vitro and in vivo mitophagy using mt\u2010Keima. Nat Protoc 12: 1576\u20131587","journal-title":"Nat Protoc"},{"key":"BFEMBR202255859_CR51","volume":"298","author":"S Sun","year":"2022","unstructured":"Sun S, Hou H, Ma G, Ma Q, Li N, Zhang L, Dong C, Cao M, Tam KY, Ying Z et\u00a0al (2022) The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy. J Biol Chem 298: 102704","journal-title":"J Biol Chem"},{"key":"BFEMBR202255859_CR52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","volume":"539","author":"JP Taylor","year":"2016","unstructured":"Taylor JP, Brown RH Jr, Cleveland DW (2016) Decoding ALS: from genes to mechanism. Nature 539: 197\u2013206","journal-title":"Nature"},{"key":"BFEMBR202255859_CR53","doi-asserted-by":"crossref","first-page":"239.e11","DOI":"10.1016\/j.neurobiolaging.2017.06.018","volume":"58","author":"E Teyssou","year":"2017","unstructured":"Teyssou E, Chartier L, Amador MD, Lam R, Lautrette G, Nicol M, Machat S, Da Barroca S, Moigneu C, Mairey M et\u00a0al (2017) Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70\u2010mediated proteolysis. Neurobiol Aging 58: 239.e11\u2013239.e20","journal-title":"Neurobiol Aging"},{"key":"BFEMBR202255859_CR54","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/cdd.2008.25","volume":"15","author":"M Vogler","year":"2008","unstructured":"Vogler M, Dinsdale D, Sun XM, Young KW, Butterworth M, Nicotera P, Dyer MJS, Cohen GM (2008) A novel paradigm for rapid ABT\u2010737\u2010induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell Death Differ 15: 820\u2013830","journal-title":"Cell Death Differ"},{"key":"BFEMBR202255859_CR55","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s40478-020-01039-9","volume":"8","author":"ST Wang","year":"2020","unstructured":"Wang ST, Tatman M, Monteiro MJ (2020) Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS\/FTD. Acta Neuropathol Commun 8: 164","journal-title":"Acta Neuropathol Commun"},{"key":"BFEMBR202255859_CR56","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2016.11.042","volume":"168","author":"Y Wei","year":"2017","unstructured":"Wei Y, Chiang WC, Sumpter R Jr, Mishra P, Levine B (2017) Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor. Cell 168: 224\u2013238","journal-title":"Cell"},{"key":"BFEMBR202255859_CR57","first-page":"E4439","volume":"111","author":"YC Wong","year":"2014","unstructured":"Wong YC, Holzbaur EL (2014) Optineurin is an autophagy receptor for damaged mitochondria in parkin\u2010mediated mitophagy that is disrupted by an ALS\u2010linked mutation. Proc Natl Acad Sci USA 111: E4439\u2013E4448","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255859_CR58","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/aps.2012.14","volume":"33","author":"JC Wu","year":"2012","unstructured":"Wu JC, Qi L, Wang Y, Kegel KB, Yoder J, Difiglia M, Qin ZH, Lin F (2012) The regulation of N\u2010terminal Huntingtin (Htt552) accumulation by Beclin1. Acta Pharmacol Sin 33: 743\u2013751","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR59","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/aps.2015.50","volume":"36","author":"JY Wu","year":"2015","unstructured":"Wu JY, Li M, Cao LJ, Sun ML, Chen D, Ren HG, Xia Q, Tao ZT, Qin ZH, Hu QS et\u00a0al (2015) Protease Omi cleaving Hax\u20101 protein contributes to\u00a0OGD\/R\u2010induced mitochondrial damage in neuroblastoma N2a cells\u00a0and cerebral injury in MCAO mice. Acta Pharmacol Sin 36: 1043\u20131052","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR60","doi-asserted-by":"crossref","first-page":"15230","DOI":"10.1073\/pnas.1917371117","volume":"117","author":"JJ Wu","year":"2020","unstructured":"Wu JJ, Cai A, Greenslade JE, Higgins NR, Fan C, Le NTT, Tatman M, Whiteley AM, Prado MA, Dieriks BV et\u00a0al (2020) ALS\/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function. Proc Natl Acad Sci USA 117: 15230\u201315241","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202255859_CR61","volume":"6","author":"Q Xia","year":"2015","unstructured":"Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Zhen X et\u00a0al (2015) Induction of COX\u20102\u2010PGE2 synthesis by activation of the MAPK\/ERK pathway contributes to neuronal death triggered by TDP\u201043\u2010depleted microglia. Cell Death Dis 6: e1702","journal-title":"Cell Death Dis"},{"key":"BFEMBR202255859_CR62","doi-asserted-by":"crossref","first-page":"19630","DOI":"10.1074\/jbc.M110.209338","volume":"286","author":"SR Yoshii","year":"2011","unstructured":"Yoshii SR, Kishi C, Ishihara N, Mizushima N (2011) Parkin mediates proteasome\u2010dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem 286: 19630\u201319640","journal-title":"J Biol Chem"},{"key":"BFEMBR202255859_CR63","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/aps.2016.68","volume":"37","author":"YX Yu","year":"2016","unstructured":"Yu YX, Li YP, Gao F, Hu QS, Zhang Y, Chen D, Wang GH (2016) Vitamin K2 suppresses rotenone\u2010induced microglial activation in vitro. Acta Pharmacol Sin 37: 1178\u20131189","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMBR202255859_CR64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/15548627.2022.2062872","volume":"19","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Fang Q, Wang H, Qi J, Sun S, Liao M, Wu Y, Hu Y, Jiang P, Cheng C et\u00a0al (2022) Increased mitophagy protects cochlear hair cells from aminoglycoside\u2010induced damage. Autophagy 19: 75\u201391","journal-title":"Autophagy"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202255859.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202255859\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202255859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202255859.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:07:16Z","timestamp":1779113236000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202255859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,6]]}},"alternative-id":["BFEMBR202255859"],"URL":"https:\/\/doi.org\/10.15252\/embr.202255859","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,28]]},"assertion":[{"value":"26 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202255859"}}