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There is an association between transcription and spatial organization; however, the molecular mechanisms behind genome organization are unclear. While\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    lacks key genome\u2010organizing proteins found in metazoans, it has all core components of the cohesin complex. To investigate the role of cohesin in\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    , we functionally characterize the cohesin subunit Structural Maintenance of Chromosomes protein 3 (SMC3). SMC3 knockdown during early stages of the intraerythrocytic developmental cycle (IDC) upregulates a subset of genes involved in erythrocyte egress and invasion, which are normally expressed at later stages. ChIP\u2010seq analyses reveal that during the IDC, SMC3 enrichment at the promoter regions of these genes inversely correlates with gene expression and chromatin accessibility. These data suggest that SMC3 binding contributes to the repression of specific genes until their appropriate time of expression, revealing a new mode of stage\u2010specific gene repression in\n                    <jats:italic>P.\u2009falciparum<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.15252\/embr.202357090","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:49:20Z","timestamp":1692647360000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cohesin contributes to transcriptional repression of stage\u2010specific genes in the human malaria parasite"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-636X","authenticated-orcid":false,"given":"Catarina","family":"Rosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-5102","authenticated-orcid":false,"given":"Parul","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-075X","authenticated-orcid":false,"given":"Ameya","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Cla\u00ebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-7000","authenticated-orcid":false,"given":"Peter R","family":"Preiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-3067","authenticated-orcid":false,"given":"Peter C","family":"Dedon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-7699","authenticated-orcid":false,"given":"Sebastian","family":"Baumgarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-3328","authenticated-orcid":false,"given":"Artur","family":"Scherf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2349-8353","authenticated-orcid":false,"given":"Jessica M","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"BFEMBR202357090_CR1","doi-asserted-by":"publisher","first-page":"D898","DOI":"10.1093\/nar\/gkab929","volume":"50","author":"B Amos","year":"2021","unstructured":"Amos B, Aurrecoechea C, Barba M, Barreto A, Basenko EY, Ba\u017cant W, Belnap R, Blevins AS, B\u00f6hme U, Brestelli J et\u00a0al (2021) VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center. 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