{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:18Z","timestamp":1791895458104,"version":"4.3.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"David M. Rubenstein Fund for Hearing Research"},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC019359"],"award-info":[{"award-number":["R01DC019359"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["F31DC020882"],"award-info":[{"award-number":["F31DC020882"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2023,9,6]]},"DOI":"10.15252\/embr.202256562","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T04:20:35Z","timestamp":1690345235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["TRIM71 reactivation enhances the mitotic and hair cell\u2013forming potential of cochlear supporting cells"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-2364","authenticated-orcid":false,"given":"Xiao\u2010Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-0954","authenticated-orcid":false,"given":"Charles","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-9069","authenticated-orcid":false,"given":"Prathamesh T","family":"Nadar\u2010Ponniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-9444","authenticated-orcid":false,"given":"Waldemar","family":"Kolanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-2112","authenticated-orcid":false,"given":"Angelika","family":"Doetzlhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"BFEMBR202256562_CR1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1242\/dev.114926","volume":"142","author":"PJ Atkinson","year":"2015","unstructured":"Atkinson PJ, Huarcaya Najarro E, Sayyid ZN, Cheng AG (2015) Sensory hair cell development and regeneration: similarities and differences. Development 142: 1561\u20131571","journal-title":"Development"},{"key":"BFEMBR202256562_CR2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.devcel.2022.03.001","volume":"57","author":"S Baek","year":"2022","unstructured":"Baek S, Tran NTT, Diaz DC, Tsai YY, Acedo JN, Lush ME, Piotrowski T (2022) Single\u2010cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration. Dev Cell 57: 799\u2013819","journal-title":"Dev Cell"},{"key":"BFEMBR202256562_CR3","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1126\/science.284.5421.1837","volume":"284","author":"NA Bermingham","year":"1999","unstructured":"Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben\u2010Arie N, Eatock RA, Bellen HJ, Lysakowski A, Zoghbi HY (1999) Math1: an essential gene for the generation of inner ear hair cells. Science 284: 1837\u20131841","journal-title":"Science"},{"key":"BFEMBR202256562_CR4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","volume":"34","author":"NL Bray","year":"2016","unstructured":"Bray NL, Pimentel H, Melsted P, Pachter L (2016) Near\u2010optimal probabilistic RNA\u2010seq quantification. Nat Biotechnol 34: 525\u2013527","journal-title":"Nat Biotechnol"},{"key":"BFEMBR202256562_CR5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2009.02.028","volume":"1277","author":"HR Brignull","year":"2009","unstructured":"Brignull HR, Raible DW, Stone JS (2009) Feathers and fins: non\u2010mammalian models for hair cell regeneration. Brain Res 1277: 12\u201323","journal-title":"Brain Res"},{"key":"BFEMBR202256562_CR6","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1073\/pnas.1202774109","volume":"109","author":"R Chai","year":"2012","unstructured":"Chai R, Kuo B, Wang T, Liaw EJ, Xia A, Jan TA, Liu Z, Taketo MM, Oghalai JS, Nusse R et\u00a0al (2012) Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci USA 109: 8167\u20138172","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202256562_CR7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1101\/gad.187641.112","volume":"26","author":"J Chen","year":"2012","unstructured":"Chen J, Lai F, Niswander L (2012) The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev 26: 803\u2013815","journal-title":"Genes Dev"},{"key":"BFEMBR202256562_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.09.015","volume":"410","author":"KS Chen","year":"2017","unstructured":"Chen KS, Lim JWC, Richards LJ, Bunt J (2017) The convergent roles of the nuclear factor I transcription factors in development and cancer. Cancer Lett 410: 124\u2013138","journal-title":"Cancer Lett"},{"key":"BFEMBR202256562_CR9","volume":"35","author":"Y Chen","year":"2021","unstructured":"Chen Y, Gu Y, Li Y, Li GL, Chai R, Li W, Li H (2021) Generation of mature and functional hair cells by co\u2010expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. Cell Rep 35: 109016","journal-title":"Cell Rep"},{"key":"BFEMBR202256562_CR10","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/ncb2783","volume":"15","author":"MR Copley","year":"2013","unstructured":"Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K et\u00a0al (2013) The Lin28b\u2010let\u20107\u2010Hmga2 axis determines the higher self\u2010renewal potential of fetal haematopoietic stem cells. Nat Cell Biol 15: 916\u2013925","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256562_CR11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2015.00020","volume":"3","author":"E Cuevas","year":"2015","unstructured":"Cuevas E, Rybak\u2010Wolf A, Rohde AM, Nguyen DT, Wulczyn FG (2015) Lin41\/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol 3: 20","journal-title":"Front Cell Dev Biol"},{"key":"BFEMBR202256562_CR12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41593-022-01043-3","volume":"25","author":"PQ Duy","year":"2022","unstructured":"Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J et\u00a0al (2022) Impaired neurogenesis alters brain biomechanics in a neuroprogenitor\u2010based genetic subtype of congenital hydrocephalus. Nat Neurosci 25: 458\u2013473","journal-title":"Nat Neurosci"},{"key":"BFEMBR202256562_CR13","doi-asserted-by":"crossref","DOI":"10.1242\/dev.183384","volume":"147","author":"L Evsen","year":"2020","unstructured":"Evsen L, Li X, Zhang S, Razin S, Doetzlhofer A (2020) Let\u20107 miRNAs inhibit CHD7 expression and control auditory\u2010sensory progenitor cell behavior in the developing inner ear. Development 147: dev183384","journal-title":"Development"},{"key":"BFEMBR202256562_CR14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2006.04.024","volume":"9","author":"M Fedele","year":"2006","unstructured":"Fedele M, Visone R, De Martino I, Troncone G, Palmieri D, Battista S, Ciarmiello A, Pallante P, Arra C, Melillo RM et\u00a0al (2006) HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell 9: 459\u2013471","journal-title":"Cancer Cell"},{"key":"BFEMBR202256562_CR15","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1080\/15384101.2020.1804232","volume":"19","author":"DJ Foster","year":"2020","unstructured":"Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ (2020) TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle 19: 2314\u20132326","journal-title":"Cell Cycle"},{"key":"BFEMBR202256562_CR16","doi-asserted-by":"crossref","first-page":"E3864","DOI":"10.1073\/pnas.1501077112","volume":"112","author":"EJ Golden","year":"2015","unstructured":"Golden EJ, Benito\u2010Gonzalez A, Doetzlhofer A (2015) The RNA\u2010binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci USA 112: E3864\u2013E3873","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202256562_CR17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2016.03.027","volume":"414","author":"R Gu","year":"2016","unstructured":"Gu R, Brown RM II, Hsu CW, Cai T, Crowder AL, Piazza VG, Vadakkan TJ, Dickinson ME, Groves AK (2016) Lineage tracing of Sox2\u2010expressing progenitor cells in the mouse inner ear reveals a broad contribution to non\u2010sensory tissues and insights into the origin of the organ of Corti. Dev Biol 414: 72\u201384","journal-title":"Dev Biol"},{"key":"BFEMBR202256562_CR18","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1242\/dev.080358","volume":"139","author":"BE Jacques","year":"2012","unstructured":"Jacques BE, Puligilla C, Weichert RM, Ferrer\u2010Vaquer A, Hadjantonakis AK, Kelley MW, Dabdoub A (2012) A dual function for canonical Wnt\/\u03b2\u2010catenin signaling in the developing mammalian cochlea. Development 139: 4395\u20134404","journal-title":"Development"},{"key":"BFEMBR202256562_CR19","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1523\/JNEUROSCI.5420-11.2012","volume":"32","author":"MC Kelly","year":"2012","unstructured":"Kelly MC, Chang Q, Pan A, Lin X, Chen P (2012) Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. J Neurosci 32: 6699\u20136710","journal-title":"J Neurosci"},{"key":"BFEMBR202256562_CR20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/nature03487","volume":"434","author":"AE Kiernan","year":"2005","unstructured":"Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, Tease C, Lovell\u2010Badge R, Steel KP, Cheah KS (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434: 1031\u20131035","journal-title":"Nature"},{"key":"BFEMBR202256562_CR21","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1038\/s41467-020-16113-y","volume":"11","author":"L Kolla","year":"2020","unstructured":"Kolla L, Kelly MC, Mann ZF, Anaya\u2010Rocha A, Ellis K, Lemons A, Palermo AT, So KS, Mays JC, Orvis J et\u00a0al (2020) Characterization of the development of the mouse cochlear epithelium at the single cell level. Nat Commun 11: 2389","journal-title":"Nat Commun"},{"key":"BFEMBR202256562_CR22","volume":"8","author":"S Korrapati","year":"2013","unstructured":"Korrapati S, Roux I, Glowatzki E, Doetzlhofer A (2013) Notch signaling limits supporting cell plasticity in the hair cell\u2010damaged early postnatal murine cochlea. PLoS ONE 8: e73276","journal-title":"PLoS ONE"},{"key":"BFEMBR202256562_CR23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108646","volume":"34","author":"M Kubota","year":"2021","unstructured":"Kubota M, Scheibinger M, Jan TA, Heller S (2021) Greater epithelial ridge cells are the principal organoid\u2010forming progenitors of the mouse cochlea. Cell Rep 34: 108646","journal-title":"Cell Rep"},{"key":"BFEMBR202256562_CR24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nbt.3781","volume":"35","author":"LD Landegger","year":"2017","unstructured":"Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR et\u00a0al (2017) A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol 35: 280\u2013284","journal-title":"Nat Biotechnol"},{"key":"BFEMBR202256562_CR25","volume":"10","author":"S Lee","year":"2020","unstructured":"Lee S, Song JJ, Beyer LA, Swiderski DL, Prieskorn DM, Acar M, Jen HI, Groves AK, Raphael Y (2020) Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea. Sci Rep 10: 21397","journal-title":"Sci Rep"},{"key":"BFEMBR202256562_CR26","doi-asserted-by":"crossref","first-page":"22225","DOI":"10.1073\/pnas.2000417117","volume":"117","author":"XJ Li","year":"2020","unstructured":"Li XJ, Doetzlhofer A (2020) LIN28B\/let\u20107 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling. Proc Natl Acad Sci USA 117: 22225\u201322236","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBR202256562_CR27","volume":"8","author":"XJ Li","year":"2022","unstructured":"Li XJ, Morgan C, Goff LA, Doetzlhofer A (2022) Follistatin promotes LIN28B\u2010mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv 8: eabj7651","journal-title":"Sci Adv"},{"key":"BFEMBR202256562_CR28","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1093\/molbev\/msm195","volume":"24","author":"YC Lin","year":"2007","unstructured":"Lin YC, Hsieh LC, Kuo MW, Yu J, Kuo HH, Lo WL, Lin RJ, Yu AL, Li WH (2007) Human TRIM71 and its nematode homologue are targets of let\u20107 microRNA and its zebrafish orthologue is essential for development. Mol Biol Evol 24: 2525\u20132534","journal-title":"Mol Biol Evol"},{"key":"BFEMBR202256562_CR29","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1523\/JNEUROSCI.0818-12.2012","volume":"32","author":"Z Liu","year":"2012","unstructured":"Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J (2012) Age\u2010dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression. J Neurosci 32: 6600\u20136610","journal-title":"J Neurosci"},{"key":"BFEMBR202256562_CR30","volume":"10","author":"Q Liu","year":"2021","unstructured":"Liu Q, Chen X, Novak MK, Zhang S, Hu W (2021) Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let\u20107 microRNAs. Elife 10: e66288","journal-title":"Elife"},{"key":"BFEMBR202256562_CR31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real\u2010time quantitative PCR and the 2(\u2010Delta Delta C(T)) method. Methods 25: 402\u2013408","journal-title":"Methods"},{"key":"BFEMBR202256562_CR32","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/nar\/gks1032","volume":"41","author":"I Loedige","year":"2013","unstructured":"Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W (2013) The mammalian TRIM\u2010NHL protein TRIM71\/LIN\u201041 is a repressor of mRNA function. Nucleic Acids Res 41: 518\u2013532","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR202256562_CR33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1567-133X(03)00089-9","volume":"3","author":"EA Lumpkin","year":"2003","unstructured":"Lumpkin EA, Collisson T, Parab P, Omer\u2010Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N et\u00a0al (2003) Math1\u2010driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns 3: 389\u2013395","journal-title":"Gene Expr Patterns"},{"key":"BFEMBR202256562_CR34","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.4161\/cc.7.24.7397","volume":"7","author":"BR Maller Schulman","year":"2008","unstructured":"Maller Schulman BR, Liang X, Stahlhut C, DelConte C, Stefani G, Slack FJ (2008) The let\u20107 microRNA target gene, Mlin41\/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 7: 3935\u20133942","journal-title":"Cell Cycle"},{"key":"BFEMBR202256562_CR35","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","volume":"315","author":"C Mayr","year":"2007","unstructured":"Mayr C, Hemann MT, Bartel DP (2007) Disrupting the pairing between let\u20107 and Hmga2 enhances oncogenic transformation. Science 315: 1576\u20131579","journal-title":"Science"},{"key":"BFEMBR202256562_CR36","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.celrep.2017.01.066","volume":"18","author":"WJ McLean","year":"2017","unstructured":"McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge ASB (2017) Clonal expansion of Lgr5\u2010positive cells from mammalian cochlea and high\u2010purity generation of sensory hair cells. Cell Rep 18: 1917\u20131929","journal-title":"Cell Rep"},{"key":"BFEMBR202256562_CR37","doi-asserted-by":"crossref","DOI":"10.1242\/dev.196642","volume":"148","author":"JA Medeiros de Ara\u00fajo","year":"2021","unstructured":"Medeiros de Ara\u00fajo JA, Bar\u00e3o S, Mateos\u2010White I, Espinosa A, Costa MR, Gil\u2010Sanz C, M\u00fcller U (2021) ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development 148: dev196642","journal-title":"Development"},{"key":"BFEMBR202256562_CR38","doi-asserted-by":"crossref","DOI":"10.1038\/srep11126","volume":"5","author":"S Mitschka","year":"2015","unstructured":"Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brustle O, Schorle H, Beyer M, Klee K et\u00a0al (2015) Co\u2010existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Sci Rep 5: 11126","journal-title":"Sci Rep"},{"key":"BFEMBR202256562_CR39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2012.10.032","volume":"77","author":"K Mizutari","year":"2013","unstructured":"Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS (2013) Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron 77: 58\u201369","journal-title":"Neuron"},{"key":"BFEMBR202256562_CR40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0925-4773(99)00066-0","volume":"84","author":"A Morrison","year":"1999","unstructured":"Morrison A, Hodgetts C, Gossler A, Hrabe de Angelis M, Lewis J (1999) Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. Mech Dev 84: 169\u2013172","journal-title":"Mech Dev"},{"key":"BFEMBR202256562_CR41","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/cdd.2017.54","volume":"24","author":"DTT Nguyen","year":"2017","unstructured":"Nguyen DTT, Richter D, Michel G, Mitschka S, Kolanus W, Cuevas E, Wulczyn FG (2017) The ubiquitin ligase LIN41\/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation. Cell Death Differ 24: 1063\u20131078","journal-title":"Cell Death Differ"},{"key":"BFEMBR202256562_CR42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","volume":"135","author":"J Nishino","year":"2008","unstructured":"Nishino J, Kim I, Chada K, Morrison SJ (2008) Hmga2 promotes neural stem cell self\u2010renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell 135: 227\u2013239","journal-title":"Cell"},{"key":"BFEMBR202256562_CR43","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1523\/JNEUROSCI.3547-10.2010","volume":"30","author":"T Ohyama","year":"2010","unstructured":"Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK (2010) BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci 30: 15044\u201315051","journal-title":"J Neurosci"},{"key":"BFEMBR202256562_CR44","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","volume":"14","author":"H Pimentel","year":"2017","unstructured":"Pimentel H, Bray NL, Puente S, Melsted P, Pachter L (2017) Differential analysis of RNA\u2010seq incorporating quantification uncertainty. Nat Methods 14: 687\u2013690","journal-title":"Nat Methods"},{"key":"BFEMBR202256562_CR45","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","volume":"403","author":"BJ Reinhart","year":"2000","unstructured":"Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G (2000) The 21\u2010nucleotide let\u20107 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901\u2013906","journal-title":"Nature"},{"key":"BFEMBR202256562_CR46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.devcel.2018.12.016","volume":"48","author":"DA Robinton","year":"2019","unstructured":"Robinton DA, Chal J, Lummertz da Rocha E, Han A, Yermalovich AV, Oginuma M, Schlaeger TM, Sousa P, Rodriguez A, Urbach A et\u00a0al (2019) The Lin28\/let\u20107 pathway regulates the mammalian caudal body Axis elongation program. Dev Cell 48: 396\u2013405","journal-title":"Dev Cell"},{"key":"BFEMBR202256562_CR47","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/ncb1987","volume":"11","author":"A Rybak","year":"2009","unstructured":"Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG (2009) The let\u20107 target gene mouse lin\u201041 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol 11: 1411\u20131420","journal-title":"Nat Cell Biol"},{"key":"BFEMBR202256562_CR48","doi-asserted-by":"crossref","first-page":"9639","DOI":"10.1523\/JNEUROSCI.1064-12.2012","volume":"32","author":"F Shi","year":"2012","unstructured":"Shi F, Kempfle JS, Edge AS (2012) Wnt\u2010responsive Lgr5\u2010expressing stem cells are hair cell progenitors in the cochlea. J Neurosci 32: 9639\u20139648","journal-title":"J Neurosci"},{"key":"BFEMBR202256562_CR49","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1523\/JNEUROSCI.4305-13.2014","volume":"34","author":"F Shi","year":"2014","unstructured":"Shi F, Hu L, Jacques BE, Mulvaney JF, Dabdoub A, Edge AS (2014) \u03b2\u2010Catenin is required for hair\u2010cell differentiation in the cochlea. J Neurosci 34: 6470\u20136479","journal-title":"J Neurosci"},{"key":"BFEMBR202256562_CR50","doi-asserted-by":"crossref","DOI":"10.1038\/srep00026","volume":"1","author":"ST Sinkkonen","year":"2011","unstructured":"Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske RD, Gahlen F, Sinkkonen W, Cheng AG, Oshima K, Heller S (2011) Intrinsic regenerative potential of murine cochlear supporting cells. Sci Rep 1: 26","journal-title":"Sci Rep"},{"key":"BFEMBR202256562_CR51","volume":"10","author":"S Sun","year":"2021","unstructured":"Sun S, Li S, Luo Z, Ren M, He S, Wang G, Liu Z (2021) Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells. Elife 10: e66547","journal-title":"Elife"},{"key":"BFEMBR202256562_CR52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ydbio.2007.04.035","volume":"307","author":"S Takebayashi","year":"2007","unstructured":"Takebayashi S, Yamamoto N, Yabe D, Fukuda H, Kojima K, Ito J, Honjo T (2007) Multiple roles of notch signaling in cochlear development. Dev Biol 307: 165\u2013178","journal-title":"Dev Biol"},{"key":"BFEMBR202256562_CR53","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1261\/rna.078696.121","volume":"27","author":"LA Torres Fern\u00e1ndez","year":"2021","unstructured":"Torres Fern\u00e1ndez LA, Mitschka S, Ulas T, Weise S, Dahm K, Becker M, H\u00e4ndler K, Beyer M, Windhausen J, Schultze JL et\u00a0al (2021) The stem cell\u2010specific protein TRIM71 inhibits maturation and activity of the pro\u2010differentiation miRNA let\u20107 via two independent molecular mechanisms. RNA 27: 805\u2013828","journal-title":"RNA"},{"key":"BFEMBR202256562_CR54","first-page":"11861","volume":"47","author":"LA Torres\u2010Fernandez","year":"2019","unstructured":"Torres\u2010Fernandez LA, Jux B, Bille M, Port Y, Schneider K, Geyer M, Mayer G, Kolanus W (2019) The mRNA repressor TRIM71 cooperates with nonsense\u2010mediated decay factors to destabilize the mRNA of CDKN1A\/p21. Nucleic Acids Res 47: 11861\u201311879","journal-title":"Nucleic Acids Res"},{"key":"BFEMBR202256562_CR55","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.658966","volume":"9","author":"LA Torres\u2010Fernandez","year":"2021","unstructured":"Torres\u2010Fernandez LA, Emich J, Port Y, Mitschka S, Woste M, Schneider S, Fietz D, Oud MS, Di Persio S, Neuhaus N et\u00a0al (2021) TRIM71 deficiency causes germ cell loss during mouse embryogenesis and is associated with human male infertility. Front Cell Dev Biol 9: 658966","journal-title":"Front Cell Dev Biol"},{"key":"BFEMBR202256562_CR56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020654","volume":"21","author":"R Vignali","year":"2020","unstructured":"Vignali R, Marracci S (2020) HMGA genes and proteins in development and evolution. Int J Mol Sci 21: 654","journal-title":"Int J Mol Sci"},{"key":"BFEMBR202256562_CR57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.celrep.2017.03.044","volume":"19","author":"BJ Walters","year":"2017","unstructured":"Walters BJ, Coak E, Dearman J, Bailey G, Yamashita T, Kuo B, Zuo J (2017) In vivo interplay between p27(Kip1), GATA3, ATOH1, and POU4F3 converts non\u2010sensory cells to hair cells in adult mice. Cell Rep 19: 307\u2013320","journal-title":"Cell Rep"},{"key":"BFEMBR202256562_CR58","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/nature04849","volume":"441","author":"PM White","year":"2006","unstructured":"White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N (2006) Mammalian cochlear supporting cells can divide and trans\u2010differentiate into hair cells. Nature 441: 984\u2013987","journal-title":"Nature"},{"key":"BFEMBR202256562_CR59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature09881","volume":"473","author":"MM Winslow","year":"2011","unstructured":"Winslow MM, Dayton TL, Verhaak RG, Kim\u2010Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S et\u00a0al (2011) Suppression of lung adenocarcinoma progression by Nkx2\u20101. Nature 473: 101\u2013104","journal-title":"Nature"},{"key":"BFEMBR202256562_CR60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.stem.2013.11.001","volume":"14","author":"KA Worringer","year":"2014","unstructured":"Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S (2014) The let\u20107\/LIN\u201041 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Cell Stem Cell 14: 40\u201352","journal-title":"Cell Stem Cell"},{"key":"BFEMBR202256562_CR61","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.celrep.2014.12.038","volume":"10","author":"KR Yu","year":"2015","unstructured":"Yu KR, Shin JH, Kim JJ, Koog MG, Lee JY, Choi SW, Kim HS, Seo Y, Lee S, Shin TH et\u00a0al (2015) Rapid and efficient direct conversion of human adult somatic cells into neural stem cells by HMGA2\/let\u20107b. Cell Rep 10: 441\u2013452","journal-title":"Cell Rep"},{"key":"BFEMBR202256562_CR62","first-page":"25","volume":"9","author":"S Zhang","year":"2020","unstructured":"Zhang S, Qiang R, Dong Y, Zhang Y, Chen Y, Zhou H, Gao X, Chai R (2020) Hair cell regeneration from inner ear progenitors in the mammalian cochlea. Am J Stem Cells 9: 25\u201335","journal-title":"Am J Stem Cells"},{"key":"BFEMBR202256562_CR63","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/75753","volume":"3","author":"JL Zheng","year":"2000","unstructured":"Zheng JL, Gao WQ (2000) Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci 3: 580\u2013586","journal-title":"Nat Neurosci"},{"key":"BFEMBR202256562_CR64","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist\u2010oriented resource for the analysis of systems\u2010level datasets. Nat Commun 10: 1523","journal-title":"Nat Commun"},{"key":"BFEMBR202256562_CR65","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2011.08.033","volume":"147","author":"H Zhu","year":"2011","unstructured":"Zhu H, Shyh\u2010Chang N, Segre AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG et\u00a0al (2011) The Lin28\/let\u20107 axis regulates glucose metabolism. Cell 147: 81\u201394","journal-title":"Cell"},{"key":"BFEMBR202256562_CR66","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1231321","volume":"340","author":"Y Zou","year":"2013","unstructured":"Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang CF, Chang C (2013) Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science 340: 372\u2013376","journal-title":"Science"}],"container-title":["EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202256562.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/embr.202256562\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/embr.202256562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/embr.202256562.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:10:36Z","timestamp":1779113436000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/embr.202256562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,6]]}},"alternative-id":["BFEMBR202256562"],"URL":"https:\/\/doi.org\/10.15252\/embr.202256562","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"27 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"EMBR202256562"}}