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Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early\u2010life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen\u2010specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    (LmOVA), we here provide evidence that OVA\u2010specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally\u2010derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.\n                  <\/jats:p>","DOI":"10.15252\/embr.202356829","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:20:54Z","timestamp":1692775254000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pregnancy\u2010induced transfer of pathogen\u2010specific T\u00a0cells from mother to fetus in mice"],"prefix":"10.1038","volume":"24","author":[{"given":"Dennis","family":"Y\u00fczen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-9133","authenticated-orcid":false,"given":"Christopher","family":"Urbschat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Schepanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-926X","authenticated-orcid":false,"given":"Petra C","family":"Arck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-4191","authenticated-orcid":false,"given":"Hans\u2010Willi","family":"Mittr\u00fccker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"BFEMBR202356829_CR1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14811","volume":"8","author":"S Abolins","year":"2017","unstructured":"Abolins S, King EC, Lazarou L, Weldon L, Hughes L, Drescher P, Raynes JG, Hafalla JCR, Viney ME, Riley EM (2017) The comparative immunology of wild and laboratory mice, Mus musculus domesticus. 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