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In tumour bearing animals, Sog also modulates TGF\u2010\u03b2 signalling to regulate ECM accumulation in the fat body. TGF\u2010\u03b2 signalling causes ECM retention in the fat body and subsequently depletes muscles of fat body\u2010derived ECM proteins. Activation of insulin signalling, inhibition of TGF\u2010\u03b2 signalling, or modulation of ECM levels via SPARC, Rab10 or Collagen IV in the fat body, is able to rescue tissue wasting in the presence of tumour. Together, our study highlights the importance of adipose ECM remodelling in the context of cancer cachexia.<\/jats:p>","DOI":"10.15252\/embr.202357695","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T04:51:40Z","timestamp":1701147100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Convergent insulin and TGF\u2010\u03b2 signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-3503","authenticated-orcid":false,"given":"Daniel","family":"Bakopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofya","family":"Golenkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum","family":"Dark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-7024","authenticated-orcid":false,"given":"Elizabeth L","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-5236","authenticated-orcid":false,"given":"Besaiz J","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-3269","authenticated-orcid":false,"given":"Brian M","family":"Stramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-4082","authenticated-orcid":false,"given":"Louise Y","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"BFEMBR202357695_CR1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12885-017-3178-8","volume":"17","author":"MJ Alves","year":"2017","unstructured":"Alves MJ, Figuer\u00eado RG, Azevedo FF, Cavallaro DA, Neto NIP, Lima JDC, Matos\u2010Neto E, Radloff K, Riccardi DM, Camargo RG et\u00a0al (2017) Adipose tissue fibrosis in human cancer cachexia: the role of TGF\u03b2 pathway. 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