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B cell receptor (BCR) signaling is known to be crucial for the pathogenesis and maintenance of CLL cells which develop from mature CD5\n                    <jats:sup>+<\/jats:sup>\n                    B cells. BCR signaling is regulated by the inhibitory co\u2010receptor Siglec\u2010G and Siglec\u2010G\u2010deficient mice have an enlarged CD5\n                    <jats:sup>+<\/jats:sup>\n                    B1a cell population. Here, we determine how Siglec\u2010G expression influences the severity of CLL. Our results show that Siglec\u2010G deficiency leads to earlier onset and more severe course of the CLL\u2010like disease in the murine E\u03bc\u2010TCL1 model. In contrast, mice overexpressing Siglec\u2010G on the B cell surface are almost completely protected from developing CLL\u2010like disease. Furthermore, we observe a downmodulation of the human ortholog Siglec\u201010 from the surface of human CLL cells. These results demonstrate a critical role for Siglec\u2010G in disease progression in mice, and suggest that a similar mechanism for Siglec\u201010 in human CLL may exist.\n                  <\/jats:p>","DOI":"10.15252\/embr.202256420","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T03:56:27Z","timestamp":1688961387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The inhibitory receptor Siglec\u2010G controls the severity of chronic lymphocytic leukemia"],"prefix":"10.1038","volume":"24","author":[{"given":"Bettina","family":"R\u00f6der","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Fahnenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-8636","authenticated-orcid":false,"given":"Bettina","family":"Budeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-3269","authenticated-orcid":false,"given":"Maria","family":"Dampmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieglinde","family":"Angerm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Brost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-379X","authenticated-orcid":false,"given":"Lars","family":"Nitschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"BFEMBR202256420_CR1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2901","volume":"11","author":"N Baumgarth","year":"2011","unstructured":"Baumgarth N (2011) The double life of a B\u20101 cell: self\u2010reactivity selects for protective effector functions. 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