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However, the molecular mechanisms underlying brain development defects induced by maternal alcohol consumption during pregnancy are unclear. We used normal and\n                    <jats:italic>Hsf2<\/jats:italic>\n                    \u2010deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure. Upon fetal alcohol exposure, HSF2 is essential for the triggering of HSF1 activation, which is accompanied by distinctive post\u2010translational modifications, and HSF2 steers the formation of atypical alcohol\u2010specific HSF1\u2013HSF2 heterocomplexes. This perturbs the\n                    <jats:italic>in vivo<\/jats:italic>\n                    binding of HSF2 to heat shock elements (HSEs) in genes that control neuronal migration in normal conditions, such as\n                    <jats:italic>p35<\/jats:italic>\n                    or the\n                    <jats:italic>MAPs<\/jats:italic>\n                    (microtubule\u2010associated proteins\n                    <jats:italic>, such as Dclk1<\/jats:italic>\n                    and\n                    <jats:italic>Dcx<\/jats:italic>\n                    ), and alters their expression. In the absence of HSF2, migration defects as well as alterations in gene expression are reduced. Thus, HSF2, as a sensor for alcohol stress in the fetal brain, acts as a mediator of the neuronal migration defects associated with FASD.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201303311","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:03:58Z","timestamp":1405469038000},"page":"1043-1061","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Heat shock factor 2 is a stress\u2010responsive mediator of neuronal migration defects in models of fetal alcohol syndrome"],"prefix":"10.1038","volume":"6","author":[{"given":"Rachid","family":"El Fatimy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Miozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Le Mou\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryma","family":"Abane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Schwendimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9lara","family":"Sab\u00e9ran\u2010Djoneidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"de Thonel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illiasse","family":"Massaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Paslaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Hashimoto\u2010Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Christians","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasko","family":"Rakic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gressens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"BFEMMM201303311_CR1","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1111\/j.1742-4658.2010.07830.x","volume":"277","author":"R Abane","year":"2010","unstructured":"Abane R, Mezger V (2010) Novel aspects of heat shock factors: roles in gametogenesis and development. 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