{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:23Z","timestamp":1792788623986,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"HHS | NIH | National Cancer Institute","award":["R01CA218140"],"award-info":[{"award-number":["R01CA218140"]}]},{"name":"HHS | NIH | National Cancer Institute","award":["R01CA206911"],"award-info":[{"award-number":["R01CA206911"]}]},{"name":"HHS | NIH | National Cancer Institute","award":["R01CA266486"],"award-info":[{"award-number":["R01CA266486"]}]},{"name":"HHS | NIH | National Cancer Institute","award":["P30CA23100"],"award-info":[{"award-number":["P30CA23100"]}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL091071"],"award-info":[{"award-number":["R01HL091071"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL138560"],"award-info":[{"award-number":["R01HL138560"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL132300"],"award-info":[{"award-number":["R01HL132300"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R56AR080153"],"award-info":[{"award-number":["R56AR080153"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR072882"],"award-info":[{"award-number":["R21AR072882"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR069775"],"award-info":[{"award-number":["R21AR069775"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"Tobacco\u2010Related Disease Research Program","doi-asserted-by":"publisher","award":["27IR\u20100013"],"award-info":[{"award-number":["27IR\u20100013"]}],"id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX001963"],"award-info":[{"award-number":["BX001963"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX005229"],"award-info":[{"award-number":["BX005229"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2023,9,6]]},"DOI":"10.15252\/embr.202256464","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T07:13:57Z","timestamp":1689232437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cancer\u2010cell\u2010secreted extracellular vesicles target p53 to impair mitochondrial function in muscle"],"prefix":"10.1038","volume":"24","author":[{"given":"Xianhui","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Z","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa B","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-9625","authenticated-orcid":false,"given":"Hemal H","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Schenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-8175","authenticated-orcid":false,"given":"Shizhen Emily","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"BFEMBR202256464_CR1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1211485","volume":"334","author":"D Anastasiou","year":"2011","unstructured":"Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS et\u00a0al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334: 1278\u20131283","journal-title":"Science"},{"key":"BFEMBR202256464_CR2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/ars.2012.4615","volume":"18","author":"K Aquilano","year":"2013","unstructured":"Aquilano K, Baldelli S, Pagliei B, Cannata SM, Rotilio G, Ciriolo MR (2013) p53 orchestrates the PGC\u20101alpha\u2010mediated antioxidant response upon mild redox and metabolic imbalance. Antioxid Redox Signal 18: 386\u2013399","journal-title":"Antioxid Redox Signal"},{"key":"BFEMBR202256464_CR3","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","volume":"14","author":"JM Argiles","year":"2014","unstructured":"Argiles JM, Busquets S, Stemmler B, Lopez\u2010Soriano FJ (2014) Cancer cachexia: understanding the molecular basis. Nat Rev Cancer 14: 754\u2013762","journal-title":"Nat Rev Cancer"},{"key":"BFEMBR202256464_CR4","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","volume":"30","author":"A Becker","year":"2016","unstructured":"Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D (2016) Extracellular vesicles in cancer: cell\u2010to\u2010cell mediators of metastasis. Cancer Cell 30: 836\u2013848","journal-title":"Cancer Cell"},{"key":"BFEMBR202256464_CR5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2004.05.013","volume":"141","author":"AM Benediktsson","year":"2005","unstructured":"Benediktsson AM, Schachtele SJ, Green SH, Dailey ME (2005) Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures. J Neurosci Methods 141: 41\u201353","journal-title":"J Neurosci Methods"},{"key":"BFEMBR202256464_CR6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cmet.2013.06.019","volume":"18","author":"CR Berkers","year":"2013","unstructured":"Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH (2013) Metabolic regulation by p53 family members. Cell Metab 18: 617\u2013633","journal-title":"Cell Metab"},{"key":"BFEMBR202256464_CR7","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/jamaoncol.2018.0137","volume":"4","author":"BJ Caan","year":"2018","unstructured":"Caan BJ, Cespedes Feliciano EM, Prado CM, Alexeeff S, Kroenke CH, Bradshaw P, Quesenberry CP, Weltzien EK, Castillo AL, Olobatuyi TA et\u00a0al (2018) Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer. JAMA Oncol 4: 798\u2013804","journal-title":"JAMA Oncol"},{"key":"BFEMBR202256464_CR8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41556-022-00919-7","volume":"24","author":"M Cao","year":"2022","unstructured":"Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S et\u00a0al (2022) Cancer\u2010cell\u2010secreted extracellular vesicles suppress insulin secretion through miR\u2010122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol 24: 954\u2013967","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR9","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1074\/jbc.M113.511535","volume":"289","author":"KL DeBalsi","year":"2014","unstructured":"DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS et\u00a0al (2014) Targeted metabolomics connects thioredoxin\u2010interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. J Biol Chem 289: 8106\u20138120","journal-title":"J Biol Chem"},{"key":"BFEMBR202256464_CR10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(02)01001-2","volume":"111","author":"J Debnath","year":"2002","unstructured":"Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS (2002) The role of apoptosis in creating and maintaining luminal space within normal and oncogene\u2010expressing mammary acini. Cell 111: 29\u201340","journal-title":"Cell"},{"key":"BFEMBR202256464_CR11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cbf.3460","volume":"38","author":"Z Ding","year":"2020","unstructured":"Ding Z, Lin J, Sun Y, Cong S, Liu S, Zhang Y, Chen Q, Chen J (2020) miR\u2010122\u20105p negatively regulates the transforming growth factor\u2010beta\/Smad signaling pathway in skeletal muscle myogenesis. Cell Biochem Funct 38: 231\u2013238","journal-title":"Cell Biochem Funct"},{"key":"BFEMBR202256464_CR12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1096\/fj.00-0262com","volume":"15","author":"RJ Donahue","year":"2001","unstructured":"Donahue RJ, Razmara M, Hoek JB, Knudsen TB (2001) Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function. FASEB J 15: 635\u2013644","journal-title":"FASEB J"},{"key":"BFEMBR202256464_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","volume":"16","author":"KC Fearon","year":"2012","unstructured":"Fearon KC, Glass DJ, Guttridge DC (2012) Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab 16: 153\u2013166","journal-title":"Cell Metab"},{"key":"BFEMBR202256464_CR14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","volume":"10","author":"K Fearon","year":"2013","unstructured":"Fearon K, Arends J, Baracos V (2013) Understanding the mechanisms and treatment options in cancer cachexia. Nat Rev Clin Oncol 10: 90\u201399","journal-title":"Nat Rev Clin Oncol"},{"key":"BFEMBR202256464_CR15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ncb3094","volume":"17","author":"MY Fong","year":"2015","unstructured":"Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR et\u00a0al (2015) Breast\u2010cancer\u2010secreted miR\u2010122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol 17: 183\u2013194","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR16","volume":"2009","author":"KM Fox","year":"2009","unstructured":"Fox KM, Brooks JM, Gandra SR, Markus R, Chiou CF (2009) Estimation of cachexia among cancer patients based on four definitions. J Oncol 2009: 693458","journal-title":"J Oncol"},{"key":"BFEMBR202256464_CR17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-370-7_2","volume":"807","author":"JT Gray","year":"2011","unstructured":"Gray JT, Zolotukhin S (2011) Design and construction of functional AAV vectors. Methods Mol Biol 807: 25\u201346","journal-title":"Methods Mol Biol"},{"key":"BFEMBR202256464_CR18","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.bbabio.2009.01.019","volume":"1787","author":"EJ Griffiths","year":"2009","unstructured":"Griffiths EJ, Rutter GA (2009) Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. Biochim Biophys Acta 1787: 1324\u20131333","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBR202256464_CR19","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1073\/pnas.1402714111","volume":"111","author":"WA He","year":"2014","unstructured":"He WA, Calore F, Londhe P, Canella A, Guttridge DC, Croce CM (2014) Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci USA 111: 4525\u20134529","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202256464_CR20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","volume":"81","author":"DA Hood","year":"2019","unstructured":"Hood DA, Memme JM, Oliveira AN, Triolo M (2019) Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Annu Rev Physiol 81: 19\u201341","journal-title":"Annu Rev Physiol"},{"key":"BFEMBR202256464_CR21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","volume":"137","author":"JP Kruse","year":"2009","unstructured":"Kruse JP, Gu W (2009) Modes of p53 regulation. Cell 137: 609\u2013622","journal-title":"Cell"},{"key":"BFEMBR202256464_CR22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","volume":"9","author":"AJ Levine","year":"2009","unstructured":"Levine AJ, Oren M (2009) The first 30\u2009years of p53: growing ever more complex. Nat Rev Cancer 9: 749\u2013758","journal-title":"Nat Rev Cancer"},{"key":"BFEMBR202256464_CR23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","volume":"307","author":"BB Lowell","year":"2005","unstructured":"Lowell BB, Shulman GI (2005) Mitochondrial dysfunction and type 2 diabetes. Science 307: 384\u2013387","journal-title":"Science"},{"key":"BFEMBR202256464_CR24","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1126863","volume":"312","author":"S Matoba","year":"2006","unstructured":"Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM (2006) p53 regulates mitochondrial respiration. Science 312: 1650\u20131653","journal-title":"Science"},{"key":"BFEMBR202256464_CR25","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EC-14-0092","volume":"4","author":"MK Montgomery","year":"2015","unstructured":"Montgomery MK, Turner N (2015) Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect 4: R1\u2013R15","journal-title":"Endocr Connect"},{"key":"BFEMBR202256464_CR26","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2147\/TCRM.S196802","volume":"15","author":"T Naito","year":"2019","unstructured":"Naito T (2019) Emerging treatment options for cancer\u2010associated cachexia: a literature review. Ther Clin Risk Manag 15: 1253\u20131266","journal-title":"Ther Clin Risk Manag"},{"key":"BFEMBR202256464_CR27","unstructured":"Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR et\u00a0al (2018) SEER Cancer Statistics Review, 1975\u20102015, National Cancer Institute. Bethesda, MD, https:\/\/seer.cancer.gov\/csr\/1975_2015\/, based on November 2017 SEER data submission, posted to the SEER web site, April 2018. National Cancer Institute"},{"key":"BFEMBR202256464_CR28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ncb2000","volume":"12","author":"M Ostrowski","year":"2010","unstructured":"Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP et\u00a0al (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12: 19\u201330","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.clnu.2017.07.010","volume":"37","author":"F Pamoukdjian","year":"2018","unstructured":"Pamoukdjian F, Bouillet T, Levy V, Soussan M, Zelek L, Paillaud E (2018) Prevalence and predictive value of pre\u2010therapeutic sarcopenia in cancer patients: a systematic review. Clin Nutr 37: 1101\u20131113","journal-title":"Clin Nutr"},{"key":"BFEMBR202256464_CR30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/CIRCRESAHA.109.205310","volume":"105","author":"JY Park","year":"2009","unstructured":"Park JY, Wang PY, Matsumoto T, Sung HJ, Ma W, Choi JW, Anderson SA, Leary SC, Balaban RS, Kang JG et\u00a0al (2009) p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ Res 105: 705\u2013712","journal-title":"Circ Res"},{"key":"BFEMBR202256464_CR31","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","volume":"15","author":"CM Prado","year":"2009","unstructured":"Prado CM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, Mackey JR, Koski S, Pituskin E, Sawyer MB (2009) Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res 15: 2920\u20132926","journal-title":"Clin Cancer Res"},{"key":"BFEMBR202256464_CR32","volume":"2012","author":"J Reid","year":"2012","unstructured":"Reid J, Mills M, Cantwell M, Cardwell CR, Murray LJ, Donnelly M (2012) Thalidomide for managing cancer cachexia. Cochrane Database Syst Rev 2012: CD008664","journal-title":"Cochrane Database Syst Rev"},{"key":"BFEMBR202256464_CR33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.breast.2016.10.014","volume":"31","author":"HN Rier","year":"2017","unstructured":"Rier HN, Jager A, Sleijfer S, van Rosmalen J, Kock M, Levin MD (2017) Low muscle attenuation is a prognostic factor for survival in metastatic breast cancer patients treated with first line palliative chemotherapy. Breast 31: 9\u201315","journal-title":"Breast"},{"key":"BFEMBR202256464_CR34","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2012.10.050","volume":"151","author":"JL Ruas","year":"2012","unstructured":"Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA et\u00a0al (2012) A PGC\u20101alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell 151: 1319\u20131331","journal-title":"Cell"},{"key":"BFEMBR202256464_CR35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiolgenomics.90346.2008","volume":"37","author":"A Saleem","year":"2009","unstructured":"Saleem A, Adhihetty PJ, Hood DA (2009) Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol Genomics 37: 58\u201366","journal-title":"Physiol Genomics"},{"key":"BFEMBR202256464_CR36","doi-asserted-by":"crossref","first-page":"C319","DOI":"10.1152\/ajpcell.00253.2014","volume":"308","author":"A Saleem","year":"2015","unstructured":"Saleem A, Iqbal S, Zhang Y, Hood DA (2015) Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle. Am J Physiol Cell Physiol 308: C319\u2013C329","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFEMBR202256464_CR37","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1158\/1078-0432.CCR-16-0940","volume":"23","author":"SS Shachar","year":"2017","unstructured":"Shachar SS, Deal AM, Weinberg M, Nyrop KA, Williams GR, Nishijima TF, Benbow JM, Muss HB (2017) Skeletal muscle measures as predictors of toxicity, hospitalization, and survival in patients with metastatic breast cancer receiving taxane\u2010based chemotherapy. Clin Cancer Res 23: 658\u2013665","journal-title":"Clin Cancer Res"},{"key":"BFEMBR202256464_CR38","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1158\/0008-5472.CAN-18-4055","volume":"79","author":"M Shen","year":"2019","unstructured":"Shen M, Dong C, Ruan X, Yan W, Cao M, Pizzo D, Wu X, Yang L, Liu L, Ren X et\u00a0al (2019) Chemotherapy\u2010induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2. Cancer Res 79: 3608\u20133621","journal-title":"Cancer Res"},{"key":"BFEMBR202256464_CR39","doi-asserted-by":"crossref","first-page":"E8987","DOI":"10.1073\/pnas.1712108114","volume":"114","author":"MJ Shurtleff","year":"2017","unstructured":"Shurtleff MJ, Yao J, Qin Y, Nottingham RM, Temoche\u2010Diaz MM, Schekman R, Lambowitz AM (2017) Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. Proc Natl Acad Sci USA 114: E8987\u2013E8995","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202256464_CR40","first-page":"7","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68: 7\u201330","journal-title":"CA Cancer J Clin"},{"key":"BFEMBR202256464_CR41","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3389\/fphys.2017.00941","volume":"8","author":"B Stocks","year":"2017","unstructured":"Stocks B, Dent JR, Joanisse S, McCurdy CE, Philp A (2017) Skeletal muscle fibre\u2010specific knockout of p53 does not reduce mitochondrial content or enzyme activity. Front Physiol 8: 941","journal-title":"Front Physiol"},{"key":"BFEMBR202256464_CR42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.omtn.2018.04.005","volume":"11","author":"Y Sun","year":"2018","unstructured":"Sun Y, Wang H, Li Y, Liu S, Chen J, Ying H (2018) miR\u201024 and miR\u2010122 negatively regulate the transforming growth factor\u2010beta\/Smad signaling pathway in skeletal muscle fibrosis. Mol Ther Nucleic Acids 11: 528\u2013537","journal-title":"Mol Ther Nucleic Acids"},{"key":"BFEMBR202256464_CR43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncb1730","volume":"10","author":"E Tasdemir","year":"2008","unstructured":"Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri\u2010Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F et\u00a0al (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 10: 676\u2013687","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbabio.2008.10.005","volume":"1787","author":"AV Vaseva","year":"2009","unstructured":"Vaseva AV, Moll UM (2009) The mitochondrial p53 pathway. Biochim Biophys Acta 1787: 414\u2013420","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBR202256464_CR45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11764-012-0234-x","volume":"6","author":"A Villasenor","year":"2012","unstructured":"Villasenor A, Ballard\u2010Barbash R, Baumgartner K, Baumgartner R, Bernstein L, McTiernan A, Neuhouser ML (2012) Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL study. J Cancer Surviv 6: 398\u2013406","journal-title":"J Cancer Surviv"},{"key":"BFEMBR202256464_CR46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","volume":"166","author":"S Vyas","year":"2016","unstructured":"Vyas S, Zaganjor E, Haigis MC (2016) Mitochondria and cancer. Cell 166: 555\u2013566","journal-title":"Cell"},{"key":"BFEMBR202256464_CR47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","volume":"39","author":"DC Wallace","year":"2005","unstructured":"Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39: 359\u2013407","journal-title":"Annu Rev Genet"},{"key":"BFEMBR202256464_CR48","volume":"7","author":"B Wang","year":"2012","unstructured":"Wang B, Wang H, Yang Z (2012) MiR\u2010122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R. PloS One 7: e47053","journal-title":"PloS One"},{"key":"BFEMBR202256464_CR49","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.3961","volume":"21","author":"DL Waning","year":"2015","unstructured":"Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M et\u00a0al (2015) Excess TGF\u2010beta mediates muscle weakness associated with bone metastases in mice. Nat Med 21: 1262\u20131271","journal-title":"Nat Med"},{"key":"BFEMBR202256464_CR50","doi-asserted-by":"crossref","first-page":"75981","DOI":"10.18632\/oncotarget.12514","volume":"7","author":"S Wen","year":"2016","unstructured":"Wen S, Gao J, Zhang L, Zhou H, Fang D, Feng S (2016) p53 increase mitochondrial copy number via up\u2010regulation of mitochondrial transcription factor A in colorectal cancer. Oncotarget 7: 75981\u201375995","journal-title":"Oncotarget"},{"key":"BFEMBR202256464_CR51","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026120","volume":"6","author":"E White","year":"2016","unstructured":"White E (2016) Autophagy and p53. Cold Spring Harb Perspect Med 6: a026120","journal-title":"Cold Spring Harb Perspect Med"},{"key":"BFEMBR202256464_CR52","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1158\/1078-0432.CCR-18-1565","volume":"25","author":"HE Wilson","year":"2019","unstructured":"Wilson HE, Rhodes KK, Rodriguez D, Chahal I, Stanton DA, Bohlen J, Davis M, Infante AM, Hazard\u2010Jenkins H, Klinke DJ et\u00a0al (2019) Human breast cancer xenograft model implicates peroxisome proliferator\u2010activated receptor signaling as driver of cancer\u2010induced muscle fatigue. Clin Cancer Res 25: 2336\u20132347","journal-title":"Clin Cancer Res"},{"key":"BFEMBR202256464_CR53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41523-020-0162-2","volume":"6","author":"HE Wilson","year":"2020","unstructured":"Wilson HE, Stanton DA, Montgomery C, Infante AM, Taylor M, Hazard\u2010Jenkins H, Pugacheva EN, Pistilli EE (2020) Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype. NPJ Breast Cancer 6: 18","journal-title":"NPJ Breast Cancer"},{"key":"BFEMBR202256464_CR54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1479-5876-10-42","volume":"10","author":"X Wu","year":"2012","unstructured":"Wu X, Somlo G, Yu Y, Palomares MR, Li AX, Zhou W, Chow A, Yen Y, Rossi JJ, Gao H et\u00a0al (2012) De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med 10: 42","journal-title":"J Transl Med"},{"key":"BFEMBR202256464_CR55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41556-018-0083-6","volume":"20","author":"W Yan","year":"2018","unstructured":"Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP et\u00a0al (2018) Cancer\u2010cell\u2010secreted exosomal miR\u2010105 promotes tumour growth through the MYC\u2010dependent metabolic reprogramming of stromal cells. Nat Cell Biol 20: 597\u2013609","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR56","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41556-022-00893-0","volume":"24","author":"W Yan","year":"2022","unstructured":"Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y et\u00a0al (2022) Cancer\u2010cell\u2010secreted miR\u2010122 suppresses O\u2010GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol 24: 793\u2013804","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256464_CR57","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41467-017-00726-x","volume":"8","author":"G Zhang","year":"2017","unstructured":"Zhang G, Liu Z, Ding H, Zhou Y, Doan HA, Sin KWT, Zhu ZJ, Flores R, Wen Y, Gong X et\u00a0al (2017) Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nat Commun 8: 589","journal-title":"Nat Commun"},{"key":"BFEMBR202256464_CR58","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","volume":"25","author":"W Zhou","year":"2014","unstructured":"Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR et\u00a0al (2014) Cancer\u2010secreted miR\u2010105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 25: 501\u2013515","journal-title":"Cancer Cell"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202256464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202256464\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202256464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202256464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:09:23Z","timestamp":1779113363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202256464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,6]]}},"alternative-id":["BFEMBR202256464"],"URL":"https:\/\/doi.org\/10.15252\/embr.202256464","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"assertion":[{"value":"10 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202256464"}}