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Here, we investigated the contribution of Langerhans cells (LCs) and plasmacytoid DCs (pDCs) in psoriasis. In human psoriatic lesions and in a psoriasis mouse model (DKO* mice), LCs are severely reduced, whereas pDCs are increased. Depletion of pDCs in DKO* mice prior to psoriasis induction resulted in a milder phenotype, whereas depletion during active disease had no effect. In contrast, while depletion of Langerin\u2010expressing APCs before disease onset had no effect, depletion from diseased mice aggravated psoriasis symptoms. Disease aggravation was due to the absence of LCs, but not other Langerin\u2010expressing APCs. LCs derived from DKO* mice produced increased IL\u201010 levels, suggesting an immunosuppressive function. Moreover, IL\u201023 production was high in psoriatic mice and further increased in the absence of LCs. Conversely, pDC depletion resulted in reduced IL\u201023 production, and therapeutic inhibition of IL\u201023R signaling ameliorated disease symptoms. Therefore, LCs have an anti\u2010inflammatory role during active psoriatic disease, while pDCs exert an instigatory function during disease initiation.<\/jats:p>","DOI":"10.15252\/emmm.201404114","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T01:48:41Z","timestamp":1410572921000},"page":"1312-1327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Specific roles for dendritic cell subsets during initiation and progression of psoriasis"],"prefix":"10.1038","volume":"6","author":[{"given":"Elisabeth","family":"Glitzner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Korosec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Drobits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Amberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia B","family":"Schonthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin F","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Holcmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"BFEMMM201404114_CR1","first-page":"288","volume":"38","author":"W Alexander","year":"2013","unstructured":"Alexander W (2013) American academy of dermatology cardiovascular research technologies 2013 american college of cardiology. 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